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Identification and characterization of novel microRNAs secreted from muscle

Research Project

Project/Area Number 20K21753
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionNagoya University

Principal Investigator

Ouchi Noriyuki  名古屋大学, 医学系研究科, 特任教授 (00595514)

Co-Investigator(Kenkyū-buntansha) 大橋 浩二  名古屋大学, 医学系研究科, 特任准教授 (10595515)
竹藤 幹人  名古屋大学, 医学部附属病院, 講師 (20709117)
Project Period (FY) 2020-07-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords持久性運動 / microRNA / 心腎血管疾患 / 運動 / 骨格筋
Outline of Research at the Start

本研究では、持久性運動により調節を受ける骨格筋由来の分泌型microRNAのスクリーニングを行い、心血管病あるいは腎臓病に対して作用を有する骨格筋由来分泌型microRNAの同定を試みる。そして、本研究で明らかとなる骨格筋由来分泌型microRNAの機能解析を行うことで、運動療法による心腎血管保護作用の機序解明と心血管病や腎臓病の病態解明と創薬開発につなげる。

Outline of Final Research Achievements

We found that miR185 acts as an exercise-inducible muscle-derived secretory microRNA “myomiRNA” in mice after screening of myomiRNAs which are upregulated in skeletal muscle by treadmill exercise training. Systemic delivery of miR185 mimic significantly reduced renal fibrosis in a mouse model of unilateral ureteral obstruction. Furthermore, miR185 suppressed expression of fibrotic markers in renal proximal tubular epithelial cells. Thus, miR185 may be a reno-protecitve secretory myomiRNA induced by endurance exercise.

Academic Significance and Societal Importance of the Research Achievements

本研究では、持久性運動により誘発され、腎臓保護作用を示す新たな骨格筋由来分泌型microRNAが明らかとなった。本研究は慢性腎臓病の病態解明につながる可能性があるだけではなく、この骨格筋由来分泌型microRNAは腎臓以外の臓器に対する作用を示す可能性もあり、学術的意義は高いと考えられる。また、この骨格筋由来分泌型microRNAは運動による腎臓保護作用にも関わるため、運動すれば何故健康に有益なのか?という疑問に対する解決の糸口になり得る可能性があり、社会的意義は高いと考えられる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (18 results)

All 2023 2022 2021 2020

All Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (7 results) (of which Invited: 4 results)

  • [Journal Article] Omentin Modulates Chronic Cardiac Remodeling After Myocardial Infarction2023

    • Author(s)
      Ito M, Shibata R, Ohashi K, Otaka N, Yamaguchi S, Ogawa H, Enomoto T, Masutomi T, Murohara T, Ouchi N.
    • Journal Title

      Circulation Reports

      Volume: 5 Issue: 2 Pages: 46-54

    • DOI

      10.1253/circrep.CR-22-0079

    • ISSN
      2434-0790
    • Year and Date
      2023-02-10
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina2022

    • Author(s)
      Inooka Daiki、Omori Yoshihiro、Ouchi Noriyuki、Ohashi Koji、Kawakami Yuto、Koyanagi Yoshito、Koike Chieko、Terasaki Hiroko、Nishiguchi Koji M.、Ueno Shinji
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 63 Issue: 5 Pages: 14-14

    • DOI

      10.1167/iovs.63.5.14

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy2022

    • Author(s)
      Ozaki Yuta、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Kawanishi Hiroshi、Takikawa Tomonobu、Fang Lixin、Tatsumi Minako、Takefuji Mikito、Enomoto Takashi、Darwish Mohamed、Iijima Yoko、Iijima Takatoshi、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 593 Pages: 5-12

    • DOI

      10.1016/j.bbrc.2022.01.028

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial‐mesenchymal transition and inflammatory response2022

    • Author(s)
      Fang Lixin、Ohashi Koji、Ogawa Hayato、Otaka Naoya、Kawanishi Hiroshi、Takikawa Tomonobu、Ozaki Yuta、Takahara Kunihiko、Tatsumi Minako、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Physiological Reports

      Volume: 10 Issue: 5

    • DOI

      10.14814/phy2.15218

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice2021

    • Author(s)
      Fang Lixin、Ohashi Koji、Otaka Naoya、Ogawa Hayato、Hiramatsu-Ito Mizuho、Kawanishi Hiroshi、Bando Yasuko K、Shibata Rei、Shimizu Yuuki、Kato Katsuhiro、Takikawa Tomonobu、Ozaki Yuta、Takefuji Mikito、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Cardiovascular Research

      Volume: ー Issue: 6 Pages: 1597-1610

    • DOI

      10.1093/cvr/cvab179

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Important Role of Concomitant Lymphangiogenesis for Reparative Angiogenesis in Hindlimb Ischemia.2021

    • Author(s)
      Pu Z, Shimizu Y, Tsuzuki K, Suzuki J, Hayashida R, Kondo K, Fujikawa Y, Unno K, Ohashi K, Takefuji M, Bando YK, Ouchi N, Calvert JW, Shibata R, Murohara T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: - Issue: 6 Pages: 2006-2018

    • DOI

      10.1161/atvbaha.121.316191

    • NAID

      120007178394

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic impact of transcardiac gradient of follistatin-like 1 reflecting hemodynamics in patients with dilated cardiomyopathy2021

    • Author(s)
      Oishi Hideo、Okumura Takahiro、Ohashi Koji、Kimura Yuki、Kazama Shingo、Shibata Naoki、Arao Yoshihito、Kato Hiroo、Kuwayama Tasuku、Yamaguchi Shogo、Tatsumi Minako、Kondo Toru、Hiraiwa Hiroaki、Morimoto Ryota、Takefuji Mikito、Ouchi Noriyuki、Murohara Toyoaki
    • Journal Title

      Journal of Cardiology

      Volume: 78 Issue: 6 Pages: 524-532

    • DOI

      10.1016/j.jjcc.2021.07.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia2021

    • Author(s)
      Tsuzuki Kazuhito、Shimizu Yuuki、Suzuki Junya、Pu Zhongyue、Yamaguchi Shukuro、Fujikawa Yusuke、Kato Katsuhiro、Ohashi Koji、Takefuji Mikito、Bando Yasuko K.、Ouchi Noriyuki、Calvert John W.、Shibata Rei、Murohara Toyoaki
    • Journal Title

      Journal of the American Heart Association

      Volume: 10 Issue: 16

    • DOI

      10.1161/jaha.121.020896

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.2020

    • Author(s)
      Kawanishi H, Ohashi K, Ogawa H, Otaka N, Takikawa T, Fang L, Ozaki Y, Takefuji M, Murohara T, Ouchi N.
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 6 Pages: e0235362-e0235362

    • DOI

      10.1371/journal.pone.0235362

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] C1q/TNF-Related Protein 9 Promotes Revascularization in Response to Ischemia via an eNOS-Dependent Manner2020

    • Author(s)
      Yamaguchi Shukuro、Shibata Rei、Ohashi Koji、Enomoto Takashi、Ogawa Hayato、Otaka Naoya、Hiramatsu-Ito Mizuho、Masutomi Tomohiro、Kawanishi Hiroshi、Murohara Toyoaki、Ouchi Noriyuki
    • Journal Title

      Frontiers in Pharmacology

      Volume: 11 Pages: 1313-1313

    • DOI

      10.3389/fphar.2020.01313

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction.2020

    • Author(s)
      Takikawa T, Ohashi K, Ogawa H, Otaka N, Kawanishi H, Fang L, Ozaki Y, Eguchi S, Tatsumi M, Takefuji M, Murohara T, Ouchi N.
    • Journal Title

      PLoS One.

      Volume: 15 Issue: 12 Pages: e0243483-e0243483

    • DOI

      10.1371/journal.pone.0243483

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨格筋由来分泌因子「マイオカイン」と加齢性疾患2022

    • Author(s)
      大内乗有
    • Organizer
      第43回日本基礎老化学会シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 運動誘発性マイオカインの心血管病における役割2021

    • Author(s)
      大内乗有
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 運動誘発性マイオカインと心血管病2021

    • Author(s)
      大内乗有
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] アディポサイトカインと心血管病2021

    • Author(s)
      大内乗有 大橋浩二 室原豊明
    • Organizer
      第58回日本臨床生理学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Role of a novel anti-inflammatory adipokine adipolin in cardiovascular and metabolic regulation.2020

    • Author(s)
      Koji Ohashi, Noriyuki Ouchi, Hayato Ogawa, Toyoaki Murohara
    • Organizer
      第84回日本循環器学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗炎症性アディポサイトカイン「アディポリン」と心血管病2020

    • Author(s)
      大内乗有 大橋浩二 室原豊明
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 運動誘発性マイオカイン「マイオネクチン」の虚血性心疾患における役割2020

    • Author(s)
      大内乗有 大橋浩二 室原豊明
    • Organizer
      第26回日本心臓リハビリテーション学会学術集会
    • Related Report
      2020 Research-status Report

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Published: 2020-08-03   Modified: 2024-01-30  

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