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Elucidation of the molecular basis of the circannual clock

Research Project

Project/Area Number 20K20459
Project/Area Number (Other) 19H05546 (2019)
Research Category

Grant-in-Aid for Challenging Research (Pioneering)

Allocation TypeMulti-year Fund (2020)
Single-year Grants (2019)
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionNagoya University

Principal Investigator

YOSHIMURA Takashi  名古屋大学, 生命農学研究科(WPI), 教授 (40291413)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2023: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2022: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords概年時計 / メダカ
Outline of Research at the Start

温暖化や気候変動により、生態系、生物多様性、農業などに影響が生じている。そのため、生物の環境適応機構の解明は世界的に緊急に取り組むべき重要課題と位置付けられている。生物の体内には約1年周期のリズムを刻む「概年時計」が存在し、遺伝することも知られているが、1年という長い周期のリズムを刻む分子基盤の解明は進んでいない。洗練された季節応答を示すメダカを屋外の自然条件下で飼育し、得られた2年間の時系列試料についてRNA-seq解析を行い、様々な遺伝子が年周リズムを刻むことを見出した。本研究ではこの膨大なRNA-seqデータを基盤として、概年時計の分子基盤を解明する。

Outline of Final Research Achievements

Circannual rhythms are approximately 1-year biological rhythms driven by the endogenous circannual clock and determines the timings of reproduction, hibernation and migration.
Although the molecular mechanisms of approximately 1-day circadian clocks are well understood, the mechanisms underlying long-term circannual clock is a challenging and unresolved mystery. In this study, we showed the existence of endogenous circannual rhythms in medaka, and we have also identified the transcriptional program underlying the circannual rhythm.

Academic Significance and Societal Importance of the Research Achievements

地球規模の温暖化や気候変動により、植物の開花や動物の冬眠、渡り、繁殖などの時期にズレが生じており、全球レベルで種間の様々な相互作用に影響が生じている。既に生態系、生物多様性、ならびに農業に様々な影響が生じていることから、生物の環境適応機構の解明は世界的に緊急に取り組むべき重要課題と位置付けられている。1年という長い周期の生命現象の分子基盤の解明は極めて挑戦的なテーマであるため、ほとんど手付かずであったが、本研究ではこれに関与する転写プログラムを明らかにした。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Annual Research Report
  • Research Products

    (60 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (7 results) Journal Article (16 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Open Access: 15 results) Presentation (35 results) (of which Int'l Joint Research: 15 results,  Invited: 35 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Uppsala University(スウェーデン)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] マンチェスター大学(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] シカゴ大学(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] マンチェスター大学(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ウプサラ大学(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] シカゴ大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] マンチェスター大学(英国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A transcriptional program underlying the circannual rhythms of gonadal development in medaka2023

    • Author(s)
      Nakayama Tomoya、Tanikawa Miki、Okushi Yuki、Itoh Thoma、Shimmura Tsuyoshi、Maruyama Michiyo、Yamaguchi Taiki、Matsumiya Akiko、Shinomiya Ai、Guh Ying-Jey、Chen Junfeng、Naruse Kiyoshi、Kudoh Hiroshi、Kondo Yohei、Naoki Honda、Aoki Kazuhiro、Nagano Atsushi J.、Yoshimura Takashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 52 Pages: 120-120

    • DOI

      10.1073/pnas.2313514120

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Variation in responses to photoperiods and temperatures in Japanese medaka from different latitudes2023

    • Author(s)
      Shinomiya A, Adachi D, Shimmura T, Tanikawa M, Hiramatsu N, Shigeho I, Naruse K, Sakaizumi M, Yoshimura T
    • Journal Title

      Zoological Letters

      Volume: 9 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s40851-023-00215-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orphan nuclear receptor nr4a1 regulates winter depression-like behavior in medaka2023

    • Author(s)
      Nakayama Tomoya、Hirano Fuka、Okushi Yuki、Matsuura Kosuke、Ohashi Miki、Matsumiya Akiko、Yoshimura Takashi
    • Journal Title

