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Research on self-assembly systems that interweave form and softness

Research Project

Project/Area Number 20K20979
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 20:Mechanical dynamics, robotics, and related fields
Research InstitutionTohoku University

Principal Investigator

Murata Satoshi  東北大学, 工学研究科, 教授 (10334533)

Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsセルフアセンブリ / かたち / やわらかさ / メゾスケール / 分子モジュール
Outline of Research at the Start

本研究の目的は,かたち・結合性・やわらかさを自在に設定することができる人工分子モジュールを用いて,大規模な分子集合体をつくる技術を開発することである.これらの特性を自由に設定することのできる分子モジュール群を作製し,望みの形状をもつネットワークの自己組織的な組み立て(セルフアセンブリ)に取り組む.こうした均質かつ大量の分子モジュールにさまざまな条件を自在に設定してアセンブル実験を行うことにより,メゾスケールのセルフアセンブリシステムに関する新しいモデルや理論を得ることを目指す.

Outline of Final Research Achievements

In this study, we aimed to develop a technique to create large-scale molecular structures by assembling artificial molecular modules whose shape, connectivity, and softness can be freely configured. A heptagonal ring-shaped modules and a 3 × 3 lattice-shaped modules were designed using the DNA origami method, and self-assembly experiments were conducted for each of them. The obtained nanostructures were evaluated using atomic force microscopy and other techniques.

Academic Significance and Societal Importance of the Research Achievements

多様な特性を持つ分子モジュールを設計し,さまざまな条件でそれらをセルフアセンブルする実験により,メゾスケールのセルフアセンブリ過程の構成論的理解が進めば,そこから分子システムの構築に関する新しいモデルや理論が得られることが期待される.こうした分子システムの構築に関する方法論は,さまざまな機能をもつ精密なナノ構造体を簡便かつ大量生産する技術につながる.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (11 results)

All 2023 2022 2021 2020

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Multi-Reconfigurable DNA Origami Nanolattice Driven by the Combination of Orthogonal Signals2023

    • Author(s)
      Kotaro Watanabe, Ibuki Kawamata, Satoshi Murata, Yuki Suzuki
    • Journal Title

      JACS Au

      Volume: To appear Issue: 5 Pages: 1-8

    • DOI

      10.1021/jacsau.3c00091

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Self-replication and Mutation of Polymeric Molecules Simulated by Simplified Chemistry2022

    • Author(s)
      Mori Taisei、Kawamata Ibuki、Murata Satoshi
    • Journal Title

      14th International Workshop on Parallel and Distributed Algorithms and Applications (PDAA)

      Volume: - Pages: 192-198

    • DOI

      10.1109/candarw57323.2022.00083

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA Ring Motif with Flexible Joints2020

    • Author(s)
      Liu Shiyun、Murata Satoshi、Kawamata Ibuki
    • Journal Title

      Micromachines

      Volume: 11 Issue: 11 Pages: 987-987

    • DOI

      10.3390/mi11110987

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Scalable design and construction of DNA truss structures2022

    • Author(s)
      Yudai Yamashita, Ibuki Kawamata and Satoshi Murata
    • Organizer
      Intl Conf. DNA Computing and Molecular Programming (DNA28)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconfigurable DNA Nanolattice Driven by DNA Signals2021

    • Author(s)
      Kotaro Watanabe, Ibuki Kawamata, Yuki Suzuki, Satoshi Murata
    • Organizer
      Intl Conf. on DNA Computing and Molecular Programming (DNA27)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 分子入力により多様に変形する格子状DNAオリガミ構造の設計と構築2021

    • Author(s)
      渡部光太郎,川又生吹,鈴木勇輝,村田智
    • Organizer
      第5回分子ロボティクス年次大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Construction of Reconfigurable DNA Nanolattice Responding to Signal DNAs2021

    • Author(s)
      Kotaro Watanabe, Ibuki Kawamata, Yuki Suzuki, Satoshi Murata
    • Organizer
      International Symposium on Nucleic Acid Chemistry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Self-assembly of a DNA Ring Motif with Programmable Flexibility and Connectivity2021

    • Author(s)
      Shiyun Liu, Satoshi Murata, Ibuki Kawamata
    • Organizer
      FNANO21
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Programmable Self-assembly of a Flexible DNA Ring Motif2020

    • Author(s)
      Shiyun Liu, Ibuki Kawamata, Satoshi Murata
    • Organizer
      DNA26
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Self-Assembly of Flexible DNA Ring Motif2020

    • Author(s)
      Shiyun Liu, Ibuki Kawamata, Satoshi Murata
    • Organizer
      第58回日本生物物理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] DNA Ring Motif with Flexible Joints2020

    • Author(s)
      Shiyun Liu, Satoshi Murata, Ibuki Kawamata
    • Organizer
      第4回分子2021クス年次大会
    • Related Report
      2020 Research-status Report

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Published: 2020-08-03   Modified: 2024-01-30  

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