| Budget Amount *help |
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2009: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
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| Research Abstract |
We systematically investigated the polymorphism of amyloid Aβ/ Cu fibrils and their catalytic oxidation activity using the liposome as a model biomembrane. It was clarified that the oxidized surface of liposome could affect the catalytic oxidation activity of amyloids as well as their morphology. It was revealed that the experiments using peptide fragments-displayed liposomes could contribute to the better understanding on the regulatory mechanism of catalytic oxidation activity of Aβ/ Cu. Besides, we developed the novel loading method of liposomes into the module. Those results suggested that a recognition system of abnormal/ damaged biomembranes for their repairmen could be in principle developed, from those results.
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