      Neuroscience Letters

      Volume: 814 Pages: 137469-137469

    • DOI

      10.1016/j.neulet.2023.137469

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mimicking seasonal changes in light-dark cycle and ambient temperature modulates gut microbiome in mice under the same dietary regimen2023

    • Author(s)
      Matsumoto Shoko、Ren Liang、Iigo Masayuki、Murai Atsushi、Yoshimura Takashi
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 2 Pages: e0278013-e0278013

    • DOI

      10.1371/journal.pone.0278013

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel hypnotics of Japanese traditional herbal medicines to caffeine-induced insomnia in Drosophila by using Newly-developed automated sleep and rhythm analysis system (AutoCircaS)2022

    • Author(s)
      Inoue Eiji、Suzuki Takahiro、Nakayama Tomoya、Yoshimura Takashi、Sudo Keiichi、Shimizu Yasuharu、Iwaki Yoshikazu、Kawasaki Haruhisa、Ishida Norio
    • Journal Title

      Gene

      Volume: 846 Pages: 146852-146852

    • DOI

      10.1016/j.gene.2022.146852

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 synchronizes lunar-regulated beach spawning in grass puffers2022

    • Author(s)
      Chen Junfeng、Katada Yuma、Okimura Kousuke、Yamaguchi Taiki、Guh Ying-Jey、Nakayama Tomoya、Maruyama Michiyo、Furukawa Yuko、Nakane Yusuke、Yamamoto Naoyuki、Sato Yoshikatsu、Ando Hironori、Sugimura Asako、Tabata Kazufumi、Sato Ayato、Yoshimura Takashi
    • Journal Title

      Current Biology

      Volume: 32 Issue: 22 Pages: 4881-4889

    • DOI

      10.1016/j.cub.2022.09.062

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real time monitoring of cold Ca2+ dependent transcription and its modulation by NCX inhibitors2022

    • Author(s)
      Wang Hsin-tzu、Miyairi Shiori、Kitamura Miho、Iizuka Kosuke、Asano Yoshimasa、Yoshimura Takashi、Kon Naohiro
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17325-17325

    • DOI

      10.1038/s41598-022-22166-4

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Level of constitutively expressed BMAL1 affects the robustness of circadian oscillations2022

    • Author(s)
      Padlom Apirada、Ono Daisuke、Hamashima Rio、Furukawa Yuko、Yoshimura Takashi、Nishiwaki-Ohkawa Taeko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19519-19519

    • DOI

      10.1038/s41598-022-24188-4

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adenylate kinase 1 overexpression increases locomotor activity in medaka fish2022

    • Author(s)
      Maruyama Michiyo、Furukawa Yuko、Kinoshita Masato、Mukaiyama Atsushi、Akiyama Shuji、Yoshimura Takashi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 1 Pages: e0257967-e0257967

    • DOI

      10.1371/journal.pone.0257967

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine2021

    • Author(s)
      Zhang M, Kobayashi K, Atsumi H, Katada Y, Nakane Y, Chen J, Nagano R, Kadofusa N, Nishiwaki-Ohkawa T, Kon N, Hirota T, Sato A, Makino T, Yoshimura T
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 21038-21038

    • DOI

      10.1038/s41598-021-00499-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish2021

    • Author(s)
      Iida M, Nakane Y, Yoshimura T, Hirota T
    • Journal Title

      The Journal of Biochemistry

      Volume: Sep Issue: 5 Pages: 501-507

    • DOI

      10.1093/jb/mvab096

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ケミカルゲノミクスで明らかにするメダカの冬季うつ様行動の分子基盤:冬季うつ病の理解と克服にむけて2021

    • Author(s)
      沖村光祐,中山友哉,吉村崇
    • Journal Title

      化学と生物

      Volume: 59 Pages: 369-376

    • NAID

      40022666131

    • Related Report
      2021 Research-status Report
  • [Journal Article] Light and Hormones in Seasonal Regulation of Reproduction and Mood2020

    • Author(s)
      Chen Junfeng、Okimura Kousuke、Yoshimura Takashi
    • Journal Title

      Endocrinology

      Volume: 161 Issue: 9 Pages: 1-8

    • DOI

      10.1210/endocr/bqaa130

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior2020

    • Author(s)
      Nakayama T, Okimura K, Shen J, Guh Y-J, Tamai K, Shimada A, Minou S, Okushi Y, Shimmura T, Furukawa Y, Kadofusa N, Sato A, Nishimura T, Tanaka M, Nakayama K, Shiina N, Yamamoto N, Loudon A.S, Nishiwaki-Ohkawa T, Shinomiya A, Nabeshima T, Nakane Y, and Yoshimura T
    • Journal Title

      PNAS

      Volume: - Issue: 17 Pages: 1-10

    • DOI

      10.1073/pnas.2000278117

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The underlying mechanisms of vertebrate seasonal reproduction2019

    • Author(s)
      GUH Ying-Jey、TAMAI Takako K、YOSHIMURA Takashi
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 95 Issue: 7 Pages: 343-357

    • DOI

      10.2183/pjab.95.025

    • NAID

      130007689022

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2019-07-31
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interconnection between circadian clocks and thyroid function2019

    • Author(s)
      Ikegami Keisuke、Refetoff Samuel、Van Cauter Eve、Yoshimura Takashi
    • Journal Title

      Nature Reviews Endocrinology

      Volume: 15 Issue: 10 Pages: 590-600

    • DOI

      10.1038/s41574-019-0237-z

    • NAID

      120006775102

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Understanding underlying mechanisms of infradian rhythms2023

    • Author(s)
      Yoshimura T
    • Organizer
      The 10th Congress of Asian Sleep Research Society and Asian Forum of Chronobiology
    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Photoperiod and seasonal reproduction2023

    • Author(s)
      Yoshimura T
    • Organizer
      InSC School in Chronobiology 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 月のリズムと季節のリズムの分子基盤2023

    • Author(s)
      吉村崇
    • Organizer
      下垂体研究会第37回学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 脊椎動物の概年リズムの分子基盤2023

    • Author(s)
      吉村崇
    • Organizer
      日本睡眠学会第45回定期学術集会第30回日本時間生物学会学術大会合同大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 脊椎動物の概年時計の分子機構2023

    • Author(s)
      吉村崇
    • Organizer
      2023年度生理学研究所研究会「極限環境適応」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Molecular basis of the circannual clock2023

    • Author(s)
      Yoshimura T
    • Organizer
      The 61st Annual Meetings of the Biophysical Society of Japan
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Understanding the mystery of biological clocks: Learning from unique animals to contribute for food production and human health2023

    • Author(s)
      Yoshimura T
    • Organizer
      JAACT2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ユニークな動物から明らかになった驚きの季節適応戦略2023

    • Author(s)
      吉村崇
    • Organizer
      第47回鳥類内分泌研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 自然条件下の魚類と哺乳類からみえてきた脊椎動物の季節適応機構2023

    • Author(s)
      吉村崇
    • Organizer
      日本比較生理生化学会第45回大阪大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Towards understanding the mystery of biological clocks: an interdisciplinary approach2022

    • Author(s)
      Yoshimura T
    • Organizer
      iCeMS Retreat
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Towards understanding molecular mechanisms of infradian rhythms2022

    • Author(s)
      Yoshimura T
    • Organizer
      19th International Conference on Retinal Proteins
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] クサフグが大潮に一斉集団産卵する仕組み2022

    • Author(s)
      吉村崇
    • Organizer
      極限環境研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 季節繁殖の分子機構~鍵分子同定までの道のりとその後の展開2022

    • Author(s)
      吉村崇
    • Organizer
      第29回日本時間生物学会学術大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Understanding infradian rhythms by multi-omics approach2022

    • Author(s)
      Yoshimura T
    • Organizer
      2nd International RMBPD Colloquium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular basis of vertebrate infradian rhythms2022

    • Author(s)
      Yoshimura T
    • Organizer
      EMBO | EMBL Symposium: Biological oscillators: design, mechanism, function
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アカゲザル全身組織の遺伝子発現地図から明らかにする動物の季節適応戦略2022

    • Author(s)
      吉村崇
    • Organizer
      第50回ホミニゼーション研究会「人類進化と遺伝子」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 脊椎動物の季節適応機構:鳥類、魚類、霊長類をモデルとした比較生物学的アプローチ2021

    • Author(s)
      吉村崇
    • Organizer
      第68回日本実験動物学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 冬季のうつ様行動の分子機構理解に向けて2021

    • Author(s)
      吉村崇
    • Organizer
      第43回日本生物学的精神医学会・日本神経精神薬理学会合同年会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Seasonal regulation of depression-like behavior2021

    • Author(s)
      Yoshimura T
    • Organizer
      5th Asian Forum on Chronobiology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards understanding molecular mechanisms of infradian rhythms2021

    • Author(s)
      Yoshimura T
    • Organizer
      The 18th Sapporo Symposium on Biological Rhythm
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] メダカ、ウズラ、マウス、アカゲザルに学ぶ動物の季節適応の仕組み2021

    • Author(s)
      吉村崇
    • Organizer
      第35回日本下垂体研究会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Molecular basis of vertebrate seasonal adaptation2021

    • Author(s)
      Yoshimura T
    • Organizer
      The 27th Japan Medaka and Zebrafish Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脊椎動物の季節適応機構の解明2021

    • Author(s)
      吉村崇
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 季節や月のリズムと動物の環境適応戦略2021

    • Author(s)
      吉村崇
    • Organizer
      2021年度生理学研究所研究会「極限環境適応」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 脊椎動物の季節適応戦略2021

    • Author(s)
      吉村崇
    • Organizer
      第28回日本時間生物学会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 比較生物学から迫る脊椎動物の季節適応機構2021

    • Author(s)
      吉村崇
    • Organizer
      第68回日本生態学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Seasonal clock: Towards the understanding of human seasonal clocks2020

    • Author(s)
      Yoshimura T
    • Organizer
      The 12th Sleep Respiration Forum online from Barcelona
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 冬季のうつ様行動の分子基盤の解明に向けて:春告げホルモンTSHの発見のその後2020

    • Author(s)
      吉村崇
    • Organizer
      63回日本甲状腺学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 脊椎動物の季節適応機構2020

    • Author(s)
      吉村崇
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Molecular and neuroendocrine mechanism of vertebrate seasonal reproduction2019

    • Author(s)
      Yoshimura T
    • Organizer
      SAGE Pre V WCC Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular basis of seasonal changes in behavior2019

    • Author(s)
      Yoshimura T
    • Organizer
      V World Congress of Chronobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding molecular basis of seasonal changes in behavior2019

    • Author(s)
      Yoshimura T
    • Organizer
      European Congress for Endocrinology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular basis of seasonal changes in behavior in medaka2019

    • Author(s)
      Yoshimura T
    • Organizer
      The 10th International Congress of Comparative Physiology and Biochemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular basis of seasonal changes in behavior2019

    • Author(s)
      Yoshimura T
    • Organizer
      XVI Congress of the European Biological Rhythms Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脊椎動物の行動の季節変化の分子基盤の解明に向けて2019

    • Author(s)
      吉村崇
    • Organizer
      日本動物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] Circadian Clocks, Neuromethods2022

    • Author(s)
      Nakayama T, Okubo K, Ansai S, Yoshimura T
    • Total Pages
      429
    • Publisher
      Humana Press
    • ISBN
      9781071625774
    • Related Report
      2022 Research-status Report
  • [Remarks] 1年のリズムを刻む概年遺伝子を発見

    • URL

      https://www.itbm.nagoya-u.ac.jp/ja/research/2023/12/post-67.php

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2019-07-04   Modified: 2025-01-30  

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