• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mitochondrial inflammation and its mechanisms in the pathogenesis of chronic pain.

Research Project

Project/Area Number 20K21635
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

amaya fumimasa  京都府立医科大学, 医学(系)研究科(研究院), 教授 (60347466)

Co-Investigator(Kenkyū-buntansha) 中川 貴之  和歌山県立医科大学, 薬学部, 教授 (30303845)
大橋 憲太郎  岐阜大学, 工学部, 准教授 (50332953)
Project Period (FY) 2020-07-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsMitochondria / ミトコンドリア / 自然免疫 / 炎症性ミトコンドリア障害 / 痛覚過敏
Outline of Research at the Start

ミトコンドリアは正常な神経活動を維持するために重要な細胞内小器官である。ミトコンドリア機能が低下すると、Nod like receptor (NLR)を介して細胞内免疫反応が進行し、慢性疾患を引き起こす原因となる。われわれは、ミトコンドリア機能の低下が糖尿病性神経障害性疼痛の発症に関与すること、慢性痛モデルにおいてNLRの活性化が認められることを明らかにした。本研究では、ミトコンドリア機能の低下が細胞内免疫を活性化して慢性痛が生じる可能性を検討する。

Outline of Final Research Achievements

Intrathecal administration of the mitochondrial inhibitor antimycin to mice did not result in the development of hyperalgesia. Mitochondrial dysfunction and increased expression of cleaved IL-1beta in neurons were observed in the dorsal root ganglia of a mouse model of neuropathic pain. Similarly, increased expression of cleaved IL-1beta was observed in the mouse plantar incision model, where caspase-1, which cleaves IL-1beta, was also expressed in dorsal root ganglion neurons, and intrathecal administration of a caspase-1 inhibitor attenuated hyperalgesia in the plantar incision model.

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアは正常な神経活動を維持するために重要な細胞内小器官である。ミトコンドリア機能が低下すると、Nod like receptor (NLR)を介して細胞内免疫反応が進行し、慢性疾患を引き起こす原因となる。本研究は、知覚神経におけるミトコンドリア機能不全と炎症性サイトカインIL-1βの活性化が関連すること、IL-1βの活性化が術後痛モデルや神経障害性疼痛モデルにおける痛覚過敏成立に関わることを明らかにした。この成果は神経炎症を標的とした新規治療法開発につながるという点において有意義である。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (16 results)

All 2024 2023 2022 2021 2020

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 4 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Post‐intensive care syndrome: Recent advances and future directions2024

    • Author(s)
      Inoue Shigeaki、Nakanishi Nobuto、Amaya Fumimasa、Fujinami Yoshihisa、Hatakeyama Junji、Hifumi Toru、Iida Yuki、Kawakami Daisuke、Kawai Yusuke、Kondo Yutaka、Liu Keibun、Nakamura Kensuke、Nishida Takeshi、Sumita Hidenori、Taito Shunsuke、Takaki Shunsuke、Tsuboi Norihiko、Unoki Takeshi、Yoshino Yasuyo、Nishida Osamu
    • Journal Title

      Acute Medicine & Surgery

      Volume: 11 Issue: 1 Pages: 929-929

    • DOI

      10.1002/ams2.929

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster‐associated pain: A placebo‐controlled randomized trial2023

    • Author(s)
      Iseki Masako、Yamamoto Takenobu、Ogawa Youichi、Majima Yuta、Abe Yoichiro、Watanabe Daisuke、Amaya Fumimasa、Hasegawa Toshio、Inafuku Kazuhiro、Kosugi Toshifumi、Nomura Yukiko、Deguchi Tokiko、Hamada Toshihisa、Shimizu Kenji、Arai Saori、Takahashi Morito、Hamada Izumi、Ishikawa Yuko、Kawashima Makoto
    • Journal Title

      The Journal of Dermatology

      Volume: 51 Issue: 2 Pages: 234-242

    • DOI

      10.1111/1346-8138.17054

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of wild-type and HSAN2B-linked FAM134B2023

    • Author(s)
      Kanamori Akane、Hinaga Shohei、Hirata Yoko、Amaya Fumimasa、Oh-hashi Kentaro
    • Journal Title

      Molecular Biology Reports

      Volume: 50 Issue: 7 Pages: 6005-6017

    • DOI

      10.1007/s11033-023-08517-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia2023

    • Author(s)
      Yamakita Shunsuke、Fujita Daisuke、Sudo Kazuki、Ishikawa Daiki、Kushimoto Kohsuke、Horii Yasuhiko、Amaya Fumimasa
    • Journal Title

      Molecular Pain

      Volume: 19 Pages: 1-16

    • DOI

      10.1177/17448069231181973

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of preoperative opioid usage and its impact on postoperative outcomes: a retrospective cohort study2023

