Mechanisms of Generation, Maintenance, and Activation of Humoral Memory

• Project/Area Number: 21229007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: KUROSAKI Tomohiro 大阪大学, 免疫学フロンティア研究センター, 特任教授 (50178125)
• Co-Investigator(Kenkyū-buntansha): BABA Yoshihiro 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (20415269)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Yoshimasa 国立感染症研究所, 免疫部, 室長 (60311403)
• Project Period (FY): 2009-05-11 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥207,220,000 (Direct Cost: ¥159,400,000、Indirect Cost: ¥47,820,000); Fiscal Year 2013: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2012: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2011: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2010: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2009: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
• Keywords: 液性免疫記憶 / 免疫記憶 / 存在部位 / メモリーTfh / 細胞増殖 / メモリー亜集団 / 液性免疫 / NP-CGG / ルモリー亜集団 / T細胞

Research Abstract

Once the pathogen invades into our body, the immune system operates and remembers this pathogen even after the pathogen is eliminated from the body. Then, when the same pathogen is invaded again, our immune system is able to respond to it quickly, thereby eliminating the pathogen very efficiently. Here, we have been addressing the mechanism underlying such quick responses. First, we have shown that memory B cells residue in the place, where these B cells easily access to the invaded pathogen. Second, memory B cells acquire the rapid differentiation activity through down-regulation of the transcription factor Bach2. This down-regulation took place during primary infection. Finally, memory B cells activate memory T cells quickly, which, in turn, facilitate differentiation of memory B cells. The above three mechanisms are operating in a cooperative manner.

Assessment Rating

Verification Result (Rating)

A+

Research Products

• [Journal Article] Intrinsic disorder mediates cooperative signal transduction in STIM1 (2014)
  • Author(s): Furukawa, Y., Teraguchi, S., Ikegami, T., Dagliyan, O., Jin, L., Hall, D., Dokholyan, N.V., Namba, K., Akira, S., Kurosaki, T., Baba, Y., Standley, D.M.
  • Journal Title: J Mol Biol Volume: 426 Issue: 10 Pages: 2082-97
  • DOI: 10.1016/j.jmb.2014.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation (2014)
  • Author(s): Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., Hoffmann, A., Kurosaki, T., Okada-Hatakeyama, M.
  • Journal Title: Science Volume: 344 Pages: 760-764
  • Peer Reviewed
• [Journal Article] STIM1 Controls Neuronal Ca^<2+> Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior (2014)
  • Author(s): Hartmann. J., Karl, R.M., Alexander, R.P., Adelsberger, H., Brill, M.S., Ruhlmann, C., Ansel, A., Sakimura, K., Baba. Y., Kurosaki, T., Misgeld, T., Konnerth, A
  • Journal Title: Neuron Volume: 82 Issue: 3 Pages: 635-44
  • DOI: 10.1016/j.neuron.2014.03.027
  • Peer Reviewed / Open Access
• [Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells (2014)
  • Author(s): Yasukawa. S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H
  • Journal Title: Nature Comm Volume: 5 Issue: 1 Pages: 3755-3755
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  • Peer Reviewed / Open Access
• [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch (2014)
  • Author(s): Masahata, K., Umemoto, E., Kayama, H., Kotani, M., Nakamura, S., Kurakawa, T., Kikuta, J., Gotoh, K., Motooka, D., Sato, S., Higuchi, T., Baba, Y., Kurosaki, T., Kinoshita, M., Shimada, Y., Kimura, T., Okumura, R., Takeda, A., Tajima, M., Yoshie, O., Fukuzawa, M., Kiyono, H., Fagarasan, S., Iida, T., Ishii, M., Takeda, K
  • Journal Title: Nature Comm Volume: 5 Issue: 1 Pages: 3704-3704
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  • Peer Reviewed / Open Access
• [Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis (2014)
  • Author(s): Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
  • Journal Title: Nature Comm Volume: 5 Issue: 1 Pages: 3555-3555
  • DOI: 10.1038/ncomms4555
  • Peer Reviewed / Open Access
• [Journal Article] The STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense (2014)
  • Author(s): Zhang, H., Clemens, R.A., Liu, F., Hu, Y., Baba, Y., Theodore, P., Kurosaki, T., and Lowell, C.A.
