• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanisms underlying gliotransmission-mediated neuronal plasticity

Research Project

Project/Area Number 21240034
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KOIZUMI Schuichi  山梨大学, 大学院・医学工学総合研究部, 教授 (10280752)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Yoshinori  岡山大学, 医歯(薬)学総合研究科, 教授 (10150658)
NAONO Kayoko  山梨大学, 医学工学総合研究部, 助教 (10443102)
KATAOKA Yasufumi  福岡大学, 薬学部, 教授 (70136513)
SHINOZAKI Youichi  山梨大学, 医学工学総合研究部, 講師 (10443772)
SHIGETOMI Eiji  山梨大学, 医学工学総合研究部, 特任助教 (00631061)
SHIBATA Keisuke  山梨大学, 医学工学総合研究部, 助教 (50580411)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywordsグリア細胞 / アストロサイト / ミクログリア / ATP / グリア伝達物質 / 開口放出 / トランスポーター
Research Abstract

Although glia are non-excitable cells, they release gliotransmitter such as ATP, and could regulate various brain functions. However, mechanisms underlying glial ATP release had remained unknown. Here we found that glia release ATP by exocytosis, for which vesicular nucleotide transporter (VNUT) has an essential role. The VNUT-dependent exocytosis was especially important in cases of various brain diseases. Taken together, glial cells control various brain functions by the VNUT-dependent ATP exocytosis.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (184 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (80 results) (of which Peer Reviewed: 69 results) Presentation (98 results) (of which Invited: 5 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] In vitro blood-brain barrier models using brain microvascular endothelial cells isolated from infant and adult rats retain age-related phenotypes in the bariier properties2013

    • Author(s)
      Takata, F., Dohgu, S., Yamauchi, A., Matsumoto, J., Machida, T., Fujishita, K., Shibata, K., Shinozaki, Y., Sato, K., Kataoka, Y. and Koizumi, S
    • Journal Title

      PLoS One

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purinergic receptors in microglia -Functional modal shift of microglia mediated by P1 and P2 receptors-2013

    • Author(s)
      Koizumi, S., Ohsawa, K., Inoue, K. and Kohsaka, S
    • Journal Title

      Glia

      Volume: 61 Pages: 47-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secreation of matrix metalloproteinase-9 by inhibition of tonic P2Y14-receptor-mediated signal(s)2013

    • Author(s)
      Kinoshita, M., Nasu-Tada, K., Fujishita, K., Sato, K. and Koizumi, S
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 33 Pages: 47-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor2013

    • Author(s)
      Sasaki, H., Tsukimoto, M., Harada, H., Moriyama, Y., Koyama, S
    • Journal Title

      PROS ONE

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The vesicular nucleotide transporter (VNUT) regulates the nucleotide content in airway epithelial mucin granules2013

    • Author(s)
      Sesma, JI., Kreda, SM., Okada, SF., van, Heusden, C., Moussa, L, Jones, LC., O'Neal, WK., Togawa, N., Hiasa, M., Moriyama, Y., Lazarowski, ER
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular neurotransmitter transporters: an approach for studying transporters with purified proteins2013

    • Author(s)
      Omote, H., Moriyama, Y
    • Journal Title

      Physiology

      Volume: 28 Pages: 39-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Purinergic receptors in microglia -Functional modal shift of microglia mediated by P2 and P1 receptors-.2013

    • Author(s)
      Koizumi, S
    • Journal Title

      Glia

      Volume: 61 Issue: 1 Pages: 47-54

    • DOI

      10.1002/glia.22358

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.2013

    • Author(s)
      Takata, F
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: 55166-55166

    • DOI

      10.1371/journal.pone.0055166

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglia release ATP by exocytosis2013

    • Author(s)
      Imura, Y
    • Journal Title

      Glia

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.2013

    • Author(s)
      Sasaki H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e59778-e59778

    • DOI

      10.1371/journal.pone.0059778

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The vesicular nucleotide transporter (VNUT) regulates the nucleotide content in airway epithelial mucin granules.2013

    • Author(s)
      Sesma JI
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular neurotransmitter transporters: an approach for studying transporters with purified proteins.2013

    • Author(s)
      Omote H
    • Journal Title

      Physiology

      Volume: 28 Issue: 1 Pages: 39-50

    • DOI

      10.1152/physiol.00033.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular nucleotide transporter: a brief history and the vesicular nucleotide transporter as a target for drug development.2013

    • Author(s)
      Hiasa M
    • Journal Title

      Curr Pharm Design

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランスポーターと疾患研究の最前線:塩素イオンにより制御されるトランスポーター群の発見と意義2013

    • Author(s)
      表 弘志
    • Journal Title

      医学の歩み

      Volume: 245 Pages: 69-73

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Purinergic signaling promotes proliferation of the adult mouse subventricular zone cells2012

    • Author(s)
      Suyama, S., Sunabori, T., Kanki, H., Sawamoto, K., Gachet, C., Koizumi, S. and Okano, H
    • Journal Title

      J. Neurosci.

      Volume: 32 Pages: 9238-9247

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microscopic visualization of ATP with luciferin-luciferase reaction in mouse skeletal muscles using "in vivo cryotechnique"2012

    • Author(s)
      Terada, N., Saitoh, Y., Saitoh, S., Ohno, N., Fujishita, K., Koizumi, S. and Ohno, S
    • Journal Title

      Microscopy and Microanalysis

      Volume: 15 Pages: 1030-1036

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-autonomous enhancement of glutamate-uptake by female astrocytes2012

    • Author(s)
      Morizawa, Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S. and Koizumi, S
    • Journal Title

      Cell. Mol. Neurobiol

      Volume: 32 Pages: 953-956

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe irritant dermatitis with loss of Langerhans cells in a mouse model of acrodermatitis enteropathica2012

    • Author(s)
      Kawamura, T., Ogawa, Y., Nakamura, Y., Nakamizo, S., Izumi, A., Nakano, H., Kabashima, K., Katayama, I., Koizumi, S., Kodama, T., Nakao, A. and Shinji Shimada
    • Journal Title

      J. Clin. Invest.

      Volume: 122 Pages: 722-732

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine regulation of TGF-β1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells2012

    • Author(s)
      Takai, E., Tsukimoto, M., Harada, H., Sawada, K., Moriyama, Y., Kojima, S
    • Journal Title

      J Cell Sci

      Volume: 125 Pages: 5051-60

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y(14)-receptor-mediated signal(s).2012

    • Author(s)
      Kinoshita, M
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 33 Issue: 1 Pages: 47-58

    • DOI

      10.1007/s10571-012-9869-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-autonomous enhancement of glutamate-uptake by female astrocytes.2012

    • Author(s)
      Morizawa, Y
    • Journal Title

      Molecular and Cellular Neurobiology

      Volume: 32 Issue: 6 Pages: 953-956

    • DOI

      10.1007/s10571-012-9829-z

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine regulation of TGF-β1-induced cell migration by exocytosis of ATP and activation of P2 receptors in human lung cancer cells.2012

    • Author(s)
      Takai E
    • Journal Title

      J Cell Sci.

      Volume: 125 Pages: 5051-60

    • DOI

      10.1242/jcs.104976

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-methylnicotinamide is an endogenous probe for evaluation of drug-drug interactions involving multidrug and toxin extrusions (MTE1 and MATE2K).2012

    • Author(s)
      Ito S
    • Journal Title

      Clin Pharmacol Ther

      Volume: 92 Issue: 5 Pages: 635-641

    • DOI

      10.1038/clpt.2012.138

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Na+/phosphate co-transporter homologue (SLC17A4 protein) is an intestinal organic anion exporter.2012

    • Author(s)
      Togawa N
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 302 Issue: 11 Pages: C1652-C1660

    • DOI

      10.1152/ajpcell.00015.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ケトン食の分子標的の発見2012

    • Author(s)
      森山芳則
    • Journal Title

      Epilepsy

      Volume: 6 Pages: 17-21

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 小胞型神経伝達物質トランスポーター:機能制御と薬物標的としての意義2012

    • Author(s)
      森山芳則
    • Journal Title

      細胞工学

      Volume: 31 Pages: 547-579

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Purinergic receptors in microglia-Functional modal shifts of microglia mediated by P2 and P1 receptors2012

    • Author(s)
      Schuichi Koizumi
    • Journal Title

      Glia

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-autonomous enhancement of glutamate-uptake by female astrocytes2012

    • Author(s)
      Morizawa Y
    • Journal Title

      Molecular and Cellular Neurobiology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe irritant dermatitis with loss of Langerhans cells in a mouse model of acrodermatitis enteropathica2012

    • Author(s)
      Kawamura, T
    • Journal Title

      J.Clin.Invest.

      Volume: 122 Pages: 722-732

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice2011

    • Author(s)
      Shibata, K., Sugawara, T., Fujishita, K., Shinozaki, Y., Matsukawa, T., Suzuki, T. and Koizumi, S
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Divalent cation transport by vesicular nucleotide transporter2011

    • Author(s)
      Miyaji, T., Sawada, K., Omote, H., Moriyama, Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 42881-42887

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Riboflavin transporter is finally identified2011

    • Author(s)
      Moriyama, Y
    • Journal Title

      J Biochem

      Volume: 150 Pages: 341-343

    • NAID

      10030587725

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional and Anatomical Identification of a Vesicular Transporter Mediating Neuronal ATP Release2011

    • Author(s)
      Larsson, M., Sawada, K., Morland, C., Hiasa, M., Ormel, L., Moriyama, Y., Gundersen, V
    • Journal Title

      Cereb Cortex

      Volume: (electric version)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transient Receptor Potential Vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse esophageal keratinocytes2011

    • Author(s)
      Mihara, H., Boudaka, A., Sugiyama, T., Moriyama Y., Tominaga, M
    • Journal Title