    • Author(s)
      Oya Rina、Ogawa Satoru、Oya Kiyofumi、Hirakawa Yuka、Maeda Chika、Amaya Fumimasa
    • Journal Title

      Journal of Anesthesia

      Volume: 37 Issue: 4 Pages: 532-538

    • DOI

      10.1007/s00540-023-03198-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic Neuropathy and Rehabilitation Treatment2022

    • Author(s)
      Ueno Hiroshi、Kakita Mari、Amaya Fumimasa、Mikami Yasuo
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 59 Issue: 12 Pages: 1222-1230

    • DOI

      10.2490/jjrmc.59.1222

    • ISSN
      1881-3526, 1881-8560
    • Year and Date
      2022-12-18
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 別冊秋号 オピオイド PART1 臨床編 6 術前オピオイド使用患者の術後鎮痛2022

    • Author(s)
      大屋(堀江) 里奈、天谷 文昌
    • Journal Title

      LiSA 別冊

      Volume: 29 Issue: 2 Pages: 37-41

    • DOI

      10.11477/mf.3104200288

    • ISSN
      1344-932X
    • Year and Date
      2022-09-15
    • Related Report
      2022 Research-status Report
  • [Journal Article] Sedation, analgesia and withdrawal syndrome in critical care settings2022

    • Author(s)
      Amaya Fumimasa
    • Journal Title

      Journal of the Japanese Society of Intensive Care Medicine

      Volume: 29 Issue: 4 Pages: 269-270

    • DOI

      10.3918/jsicm.29_269

    • ISSN
      1340-7988, 1882-966X
    • Year and Date
      2022-07-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 末梢神経-Current Concept in 2022 Ⅹ.最近の話題 神経障害性疼痛のメカニズムと治療における最近のトピックス2022

    • Author(s)
      谷口 彩乃、天谷 文昌
    • Journal Title

      整形・災害外科

      Volume: 65 Issue: 5 Pages: 715-723

    • DOI

      10.18888/se.0000002144

    • ISSN
      0387-4095
    • Year and Date
      2022-04-30
    • Related Report
      2022 Research-status Report
  • [Journal Article] A case of hypertension requiring differentiation from pheochromocytoma during treatment with duloxetine2022

    • Author(s)
      松岡 豊、天谷 文昌
    • Journal Title

      Journal of Japan Society of Pain Clinicians

      Volume: 29 Issue: 3 Pages: 27-30

    • DOI

      10.11321/jjspc.21-0018

    • ISSN
      1340-4903, 1884-1791
    • Year and Date
      2022-03-25
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Localization of Chronic Pain in Postmastectomy Patients2022

    • Author(s)
      Shiraishi Makoto、Sowa Yoshihiro、Kodama Takuya、Numajiri Toshiaki、Taguchi Tetsuya、Amaya Fumimasa
    • Journal Title

      Annals of Plastic Surgery

      Volume: 88 Issue: 5 Pages: 490-495

    • DOI

      10.1097/sap.0000000000003146

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparison of the ClotPro system with rotational thromboelastometry in cardiac surgery: a prospective observational study2022

    • Author(s)
      Yoshii Ryogo、Sawa Teiji、Kawajiri Hidetake、Amaya Fumimasa、Tanaka Kenichi A.、Ogawa Satoru
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17269-17269

    • DOI

      10.1038/s41598-022-22119-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IGF1-driven induction of GPCR kinase 2 in the primary afferent neuron promotes resolution of acute hyperalgesia2021

    • Author(s)
      Takemura Hitomi、Kushimoto Kohsuke、Horii Yasuhiko、Fujita Daisuke、Matsuda Megumi、Sawa Teiji、Amaya Fumimasa
    • Journal Title

      Brain Research Bulletin

      Volume: 177 Pages: 305-315

    • DOI

      10.1016/j.brainresbull.2021.10.011

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spinal and Peripheral Mechanisms Individually Lead to the Development of Remifentanil-induced Hyperalgesia2020

    • Author(s)
      Horii Yasuhiko、Matsuda Megumi、Takemura Hitomi、Ishikawa Daiki、Sawa Teiji、Amaya Fumimasa
    • Journal Title

      Neuroscience

      Volume: 446 Pages: 28-42

    • DOI

      10.1016/j.neuroscience.2020.08.014

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 若手研究者から痛み治療への提言 オピオイド痛覚過敏の末梢メカニズム(後根神経節)2021

    • Author(s)
      山北 俊介 天谷 文昌
    • Organizer
      日本ペインクリニック学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 慢性痛の末梢神経における発生メカニズム2021

    • Author(s)
      天谷 文昌
    • Organizer
      日本ペインクリニック学会
    • Related Report
      2021 Research-status Report
    • Invited

URL: 

Published: 2020-08-03   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi