In-depth Analysis of Proteasome-Mediated Regulatory Proteolysis

• Project/Area Number: 21000012
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: TANAKA Keiji 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 所長 (10108871)
• Co-Investigator(Kenkyū-buntansha): MURATA Shigeo 東京大学, 大学院・薬学系研究科, 教授 (20344070)
• Project Period (FY): 2009 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥643,500,000 (Direct Cost: ¥495,000,000、Indirect Cost: ¥148,500,000); Fiscal Year 2013: ¥157,950,000 (Direct Cost: ¥121,500,000、Indirect Cost: ¥36,450,000); Fiscal Year 2012: ¥157,950,000 (Direct Cost: ¥121,500,000、Indirect Cost: ¥36,450,000); Fiscal Year 2011: ¥163,800,000 (Direct Cost: ¥126,000,000、Indirect Cost: ¥37,800,000); Fiscal Year 2010: ¥163,800,000 (Direct Cost: ¥126,000,000、Indirect Cost: ¥37,800,000)
• Keywords: 蛋白質 / バイオテクノロジー / 酵素 / 脳神経疾患 / 免疫学 / プロテオーム / proteasome / ubiquitin / autophagy

Research Abstract

Over the past 25 years, our research work focused on elucidating comprehensively the structure and molecular/physiological functions of the proteasome, a 2.5-MDa sophisticated multisubunit protease complex. During this program, we have studied spatio-temporal dynamics and action mechanisms such as nuclear translocation and identification of ubiquitin receptors, in-depth mechanisms underling proteasome assembly by identifying as multiple proteasome-dedicated chaperones, and the immunological roles of the newly-discovered thymoproteasome that govern positive selection of CD8+ T cells in the thymus. In addition, we also conducted not only ubiquitin study; i.e., quality-control of mitochondria by the PINK1/Parkin pathway, but also autophagy study involving a novel Nrf2-dependent stress-regulated system by p62, an autophagy selective substrate.

Assessment Rating

Verification Result (Rating)

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Research Products

• [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin (2014)
  • Author(s): Koyano,F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E.A., Trempe, J.F., Saeki, Y., Tanaka, K., and Matsuda, N.
  • Journal Title: Nature Volume: 510 Pages: 162-166
  • Peer Reviewed
• [Journal Article] Quantitative live-cell imagingreveals moleculardynamics andcytoplasmic assembly ofthe 26Sproteasome (2014)
  • Author(s): Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo,T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y.
  • Journal Title: Nat Commun. Volume: 2014
  • Peer Reviewed
• [Journal Article] Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas2 (2014)
  • Author(s): Satoh T, Saeki Y, Hiromoto T, Wang YH, Uekusa Y, Yagi H, Yoshihara H, Yagi-Utsumi M, Mizushima T, Tanaka K, Kato K
  • Journal Title: Structure Volume: (掲載確定) Issue: 5 Pages: 731-743
  • DOI: 10.1016/j.str.2014.02.014
  • Peer Reviewed
• [Journal Article] Ubiquitin is phosphorylated by PINK1 to activate parkin. (2014)
  • Author(s): Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon. E. A., Trempe, J. F., Saeki, Y., Tanaka, K., and Matsuda, N.
  • Journal Title: Nature Volume: 510(in press) Issue: 7503 Pages: 162-166
  • DOI: 10.1038/nature13392
  • Peer Reviewed
• [Journal Article] Quantitative live-cell imaging reveals spatiotemporal dynamics and cytoplasmic assembly of the 26S proteasome (2014)
  • Author(s): Pack, Chan-Gi., Yukii, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y
  • Journal Title: Nat Commun. Volume: 5
  • Peer Reviewed
• [Journal Article] Dissection of the role of p62/Sqstml in activation of Nrf2 during xenophagy. (2014)
  • Author(s): Ishimura, R., Tanaka, K., and Komatsu, M.
  • Journal Title: FEBS Lett. Volume: 588 Issue: 5 Pages: 822-828
  • DOI: 10.1016/j.febslet.2014.01.045
  • Peer Reviewed
• [Journal Article] Involvement of Bag6 and theTRC pathwayin proteasome assembly (2013)
  • Author(s): Akahane, T., Sahara, K., Yashiroda, H., Tanaka, K., andMurata, S.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 2234-2234
  • DOI: 10.1038/ncomms3234
  • Peer Reviewed
• [Journal Article] Phosphorylation ofp62 activatesthe Keap1-Nrf2 pathway duringselective autophagy (2013)
  • Author(s): Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T.,Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T.,Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
  • Journal Title: Mol Cell Volume: 51 Pages: 618-631
  • Peer Reviewed
• [Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment (2013)
  • Author(s): OkatsuK, Uno M, Koyano F,Go E, KimuraM, Oka T,Tanaka K, Matsuda N.
  • Journal Title: J. Biol. Chem. Volume: 288 Pages: 36372-36384
  • Peer Reviewed
• [Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation (2013)
  • Author(s): Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., and Matsuda, N.
  • Journal Title: J Biol Chem Volume: 288 Pages: 22019-22032
  • Peer Reviewed
• [Journal Article] Parkin catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation (2013)
  • Author(s): Masahiro Iguchi, Yuki Kujuro, Kei Okatsu, Fumika Koyano, Hidetaka Kosako, Mayumi Kimura, Norihiro Suzuki, Shinichiro Uchiyama, Keiji Tanaka, Noriyuki Matsuda
  • Journal Title: The Journal of Biological Chemistry Volume: 288 Issue: 30 Pages: 22019-32
  • DOI: 10.1074/jbc.m113.467530
  • Peer Reviewed
• [Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification. (2013)
  • Author(s): Tsuchiya, H., Tanaka, K., and Saeki, Y.
  • Journal Title: Biochem Biophys Res Commun. Volume: 436 Issue: 2 Pages: 223-229
  • DOI: 10.1016/j.bbrc.2013.05.080
  • Peer Reviewed
• [Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae. (2013)
  • Author(s): Tsuchiya, H., Arai, N., Tanaka, K., and Saeki, Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 436 Issue: 3 Pages: 372-376
  • DOI: 10.1016/j.bbrc.2013.05.105
  • Peer Reviewed
• [Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential also occur in primary neurons (2013)
  • Author(s): Fumika Koyano, Kei Okatsu, Shinsuke Ishigaki, Yusuke Fujioka, Mayumi Kimura, Keiji Tanaka, Noriyuki Matsuda
  • Journal Title: Genes to Cells Volume: 18 Issue: 8 Pages: 672-81
  • DOI: 10.1111/gtc.12066
  • Peer Reviewed
• [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein. (2013)
  • Author(s): Sangawa, T., Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
  • Journal Title: Protein Science Volume: 22 Issue: 6 Pages: 840-850
  • DOI: 10.1002/pro.2254
  • Peer Reviewed
• [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells. (2013)
  • Author(s): Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Issue: 24 Pages: 9885-9890
  • DOI: 10.1073/pnas.1301799110
  • Peer Reviewed
• [Journal Article] Spatial arrangement and functional role of α subunits of proteasome activator PA28 in hetero-oligomeric form. (2013)
  • Author(s): Sugiyama, M., Sahashi, H., Kurimoto, E., Takata, S., Yagi, H., Kanai, K., Sakata, E., Minami, Y., Tanaka, K., and Kato K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 432 Issue: 1 Pages: 141-145
  • DOI: 10.1016/j.bbrc.2013.01.071
  • Peer Reviewed
• [Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment (2013)
  • Author(s): Kei Okatsu, Midori Uno, Fumika Koyano, Etsu Go, Mayumi kimura, Toshihiko Oka, Keiji Tanaka, Noriyuki Matsuda
  • Journal Title: The Journal of Biological Chemistry Volume: 288 Issue: 51 Pages: 36372-84
  • DOI: 10.1074/jbc.m113.509653
  • Peer Reviewed
• [Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. (2013)
  • Author(s): Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
  • Journal Title: Mol. Cell Volume: 52 Issue: 6 Pages: 794-804
  • DOI: 10.1016/j.molcel.2013.10.024
  • Peer Reviewed / Open Access
• [Journal Article] Different dynamic movements of wild-type and pathogenic VCPs and the ir cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system (2013)
  • Author(s): Yoko Kimura, Junpei Fukushi, Seiji Hori, Noriyuki Matsuda, Kei Okatsu, Yukie Kakiyama, Junko Kawawaki, Akira Kakizuka, Keiji Tanaka
  • Journal Title: Genes to Cells Volume: 18 Issue: 12 Pages: 1131-43
  • DOI: 10.1111/gtc.12103
  • Peer Reviewed
• [Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells (2013)
  • Author(s): Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
  • Journal Title: EMBO J. Volume: 32 Issue: 18 Pages: 2463-2476
  • DOI: 10.1038/emboj.2013.184
  • Peer Reviewed
• [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013)
  • Author(s): Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
  • Journal Title: Mol Cell Volume: 51 Issue: 5 Pages: 618-631
  • DOI: 10.1016/j.molcel.2013.08.003
  • Peer Reviewed / Open Access
• [Journal Article] The proteasome : from basic mechanisms to emerging roles. (2013)
  • Author(s): Tanaka, K.
  • Journal Title: Keio J Med. Volume: 62 Pages: 1-12
  • NAID: 10031160102
  • Peer Reviewed
• [Journal Article] Proteostasis and neurodegeneration : the roles of proteasomal degradation and autophagy. (2013)
  • Author(s): Tanaka, K. and Matsuda, N.
  • Journal Title: Biochim. Biophys. Acta (Molecular Cell Research) Volume: 1843 Issue: 1 Pages: 197-204
  • DOI: 10.1016/j.bbamcr.2013.03.012
  • Peer Reviewed
• [Journal Article] The parallel reaction monitoring method contributes to highly sensitive polyubiquitin chain quantification (2013)
  • Author(s): Hikaru Tsuchiya1, Keiji Tanaka1*, and Yasushi Saeki1*
  • Journal Title: Biochem Biophys Res Commun. in press. (*cocorespondences) Volume: in press
  • Peer Reviewed
• [Journal Article] Cytoplasmic proteasomes are not indispensable for cell growth in Saccharomyces cerevisiae (2013)
  • Author(s): Hikaru Tsuchiya1, Naoko Arai1, Keiji Tanaka1*, and Yasushi Saeki1*
  • Journal Title: Biochem Biophys Res Commun. in press. (*cocorespondences) Volume: in press
  • Peer Reviewed
• [Journal Article] The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons. (2013)
  • Author(s): Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K.* and Matsuda, N*
  • Journal Title: Genes Cells in press. (*cocorespondences) Volume: in press
  • Peer Reviewed
• [Journal Article] A multi-purpose fusion tag derived from an unstructured and hyper-acidic region of the amyloid precursor protein. (2013)
  • Author(s): Sangawa, Tabata, S., Suzuki, K., Saeki, Y., Tanaka, K., and Takagi, J.
  • Journal Title: Protein Science in press Volume: in press
  • Peer Reviewed
• [Journal Article] Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells. (2013)
  • Author(s): Ohigashi, I., Zuklys, S., Sakata, M., Mayer, GE., Zhanybekova. S., Murata, S., Tanaka, K., Hollander, G., and Takahama, Y.
  • Journal Title: Proc Natl Acad Sci USA in press. Volume: in press
  • Peer Reviewed
• [Journal Article] The proteasome: from basic mechanisms to emerging roles. (2013)
  • Author(s): Tanaka, K.
  • Journal Title: Keio J. Med. Volume: 62 Pages: 1-12
  • NAID: 10031160102
  • Peer Reviewed
• [Journal Article] Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy. (2013)
  • Author(s): Tanaka, K., and Matsuda, N.
  • Journal Title: Biochim. Biophys. Acta Molecular Cell Research in press Volume: in press
  • Peer Reviewed
• [Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria (2012)
  • Author(s): 尾勝圭
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1016-1016
  • DOI: 10.1038/ncomms2016
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities. (2012)
  • Author(s): Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, and Kasahara M.
  • Journal Title: Am. J. Pathol. Volume: 180 Pages: 963-972
  • Peer Reviewed
• [Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy (2012)
  • Author(s): Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Förster F, and Baumeister W.
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 1479-1484
  • Peer Reviewed
• [Journal Article] Structural basis for specific recognition of Rpt1, an ATPase subunit of the 26S proteasome, by the proteasome-dedicated chaperone Hsm3 (2012)
  • Author(s): Takagi, K., Kim, S., Yukii, H., Ueno, M., Morishita , R., Endo, Y., Kato, K., K., Tanaka, K., Saeki, Y., and Mizushima, Y.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 12172-12182
  • Peer Reviewed
• [Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing. (2012)
  • Author(s): Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., and Pellman, D.
  • Journal Title: Cell Volume: 150 Pages: 151-164
  • Peer Reviewed
• [Journal Article] Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase. (2012)
  • Author(s): Okatsu, K., Iemura, S., Koyano, F., Go, E., Kimura, M., Natsume, T., Tanaka, K., and Matsuda, N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 428 Pages: 197-202
  • Peer Reviewed
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. (2012)
  • Author(s): Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa. H., Sakimura, K., Ito, H., and Takahashi, R.
  • Journal Title: J. Biol, Chem. Volume: 287 Pages: 42984-42994
  • Peer Reviewed
• [Journal Article] Thymic nurse cells do not nurse most T cells but support TCR revision in cortical thymocytes. (2012)
  • Author(s): Nakagawa, Y., Ohigashi, I., Nitta, T., Tanaka, K., Murata, S., Sakata, M., and Takahama, Y.
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 20572-20577
  • Peer Reviewed
• [Journal Article] β5t-containing thymoproteasome: thymic cortical epithelial cell-specific expression and role in positive selection of CD8+ T cells. (2012)
  • Author(s): Takahama, Y., Takada, K., Murata, S., and Tanaka, K.
  • Journal Title: Curr. Opini. Immunol. Volume: 24 Pages: 92-98
  • Peer Reviewed
• [Journal Article] Assembly and function of the proteasome. (2012)
  • Author(s): Saeki, Y and Tanaka, K.
  • Journal Title: Methods Mol Biol Volume: 832 Pages: 315-337
  • Peer Reviewed
• [Journal Article] The proteasome: molecular machinery and pathophysiological roles. (2012)
  • Author(s): Tanaka, K., Mizushima, T., and Saeki, Y.
  • Journal Title: Biol Chem. Volume: 393 Pages: 217-234
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities (2012)
  • Author(s): Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
  • Journal Title: Am.J.Pathol. Volume: 180 Issue: 3 Pages: 963-972
  • DOI: 10.1016/j.ajpath.2011.11.012
  • Peer Reviewed
• [Journal Article] Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy (2012)
  • Author(s): Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, Nickell S, Tanaka K, Saeki Y, Forster F, Baumeister W
  • Journal Title: Proc Nall Acad Sci USA Volume: 109 Issue: 1 Pages: 1479-1484
  • DOI: 10.1073/pnas.1117648108
  • Peer Reviewed
• [Journal Article] Smad7-deficient mice show growth retardation with reduced viability (2012)
  • Author(s): Tojo M, Takebe A, Takahashi S, Tanaka K, Imamura T, Miyazono K, Chiba T
  • Journal Title: J Biochem. Volume: (in press) Issue: 6 Pages: 621-631
  • DOI: 10.1093/jb/mvs022
  • NAID: 10031166104
  • Peer Reviewed
• [Journal Article] Proteasomal degradation resolves competition between cell polarization and cellular wound healing (2012)
  • Author(s): Kono, K., Saeki, Y., Yoshida, S., Tanaka, K., Pellman, D.
  • Journal Title: Cell Volume: (in press)
  • Peer Reviewed
• [Journal Article] β5t-containing thymoproteasome : thymic cortical epithelial cell-specific expression and role in positive selection of CD8^+ T cells (2012)
  • Author(s): Takahama, Y., Takada, K., Murata, S., Tanaka, K.
  • Journal Title: Curr.Opini.Immunol. Volume: 24 Pages: 92-98
  • Peer Reviewed
• [Journal Article] The proteasome : molecular machinery and pathophysiological roles (2012)
  • Author(s): Tanaka, K., Mizushima, T., Saeki, Y.
  • Journal Title: Biol Chem. Volume: 393 Issue: 4 Pages: 217-234
  • DOI: 10.1515/hsz-2011-0285
  • Peer Reviewed
• [Journal Article] The proteasome : from basic mechanisms to emerging roles (2012)
  • Author(s): Tanaka, K.
  • Journal Title: Keio J.Med. Volume: (in press)
  • NAID: 10031160102
  • Peer Reviewed
• [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle (2011)
  • Author(s): Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., and Robinson, CV.
  • Journal Title: Mol. Cell Volume: 42 Pages: 637-649
  • Peer Reviewed
• [Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex (2011)
  • Author(s): Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
  • Journal Title: Nature Volume: 471 Issue: 7340 Pages: 633-636
  • DOI: 10.1038/nature09815
  • Peer Reviewed
• [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice (2011)
  • Author(s): Tatsumi, K., Yamamoto-Mukai, H., Shimizu, R., Waguri, S., Sou, Y-S., Sakamoto, A., Taya, C., Shitara, H., Hara, T., Chung, C.H., Tanana, K., Yamamoto, M., Komatsu, M.
  • Journal Title: Nat.Commun. Volume: 2 Issue: 1 Pages: 181-181
  • DOI: 10.1038/ncomms1182
  • Peer Reviewed
• [Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP2 (2011)
  • Author(s): Ha, B.H., Jeon, Y.J., Shin, S.C., Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
  • Journal Title: J.Biol.Chem. Volume: 286 Issue: 12 Pages: 10248-10257
  • DOI: 10.1074/jbc.m110.172171
  • Peer Reviewed
• [Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation (2011)
  • Author(s): Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
  • Journal Title: Arch.Biochem.Biophys. Volume: 506 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit beta5t (2011)
  • Author(s): Mat Ripen A
  • Journal Title: European Journal of Immunology Volume: 41 Issue: 5 Pages: 1278-1287
  • DOI: 10.1002/eji.201041375
  • Peer Reviewed
• [Journal Article] Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy (2011)
  • Author(s): Chens, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
  • Journal Title: J.Neurosci. Volume: 31 Issue: 6 Pages: 2125-2135
  • DOI: 10.1523/jneurosci.5519-10.2011
  • Peer Reviewed
• [Journal Article] Autophagy-deficient mice develop multiple liver tumors (2011)
  • Author(s): Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N
  • Journal Title: Genes Dev. Volume: 25 Issue: 8 Pages: 795-800
  • DOI: 10.1101/gad.2016211
  • Peer Reviewed
• [Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis (2011)
  • Author(s): Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamatmto, M., Lee. M-S., Tanaka, K., Komatsu, K.
  • Journal Title: J.Cell.Biol. Volume: 193 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels (2011)
  • Author(s): Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Ueno, T.
  • Journal Title: Autophagy Volume: 7 Issue: 7 Pages: 727-736
  • DOI: 10.4161/auto.7.7.15371
  • Peer Reviewed
• [Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme (2011)
  • Author(s): Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
  • Journal Title: Cell Death Differ. Volume: 18 Issue: 8 Pages: 1326-1336
  • DOI: 10.1038/cdd.2011.3
  • Peer Reviewed
• [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle (2011)
  • Author(s): Sakata, E., Stengel, F., Fukunaga, K., et al
  • Journal Title: Molecular Cell Volume: 42 Issue: 5 Pages: 637-649
  • DOI: 10.1016/j.molcel.2011.04.021
  • Peer Reviewed
• [Journal Article] Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination (2011)
  • Author(s): Chew, KCM*., Matsuda, M*., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim, K-L.(*equally contribution)
  • Journal Title: PloS ONE. Volume: 6(5) Issue: 5 Pages: e19720-e19720
  • DOI: 10.1371/journal.pone.0019720
  • Peer Reviewed
• [Journal Article] Skp1 stabilizes the conformation of F-box proteins (2011)
  • Author(s): Yoshida, Y., Murakami, A., Tanaka, K.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 41 Issue: 1 Pages: 24-28
  • DOI: 10.1016/j.bbrc.2011.05.098
  • Peer Reviewed
• [Journal Article] Crystal structure of the UBA domain of p62 and its interaction with ubiquitin (2011)
  • Author(s): Isogai, S., Morimoto, D., Arita, K., Unzai, S., Tenno, T., Hasegawa, J., Sou, Y.S., Komatsu, M., Tanaka, K., Shirakawa, M., Tochio, H.
  • Journal Title: J Biol Chem. Volume: 286 Issue: 36 Pages: 31864-318674
  • DOI: 10.1074/jbc.m111.259630
  • Peer Reviewed
• [Journal Article] Assembly defect due to a PSMB8 mutation reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome (2011)
  • Author(s): Arima, K., Kinoshita, A., Mishima, H., Kanazawa, N., Kaneko, T., Mizushima, T., Ichinose, K., Nakamura, H., Tsujino, A., Kawakami, A., Matsunaka, M., Kasagi, S., Kawano, S., Kumagai, S., Ohmura, K., Mimori, T., Hirano, M., Ueno, S., Tanaka, K., Tanaka, M., Toyoshima, I., Sugino, H., Yamakawa, A., Tanaka, K., Niikawa, N., Furukawa, F., Murata, S., Eguchi, K., Ida, H., Yoshiura, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Issue: 36 Pages: 14914-14919
  • DOI: 10.1073/pnas.1106015108
  • Peer Reviewed
• [Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans (2011)
  • Author(s): Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
  • Journal Title: J Clin Invest Volume: 121 Issue: 10 Pages: 4150-4160
  • DOI: 10.1172/jci58414
  • Peer Reviewed
• [Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex. (2011)
  • Author(s): Tokunaga, F., Nakagawa, T., Nakaharal, M., Saeki, Y., Taniguchi, M., Sakata, S., Tanaka, K., Nakano, H., Iwai, I.
  • Journal Title: Nature Volume: 471 Pages: 633-636
  • Peer Reviewed
• [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. (2011)
  • Author(s): Tatsumi, K., Yamamoto-Mukai, H., Shimizu, R., Waguri, S., Sou, Y-S., Sakamoto, A., Taya, C., Shitara, H., Hara, T., Chung, C.H., Tanana, K., Yamamoto, M., Komatsu, M.
  • Journal Title: Nat.Commun. Volume: 2 Pages: 181-181
  • Peer Reviewed
• [Journal Article] Structure of ubiquitin-fold modifier 1 specific protease, UfSP2. (2011)
  • Author(s): Ha, B.H., Jeon, Y.J., Shin, S.C, Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C.M., Wallis, G., Chung, C.H., Kim, E.E.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 10248-10257
  • Peer Reviewed
• [Journal Article] Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation. (2011)
  • Author(s): Fujishima, Y., Nishiumi, S., Masuda, A., Inoue, J., Nguyen, G.M., Irino, Y., Komatsu, M., Tanaka, K., Kutsumi, H., Azuma, T., Yoshida, M.
  • Journal Title: Arch.Biochem.Biophys. Volume: 506 Pages: 223-235
  • Peer Reviewed
• [Journal Article] The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Г-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels. (2011)
  • Author(s): Portillo, J.A., Okenka, G., Reed, E., Subauste, A., Van, Grol, J., Gentil, K., Komatsu, M., Tanaka, K., Landreth, G., Levine, B., Subauste, C.S.
  • Journal Title: PLoS One. Volume: 5
  • Peer Reviewed
• [Journal Article] Ontogeny of thymic cortical epithelial cells expressing thymoproteasome subunit β5t. (2011)
  • Author(s): Ripen, AM., Nitta, T., Murata, S., Tanaka, K., Takahama, Y.
  • Journal Title: Eur.J.Immunol. Volume: 32 Pages: 29-40
  • Peer Reviewed
• [Journal Article] Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy. (2011)
  • Author(s): Cheng, H-C., Kim, SR., Oo, TF., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M., Talloczy, Z., Tanaka, K., Komatsu, M., Kobayashi, K., Okano, H., Kholodilov, N., Burke, RE.
  • Journal Title: J.Neurosci. Volume: 31 Pages: 2125-2135
  • Peer Reviewed
• [Journal Article] Autophagy-deficient mice develop multiple liver tumors. (2011)
  • Author(s): Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino O., Tanaka, K., Mizushima, N.
  • Journal Title: Genes Dev. Volume: 25 Pages: 795-800
  • Peer Reviewed
• [Journal Article] Role of persistent activation of Nrf2 through p62 in hepatocarcinogenesis. (2011)
  • Author(s): Inami, Y., Waguri, S., Sakamoto, A., Kouno, T., Nakada, K., Hino, O., Watanabe, S., Andoh, J., Iwadate, M., Yamamoto, M., Lee.M-S., Tanaka, K., Komatsu, K.
  • Journal Title: J.Cell.Biol. Volume: 193 Pages: 275-284
  • Peer Reviewed
• [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. (2011)
  • Author(s): Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Uenol, T.
  • Journal Title: Autophagy Volume: (In press)
  • Peer Reviewed
• [Journal Article] Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme. (2011)
  • Author(s): Oh, K.H., Yang, S.W., Park, J.M., Seol, J.H., Iemura, S., Natsume, T., Murata, S., Tanaka, K., Jeon, Y.J., Chung, C.H.
  • Journal Title: Cell Death and Differ. Volume: (In press)
  • Peer Reviewed
• [Journal Article] The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. (2011)
  • Author(s): Sakata, E., Stengel, F., Fukunaga, K., Zhou, M., Saeki, Y., Forster, F., Baumeister, W., Tanaka, K., Robinson, CV.
  • Journal Title: Mol.Cell Volume: (In press)
  • Peer Reviewed
• [Journal Article] Parkin Mediates Apparent E2-independent Monoubiquitination In Vitro and Contains an Intrinsic Activity that Catalyzes Polyubiquitination. (2011)
  • Author(s): Chew, KCM., Matsuda, M., Saisho, K., Lim, GGY., Chai, C., Tan, HM., Tanaka, K., Lim 1, K-L.
  • Journal Title: PLoS ONE. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells (2010)
  • Author(s): Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A. M., Ishimaru, N., Koyasu, S., Tanaka, K., and Takahama, Y.
  • Journal Title: Immunity Volume: 32 Pages: 29-40
  • Peer Reviewed
• [Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy (2010)
  • Author(s): Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., and Tanaka, K.
  • Journal Title: J Cell Biol. Volume: 189 Pages: 211-221
  • Peer Reviewed
• [Journal Article] Thymoproteasome shapes immunocompetent repertoire of CD8 T cells. (2010)
  • Author(s): Nitta, T., Murata, S., Sasaki, K., Fujii, H., Ripen, A.M., Ishimaru, N., Koyasu, S., Tanaka, K., Takahama, Y.