      J Physiol

      Volume: 589(Pt 14) Pages: 3471-82

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グリオトランスミッターとシナプス制御2011

    • Author(s)
      小泉修一
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 1273-1277

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 中枢神経障害とグリア2011

    • Author(s)
      小泉修一
    • Journal Title

      Cardiovascular Anesthesia

      Volume: 15 Pages: 83-89

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Functional and Anatomical Identification of a Vesicular Transporter Mediating Neuronal ATP Release2011

    • Author(s)
      Larsson M
    • Journal Title

      Cereb Cortex

      Volume: (electric version)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular neurotransmitter transporter : bioenergetics and regulation of glutamate transport2011

    • Author(s)
      Omote H
    • Journal Title

      Biochemistry

      Volume: 50(25) Pages: 5558-65

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of vesicular excitatory amino acid transport by human sialin2011

    • Author(s)
      Miyaji T
    • Journal Title

      J.Neurochem

      Volume: 119(1) Pages: 1-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects2011

    • Author(s)
      Kusuhara H
    • Journal Title

      Clin Pharmacol Ther

      Volume: 89(6) Pages: 837-44

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter2011

    • Author(s)
      Komatsu T
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 43(6) Pages: 913-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 構成的手法によるトランスポーター研究の最前線:化学伝達を制御するイオンスイッチの発見2011

    • Author(s)
      森山芳則
    • Journal Title

      生化学

      Volume: Vol.83 No.4 Pages: 294-303

    • NAID

      10029068137

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 第4章残されたトランスポーターへのアプローチ、1.構成的手法による小胞型神経伝達物質トランスポーターの分子同定と機能解析:トランスポートソーム生体膜輸送機構の全体像に迫る基礎、臨床、創薬応用研究の最新成果2011

    • Author(s)
      森山芳則
    • Journal Title

      遺伝子医学

      Volume: MOOK19 Pages: 110-115

    • Related Report
      2011 Annual Research Report
  • [Journal Article] New roles of astrocytes2011

    • Author(s)
      Koizumi S.
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グリア・ニューロン連関2011

    • Author(s)
      小泉修一
    • Journal Title

      BioClinica

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronized Ca2+ oscillations in astrocytes2010

    • Author(s)
      Koizumi, S
    • Journal Title

      FEBS J

      Volume: 277 Pages: 286-292

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronized Ca^<2+> oscillations in astrocytes.2010

    • Author(s)
      Koizumi S.
    • Journal Title

      FEBS J.

      Volume: 277 Pages: 286-292

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic Control of Vesicular Glutamate Transport and Release.2010

    • Author(s)
      Juge N, et al.
    • Journal Title

      Neuron

      Volume: 68 Pages: 99-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human sodium-phosphate transporter 4(hNPT4/SLC17A3)as a commonrenal secretory pathway for drugs and urate.2010

    • Author(s)
      Jutabha P, et al.
    • Journal Title

      J Biol Chem.

      Volume: An electric version

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 1 sodium dependent phosphate transporter(SLCl7A1 protein)is a CI^<->-dependent urate exporter.2010

    • Author(s)
      Iharada M, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 26107-26113

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A combinatorial method for overexpression of of membrane proteins in E.. cola.2010

    • Author(s)
      Leviatan S, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 23548-23556

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during Tcell activation.2010

    • Author(s)
      Tokunaga A, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 17406-17416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronized Ca^<2+> oscillations in astrocytes.2010

    • Author(s)
      Koizumi S
    • Journal Title

      FEBS J 277

      Pages: 286-292

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プリン作動性化学伝達のミッシングリンク:小胞型ヌクレオチドトランスポーター2010

    • Author(s)
      森山芳則
    • Journal Title

      日薬理誌 135

      Pages: 14-14

    • NAID

      10026543969

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures2009

    • Author(s)
      Mochizuki, T., Tokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M. and Tominaga, M
    • Journal Title

      J. Bio. Chem

      Volume: 284 Pages: 21257-21264

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of ATP-induced conformational changes in single P2X4receptors2009

    • Author(s)
      Shinozaki, Y., Sumitomo, K., Tsuda, M., Koizumi, S., Inoue, K. and Torimitsu, K
    • Journal Title

      PLoS Biology

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca^<2+> influx and ATP release in primary urothelial cell cultures.2009

    • Author(s)
      Mochizuki T
    • Journal Title

      J.Bio.Chem 284

      Pages: 21257-21264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grape seed extract(GSE)acting on astrocytes, reveals its neuronal protection against oxidative stress via interleukin-6-mediated mechanisms.2009

    • Author(s)
      Fujishita K
    • Journal Title

      Cell Mol Neurobiol 29

      Pages: 1121-1129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of ATP-induced conformational changes in single P2X_4 receptors.2009

    • Author(s)
      Shinozaki Y
    • Journal Title

      PLoS Biology 7

    • NAID

      120001788295

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2Y_6-evoked microglial phagocytosis.2009

