| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Yoshinori 岡山大学, 医歯(薬)学総合研究科, 教授 (10150658)
NAONO Kayoko 山梨大学, 医学工学総合研究部, 助教 (10443102)
KATAOKA Yasufumi 福岡大学, 薬学部, 教授 (70136513)
SHINOZAKI Youichi 山梨大学, 医学工学総合研究部, 講師 (10443772)
SHIGETOMI Eiji 山梨大学, 医学工学総合研究部, 特任助教 (00631061)
SHIBATA Keisuke 山梨大学, 医学工学総合研究部, 助教 (50580411)
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| Budget Amount *help |
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2012: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Research Abstract |
Although glia are non-excitable cells, they release gliotransmitter such as ATP, and could regulate various brain functions. However, mechanisms underlying glial ATP release had remained unknown. Here we found that glia release ATP by exocytosis, for which vesicular nucleotide transporter (VNUT) has an essential role. The VNUT-dependent exocytosis was especially important in cases of various brain diseases. Taken together, glial cells control various brain functions by the VNUT-dependent ATP exocytosis.
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