  • Journal Title: Immunity Volume: 32 Pages: 29-40
  • Peer Reviewed
• [Journal Article] Crystal structure of UbcH5b～ubiquitin intermediate : Insight into the formation of the self-assembled E2～Ub conjugates. (2010)
  • Author(s): Sakata, E., Satoh, T., Yamamoto, S., Yamaguchi, Y., Yagi-Utsumi, M., Kurimoto, E., Tanaka, K., Wakatsuki, S., Kato, K.
  • Journal Title: Structure Volume: 18 Pages: 138-147
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray characterization of Skp1-FBG3 complex. (2010)
  • Author(s): Kumanomidou, T., Nakagawa, T., Mizushima, T., Suzuki, A., Tokunaga, F., Iwai, K., Yoshida, Y., Tanaka, K., Yamane, T.
  • Journal Title: Acta Crystallogr Sect F Struct Biol Cryst Commun. Volume: 66 Pages: 95-98
  • Peer Reviewed
• [Journal Article] Novel type of E3 ligase for Ufm1-conjugating system. (2010)
  • Author(s): Tatsumi, K., Sou, Y., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, SW., Chung, CH., Kasahara, M., Kominami, E., Tanaka, K., Komatsu, M.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 5417-5427
  • Peer Reviewed
• [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. (2010)
  • Author(s): Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y-S., Ueno, I., Sakamoto, A., Tong.K.I., Kim, M., Nishito Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M.
  • Journal Title: Nat.Cell Biol. Volume: 12 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Crystal structure of yeast Rpn14, a chaperone of the 19S regulatory particles of the proteasome. (2010)
  • Author(s): Kim, S., Saeki, S., Fukunaga, K., Suzuki, A., Takagi, K., Yamane, T., Tanaka, K., Mizushima, T., Kato, K.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 15159-151566
  • Peer Reviewed
• [Journal Article] PINK1 stabilized by depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. (2010)
  • Author(s): Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, CA Sou, Y., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., Tanaka, K.
  • Journal Title: J Cell Biol. Volume: 189 Pages: 211-221
  • Peer Reviewed
• [Journal Article] p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. (2010)
  • Author(s): Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., Tanaka.K., Matsuda, N.
  • Journal Title: Genes Cells Volume: 15 Pages: 887-900
  • Peer Reviewed
• [Journal Article] Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae. (2010)
  • Author(s): Fukunaga, K., Kudo, T., Toh-e, A., Tanaka, K., Saeki, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 396 Pages: 1048-1053
  • Peer Reviewed
• [Journal Article] PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and importance of latent 20S proteasomes in maintaining cellular homeostasis. (2010)
  • Author(s): Sasaki, K., Hamazaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K., Murata, M.
  • Journal Title: Mol Cell.Biol. Volume: 30 Pages: 3864-3874
  • Peer Reviewed
• [Journal Article] Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. (2010)
  • Author(s): Arimoto, K.I., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., Shimotohno, K.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 07 Pages: 15856-15861
  • Peer Reviewed
• [Journal Article] Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. (2010)
  • Author(s): Florea, B.I., Verdoes, M., Li, N., van den Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., Overkleeft, H.S.
  • Journal Title: Chem Biol. Volume: 17 Pages: 795-801
  • Peer Reviewed
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. (2010)
  • Author(s): Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishito, h H., Ichijo, H.
  • Journal Title: EMBO J. Volume: 9 Pages: 2501-2514
  • Peer Reviewed
• [Journal Article] Ubiquitin accumulation in autophagy-deficinet mice is dependent on the Nrf2-mediated stress response pathway : a potential role for protein aggregation in autophagic substrate selection. (2010)
  • Author(s): Riley, B.E., Kaiser, S.E., Shaler, T.A., Ng, A.C.Y., Hara, T., Hipp, M.S., Lage, K., Xavier, R.J., Ryu, K-Y., Taguchi, K., Yamamoto, M., Tanaka, K., Mizushima, N., Komatsu, M., Kopito, R.R.
  • Journal Title: J.Cell Biol. Volume: 191 Pages: 537-552
  • Peer Reviewed
• [Journal Article] Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease? (2010)
  • Author(s): Matsuda, N., Tanaka, K.
  • Journal Title: J Alzheimer's Dis. Volume: 19 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Lectin-like ERAD players in ER and cytosol. (2010)
  • Author(s): Yoshida, Y., Tanaka, K.
  • Journal Title: Biochem.Biophys.Acta Volume: 1800 Pages: 172-180
  • Peer Reviewed
• [Journal Article] Role of thymic cortex-specific self-peptides in positive selection of T cells. (2010)
  • Author(s): Takahama, Y., Nitta, T., Ripen, A.M., Nitta, S., Murata, M., Tanaka, K.
  • Journal Title: Semin.Immunol. Volume: 22 Pages: 287-293
  • Peer Reviewed
• [Journal Article] Regulatory mechanisms involved in the control of ubiquitin homeostasis. (2010)
  • Author(s): Kimura, Y., Tanaka, K.
  • Journal Title: J.Biochem. Volume: 147 Pages: 793-798
  • NAID: 10027876238
  • Peer Reviewed
• [Journal Article] An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis (2009)
  • Author(s): Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K.
  • Journal Title: Cell Volume: 137 Pages: 549-559
  • Peer Reviewed
• [Journal Article] Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones (2009)
  • Author(s): Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K., and Murata, S.
  • Journal Title: Cell Volume: 137 Pages: 914-925
  • Peer Reviewed
• [Journal Article] Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle (2009)
  • Author(s): Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K.
  • Journal Title: Cell Volume: 137 Pages: 900-913
  • Peer Reviewed
• [Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes. (2014)
  • Author(s): K. Tanaka
  • Organizer: A lecture in "Karolinska Research Lectures" series at Nobel Forum
  • Place of Presentation: Stockholm, (Sweden)
  • Year and Date: 2014-09-18
• [Presentation] Basic mechanisms and physiopathological roles of eukaryotic proteasomes (2014)
  • Author(s): Keiji Tanaka
  • Organizer: A lecture in "Karolinska Research Lectures" series at Nobel Forum
  • Place of Presentation: Stockholm, Sweden(発表確定)
  • Year and Date: 2014-09-18
  • Invited
• [Presentation] タンパク質の新陳代謝～健康と病気のみなもと～ (2014)
  • Author(s): 田中啓二
  • Organizer: サイエンステクノフロンティアフォーラムサイテックサロン
  • Place of Presentation: 駒場ファカルティハウス(東京大学駒場キャンパス内、)東京(発表確定)
  • Year and Date: 2014-06-28
  • Invited
• [Presentation] Oxidative Stress, Mitophagy, and the PINK1-Parkin System (2014)
  • Author(s): Keiji Tanaka
  • Organizer: Symposium 17 on Oxidative Stress and Autophagy. 17th Biennial Meeting of Society for Free Radical Research International (SFRRI 2014)
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 2014-03-26
  • Invited
• [Presentation] The PINK1-Parkin system controls mitochondrial homeostasis to suppress the cause of 'Parkinson's disease. (2014)
  • Author(s): Keiji Tanaka
  • Organizer: "KSU International Symposium : Cutting-edge of Life Sciences".
  • Place of Presentation: Kyoto, Japan(発表確定)
  • Invited
• [Presentation] 私のプロテアソーム研究を回想して… (2014)
  • Author(s): 田中啓二
  • Organizer: 第66回細胞生物学会大会 S11 七人の侍からのメッセージ～私の仕事を通じて若者達に伝えたきこと～
  • Place of Presentation: 奈良県新公会堂・東大寺総合文化センター、奈良(発表確定)
  • Invited
• [Presentation] プロテアソーム : 動作原理から炎症免疫疾患制御への展望 (2014)
  • Author(s): 田中啓二
  • Organizer: 第35回日本炎症・再生医学会 : 教育講演
  • Place of Presentation: 万国津梁館、沖縄(発表確定)
  • Invited
• [Presentation] 生化学の立場から (2014)
  • Author(s): 田中啓二
  • Organizer: 第61回日本栄養改善学会学術集会8/21メインシンポジウムI「栄養学―新たな挑戦 日本栄養改善学会60周年シンポジウム」
  • Place of Presentation: パシフィコ横浜、横浜(発表確定)
  • Invited
• [Presentation] 神経変性疾患の謎を解く―タンパク分解系からのアプローチ (2014)
  • Author(s): 田中啓二
  • Organizer: 第37回日本神経科学会Neuroscience2014, 教育講演
  • Place of Presentation: パシフィコ横浜、横浜(発表確定)
  • Invited
• [Presentation] Thymoproteasomes play an essential role for the formation of immunocompetent repertoire of CD8 T cells (2014)
  • Author(s): Keiji Tanaka
  • Organizer: EMBO Conference on Ubiquitin & ubiquitin-like proteins : At the crossroads from chromatin to protein.