    • Author(s)
      Inoue K
    • Journal Title

      International Review of Neurobiology 85

      Pages: 159-163

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高速原子間力顕微鏡を用いた受容体の一分子イメージング2009

    • Author(s)
      篠崎陽一
    • Journal Title

      日薬理誌 133

      Pages: 68-72

    • NAID

      10025741229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳内グリア細胞におけるATPセンサーを介した情報伝達2009

    • Author(s)
      小泉修一
    • Journal Title

      生化学 81

      Pages: 35-38

    • NAID

      10024915713

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion(MATE)transporter in Nicotiana tabacum.2009

    • Author(s)
      Morita M
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(7)

      Pages: 2447-2452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the vesicular nucleotide transporter(VNUT)in taste cells.2009

    • Author(s)
      Iwatsuki K
    • Journal Title

      Biochem.Biophys.Res.Commun. 388

      Pages: 1-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesicular inhibitory amino acid transporter is a C1-/γ-Aminobutirate co-transporter.2009

    • Author(s)
      Juge N
    • Journal Title

      J.Biol.Chem. 284(50)

      Pages: 35073-35078

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and-renal inflammation.2009

    • Author(s)
      Toyohara T
    • Journal Title

      J.Am.Soc.Nephrol. 20(12)

      Pages: 2546-2555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATPとアスパラギン酸の化学伝達を司る小胞型トランスポーターの発見2009

    • Author(s)
      森山芳則
    • Journal Title

      蛋白質・核酸・酵素 54(2)

      Pages: 148-155

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 私のパラ神経研究 その1 神経とパラ神経の狭間で2009

    • Author(s)
      森山芳則
    • Journal Title

      ミクロスコピア 26(2)

      Pages: 92-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 私のパラ神経研究 その2 ATPトランスポーターの発見2009

    • Author(s)
      森山芳則
    • Journal Title

      ミクロスコピア 26(3)

      Pages: 187-191

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 構成的生化学による小胞型神経伝達物質トランスポーター研究の新展開2009

    • Author(s)
      森山芳則
    • Journal Title

      医学のあゆみ 230(13)

      Pages: 1167-1168

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model.2009

    • Author(s)
      Sejima H
    • Journal Title

      Eur J Pharmacol. 624

      Pages: 66-70

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬学教育における治験実習プログラムの構築2009

    • Author(s)
      小柳多恵子
    • Journal Title

      医療薬学 35

      Pages: 636-643

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel cell-based assay to evaluate the malignant potential of cancer in vitro.2009

    • Author(s)
      Hirakawa C
    • Journal Title

      Anticancer Res 29

      Pages: 2541-2545

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice.2009

    • Author(s)
      Nishioku T
    • Journal Title

      Cell Mol Neurobiol 29

      Pages: 309-316

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway.2009

    • Author(s)
      Takata F
    • Journal Title

      Neurosci Lett. 449

      Pages: 71-75

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for leukemia inhibitory factor in melanoma-induced bone metastasis.2009

    • Author(s)
      Maruta S
    • Journal Title

      Clin Exp Metastasis 26

      Pages: 133-141

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microglia release ATP by exocytosis

    • Author(s)
      Imura, Y., Morizawa, Y., Komatsu, R., Shibata, K., Shinozaki, Y., Moriyama, Y. and Koizumi S
    • Journal Title

      Glia

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells.

    • Author(s)
      Nishioku T
    • Journal Title

      J Pharmacol Sci. (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Medication use as a risk factor for inpatient falls in an acute care hospital : a case-crossover study.

    • Author(s)
      Shuto H
    • Journal Title

      Br J Clin Pharmacol. (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood-Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia.

    • Author(s)
      Sumi N
    • Journal Title

      Cell Mol Neurobio. (in press)

    • Related Report
      2009 Annual Research Report
  • [Presentation] シナプス再編とグリア-ニューロン連関2013

    • Author(s)
      小泉修一
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Final Research Report
  • [Presentation] シナプス再編とグリア-ニューロン連関2013

    • Author(s)
      小泉修一
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小胞型神経伝達物質トランスポーターの生化学と薬理学2013

    • Author(s)
      森山芳則
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 液胞型H+輸送性ATPaseと二次性トランスポーター群の構造・機能・生理的意義に関する研究2013

    • Author(s)
      森山芳則
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clean biochemical approach により解明された小胞型神経伝達物質トランスポーターの新機能(Structural and functional studies on the vesicular neurotransmitter transporters by clean biochemical approach)2012

    • Author(s)
      森山芳則
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of glial out-put signals on brain function2012

    • Author(s)
      小泉修一
    • Organizer
      GCOE ニューロサイエンス
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] グリア細胞の情報発信と脳機能2012

    • Author(s)
      小泉修一
    • Organizer
      第6回Brain Science Conference
    • Place of Presentation
      京都ブライトンホテル(京都市)
    • Year and Date
      2012-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Synaptic Effects of Ketones2012