  • Journal Title: Blood Volume: 123 Issue: 14 Pages: 2238-49
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• [Journal Article] Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse. (2014)
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  • Journal Title: Dev. Biol. Volume: 386 Issue: 2 Pages: 419-427
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• [Journal Article] Generation of colonic IgA-secreting cells in the cecal patch. (2014)
  • Author(s): Masahata, K. et al
  • Journal Title: Nature Comm. Volume: e-pub ahead of print
  • Peer Reviewed
• [Journal Article] An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. (2014)
  • Author(s): Yasukawa. S. et al
  • Journal Title: Nature Comm. Volume: e-pub ahead of print
  • Peer Reviewed
• [Journal Article] TAK1-IKKbeta positive feedback enforced by CARMA1 functions as a switch mechanism for NF-kappaB activation. (2014)
  • Author(s): Shinohara, H. et al
  • Journal Title: Science Volume: e-pub ahead of print
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• [Journal Article] Calcium signaling in B cells : Regulation of cytosolic Ca^<2+> increase and its sensor molecules, STIM1 and STIM2 (2013)
  • Author(s): Baba, Y., Matsumoto, M., Kurosaki, T
  • Journal Title: Mol. Immunol Volume: 39 Issue: 2 Pages: 136-147
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• [Journal Article] Downregulation of PLCγ2/β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer (2013)
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  • Journal Title: J. Exp. Med Volume: 210 Issue: 11 Pages: 2257-2271
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• [Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells (2013)
  • Author(s): Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
  • Journal Title: EMBO J. Volume: 32 Issue: 18 Pages: 2463-2476
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• [Journal Article] PDK1 controls upstream PI3K expression and PIP3 generation (2013)
  • Author(s): Dieterle, A.M., Bohler, P., Keppeler, H., Alers, S., Berleth, N., Drieβen, S., Hieke, N., Pietkiewicz, S., Loffler, A.S., Peter, C., Gray, A., Leslie, N.R., Shinohara, H., Kurosaki, T., Engelke, M., Wienands, J., Bonin, M., Wesselborg, S., and Stork, B
  • Journal Title: Oncogene Volume: 39 Issue: 23 Pages: 136-147
  • DOI: 10.1038/onc.2013.266
  • Peer Reviewed
• [Journal Article] Bach2 maintains T cells in a naive state by suppressing effector memory-related genes (2013)
  • Author(s): Tsukumo, S., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K., Saito, T
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume: 110 Issue: 26 Pages: 10735-40
  • DOI: 10.1073/pnas.1306691110
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• [Journal Article] Repression of Bach2 predisposes IgG1 memory B cells toward plasma cell differentiation. (2013)
  • Author(s): Kometani, K. et al
  • Journal Title: Immunity Volume: 未定
  • Peer Reviewed
• [Journal Article] B-Cell Responses to Pulmonary Virus Infection (2012)
  • Author(s): Takahashi, Y., Onodera, T., Kobayashi, K., and Kurosaki, T
  • Journal Title: Infec. Disord. Drug. Targets Volume: 12 Pages: 232-40
• [Journal Article] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection (2012)
  • Author(s): Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachimura, S., Kurosaki, T., and Kobayashi, K
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume: 109 Issue: 7 Pages: 2485-90
  • DOI: 10.1073/pnas.1115369109
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• [Journal Article] Primary and Secondary B-Cell Responses to Pulmonary Virus Infection. (2012)
  • Author(s): Takahashi, Y. et al
  • Journal Title: Infec Disord Drug Targets. Volume: 12 Issue: 3 Pages: 232-240
  • DOI: 10.2174/187152612800564400
• [Journal Article] Surf4 modulates STIM1-dependent calcium entry. (2012)
  • Author(s): Fujii, Y. et al
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 422 Issue: 4 Pages: 615-620
  • DOI: 10.1016/j.bbrc.2012.05.037
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• [Journal Article] The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells. (2012)
  • Author(s): Dong, Z. et al
  • Journal Title: Immunity Volume: 36 Issue: 6 Pages: 974-985
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• [Journal Article] Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses (2012)
  • Author(s): Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H., Wang. J. -Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 40 Pages: 2699-2706
  • DOI: 10.1073/pnas.1210706109
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• [Journal Article] Distinct cellular pathways select germ-line encoded and somatically mutated antibodies into immunological memory. (2012)
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  • Journal Title: J. Exp. Med. Volume: 209 Issue: 11 Pages: 2079-2097
