Analysis of dynamic structure-function network of heterochromatin
| Project/Area Number |
21247001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Hokkaido University |
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Principal Investigator |
MURAKAMI Yota 北海道大学, 大学院・理学研究院, 教授 (20260622)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Katsunori 関西学院大学, 理工学部, 教授 (60273926)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2011: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2010: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2009: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Keywords | ヘテロクロマチン / RNAi / 転写 / 非コードRNA / RNAポリメラーゼII / 分裂酵母 / Two hybrid法 |
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| Research Abstract |
Heterochromatin is an important for epigenetic gene regulation and maintenance of genetic information. Using fission yeast as a model organism, we focused on RNAi-directed heterochromatin formation and tried to understand the molecular mechanism of its formation and function. We revealed a part of network of transcription factors that regulate the formation and function of heterochromatin. In addition, we also presented a novel concept : factory for RNAi-directed heterochromatin formation is formed at nuclear periphery.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly2012
Author(s)
Hayashi, A., Ishida, M., Kawaguchi, R., Urano, T., Murakami, Y., Nakayama, J-I.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: (印刷中)
Issue: 16
Pages: 6159-64
DOI
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Peer Reviewed
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[Presentation] Phosphorylations of RNAPII-CTD have two essential roles for centromeric silencing2011
Author(s)
Kajitani, T., Hermand, D., Ishii, K., Kimura, H., Murakami, Y.
Organizer
Cell : Symposium : Epigenetics and the Inheritance o Acquired States
Place of Presentation
The Westin Boston Waterfront (Boston, USA)
Year and Date
2011-10-31
Related Report
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[Presentation] yeast2011
Author(s)
村上洋太
Organizer
第63回日本細胞生物学会大会シンポジウム
Place of Presentation
北海道大学(札幌市)
Year and Date
2011-06-27
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