    • Author(s)
      森山芳則
    • Organizer
      (Third International Symposium: Dietary Therapy for Epilepsy & Other Neurological Disorders)
    • Place of Presentation
      Hilton Chicago Indian Lakes Resort(シカゴ アメリカ)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] アストロサイトの情報発信と脳機能2012

    • Author(s)
      小泉修一
    • Organizer
      第117回日本解剖学会総会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 向精神薬の標的としてのアストロサイト2012

    • Author(s)
      小泉修一
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経障害性疼痛におけるグリア細胞の役割と生薬ブシ末の鎮痛メカニズム2012

    • Author(s)
      柴田圭輔
    • Organizer
      日本東洋医学会関東甲信越支部山梨県部会
    • Place of Presentation
      山梨県(招待講演)
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional modal shift of microglia mediated by astrocytes2012

    • Author(s)
      小泉修一
    • Organizer
      8th FENS Forum of Neuroscience
    • Place of Presentation
      International Convention Center(バルセロナ スペイン)
    • Related Report
      2012 Final Research Report
  • [Presentation] Exocytosis ATP and Cellular Functions2012

    • Author(s)
      小泉修一
    • Organizer
      Purine2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism and Function of Vesicular Nucleotide Transporter (VNUT)2012

    • Author(s)
      森山芳則
    • Organizer
      Purine 2012
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Exocytosis ATP and Cellular Functions2012

    • Author(s)
      小泉修一
    • Organizer
      Purine2012
    • Place of Presentation
      九州大学百年講堂(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Microglia Release ATP by a Mechanism of Exocytosis2012

    • Author(s)
      Yoshio Imura
    • Organizer
      Purine2012
    • Place of Presentation
      九州大学百年講堂(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional modal shift of microglia mediated by astrocytes2012

    • Author(s)
      小泉修一
    • Organizer
      8th FENS Forum of Neuroscience
    • Place of Presentation
      International Convention Center(Barcelona)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ATPエキソサイトーシスによるミクログリアの情報発信機構の解明2012

    • Author(s)
      井村 誉史雄
    • Organizer
      第14回応用薬理シンポジウム
    • Place of Presentation
      ベルクラシック甲府(甲府市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanism and Function of Vesicular Nucleotide Transporter (VNUT)2012

    • Author(s)
      森山芳則
    • Organizer
      Purine 2012
    • Place of Presentation
      九州大学百年講堂(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synaptic Effects of Ketones.2012

    • Author(s)
      森山芳則
    • Organizer
      Third International Symposium
    • Place of Presentation
      Hilton Chicago Indian Lakes Resort(シカゴ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clean biochemical approachにより解明された小胞型神経伝達物質トランスポーターの新機能2012

    • Author(s)
      森山芳則
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経疾患の標的としてのグリア細胞2011

    • Author(s)
      小泉修一
    • Organizer
      第21回日本臨床精神神経薬理学会、第41回日本精神神経薬理学会・合同大会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATPエキソサイトーシスによるミクログリアの情報発信2011

    • Author(s)
      井村誉史雄
    • Organizer
      第54回日本神経化学大会
    • Place of Presentation
      石川
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Highlighting the Molecular Basis of Purinergic Transmission2011

    • Author(s)
      森山芳則
    • Organizer
      ISN-ESN-2011
    • Place of Presentation
      Megaron Athens International Conference Centre(アテネ ギリシャ)
    • Year and Date
      2011-08-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Highlighting the Molecular Basis of Purinergic Transmission2011

    • Author(s)
      森山芳則
    • Organizer
      ISN-ESN-2011
    • Place of Presentation
      アテネ(招待講演)
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] グリアと脳機能・病態2011

    • Author(s)
      小泉修一
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-08-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms underlying gliotransmitter ATP and their dysfunctions.2011

    • Author(s)
      Koizumi, S
    • Organizer
      The 23rd bennial meeting of international society for Neurochemistry
    • Place of Presentation
      Megaron Athens International Conference Centre、(Athens,Greece)
    • Related Report
      2012 Final Research Report
  • [Presentation] 海馬アストロサイトにおける抗うつ薬fluoxetineのBDNF発現メカニズム2011

    • Author(s)
      木下真直
    • Organizer
      生理研研究会
    • Place of Presentation
      岡崎
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms underlying gliotransmitters and their dysfunctions. International Society for Nenrocemistry2011

    • Author(s)
      Koizumi, S.
    • Organizer
      The 23^<rd> ISN Satellite Symposium
    • Place of Presentation
      Ljubliana, Slovenia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms underlying gliotransmitter ATP and their dysfunctions2011

    • Author(s)
      Koizumi, S.
    • Organizer
      The 23rd bennial meeting of international society for Neurochemistry
    • Place of Presentation
      Athens, Greece(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Direct visualization of single receptor structure/dynamics with fast-scanning atomic force microscopy2011

