Spacial regulation of cells during organogenesis
Project/Area Number |
21247035
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | Kyoto University (2011-2012) Nara Institute of Science and Technology (2009-2010) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SAITO Daisuke 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (90403360)
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Project Period (FY) |
2009 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|
Keywords | 器官ネットワーク / 神経 / 血管 / 細胞挙動 / 空間配置 / 発生・分化 / 末梢神経 / 神経堤細胞 / 副腎 / 神経科学 / 細胞・組織 / 細胞移動 |
Research Abstract |
During development, cell differentiation and tissue formation need to proceed at the right time and right space. The aim of this research is to understand how cells and tissues are correctly distributed in the developing embryo. We address such questions with a particular focus on neural crest cells, which undergo dynamic migration after emigrating from the neural tube. We found that neural crest cells intimately interact with non-neural crest cells, and also that complex molecular cascades are involved in such interactions. The cellular and molecular mechanisms revealed in this study are expected to be shared by other morphogenetic processes.
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Report
(5 results)
Research Products
(92 results)
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[Journal Article] Efficient genetic modification and germ-line transmission of pr imordial germ cells using piggyBac and Tol2 transposons.2012
Author(s)
Macdonald, J., Taylor, L., Sherman, A., Kawakami, K., Takahashi, Y., Sang, HM. and McGrew, MJ.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Pages: 1466-1472
DOI
Related Report
Peer Reviewed
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[Journal Article] Stable, conditional, and muscle-fiber-specific expression of electroporated transgenes in chick limb muscle cells.2011
Author(s)
Wang, H., Bonnet, A., Delfini, MC., Kawakami, K., Takahashi, Y. and Duprez, D.
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Journal Title
Dev. Dyn
Volume: 240
Pages: 1223-1232
DOI
Related Report
Peer Reviewed
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[Journal Article] Conditional knockdown of target gene expression by tetracycline regulated transcription of double strand RNA.2011
Author(s)
Hou, X., Omi, M., Harada, H., Ishii, S., Takahashi, Y. and Nakamua, H.
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Journal Title
Dev. Growth Differ
Volume: 53(1)
Pages: 69-75
DOI
Related Report
Peer Reviewed
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[Journal Article] Simultaneous expression of different transgenes in neurons and glia by combining in utero electroporation with Tol2 transposon mediated gene transfer system.2010
Author(s)
Yoshida, A., Yamaguchi, Y., Nonomura, K., Kawakami, K., Takahashi, Y. and Miura, M
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Journal Title
Genes to Cells
Volume: 15(5)
Pages: 501-12
DOI
Related Report
Peer Reviewed
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[Journal Article] A combination of transposable elements and magnetic cell sorting provides a very efficient transgenesis system for chicken primary erythroid progenitors.2009
Author(s)
Mejia-Pous, C., Vinuelas, J., Faure, C., Koszela, J., Kawakami, K., Takahashi,Y. and Gandrillon, O.
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Journal Title
BMC Biotechnology
Volume: 9
Pages: 81
DOI
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
大畑絵美
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Journal Title
実験医学「胚体内の初期血管パターニングとガイダンス因子-Notch-ephrinシグナルが制御する細胞のふるまい」(羊土社)
Pages: 1697-1703
Related Report
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[Journal Article]2009
Author(s)
齋藤大介
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Journal Title
最新医学「幹細胞研究の最近の進歩(後編)-組織幹細胞-「発生と幹細胞:神経冠細胞の移動機構」(最新医学社)
Pages: 1244-1258
Related Report
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[Journal Article]2009
Author(s)
渡邉忠由
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Journal Title
生体の医学「境界形成とEph-Ephrinシグナル」(医学書院)
Pages: 330-336
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