  • Place of Presentation: Buenos Aires, Argentina(発表確定)
  • Invited
• [Presentation] The vertebrate-specific thymoproteasome governs positive selection in the development of CD8 T lymphocytes (2014)
  • Author(s): Keiji Tanaka
  • Organizer: The Zomes VIII Conference, Biology of the Zomes-Proteasome, COP9 Signalosome and associated processes.
  • Place of Presentation: Xiamen, China(発表確定)
  • Invited
• [Presentation] プロテアソームの発見から現在に至る研究の軌跡. (2013)
  • Author(s): 田中啓二
  • Organizer: 第29回 前立腺シンポジウム : 教育セミナー1
  • Place of Presentation: 東京コンファレンスセンター・品川、東京
  • Year and Date: 2013-12-14
  • Invited
• [Presentation] ミトコンドリアストレスとユビキチン・プロテアソームシステム (2013)
  • Author(s): 田中啓二
  • Organizer: 第8回臨床ストレス応答学会
  • Place of Presentation: 信州大学医学部、松本
  • Year and Date: 2013-11-16
  • Invited
• [Presentation] 私のプロテアソーム研究～成功と失敗の狭間で… (2013)
  • Author(s): 田中啓二
  • Organizer: 新学術研究「修飾シグナル病」第2回 若手ワークショップ 別講演
  • Place of Presentation: 伊香保温泉:雨情の湯 森秋旅館、群馬
  • Year and Date: 2013-10-22
  • Invited
• [Presentation] オートファジーKOマウスとその応用 (2013)
  • Author(s): 田中啓二, 小松雅明
  • Organizer: BioJapan 2013 World Business Forum
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2013-10-11
  • Invited
• [Presentation] The Keap1-Nrf2 activation during selective autophagy : its implication in tumor development. (2013)
  • Author(s): Keiji Tanaka and Masaaki Komatsu
  • Organizer: The 72nd Annual Meeting of Japanese Cancer Association Cancer research providing hope to fight against cancer Pacifico Yokohama Symposium 10 on Autophagy in Cancer.
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2013-10-03
  • Invited
• [Presentation] The Ubiquitin-Proteasome System. (2013)
  • Author(s): Keiji Tanaka
  • Organizer: HUPO 2013 Congress in Yokohama Proteomics of Protein Degradation : Session 11. Keynote Lecture
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2013-09-16
  • Invited
• [Presentation] Proteasome-over a quarter of a century from its discoveryプロテアソーム-その発見から四半世紀の軌跡 (2013)
  • Author(s): 田中啓二
  • Organizer: The 86th Annual Meeting of the Japanese Biochemical Society Globalizing Biochemistry's Future. Plenary Lecture
  • Place of Presentation: Yokohama (Japan)
  • Year and Date: 2013-09-13
  • Invited
• [Presentation] 二つの免疫型プロテアソームの発見-偶然から免疫学の檜舞台へ- (2013)
  • Author(s): 田中啓二
  • Organizer: 15th免疫サマースクール2013 in Hakata
  • Place of Presentation: 福岡
  • Year and Date: 2013-07-31
  • Invited
• [Presentation] プロテアソーム―発見から四半世紀の軌跡― (2013)
  • Author(s): Keiji Tanaka
  • Organizer: 大阪大学生命機能研究科研究交流会Frontier Bioscience Colloquium特別講演
  • Place of Presentation: 大阪
  • Year and Date: 2013-05-29
  • Invited
• [Presentation] Pathophysiological roles of the proteasome in vertebrate (2013)
  • Author(s): K. Tanaka
  • Organizer: The EUROMEDLAB Milano 2013 Congress
  • Place of Presentation: Milano Convention Center, Milano (Italy)
  • Year and Date: 2013-05-19
• [Presentation] Pathophysiological Roles of the Proteasome in Vertebrate. (2013)
  • Author(s): Keiji Tanaka
  • Organizer: The EUROMEDLAB Milano 2013 Congress. [OPENING LECTURE]
  • Place of Presentation: Milano Convention Center, Milano, Italy.
  • Year and Date: 2013-05-19
  • Invited
• [Presentation] The mechanism for molecular assembly of the proteasome (2013)
  • Author(s): S. Murata
  • Organizer: 54th international symposium on " Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues"
  • Place of Presentation: Bologna (Italy)
• [Presentation] In vivo interplay between the proteasome and autophagy in the mouse liver. (2013)
  • Author(s): Keiji Tanaka
  • Organizer: The 35th Naito Conference entitled The Ubiquitin-Proteasome. System : From Basic Mechanisms to Pathophysiological Roles.
  • Place of Presentation: Chateraise Gateaux Kingdom, Sapporo, Japan.
  • Invited
• [Presentation] Selective Autophagy, Mitochondria, and Tumor Development (2013)
  • Author(s): Keiji Tanaka
  • Organizer: The 4th International Symposium on Dynamics of Mitochondria (DynaMito 2013)
  • Place of Presentation: Okinawa Zanpamisaki Royal Hotel, Okinawa, Japan
  • Invited
• [Presentation] Physiopathological Roles of the Immune-dedicated Proteasomes in Vertebrate. (2013)
  • Author(s): Keiji Tanaka
  • Organizer: The Second Immunology Symposium of The University of Tokushima“Immune Development, Deviation, and Regulation”
  • Place of Presentation: Nichia Medical Hall, Tokushima University Hospital, Tokushima
  • Invited
• [Presentation] Discovery and pathophysiology of immuno-typed proteasomes (2012)
  • Author(s): K. Tanaka
  • Organizer: Goldberg Lab Reunion and Symposium Joseph B. Markin Conference Center Harvard Medical School
  • Place of Presentation: USA
  • Year and Date: 2012-09-14
• [Presentation] プロテアソーム～構造から見た作動・形成機構～ (2012)
  • Author(s): 田中啓二
  • Organizer: 平成23年度ターゲットタンパク研究プロジェクト公開シンポジウム「ターゲットタンパク研究から見える未来5」
  • Place of Presentation: 学術会議、東京(招待講演)
  • Year and Date: 2012-03-12
• [Presentation] PINK1/Parkinによるミトコンドリアの品質管理機構～パーキンソン病の発症機構に挑む～ (2012)
  • Author(s): 田中啓二
  • Organizer: 九州大学グローバルCOEプログラム理医連携特別講演会:独創的研究の世界発信を続ける「7人の侍」コラボステーションI
  • Place of Presentation: 九州大学・視聴覚ホール、福岡(招待講演)
  • Year and Date: 2012-02-29
• [Presentation] 巨大で複雑な超分子複合体の構造生命科学-プロテアソームを例とした動態解明- (2012)
  • Author(s): 田中啓二
  • Organizer: 学術会議シンポジウム「先端的異分野融合を核とした構造生命科学の飛躍に向けて」
  • Place of Presentation: 日本学術会議講堂、東京(招待講演)
  • Year and Date: 2012-01-09
• [Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson's disease Gordon Research Conference (GRC) (2012)
  • Author(s): K.Tanaka
  • Organizer: Neurobiology of Brain Disorders Stonehill College
  • Place of Presentation: Easton, MA (USA)
• [Presentation] Pathophysiological roles of immuno-typed proteasomes in vertebrate (2012)
  • Author(s): K. Tanaka
  • Organizer: ZOMES VII"Ubiquitin family proteins and their cognate PCI complexes"Munich
  • Place of Presentation: Germany
• [Presentation] Involvement of TRC/Get pathway in proteasome assembly (2012)
  • Author(s): S. Murata
  • Organizer: FASEB summer research conference "Ubiquitin and cellular regulation"
  • Place of Presentation: Vermont (USA)
• [Presentation] オートファジーとミトコンドリア・ストレス ～その破綻による重篤疾病の発症機構～ (2012)
  • Author(s): 田中啓二
  • Organizer: 第65回 日本酸化ストレス学会学術集会
  • Place of Presentation: あわぎんホール 徳島郷土文化会館 、徳島
  • Invited
• [Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose collapse causes Parkinson’s disease (2012)
  • Author(s): Keiji Tanaka
  • Organizer: Gordon Research Conference (GRC) Neurobiology of Brain Disorders
  • Place of Presentation: Stonehill College, Easton, MA,（August 5-12, 2012）USA
  • Invited
• [Presentation] Pathophysiological Roles of Immuno-typed Proteasomes in Vertebrate. (2012)
  • Author(s): Keiji Tanaka
  • Organizer: ZOMES VII“Ubiquitin family proteins and their cognate PCI complexes”
  • Place of Presentation: Munich, German
  • Invited
• [Presentation] Mitochondrial Quality Control by The PINK1-Parkin System whose collapse causes Parkinson’s Disease. (2012)
  • Author(s): Keiji Tanaka
  • Organizer: 6th International Symposium on Autophagy (ISA 2012)
  • Place of Presentation: Okinawa, Japan
  • Invited
• [Presentation] Physiopathological Roles of The Vertebrate- Specific Immuno-type Proteasomes. (2012)
  • Author(s): Keiji Tanaka
  • Organizer: The Centennial of Hashimoto Disease：Symposium II Autoimmune Diseases - Etiology and Therapeutics
  • Place of Presentation: Fukuoka, Japan
  • Invited
• [Presentation] プロテアソームの多様性による免疫システム制御 (2011)
  • Author(s): 田中啓二
  • Organizer: 第7回骨免疫ワークショップ
  • Place of Presentation: パークハイアットホテル東京、東京(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] プロテアソームを基軸としたタンパク質分解研究 (2011)
  • Author(s): 田中啓二
  • Organizer: 先端医療センターMonthly Lecture
  • Place of Presentation: 財団法人先端医療振興財団、神戸(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] プロテアソームを基軸とした細胞内リサイクルシステム (2011)
  • Author(s): 田中啓二
  • Organizer: 日本DNA多型学会第20回学術集会
  • Place of Presentation: はまぎんホールヴァイマーレ、横浜(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] プロテアソームとオートファジーの生理と病態.細胞・脳機能研究の融合による神経疾患診断・治療法開発拠点の形成 (2011)
  • Author(s): 田中啓二
  • Organizer: 第1回公開シンポジウム
  • Place of Presentation: 順天堂大学、東京(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] 私のプロテアソーム研究～分子から個体レベルまで～ (2011)
  • Author(s): 田中啓二
  • Organizer: 日本蛋白質科学会創立10周年記念シンポジウム
  • Place of Presentation: 大阪大学・銀杏会館大阪、大阪(招待講演)
  • Year and Date: 2011-06-06
• [Presentation] オートファジー"加齢、酸化ストレス応答と肝細胞がん" (2011)
  • Author(s): 田中啓二
  • Organizer: 第11回日本抗加齢医学会総会:アンチエイジングの心の眼を拓く:ベーシックサイエンス企画シンポジウム1「抗酸化環境応答と加齢」
  • Place of Presentation: 国立京都国際会館、京都(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] ユビキチン・プロテアソームシステムによるタンパク質分解 (2011)
  • Author(s): 田中啓二
  • Organizer: 京都産業大学・総合生命科学部 開設記念シンポジウム"タンパク質の一生と生命システム」
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-03-10
• [Presentation] 細胞内リサイクルシステム-新陳代謝の科学- (2011)
  • Author(s): 田中啓二
  • Organizer: 第5回炎症・脂質代謝・メタボリサーチフォーラム
  • Place of Presentation: 東京大学医学部教育研究棟、東京(招待講演)
  • Year and Date: 2011-02-12
• [Presentation] In-depth study of structure and functions of eukaryotic proteasomes (2011)
  • Author(s): K. Tanaka
  • Organizer: The 3rd Asia Pacific Protein Association (APPA) Conference
  • Place of Presentation: Shanghai University, Shanghai (China)
• [Presentation] In-depth analysis of proteasomal assembly and diversity in eukaryotes (2011)
  • Author(s): K. Tanaka
  • Organizer: International GMB Symposium "Molecular Life Science 2011" by GMB (The German Society for Biochemistry and Molecular Biology) Goethe-University, Frankfurt am Main
  • Place of Presentation: Germany
• [Presentation] Assembly and diversity of eukaryotic proteasomes (2011)
  • Author(s): K. Tanaka
  • Organizer: The 7th General Meeting of the International Proteolysis Society (IPS) Hilton San Diego Resort and Spa
  • Place of Presentation: San Diego (USA)
• [Presentation] In-depth Study of Structure and Functions of Eukaryotic Proteasomes (2011)
  • Author(s): Keiji Tanaka
  • Organizer: The 3^<rd> Asia Pacific Protein Association (APPA) Conference
  • Place of Presentation: Shanghai University, Shanghai, China(招待講演)
• [Presentation] In-depth Analysis of Proteasomal Assembly and Diversity in Eukaryotes (2011)
  • Author(s): Keiji Tanaka
  • Organizer: International GMB Symposium "Molecular Life Science 2011" by GMB (The German Society for Biochemistry and Molecular Biology)
  • Place of Presentation: Goethe-University, Frankfurtam Main, Germany(招待講演)
• [Presentation] Up-to-date Study of Eukaryotic Proteasomes (2011)
  • Author(s): Keiji Tanaka
  • Organizer: The 2^<nd> Japan-Sino Autophagy Symposium
  • Place of Presentation: Shonan Village Center, Kanagawa, Japan(招待講演)
• [Presentation] Assembly and Diversity of Eukaryotic Proteasomes (2011)
  • Author(s): Keiji Tanaka
  • Organizer: The 7^<th> General Meeting of the International Proteolysis Society (IPS)
  • Place of Presentation: Hilton San Diego Resort and Spa., San Diego, USA(招待講演)
• [Presentation] 細胞内タンパク質分解系の病態生理学研究 (2011)
  • Author(s): 田中啓二
  • Organizer: 第84回日本内分泌学会学術総会内分泌代謝学の多領域との融合と新たな展開"マイスター賞受賞講演"
  • Place of Presentation: 神戸国際会議場、神戸(招待講演)
• [Presentation] プロテアソームとオートファジー～病態生理学の最新研究～ (2011)
  • Author(s): 田中啓二
  • Organizer: 第25回モロシヌス研究会
  • Place of Presentation: 当間高原リゾート・ベルナティオ(新潟県十日町)、新潟(招待講演)
• [Presentation] プロテアソームの生物学～免疫型酵素の発見と分子免疫学への貢献～ (2011)
  • Author(s): 田中啓二
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテ新高輪国際館パミール、東京(招待講演)
• [Presentation] Parkinson's disease : a quality control disease of depolaized mitochondoria. (2011)
  • Author(s): Keiji Tanaka
  • Organizer: The 1^<st> small Korea/Japan symposium
  • Place of Presentation: Seoul, Korea(招待講演)
• [Presentation] 細胞内リサイクルシステム-新陳代謝の科学- (2010)
  • Author(s): 田中啓二
  • Organizer: JSTさきがけ「代謝と機能制御」領域 研究報告会シンポジウム:特別講演
  • Place of Presentation: 東京大学弥生講堂・一條ホール、東京(招待講演)
  • Year and Date: 2010-12-13
• [Presentation] Role of Proteolysis in Liver Pathophysiology. (2010)
  • Author(s): Keiji Tanaka
  • Organizer: The 9^<th> JSH Single Topic Conference "NASH 2010"
  • Place of Presentation: Tokyo, Japan(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] 私の履歴書 -プロテアソームを基軸としたタンパク質分解研究- (2010)
  • Author(s): 田中啓二
  • Organizer: 第15回病態プロテアーゼ学会学術集会"『日本学士院賞』受賞記念講演
  • Place of Presentation: 千里ライフサイエンスセンター、大阪(招待講演)
  • Year and Date: 2010-08-20
• [Presentation] 細胞内リサイクルシステム-新陳代謝と健康- (2010)
  • Author(s): 田中啓二
  • Organizer: 徳島大学市民公開講演会～生命の謎に迫る～
  • Place of Presentation: 長井記念ホール、徳島(招待講演)
  • Year and Date: 2010-07-31
• [Presentation] パーキンソン病の分子病態機序のブレイクススルー:Parkin/PINK1の機能"パーキンソン病の分子病態機序 (2010)
  • Author(s): 田中啓二、松田憲之、尾勝圭
  • Organizer: 新世代の神経学-Breakthrough to the NEXT STAGE-、第51回日本神経学会総会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-05-22
• [Presentation] The Structure and Biological Functions of Proteasomes (+The Role of PINK1/Parkin in Mitophagy and Parkinson's Disease). (2010)
  • Author(s): 田中啓二
  • Organizer: 第62回日本細胞生物学会大会 (The 62nd Annual Meeting of the Japanese Society of Cell Biology)・特別講演
  • Place of Presentation: Osaka(招待講演)
  • Year and Date: 2010-05-20
• [Presentation] プロテアソーム:オーバービューと免疫研究の最前線 (2010)
  • Author(s): 田中啓二
  • Organizer: 第54回日本リウマチ学会総会・学術集会:特別講演
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2010-04-23
• [Presentation] 蛋白質リサイクルシステムの意義とその破綻による疾病 (2010)
  • Author(s): 田中啓二
  • Organizer: 科学技術政策研究所シンポジウム:近未来への招待状～ナイスステップな研究者2009からのメッセージ～
  • Place of Presentation: 文部科学省第2講堂、東京(招待講演)
  • Year and Date: 2010-04-22
• [Presentation] The Role of the PINK1/Parkin Pathway on the Autophagic Clearance of Damaged Mitochondria (2010)
  • Author(s): Keiji Tanaka
  • Organizer: The 2010 Rappaport Research Institute Ubiquitin Day
  • Place of Presentation: Cancer Center, Rappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel(招待講演)
  • Year and Date: 2010-03-11
• [Presentation] In-depth Analysis of Structure and Functions of Eukaryotic Proteasomes (2010)