    • Author(s)
      Shinozaki, Y.
    • Organizer
      The 23rd bennial meeting of international society for Neurochemistry
    • Place of Presentation
      Athens, Greece
    • Related Report
      2011 Annual Research Report
  • [Presentation] The astrocyte-targeted therapy by Bushi for the neuropathic pain2011

    • Author(s)
      柴田圭輔
    • Organizer
      第34回日本神経科学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms underlying fluoxetine-evoked increase in BDNF in hippocampal astrocytes2011

    • Author(s)
      木下真直
    • Organizer
      第54回日本神経化学会
    • Place of Presentation
      石川
    • Related Report
      2011 Annual Research Report
  • [Presentation] ATP情報が発信されるメカニズム2011

    • Author(s)
      小泉修一
    • Organizer
      生理研プリン研究会2011
    • Place of Presentation
      岡崎(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice2011

    • Author(s)
      Shibata, K.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      Washington D.C.
    • Related Report
      2011 Annual Research Report
  • [Presentation] Astrocytic ATP release and brain functions.2011

    • Author(s)
      Koizumi, S.
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] グリア細胞と痛み2010

    • Author(s)
      小泉修一
    • Organizer
      第5回埼玉ペインクリニック研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying upregulation of microglial P2Y6 receptors2010

    • Author(s)
      Koizumi, S
    • Organizer
      Society for Neuroscience Meeting. San Diego Convention Center
    • Place of Presentation
      (San Diego, USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] Astrocytesの新しい役割2010

    • Author(s)
      小泉修一
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gliotransmitter release and regulation of synaptic transmission by astrocytes.2010

    • Author(s)
      Koizumi, S.
    • Organizer
      DFG-Priority Programme 1176
    • Place of Presentation
      Kaiserslautern, Germany
    • Related Report
      2010 Annual Research Report
  • [Presentation] Astrocytes respond to anti-depressants and contribute to its therapeutic effects.2010

    • Author(s)
      Koizumi, S.
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanisms underlying upregulation of microglial P2Y6 receptors.2010

    • Author(s)
      Koizumi. S.
    • Organizer
      Society for Neuroscience Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glia and diseases.2010

    • Author(s)
      Koizumi S
    • Organizer
      Japan-France Frontier of Sciences
    • Place of Presentation
      France
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of glial activation by KAMPO-therapeutic strategy for neuropathic pain.2010

    • Author(s)
      Koizumi S
    • Organizer
      (シンポジウム)第83回旧本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] The pathology of neuropathic pain characterized by mechanisms of analgesic effect of Bushimatsu.2010

    • Author(s)
      Shibata K
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying fluoxetine-evoked increase in BDNF in hippocampal astrocytes.2010

    • Author(s)
      Koizumi S
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Loss of UDP-glucose signaling evokes release of MMP-9 in astrocytes.2010

    • Author(s)
      Kinoshita M
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protection of the methylmercury-induced neuronal cell death by astrocytes via interleukin-6-mediated mechanisms.2010

    • Author(s)
      Noguchi Y
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying upregulation of microglial P2Y6 receptors after kainic acid treatment2010

    • Author(s)
      Fujishita K
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗うつ薬の有望な標的としてのアストロサイト2010

    • Author(s)
      小泉修一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリア細胞のATPセンサーによる脳機能制御2010

    • Author(s)
      小泉修一
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] A role of hypothalamic AMP-activated protein kinase in the mediation of olanzapine-induced hyperphagia and weight-gain in female rats2010

    • Author(s)
      Kengo Nakagama
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Influence of olanzapine on glycogen metabolism in HepG2 cells2010

    • Author(s)
      Keiichi Fujimoto
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reactive oxygen species(ROS)-mediated regulation of MMP-9 expression in the brain pericytes2010

    • Author(s)
      Kousuke Matsumoto
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Calcineurin/NFAT signaling regulates MMP-9 expression in brain pericytes2010

    • Author(s)
      Takashi Machida
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Disruption of the blood-brain barrier in collagen-induced arthritic mice2010

    • Author(s)
      Koki Furusho
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] BBB hyperpermeability to sodium fluorescein in obese mice with impaired glucose tolerance induced by high-fat diet2010

    • Author(s)
      Fuyuko Takata
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] A correlation between tail-skin temperature induced by forced exercise and metabolic parameters in ovariectomized mice fed high-fat diet2010

    • Author(s)
      Satoko Kawahara
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] メチルグリオキサール修飾アルブミンを指標にしたレドックス制御医薬品評価系の構築2010

    • Author(s)
      中尾麻衣子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 治験実施計画書を題材としたSGD&ロールプレイ形式による治験実習の試み2010

    • Author(s)
      今給黎修
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] ICU患者におけるニカルジピン注射剤投与による静脈炎に関する前向き観察研究2010

    • Author(s)
      立石夕香理
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニューロン-グリア連関2009

    • Author(s)
      小泉修一
    • Organizer
      第25回脳機能分子研究会
    • Place of Presentation
      京都大学、京都市
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニューロン-グリア連関-アストロサイトの情報発信メカニズムを甲心として-2009