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• [Journal Article] C.Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt (2012)
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  • Journal Title: Proceedings of the National Academy of Sciences of the U.S.A. Volume: 109 Issue: 1 Pages: 273-278
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• [Journal Article] Primary and Secondary B-Cell Responses to Pulmonary Virus Infection (2012)
  • Author(s): Takahashi, Y., et al
  • Journal Title: Infectious Disorders Volume: (印刷中)
• [Journal Article] CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway (2011)
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  • Journal Title: J. Exp. Med Volume: 208 Issue: 7 Pages: 1447-1457
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• [Journal Article] Regulation of BCR Signaling (2011)
  • Author(s): Kurosaki, T
  • Journal Title: Mol. Immunol Volume: 48 Issue: 11 Pages: 1287-1291
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• [Journal Article] Stim1, PKCδ and RasGRP set a threshold for pro-apoptotic Erk signaling during B cell development (2011)
  • Author(s): Limnander, A., Depeille, P., Freedman, T.S., Liou, J., Leitges, M., Kurosaki, T., Roose, J.P. and Weiss, A
  • Journal Title: Nat. Immunol Volume: 12 Issue: 5 Pages: 425-433
  • DOI: 10.1038/ni.2016
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• [Journal Article] The calcium sensors STIM1 and STIM2 control B cell regulatory function through IL-10 production (2011)
  • Author(s): Matsumoto, M., Fujii, Y., Baba, A., Hikida, M., Kurosaki, T. and Baba, Y.
  • Journal Title: Immunity Volume: 34 Issue: 5 Pages: 703-714
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• [Journal Article] ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation (2011)
  • Author(s): Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T
  • Journal Title: Sci. Signal Volume: 4, (169) Issue: 169 Pages: 104-16
  • DOI: 10.1126/scisignal.2001592
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• [Journal Article] A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress (2011)
  • Author(s): Song, SW., et al
  • Journal Title: Journal of Immunology Volume: 187 Issue: 2 Pages: 619-625
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• [Journal Article] Impact of Ca2^+ signaling on B cell function (2011)
  • Author(s): Baba, Y., Kurosaki, T.
  • Journal Title: Trends in Immunology Volume: 32 Issue: 12 Pages: 589-594
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• [Journal Article] Erk kinases control plasma cell differentiation by regulating expression of Blimp-1. (2011)
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  • Journal Title: Science Signal Volume: (in press)
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• [Journal Article] The calcium sensors STIM1 and STIM2 control B cell regulatory function through IL-10 production. (2011)
  • Author(s): Matsumoto M., Kurosaki T, et al.
  • Journal Title: Immunity Volume: (in press)
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• [Journal Article] Preferential localization of IgG memory B cells adjacent to contracted germinal centers (2010)
  • Author(s): Aiba, Y., Kometani, K., Hamadate, M., Moriyama, S., Sakaue-Sawano, A., Tomura, M., Luche, H., Fehling, H.J., Casella, R., Kanagawa, O., Miyawaki, A., and Kurosaki, T
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. Volume: 107 Issue: 27 Pages: 12192-7
  • DOI: 10.1073/pnas.1005443107
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• [Journal Article] Ca^<2+> influx and protein scaffolding via TRPC3 sustain PKCβand ERK activation in B cells (2010)
  • Author(s): Numaga T, Nishida M, Kiyonaka S, Kato K, Katano K, Mori E, Kurosaki T, Inoue R, Hikida T, Putney Jr JW & Mori M
  • Journal Title: J. Cell Sci. Volume: 123 Issue: 6 Pages: 927-938
  • DOI: 10.1242/jcs.061051
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• [Journal Article] MAGUK-controlled ubiquitination of CARMA1 modulates Lymphocyte NF-κB activity (2010)
  • Author(s): Moreno-Garcia, M.E., Sommer, K., Shinohara, H., Bandaranayake, A.D., Kurosaki, T., and Rawlings, D.J.
  • Journal Title: Mol. Cell. Biol Volume: 30 Issue: 4 Pages: 922-934
  • DOI: 10.1128/mcb.01129-09
• [Journal Article] Immobile BCRs : The safety on the signal trigger (2010)
  • Author(s): Sasaki, Y. and Kurosaki, T
  • Journal Title: Immunity Volume: 32 Issue: 2 Pages: 143-144
  • DOI: 10.1016/j.immuni.2010.02.007
• [Journal Article] Preferential localization of IgG memory B cells adjacent to contracted germinal centers. (2010)
  • Author(s): Aiba Y., Kurosaki T, et al.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 107(27) Pages: 12192-12197
  • Peer Reviewed
• [Journal Article] A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation. (2010)
  • Author(s): Ouchida, R., Kurosaki T., et al.
  • Journal Title: The Journal of Immunology Volume: 185 Pages: 294-301
  • Peer Reviewed
• [Journal Article] S-glutathionylation activates STIM1 and alters mitochondrial homeostaisis. (2010)
  • Author(s): Hawkins, B.J., Kurosaki T., et al.
  • Journal Title: The Journal of Cell Biology Volume: 190(3) Pages: 391-405
  • Peer Reviewed
• [Journal Article] Dephosphorylation of Carmal by PP2A negatively regulates T-cell activation. (2010)
  • Author(s): Eitelhuber, A.C., Kurosaki T, et al.
  • Journal Title: The EMBO Journal Volume: 30 Pages: 594-605
  • Peer Reviewed
• [Journal Article] B Cell Signaling and Fate Decision. (2010)
  • Author(s): Kurosaki T., et al.
  • Journal Title: Annual Review of Immunology Volume: 28 Pages: 21-55
• [Journal Article] Unique properties of memory B cells of different isotypes. (2010)
  • Author(s): Kurosaki T., et al.
  • Journal Title: Immunological Reviews Volume: 237(1) Pages: 104-116
• [Journal Article] MAGUK-controlled ubiquitination of CARM1 modulates Lymphocyte NF κB activity. (2010)
  • Author(s): Monreno-Garcia, M.E., et al.
  • Journal Title: Molecular and Cellular Biology 30 Pages: 922-934
  • Peer Reviewed
• [Journal Article] B cell singaling and fate decision. (2010)
  • Author(s): Kurosaki, T., et al
  • Journal Title: Annual Review of Immunology 28(In press)
• [Journal Article] Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling (2009)
  • Author(s): Shinohara, H. and Kurosaki, T
  • Journal Title: Immunol. Rev Volume: 232 Issue: 1 Pages: 300-318
  • DOI: 10.1111/j.1600-065x.2009.00836.x
• [Journal Article] FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-Cell receptor-mediated signaling (2009)
  • Author(s): Kochi, Y., Kyouzen, K., Yamada, R., Suzuki, A., Kurosaki, T., Nakamura, Y., and Yamamoto, K
  • Journal Title: J. Immunol Volume: 183 Issue: 9 Pages: 5502-5510
  • DOI: 10.4049/jimmunol.0901982
  • Peer Reviewed
• [Journal Article] Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells (2009)
  • Author(s): Baba, Y. and Kurosaki, T
  • Journal Title: Immunol. Rev Volume: 231 Issue: 1 Pages: 174-88
  • DOI: 10.1111/j.1600-065x.2009.00813.x
• [Journal Article] STIM protein couping in the activation of Orai channels. (2009)
  • Author(s): Wang, Y., et al.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America 106 Pages: 7391-7396
  • Peer Reviewed
• [Journal Article] STIM protein coupling in the activation of Orai channels. (2009)
  • Author(s): Wang, Y., et al.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 Pages: 7391-7396
  • Peer Reviewed
• [Journal Article] Memory B cells contribute to rapid Bcl6 expression by memory T_<FH> cells
  • Author(s): Ise, W., Inoue, T., McLachlan, JB, Kometani, K., Kubo, M., Okada, T., Kurosaki T
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A Volume: (in press)
  • Peer Reviewed
• [Presentation] Calcium Signaling in B Lymphocytes. (2014)
  • Author(s): Kurosaki, T
  • Organizer: Keystone Symposia : Biolgy of B Cell Reponses
  • Place of Presentation: Keystone, USA
  • Year and Date: 2014-02-11
• [Presentation] 液性免疫記憶の迅速反応性を支えるメカニズム (2014)
  • Author(s): 黒崎知博
  • Organizer: 先端免疫ワークショップ
  • Place of Presentation: 東北大学加齢医学研究所
  • Invited
• [Presentation] Calcium Signaling in B Lymphocytes. (2014)
  • Author(s): Kurosaki, T
  • Organizer: Keystone Symposia: Biolgy of B Cell Reponses
  • Place of Presentation: Keystone Resort
  • Invited
• [Presentation] 免疫レセプター抑制(ITIM)モチーフの発見 (2013)
  • Author(s): 黒崎知博
  • Organizer: 文部科学省卓越プログラムシンポジューム免疫科学のフロンティアー牟田達史博士メモリアルシンポジューム
  • Place of Presentation: 仙台
  • Year and Date: 2013-12-21
• [Presentation] B cell intrinsic and extrinsic mechanisms for rapid responsiveness of IgG1 type memory B cells (2013)
  • Author(s): Kurosaki, T., Kometani, K., Ise, W. , Shinnakasu, R
  • Organizer: 第36回分子日本分子生物学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-05
• [Presentation] B cell intrinsic and extrinsic mechanisms for rapid responsiveness of IgG1 type memory B cells (2013)
  • Author(s): Kurosaki, T
  • Organizer: 2013 Oversea Scholar Seminar, Tsinghua University
  • Place of Presentation: Beijing, China
  • Year and Date: 2013-11-14
• [Presentation] Calcium Signaling in B Lymphocytes (2013)
  • Author(s): Kurosaki, T
  • Organizer: Immune-related Pathologies : Understanding Leukocyte Signaling and Emerging therapies - IMPULSE 2013
  • Place of Presentation: Matrahaza, Hungary
  • Year and Date: 2013-09-02
• [Presentation] Cellular and molecular mechanisms for rapid responsiveness of humoral memory responses (2013)
  • Author(s): Kurosaki, T
  • Organizer: Seminar, Okinawa Institute of Science and Technology Graduate University
  • Place of Presentation: Okinawa
  • Year and Date: 2013-05-04
• [Presentation] B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells (2013)
  • Author(s): Kurosaki, T
  • Organizer: Keystone Symposia : B Cell Development and Function
  • Place of Presentation: Keystone Resort, USA
  • Year and Date: 2013-02-13
• [Presentation] カルシウムによる免疫制御 (2013)
  • Author(s): 黒崎知博
  • Organizer: JSI免疫サマースクール
  • Place of Presentation: ザ・ルイガンズ
  • Invited
• [Presentation] Calcium Signaling in B Lymphocytes (2013)
  • Author(s): Kurosaki, T.
  • Organizer: The 5th International Conference on B cell and Autoimmunity
  • Place of Presentation: Spazio Como
  • Invited
• [Presentation] B細胞分化におけるCNOT3の機能解析 (2013)
  • Author(s): 井上毅、黒崎知博
  • Organizer: 第5回シグナルネットワーク研究会
  • Place of Presentation: 北海道大学医学部フラテ会館
  • Invited
• [Presentation] Calcium Signaling in B Lymphocytes (2013)
  • Author(s): Kurosaki, T.
  • Organizer: Immune-related Pathologies: Understanding Leukocyte Signaling and Emerging therapies &#8211; IMPULSE 2013
  • Place of Presentation: Matrahaza
  • Invited
• [Presentation] B cell intrinsic and extrinsic mechanisms for rapid responsiveness of IgG1 type memory B cells (2013)
  • Author(s): Kurosaki, T, Kometani, K., Ise, W. , Shinnakasu, R.
  • Organizer: The 36th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Portpia Hotel
  • Invited
• [Presentation] Memory B and Tfh cells (2013)
  • Author(s): Kurosaki, T.
  • Organizer: The 42nd Annual Meeting of Japanese Society for Immunology
  • Place of Presentation: Makuhari messe
  • Invited
• [Presentation] Regulation of memory antibody response by antigen-specific memory CD4 T cells. (2012)
  • Author(s): Ise, W., Kurosaki, T
  • Organizer: The 41st Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-12-06
• [Presentation] Signaling to Control Developmental Transitions (2012)
  • Author(s): Kurosaki, T
  • Organizer: Keystone Symposia "Regulation of Lymphocyte Signaling."
  • Place of Presentation: Keystone, USA
  • Year and Date: 2012-03-14
• [Presentation] Signaling to Control Developmental Transitions (2012)
  • Author(s): Kurosaki, T.
  • Organizer: Keystone Symposia "Regulation of Lymphocyte Signaling."
  • Place of Presentation: Keystone, USA(招待講演)
  • Year and Date: 2012-03-14
• [Presentation] Contribution of transcription factors to rapid responsiveness of IgG type memory B cells (2012)
  • Author(s): Kurosaki, T.
  • Organizer: The 4th Joint RCAI-LIAI Workshop Program
  • Place of Presentation: San Diego, USA(招待講演)
  • Year and Date: 2012-02-07
• [Presentation] B Cell Signaling and its Biological Outcomes (2012)
  • Author(s): Kurosaki, T.
  • Organizer: The 1^<st> Winter School on Advanced Immunology
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] Contribution of transcription factors to rapid responsiveness of IgG type memory B cells (2011)
  • Author(s): Kurosaki, T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Protective memory B cell responses to influenza virus infection (2011)
  • Author(s): Takahashi, Y
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Contribution of transcription factors to rapid responsiveness of IgG type memory B cells (2011)
  • Author(s): Kurosaki, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)(招待講演)
  • Year and Date: 2011-11-28
• [Presentation] STIM/Oraiを介するBリンパ球カルシウムシグナル (2011)
  • Author(s): Kurosaki, T.
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: プリンスホテル新高輪(東京)(招待講演)
  • Year and Date: 2011-11-10
• [Presentation] Function of Calcium Signaling in B Lymphocytes (2011)
  • Author(s): Kurosaki, T
  • Organizer: The 1st International Meeting on Ion Channel Signaling Mechanisums : from Basic Science to Clinical Application
  • Place of Presentation: Marrakesh, Morocco
  • Year and Date: 2011-11-01
• [Presentation] Function of Calcium Signaling in B Lymphocytes (2011)
  • Author(s): Kurosaki, T.
  • Organizer: The 1^<st> International Meeting on Ion Channel Signaling Mechanisums
  • Place of Presentation: Marrakesh, Morocco(招待講演)
  • Year and Date: 2011-11-01
• [Presentation] Bリンパ球の基礎とその治療応用 (2011)
  • Author(s): Kurosaki, T.
  • Organizer: 第39回日本臨床免疫学会総会
  • Place of Presentation: 京王プラザホテル(東京)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] カルシウムによる免疫応答の負の制御 (2011)
  • Author(s): Kurosaki, T.
  • Organizer: 第13回免疫サマースクール
  • Place of Presentation: ラフォーレ蔵王リゾート&スパ(仙台)(招待講演)
  • Year and Date: 2011-08-02
• [Presentation] Calcium Signaling in immune cells (2011)
  • Author(s): Kurosaki, T
  • Organizer: FASEB Summer Research Conferences - Signal Transduction in the Immune System
  • Place of Presentation: Snowmass, USA
  • Year and Date: 2011-06-21
• [Presentation] Calcium Signaling in Immune Cells (2011)
  • Author(s): Kurosaki, T.
  • Organizer: FASEB Summer Research Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass, USA(招待講演)
  • Year and Date: 2011-06-21
• [Presentation] Function of Calcium in Lymphocytes (2011)
  • Author(s): Kurosaki, T
  • Organizer: Advances in Immunology and Cancer Biology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-04-17
• [Presentation] Function of Calcium in Lymphocytes (2011)
  • Author(s): Kurosaki, T.
  • Organizer: Advances in Immunology and Cancer Biology
  • Place of Presentation: Istanbul, Turkey(招待講演)
  • Year and Date: 2011-04-17
• [Presentation] Function of Store-Operated Calcium Entry in B Lymphocytes (2011)
  • Author(s): Kurosaki, T
  • Organizer: Keystone Symposia, B Cells : New Insights into Normal versus Dysregulated Function
  • Place of Presentation: Whistler, Canada
  • Year and Date: 2011-04-13
• [Presentation] Function of Store-Operated Calcium Entry in B Lymphocytes.Keystone Symposia, B Cells : New Insights into Normal versus Dysregulated Function (2011)
  • Author(s): Kurosaki, T.
  • Organizer: Keystone Symposia, B Cells : New Insights into Normal versus Dysregulated Function
  • Place of Presentation: Whistler, Canada(招待講演)
  • Year and Date: 2011-04-13
• [Presentation] Bリンパ球の発生と活性化 (2010)
  • Author(s): 黒崎知博
  • Organizer: 第22回新潟移植再生研究会
  • Place of Presentation: 有壬記念館、新潟(招待講演)
  • Year and Date: 2010-11-15
• [Presentation] CIN85 regulates canonical NF-□B pathway and subsequent B cell responses. (2010)
  • Author(s): 黒崎知博
  • Organizer: IFReC-CSI Joint Symposium
  • Place of Presentation: Zhejiang Xizi Hotel、杭州、中国(招待講演)
  • Year and Date: 2010-11-03
• [Presentation] Localization of IgM and IgG memory B cells. (2010)
  • Author(s): 黒崎知博
  • Organizer: INSERM RCAI Joint Workshop
  • Place of Presentation: 理化学研究所、横浜(招待講演)
  • Year and Date: 2010-08-30
• [Presentation] Store-operated Calcium Entry in B cells (2010)
  • Author(s): Kurosaki, T
  • Organizer: Symposia Track 4-1 : Lymphocyte Signaling. The 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] Store-operated Calcium Entry in B cells. (2010)
  • Author(s): 黒崎知博
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル、神戸(招待講演)
  • Year and Date: 2010-08-23
• [Presentation] Preferential localization of IgG memory B cells adjacent to contracted germinal centers (2010)
  • Author(s): Kurosaki, T
  • Organizer: The 4th International Symposium on B cells and Autoimmunity
  • Place of Presentation: Nara, Japan
  • Year and Date: 2010-08-20
• [Presentation] Preferential localization of IgG memory B cells adjacent to contracted germinal centers. (2010)
  • Author(s): 黒崎知博
  • Organizer: 第4回「B細胞と自己免疫」国際会議
  • Place of Presentation: 奈良ロイヤルホテル、奈良(招待講演)
  • Year and Date: 2010-08-20
• [Presentation] Unique properties of memory B lymphocytes (2010)
  • Author(s): Kurosaki, T
  • Organizer: Freiburg Institute for Advanced Studies Monday Seminar Series
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2010-06-21
• [Presentation] Unique properties of memory B lymphocytes. (2010)
  • Author(s): 黒崎知博
  • Organizer: Freiburg Institute for Advanced Studies Monday Seminar Series
  • Place of Presentation: University of Freiburg, Freiburg、ドイツ(招待講演)
  • Year and Date: 2010-06-21
• [Presentation] ストア作動性カルシウム流入活性化機構とその生理的役割 (2010)
  • Author(s): Baba, Y
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-19
• [Presentation] Regulation of B Cell Development (2010)
  • Author(s): Kurosaki, T
  • Organizer: Renal Transplantation Forum 2010
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-05-15
• [Presentation] Regulation of B Cell Development. (2010)
  • Author(s): 黒崎知博
  • Organizer: Renal Transplantation Forum 2010
  • Place of Presentation: 経団連会館、東京(招待講演)
  • Year and Date: 2010-05-15
• [Presentation] Preferential locaization of IgG memory B cells adjacent to waned germinal centers. (2009)
  • Author(s): 黒崎知博
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] Preferential localization of IgG memory B cells adjacent to waned germinal centers. (2009)
  • Author(s): 黒崎 知博
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] Store-operated calcium entry in B cells (2009)
  • Author(s): Baba, Y., Matsumoto, M., Kurosaki, T
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Role of PLCγ2 in humoral memory (2009)
  • Author(s): Kurosaki, T
  • Organizer: EMBO Conference Signaling in the Immune System : Lymphocyte signaling from development to effector function
  • Place of Presentation: Siena, Italy
  • Year and Date: 2009-09-15
• [Presentation] Cellular and molecular mechanisms for rapid responsiveness of humoral memory responses
  • Author(s): Kurosaki, T.
  • Organizer: Seminar, Okinawa Institute of Science and Technology Graduate University.
  • Place of Presentation: 沖縄科学技術大学院大学
  • Invited
• [Presentation] Bリンパ球の発生・活性化メカニズム
  • Author(s): 黒崎知博
  • Organizer: ＪＳＩ免疫サマースクール
  • Place of Presentation: 「ラフォーレ那須」栃木県
  • Invited
• [Presentation] 液性免疫記憶を支える細胞・分子メカニズム
  • Author(s): 黒崎知博
  • Organizer: ＪＳＩ免疫サマースクール
  • Place of Presentation: 「ラフォーレ那須」栃木県
  • Invited
• [Presentation] 免疫記憶の謎に挑む
  • Author(s): 黒崎知博
  • Organizer: WPI6拠点合同シンポジウム世界トップレベルの科学を愉しむ
  • Place of Presentation: 「つくば国際会議場」茨城県
  • Invited
• [Presentation] Regulation of memory antibody response by antigen-specific memory CD4 T cells
  • Author(s): 黒崎知博
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 「神戸国際会議場」兵庫県
  • Invited
• [Presentation] B cell intrinsic and extrinsic mechanisms for rapid responsiveness of IgG1 type memory B cells.
  • Author(s): 黒崎知博
  • Organizer: RCAI Michigan Joint Workshop
  • Place of Presentation: Univ. of Michigan, Ann Arbor, USA
  • Invited
• [Presentation] Humoral Memory Responses.
  • Author(s): 黒崎知博
  • Organizer: The 2nd NIF Winter School on Advanced Immunology.
  • Place of Presentation: Amara Sanctuary Resort, Sentosa Island, Singapore
  • Invited
• [Presentation] B cell intrinsic and extrinsic mechanisms for rapid responsiveness of IgG1 type memory B cells.
  • Author(s): 黒崎知博
  • Organizer: The 1st Symposium of International Immunological Memory and Vaccine Forum.
  • Place of Presentation: 「サピアホール」東京都
  • Invited
• [Presentation] Bリンパ球を介する免疫制御
  • Author(s): 黒崎知博
  • Organizer: 第７回福岡膠原病研究会
  • Place of Presentation: 「ホテル日航福岡」福岡県
  • Invited
• [Presentation] B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells.
  • Author(s): 黒崎知博
  • Organizer: Keystone Symposia: B Cell Development and Function.
  • Place of Presentation: Keystone Reseort, Denver, USA
  • Invited
• [Presentation] B細胞の免疫応答の基礎
  • Author(s): 黒崎知博
  • Organizer: 第1回日本移植学会若手育成教育セミナー
  • Place of Presentation: 「都市センターホテル」東京都
  • Invited
• [Presentation] Bリンパ球を介する免疫活性・抑制化メカニズム
  • Author(s): 黒崎知博
  • Organizer: 田辺三菱製薬 Special Seminar
  • Place of Presentation: 「山の上ホテル」東京都
  • Invited
• [Remarks] 日経産業新聞(10面)「免疫細胞の記憶解明」2013年7月12日化学工業日報(9面)「転写因子発現量に依存」2013年7月12日 ■新聞報道
• [Remarks] 日経産業新聞(10面)「多発性硬化症悪化防ぐ仕組み解明」2011年7月15日 ■新聞報道
• [Remarks] 化学工業日報(朝刊9面)「B細胞活性化の仕組み解明アダプター分子『CIN85』シグナル伝達に必須」2011年6月28日 ■新聞報道
• [Remarks] 日刊工業新聞(朝刊27面)「肺炎球菌へのB細胞抗体必須分子を特定」2011年6月28日 ■新聞報道
• [Remarks] 日刊工業新聞(朝刊27面)「肺炎球菌へのB細胞抗体必須分子を特定」2011年6月28日 ■新聞報道
• [Remarks] 化学工業日報(朝刊9面)「免疫応答の可視化成功」2011年6月3日 ■新聞報道
• [Remarks] 科学新聞(4面)「Bリンパ球の抗体産生細胞への分化」2011年4月29日 ■新聞報道
• [Remarks] 黒崎知博「超初心者向け『先生, 免疫って何ですか』」ラボカフェ, 10月25日,2013,大阪 ■アウトリーチ活動
• [Remarks] 黒崎知博「免疫記憶の謎に挑む」WPI6拠点合同シンポジウム世界トップレベルの科学を愉しむ. 11月24日, 2012, つくば ■アウトリーチ活動
• [Remarks] 黒崎知博「いちばん新しい免疫の話」サイエ ンスカフェ・オンザエッジ, 11月10日, 2012, 福岡 ■アウトリーチ活動
• [Remarks] 審良静男, 黒崎知博「第3回免疫の不思議」サイエンスカフェ・オンザエッジ, 1月18日, 2011, 大阪 ■アウトリーチ活動
• [Remarks] ホームページ
  • URL: http://lymph.ifrec.osaka-u.ac.jp/research_j.htm1
• [Remarks] 記憶B細胞が抗体産生細胞に分化しやすくなる仕組みを解明
  • URL: http://www.ifrec.osaka-u.ac.jp/jpn/research/2013/07/20130712-immunity.php
• [Remarks] 大阪大学免疫学フロンティア研究センター分化制御研究室ホームページ
  • URL: http://lymph.ifrec.osaka-u.ac.jp/index_j.html
• [Remarks] 大阪大学免疫学フロンティア研究センター分化制御研究室
  • URL: http://lymph.ifrec.osaka-u.ac.jp/index_j.html
• [Remarks]
  • URL: http://lymph.ifrec.osaka-u.ac.jp/research_j.html
• [Remarks]
  • URL: http://www.ifrec.osaka-u.ac.jp/jpn/laboratory/lymphocytedifferentiation/outline.php