  • Author(s): Keiji Tanaka
  • Organizer: "Global COE" Integrative Life Science" Meeting, Based on the Study of Biosignaling Mechanisms
  • Place of Presentation: The University of Tokyo, Japan(招待講演)
  • Year and Date: 2010-03-05
• [Presentation] Overview of My Proteasome Study, focusing on the Structure and Functions. (2010)
  • Author(s): Keiji Tanaka
  • Organizer: International Conference on Radiation and Cancer Biology
  • Place of Presentation: Nagasaki, Japan(招待講演)
  • Year and Date: 2010-01-17
• [Presentation] Immunological roles of the thymoproteasome (2010)
  • Author(s): K. Tanaka
  • Organizer: "Biology of the Ubiquitin and the Ubiquitin-Like Systems"
  • Place of Presentation: Jerusalem (Israel)
• [Presentation] Autophagic Control of Mitochondrial Homeostasis and Neurodegeneration (2010)
  • Author(s): K. Tanaka
  • Organizer: "Proteolysis and Neurodegeneration : 5th INPROTEOLYSIS meeting", EMBO Workshop
  • Place of Presentation: Madrid (Spain)
• [Presentation] Impairment of proteolytic homeostasis as cause of neurodegeneration"in S1 JOINT SYMPOSIUM (2010)
  • Author(s): K. Tanaka
  • Organizer: PRION & ICN Congress
  • Place of Presentation: Salzburg (Austria)
• [Presentation] Proteasome diversity (2010)
  • Author(s): S. Murata
  • Organizer: The Banbury symposium "Signaling through ubiquitin"
  • Place of Presentation: Cold Spring Harbor (USA)
• [Presentation] Autophagic Control of Mitochondrial Homeostasis and Neurodegeneration" [Mechanism underling the cause of Parkinson's Disease : The functions of Parkin/PINK1] (2010)
  • Author(s): Keiji Tanaka
  • Organizer: Proteolysis and Neurodegeneration : 5th INPROTEOLYSIS meeting, EMBO Workshop
  • Place of Presentation: Madrid, Spain(招待講演)
• [Presentation] Impairment of proteolytic homeostasis as cause of neurodegeneration (2010)
  • Author(s): Keiji Tanaka
  • Organizer: S1 JOINT SYMPOSIUM [Key Mechanisms in Neurodegeneration] PRION & ICN Congress
  • Place of Presentation: Salzburg, Austria(招待講演)
• [Presentation] Assembly of Eukaryotic Proteasomes assisted by Molecular Chaperones" (2010)
  • Author(s): Keiji Tanaka
  • Organizer: The 3^<rd> International Symposium on Protein Community
  • Place of Presentation: Hotel Nikko Nara, Nara, Japan(招待講演)
• [Presentation] Autophagy and Parkinson's Disease (2010)
  • Author(s): Keiji Tanaka
  • Organizer: 1^<st> Sino-Japan Autophagy Symposium
  • Place of Presentation: Xi'an, China(招待講演)
• [Presentation] The PINK1/Parkin pathway controls mitochondrial homeostasis whose impairment causes Parkinson's disease. (2010)
  • Author(s): Keiji Tanaka
  • Organizer: Global COE International Symposium/Retreat 2010
  • Place of Presentation: Awaji Island, Japan(招待講演)
• [Presentation] 私のプロテアソーム研究-免疫との予期しなかった遭遇- (2010)
  • Author(s): 田中啓二
  • Organizer: 千葉大学G-COEプログラム"免疫システム統御治療学"免疫学リトリート
  • Place of Presentation: 千葉生命の森リゾート、千葉(招待講演)
• [Presentation] In Depth Analysis of protein Degradation in the Life Science Field. (2010)
  • Author(s): 田中啓二
  • Organizer: 69^<th> Annual Meeting of The Japanese Cancer Association "Conquering Cancer and Collective Wisdom
  • Place of Presentation: 大阪(招待講演)
• [Presentation] Immunological Roles of the Thymoproteasome. (2010)
  • Author(s): Keiji Tanaka
  • Organizer: Biology of the Ubiquitin and the Ubiquitin-Like Systems
  • Place of Presentation: Jerusalem, Israel(招待講演)
• [Presentation] 細胞内リサイクルシステム.回想と論文執筆奮戦記 (2009)
  • Author(s): 田中啓二
  • Organizer: 筑波大学医科学セミナー
  • Place of Presentation: 筑波(招待講演)
  • Year and Date: 2009-12-18
• [Presentation] トップジャーナルの目指し方～私の経験から～ (2009)
  • Author(s): 田中啓二
  • Organizer: 精神研特別企画セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2009-12-17
• [Presentation] プロテアソームを基軸としたタンパク質分解系の先駆的研究 (2009)
  • Author(s): 田中啓二
  • Organizer: 2009年度「武田医学賞」受賞講演
  • Place of Presentation: ホテルオークラ、東京(招待講演)
  • Year and Date: 2009-11-13
• [Presentation] オートファジーと神経変性疾患 (2009)
  • Author(s): 田中啓二
  • Organizer: 第1回ニューロフォーラム東京
  • Place of Presentation: 京王プラザホテル、東京(招待講演)
  • Year and Date: 2009-10-01
• [Presentation] Molecular Assembly and Diversity of Eukaryotic Proteasomes. (2009)
  • Author(s): Keiji Tanaka
  • Organizer: Proteolysis Research : Succession and Development
  • Place of Presentation: Tokyo Garden Palace, Tokyo, Japan(招待講演)
  • Year and Date: 2009-07-05
• [Presentation] 細胞内タンパク質の動態と生命科学 (2009)
  • Author(s): 田中啓二
  • Organizer: 第63回日本栄養・食糧学会大会特別講演
  • Place of Presentation: 長崎(招待講演)
  • Year and Date: 2009-05-22
• [Presentation] Molecular assembly and diversity of proteasomes (2009)
  • Author(s): K. Tanaka
  • Organizer: Ubiquitin, Ubiquitin-like Proteins and Proteasomes : Functions and Dysfunctions, Inserm Workshop
  • Place of Presentation: Saint-Raphael, (France)
• [Presentation] Proteasome assembly in mammals (2009)
  • Author(s): S. Murata
  • Organizer: EMBO conference on "Ubiquitin and ubiquitin-like modifiers in health and disease"
  • Place of Presentation: Riva del Garda (Italy)
• [Presentation] 細胞内大規模タンパク質分解システムの作動機構と生理機構 (2009)
  • Author(s): 田中啓二
  • Organizer: 日本分子生物学会第9回春期シンポジウム(090511-12)分子生物学の新たな胎動～宮崎から黎明の曙光～
  • Place of Presentation: 宮崎(招待講演)
• [Presentation] Molecular Assembly and Diversity of Proteasomes (2009)
  • Author(s): Keiji Tanaka
  • Organizer: Ubiquitin, Ubiquitin-like Proteins and Proteasomes : Functions and Dysfunctions, Inserm Workshop
  • Place of Presentation: Saint-Raphael, France(招待講演)
• [Presentation] Molecular Assembly and Diversity of Eukaryotic Proteasomes. (2009)
  • Author(s): Keiji Tanaka
  • Organizer: EMBO CONFERENCE on "Ubiquitin and Ubiqutin-like Modifiers in Health and Disease"
  • Place of Presentation: Riva Del Garda, Italy(招待講演)
• [Presentation] Molecular Mechanisms of Chaperone-assisted Proteasome Assembly. (2009)
  • Author(s): Keiji Tanaka
  • Organizer: The 4th International Congress on Stress Responses in Biology and Medicine. The 4th Annual Meeting of The Biomedical Society for Stress Response
  • Place of Presentation: Sapporo, Japan(招待講演)
• [Presentation] The Proteasome - From Molecular Mechanisms to Pathophysiological Roles -
  • Author(s): Keiji Tanaka
  • Organizer: Scienticf Forum
  • Place of Presentation: Peking University Health Science Center & Main Campus Beijing, China
  • Invited
• [Presentation] ユビキチン化とは何か
  • Author(s): 田中啓二
  • Organizer: 第76回 日本生化学会 中部支部 例会・シンポジウム 「タンパク質の翻訳後修飾の役割」
  • Place of Presentation: 自然科学研究機構 岡崎コンファレンスセンター, 岡崎
  • Invited
• [Presentation] プロテアソーム ～発見の糸口から病態生理研究に迫る～
  • Author(s): 田中啓二
  • Organizer: 「先端研セミナー」
  • Place of Presentation: 第一三共株式会社 品川研究開発センター 東京
  • Invited
• [Presentation] プロテオゲノミクス研究 ～私の研究から～ ヒトプロテオゲノミクスの現状とロードマップによる推進 「エピゲノムとプロテオームの統合によるヒトの生命と病気の解明」
  • Author(s): 田中啓二
  • Organizer: 学術研究プロジェクトシンポジウム
  • Place of Presentation: 日本学術会議講堂、東京
  • Invited
• [Presentation] Discovery and Pathophysiology of Immuno-typed Proteasomes.
  • Author(s): Keiji Tanaka
  • Organizer: Goldberg Lab Reunion and Symposium
  • Place of Presentation: Joseph B. Markin Conference Center Harvard Medical School, USA
  • Invited
• [Presentation] CREST「構造生命科学」H24年度 採択課題の紹介とプロテアソームの構造研究：プラットフォームの「支援」と「高度化」への期待
  • Author(s): 田中啓二
  • Organizer: 創薬等支援技術基盤プラットフォーム 第１回研究交流会
  • Place of Presentation: 神戸ポートピアホテル 神戸
  • Invited
• [Presentation] プロテアソーム（蛋白質分解酵素複合体）の動態と病態生理に関する研究動向
  • Author(s): 田中啓二
  • Organizer: 第26回 日本臨床内科医学会-いのちを支える地域医療の再生- 特別講演 II
  • Place of Presentation: ホテルクレメント徳島 徳島
  • Invited
• [Presentation] プロテアソームの発見から最新の動態解析まで
  • Author(s): 田中啓二
  • Organizer: 文部科学省「理数学生育成支援事業」独創的発想に富む科学者育成プログラム「出る杭を伸ばすヘリックスプロヘクト」採択事業「七人の侍」による記念講演会「大学コンソーシャム秋田」
  • Place of Presentation: カレッジプラザ講堂 秋田
  • Invited
• [Presentation] The Proteasome- From Basic Mechanisms To Immunological Roles
  • Author(s): Keiji Tanaka
  • Organizer: 10th RCGN International Symposium of Academic Frontier“Genome Information and Cellular Systems - New Frontier of Medicine
  • Place of Presentation: Saitama Medical University Hidaka Campus Saitama
  • Invited
• [Presentation] 未知への探究心 私のプロテアソーム研究から・・・
  • Author(s): 田中啓二
  • Organizer: 第64回 日本泌尿器科学会 西日本総会 知・技・心 ～ 求められる泌尿器科を目指して ～
  • Place of Presentation: 徳島県郷土文化会館 あわぎんホール、徳島
  • Invited
• [Presentation] PINK1（家族性パーキンソン病の責任遺伝子産物）によるミトコンドリアの品質管理機構.
  • Author(s): 田中啓二
  • Organizer: 第85回 日本生化学会大会 シンポジウム（1S17）ミトコンドリアの動的な構造・機能変換とその生理機能
  • Place of Presentation: 福岡
  • Invited
• [Presentation] The PINK1-Parkin system controls mitochondrial homeostasis whose collapse causes Parkinson’s disease.
  • Author(s): Keiji Tanaka
  • Organizer: The 4th Korea-Japan Symposium
  • Place of Presentation: Seoul National University, Korea
  • Invited
• [Presentation] 新しい免疫学への期待 ー 私の免疫研究を振り返って ー
  • Author(s): 田中啓二
  • Organizer: 東京大学免疫学教室（高柳研）研究室オープン記念講演会
  • Place of Presentation: 東京大学医学系研究科教育研究棟14階鉄門記念講堂、東京
  • Invited
• [Presentation] プロテアソームの基礎と生理病態学
  • Author(s): 田中啓二
  • Organizer: 日本薬学会第133年回 「薬科学の底力」
  • Place of Presentation: パシフィコ横浜、横浜
  • Invited
• [Presentation] Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System
  • Author(s): Keiji Tanaka
  • Organizer: Post-GCOE Program/Grants for Excellent Graduate Schools Organelle Homeostasis Research Center: Kick-off Symposium
  • Place of Presentation: Audio-Visual Hall, Collaborative Research Station-I, Kyushu University
  • Invited
• [Presentation] Pathophysiological Roles of the Proteasome in Vertebrate
  • Author(s): Keiji Tanaka
  • Organizer: OPENING LECTURE The EUROMEDLAB Milano 2013 Congress
  • Place of Presentation: Milano Convention Center, Milano, Italy
  • Invited
• [Book] Curr.Opini.Immunol (2012)
  • Author(s): Takahama, Y., Takada, K., Murata, S., Tanaka, K.
  • Total Pages: 7
  • Publisher: Elsevier Ltd.
• [Book] Keio J.Med. (2012)
  • Author(s): Tanaka, K.
  • Publisher: 慶應義塾大学(in press)
• [Book] Brain and Nerve (2012)
  • Author(s): 松田憲之, 田中啓二, 小松雅明
  • Total Pages: 6
  • Publisher: 医学書院
• [Book] Annual Review 2012神経 (2012)
  • Author(s): 田中啓二, 松田憲之, 尾勝圭
  • Total Pages: 6
  • Publisher: 中外医学社
• [Book] 「アレルギー」(社)日本アレルギー学会編 (2012)
  • Author(s): 田中啓二
  • Publisher: (社)日本アレルギー学会(印刷中)
• [Book] Methods in Molecular Biology (2011)
  • Author(s): Saeki, Y, Tanaka, K.
  • Total Pages: 23
  • Publisher: Humana Press. New York (USA)
• [Book] 日本栄養・食糧学会誌 (2011)
  • Author(s): 田中啓二
  • Total Pages: 8
  • Publisher: 公益社団法人日本栄養・食糧学会(総説)
• [Book] Surgery Frontier 2011年6月号特集 (2011)
  • Author(s): 田中啓二
  • Total Pages: 6
  • Publisher: メジカルビュー社
• [Book] 実験医学2011年7月増刊 (2011)
  • Author(s): 田中啓二
  • Total Pages: 8
  • Publisher: 羊土社
• [Book] ライフサイエンス「新着論文レビュー」 (2011)
  • Author(s): 佐伯泰、田中啓二
  • Publisher: 大学共同利用機関法人情報・システム研究機構ライフサイエンス統合データベースセンター
• [Book] 化学と生物(日本農芸化学会学会誌) (2011)
  • Author(s): 松田憲之, 田中啓二
  • Total Pages: 7
  • Publisher: 日本農芸化学会
• [Book] 実験医学 (2011)
  • Author(s): 松田憲之, 尾勝圭, 田中啓二
  • Total Pages: 7
  • Publisher: 羊土社
• [Book] 神経内科 (2011)
  • Author(s): 井口正寛, 松田憲之, 田中啓二
  • Total Pages: 7
  • Publisher: 科学評論社
• [Book] Bio Clinica (2011)
  • Author(s): 松田憲之, 田中啓二
  • Total Pages: 5
  • Publisher: 北隆館
• [Book] 病理と臨床 (2011)
  • Author(s): 田中啓二
  • Total Pages: 5
  • Publisher: 文光堂
• [Book] Assembly and function of the proteasome. "Ubiquitin Family Modifiers and the Proteasome : Reviews and Protocols" (2011)
  • Author(s): Saeki, Y, Tanaka, K.
  • Publisher: Humana Press. SPRINGER SCIENCE+BUSINESS MEDIA, New York, (USA)(In press)
• [Remarks] 研究代表者 田中 啓二
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks] 研究分担者 村田 茂穂
  • URL: http://www.f.u-tokyo.ac.jp/~tanpaku/
• [Remarks]
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks]
  • URL: http://www.igakuken.or.jp/pro-meta/
• [Remarks]
  • URL: http://www.igakuken.or.jp/
• [Remarks]
  • URL: http://www.igakuken.or.jp/
• [Patent(Industrial Property Rights)] ポリユビキチン化基質の同定方法 (2013)
  • Inventor(s): 吉田雪子、佐伯泰、土屋光、村上有沙、田中啓二
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Filing Date: 2013-11-15
• [Patent(Industrial Property Rights)] A novel versatile method for determining ubiquitin chain length reveals functional units of polyyubiquitin chains in cells (2013)
  • Inventor(s): 佐伯泰、土屋光、海保愛、田中啓二
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Filing Date: 2013-11-08
  • Overseas
• [Patent(Industrial Property Rights)] ポリユビキチン化基質の同定方法 (2013)
  • Inventor(s): 吉田雪子, 佐伯 泰, 土屋 光, 村上有沙, 田中啓二
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-15
• [Patent(Industrial Property Rights)] A novel versatile method for determining ubiuuitin chain length reveals functional units of polyyubiguitin chains in cells (2013)
  • Inventor(s): 佐伯 泰, 土屋 光, 海保 愛, 田中啓二
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-11-08
  • Overseas
• [Patent(Industrial Property Rights)] 肝疾患治療薬 (2011)
  • Inventor(s): 田中啓二、小松雅明、丹羽眞一郎、牧野泰孝、笠間隆志
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Filing Date: 2011-07-14
• [Patent(Industrial Property Rights)] 条件的自食作用欠損動物及び疾患モデル動物 (2011)
  • Inventor(s): 田中啓二、千葉智樹、小松雅明
  • Industrial Property Rights Holder: (公財)東京都医学総合研究所
  • Acquisition Date: 2011-05-27