    • Author(s)
      小泉修一
    • Organizer
      東京大学新領域特別講義
    • Place of Presentation
      柏市
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of vesicular neurotransmitter transpoters in the metabolic reglation2009

    • Author(s)
      森山芳則
    • Organizer
      第36回国際生理学会生会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2009-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuron-to-glia communication in the CNS.2009

    • Author(s)
      Koizumi S
    • Organizer
      The 6^<th> Joint Symposium between Univ.Bonn and Waseda Univ.
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経伝達物質トランスポーターの構造・機能・制御:化学伝達の人工制御を目指して2009

    • Author(s)
      森山芳則
    • Organizer
      第2回Bimonthly Symposiumトランスポーターシンポジウム:トランスポーター研究の新たな展開-トランスポーターを標的とした創薬への動向-
    • Place of Presentation
      神戸、神戸臨床研究情報センター(TRI)
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell-to-cell communication mediated by extracellular nucleotides in the CNS2009

    • Author(s)
      Koizumi, S
    • Organizer
      A lecture in commemoration of receiving prize "Japan Academy Medal" Fukuoka Purine2009
    • Place of Presentation
      ホテル・ザ・ルイガンズ福岡(福岡市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経因性疼痛へのブシ末の鎮痛効果2009

    • Author(s)
      柴田圭輔
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリア細胞の神経化学2009

    • Author(s)
      小泉修一
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell-to-cell communication mediated by extracellular nucleotides in the CNS.2009

    • Author(s)
      Koizumi S
    • Organizer
      A lecture in commemoration of receiving prize"Japan Academy Medal"Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuron-microglia interaction mediated by multiple P2Y receptors.2009

    • Author(s)
      Koizumi S
    • Organizer
      IUPS
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model2009

    • Author(s)
      Fujishita K
    • Organizer
      IUPS
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Contribution of astrocytes to the"French paradox"in the CNS.2009

    • Author(s)
      Koizumi S
    • Organizer
      Euroglia
    • Place of Presentation
      Paris, France.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying upregulation of P2Y_6 receptors in microglia in kainate-induced injury model.2009

    • Author(s)
      Fujishita K
    • Organizer
      Euroglia
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Annual Research Report
  • [Presentation] Contribution of astrocytes to the"French paradox"in the CNS.2009

    • Author(s)
      Koizumi S
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vesicular glutamate transporter acts as a metabolic regulator2009

    • Author(s)
      森山芳則
    • Organizer
      the 2009 Annual meeting of Korean Endocrine Society
    • Place of Presentation
      韓国(ソウル)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vesicular nucleotide transporter : From molecule to physiology.2009

    • Author(s)
      森山芳則
    • Organizer
      Fukuoka Purine 2009(同大会のランチョンセミナーThe Fifth Vesicular Transporter(VNUT)and The Fifth Taste(umami)にて講演。Iternational Symposiumon Purinergog Signalling in New Strategy of Drug Discoveryのオーガナイザー)
    • Place of Presentation
      福岡、Hotel The LUIGANS
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of vesicular neurotransmitter transporters in the metabolic regulation.2009

    • Author(s)
      森山芳則
    • Organizer
      第36回国際生理学会世界大会(IUPS)シンポジウムPhysiology of gut nutrient perception
    • Place of Presentation
      京都、国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of vesicular neurotransmitter transporters in regulation of endocrine function2009

    • Author(s)
      森山芳則
    • Organizer
      19th International congress of Nutrition(ICN2009) : Amino acid and related metabolites ; nutrition al and physiological significance normal appetite, digestion and homeostasis for healthier life
    • Place of Presentation
      タイ(バンコク)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポストゲノム時代に対応したトランスポーターの大量増調製法A large scale purification of fundtional human transporters2009

    • Author(s)
      森山芳則
    • Organizer
      第82回日本生化学会大会シンポジウム2S20p「トランスポーター研究のパラダイムシフト:ヒトシステムの理解を目指して」で発表、オーガナイザー。
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brainbarrier caused by lipopolysaccharide-induced sepsis in mice.2009

    • Author(s)
      Tsuyoshi Nishioku
    • Organizer
      8^<th> Cerebral Vascular Biology International Confe rence.
    • Place of Presentation
      Sendai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Significance of blood concentration of cyclosporine at 2 hours after administration for the treatment of idiopathic membranous nephropathy with steroid resistant nephritic syndrome.2009

    • Author(s)
      Takao Saito
    • Organizer
      WCN 2009, World Congress of Nephrology
    • Place of Presentation
      Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] TNF-・stimulates MMP-9 secretion in the brain pericytes by activating ERK1/2, JNK and PI3 kinase signaling pathway.2009

    • Author(s)
      Fuyuko Takata
    • Organizer
      12^<th> international symposium, Signaling at Blood-Brain and Blood Retinal Barriers
    • Place of Presentation
      London
    • Related Report
      2009 Annual Research Report
  • [Presentation] Increased blood-brain barrier permeability to sodium fluorescein in high fat diet-induced obese mice with impaired glucose tolerance : A comparison study among ICR, C57BL/6J, and db/db mice2009

    • Author(s)
      Shinya Dohgu
    • Organizer
      12^<th> international symposium, Signaling at Blood-Brain and Blood Retinal Barriers
    • Place of Presentation
      London
    • Related Report
      2009 Annual Research Report
  • [Presentation] Population pharmacokinetics and dose adjustment strategy of cyclosporine in steroid-resistant nephrotic patients2009

    • Author(s)
      Satoru Ogahara
    • Organizer
      11^<th> International Congress of Therapeutic Drug M onitoring & Clinical Toxicology
    • Place of Presentation
      Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynamin 1 depletion and memory deficits in rats treated with A・ and cerebral ischemia2009

    • Author(s)
      Takuya Watanabe
    • Organizer
      The 1^<at> Meeting of the Asian College of Neuropsyc hopharmacology(AsCNP)
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of Microglia and Migration of Brain Pericytes are Involved in Disruption of the Blood-brain Barrier Caused by Lipoplysaccharide2009

    • Author(s)
      Tsuyoshi Nishioku
    • Organizer
      The 1^<st> Meeting of the Asian College of Neuropsyc hopharmacology(AsCNP)
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Olanzapine on Glucose Transport System in 3T3-L1 Adipocytes2009

    • Author(s)
      Atsushi Yamauchi
    • Organizer
      The 1^<st> Meeting of the Asian College of Neuropsyc hopharmacology(AsCNP)
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] 難治性ネフローゼ症候群における母集団薬物動態解析を用いたシクロスポリンの至適投与2009

    • Author(s)
      小河原悟
    • Organizer
      第52回臼本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] ステロイド抵抗性ネフローゼ症候群のプレドニゾロンとシクロスポリン併用療法における血中濃度測定の意義2009

    • Author(s)
      斉藤喬雄
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 長期実務実習トライアルにおけるモデル・コアリキュラム到達目標(SBOs)達成度の調査2009

    • Author(s)
      今給黎修
    • Organizer
      第19回日本医療薬学大会
    • Place of Presentation
      長崎
    • Related Report
      2009 Annual Research Report
  • [Presentation] BBB hyperpermeability to sodium fluorescein in high fat diet-induced obese mice with impaired glucose tolerance : A comparison study using ICR, C57BL/6J, and db/db mice2009

    • Author(s)
      Takashi Obara
    • Organizer
      日本薬物動態学会 第24回年会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immunosuppressant-induced dysfunction of the blood-brain barrier2009

    • Author(s)
      Junichi Matsumoto
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] TNF-・によるERKI/2,JNKおよびPI3 kinaseを介した脳ペリサイトMMP-9産生2009

    • Author(s)
      古野龍也
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      愛媛
    • Related Report
      2009 Annual Research Report
  • [Presentation] ICUにおける薬剤管理業務の必要性-プレアボイド報告の解析-2009

    • Author(s)
      安藝敬生
    • Organizer
      医療薬学フォーラム2009第17回クリニカルファーマシーシンポジウム
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリア細胞の情報発信と脳機能

    • Author(s)
      小泉修一
    • Organizer
      第6回Brain Science Conference
    • Place of Presentation
      京都ブライトンホテル(京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Effects of glial out-put signals on brain function

    • Author(s)
      小泉修一
    • Organizer
      GCOEニューロサイエンス
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The metabolic control of vesicular glutamate transport.

    • Author(s)
      森山芳則
    • Organizer
      A satellite event of the 8th FENS forum
    • Place of Presentation
      International Convention Center(Barcelona)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] リッピンコットシリーズ イラストレイテッド細胞分子生物学2012

    • Author(s)
      森山芳則 水島 昇
    • Publisher
      丸善出版
    • Related Report
      2012 Final Research Report
  • [Book] リッピンコットシリーズ イラストレイテッド細胞分子生物学2011

    • Author(s)
      訳者森山芳則, 監訳者水島昇
    • Publisher
      丸善出版
    • Related Report
      2011 Annual Research Report
  • [Remarks] なし

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] グリア細胞の活性化抑制組成物2012

    • Inventor(s)
      小泉修一、松川隆、藤下加代子、菅原健、柴田圭輔
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Number
      2009-267902
    • Filing Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリアミンの化学伝達を司るトランスポーターの同定とその利用2012

    • Inventor(s)
      山芳則・表弘志・宮地孝明・日浅未来
    • Industrial Property Rights Holder
      山芳則・表弘志・宮地孝明・日浅未来
    • Industrial Property Number
      2012-243730
    • Filing Date
      2012-11-05
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ポリアミンの化学伝達を司るトランスポーターの同定とその利用2012

    • Inventor(s)
      森山芳則・表弘志・宮地孝明・日浅未来
    • Industrial Property Rights Holder
      森山芳則・表弘志・宮地孝明・日浅未来
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-05
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi