HOMINIZATION IN LIFESPAN AND ADAPTATION

• Project/Area Number: 21247039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical anthropology
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIDA Takafumi 東京大学, 大学院・理学系研究科, 准教授 (20184533)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Juri 京都大学, 霊長類研究所, 准教授 (10175408)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000); Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000); Fiscal Year 2010: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000); Fiscal Year 2009: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
• Keywords: ゲノム / バイオリソース / 適応 / ヒト化 / ゲノム維持 / 老化 / 細胞 / ｐ５３ / ＧＳＴ

Research Abstract

Mammalian cell and DNA repository was established for more than 100 species. Primate p53 genes were highly conserved in the coding regions; however,cellular constraints on the p53 modification during cell senescence were strengthened along hominization. In humans, p53 codon 72 polymorphism is ubiquitously observed with a variety of frequencies; a meta-analysis for this polymorphism suggested an association between its prevalence and UV.

Research Products

• [Journal Article] Molecular requirements for T cell recognition of N-myristoylated peptides derived from the simian immunodeficiency virus Nef protein (2013)
  • Author(s): Morita D, Yamamoto Y, Suzuki J, Mori N, Igarashi T, Sugita M
  • Journal Title: Journal of Virology Volume: 87(1) Pages: 482-488
  • Peer Reviewed
• [Journal Article] Spontaneous T/NK-cell lymphoma associated with simian lymphocryptovirus in a Japanese macaque (Macaca fuscata) (2013)
  • Author(s): Hirata A, Tachikawa Y, Hashimoto K, Sakai H, Kaneko A, Suzuki J, Eguchi K, Shigematsu K,Nikami H, Yanai T
  • Journal Title: Journal of Comparative Pathology Volume: 148 Pages: 43-46
  • Peer Reviewed
• [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia (2013)
  • Author(s): Furusawa T
  • Journal Title: Journal of Human Genetics Volume: (in press) Issue: 3 Pages: 142-149
  • DOI: 10.1038/jhg.2012.147
  • Peer Reviewed
• [Journal Article] A "functional SNP upstream of the beta-2 adrenergic receptor gene (ADRE2)is associated with obesity in Oceanic populations (2013)
  • Author(s): Naka l
  • Journal Title: International Journal of Obesity Volume: (in press) Issue: 9 Pages: 1204-1210
  • DOI: 10.1038/ijo.2012.206
  • Peer Reviewed
• [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia. (2012)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T.,Natsuhara, K., Eddie, R., Kimura, R., Nakazawa, M., Ishida, T., Inaoka, T., Matsumura, Y., Ataka,Y., Ohtsuka, R. and Ohashi, J.
  • Journal Title: Journal of Human Genetics Pages: 147-147
  • NAID: 10031164071
  • Peer Reviewed
• [Journal Article] A functional promoter polymorphism of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. (2012)
  • Author(s): Naka, I., Hikami, K., Nakayama, K., Koga, M., NIshida, N., Kimura, R., Furusawa, T., Natsuhara,K., Yamauchi, T., Nakazawa, M., Ataka, Y.,Ishida, T., Inaoka, T., Munkhtulga, L., Iwamoto,S., Matsumura, Y., Ohtsuka, R. Tsuchiya, N. and Ohashi, J.
  • Journal Title: International Journal of Obesity Pages: 206-206
  • Peer Reviewed
• [Journal Article] Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates. (2012)
  • Author(s): Ohtani, H., Naruse, T.K., Iwasaki, Y., Akari, H., Ishida, T., Matano, T. and Kimura, A.
  • Journal Title: Immunogenetics Volume: 64 Pages: 669-678
  • Peer Reviewed
• [Journal Article] DRD4 VNTR polymorphism in Oceanic populations. (2012)
  • Author(s): Naka, I., Ohashi, J., Kimura, R., Furusawa, T.,Yamauchi, T., Nakazawa, M., Natsuhara, K., Ataka, Y., Nishida, N., Ishida, T., Inaoka, T.,Matsumura, Y. and Ohtsuka, R.
  • Journal Title: Anthropological Science Volume: 120 Pages: 151-155
  • NAID: 10031057349
  • Peer Reviewed
• [Journal Article] The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome. (2012)
  • Author(s): Kurosaki, T., Ueda, S., Ishida, T., Abe, K.,Ohno, K. and Matsuura, T.
  • Journal Title: PLos One Volume: 7
  • Peer Reviewed
• [Journal Article] Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan. (2012)
  • Author(s): Sakae, C. and Ishida, T.
  • Journal Title: J. Parasitology Volume: 98 Pages: 224-225
  • Peer Reviewed
• [Journal Article] Hepatitis E virus outbreak in monkey facility, Japan. (2012)
  • Author(s): Yamamoto H, Suzuki J, Matsuda A, Ishida T,Ami Y, Suzaki Y, Adachi I, Wakita T, Takeda N,Li T-C
  • Journal Title: Emerging Infectious Diseases Volume: 18 (12) Pages: 2032-2034
  • Peer Reviewed
• [Journal Article] <i>DRD4</i> VNTR polymorphism in Oceanic populations (2012)
  • Author(s): Naka, I. et al.
  • Journal Title: Anthropological Science Volume: 120 Issue: 2 Pages: 151-155
  • DOI: 10.1537/ase.110901
  • NAID: 10031057349
  • ISSN: 0918-7960, 1348-8570
  • Peer Reviewed
• [Journal Article] High prevalence of an anti-ypertriglyceridemic variant of the MLXIPL gene in Central Asia. (2011)
  • Author(s): Nakayama, K., Yanagisawa, Y., Ogawa, A.,Ishizuka, Y., Munkhtulga, L., Charupoonphol, P.,Supannnatas, S., Kuartei, S., Chimedregzen, U.,Koda, Y., Ishida, T., Kagawa, Y. and Iwamoto, S.
  • Journal Title: Journal of Human Genetics Volume: 56 Pages: 828-833
  • Peer Reviewed
• [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand. (2011)
  • Author(s): Settheetham-Ishida, W., Yuenyao, P., Natphopsuk, S., Settheetham, D. and Ishida, T.
  • Journal Title: Asian Pacific J.Cancer Prev. Volume: 12 Pages: 963-966
  • Peer Reviewed
• [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates. (2011)
  • Author(s): Ohtani, H., Nakajima, T., Akari, H., Ishida, T.and Kimura, A.
  • Journal Title: Immunogenetics Volume: 63 Pages: 417-428
  • Peer Reviewed
• [Journal Article] The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization. (2011)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T., Kimura, R., Nakazawa, M., Ishida, T., Nishida, N., Eddie, R., Ohtsuka, R. and Ohashi, J.
  • Journal Title: American Journal of Human Biology Volume: 23 Pages: 435-444
  • Peer Reviewed
• [Journal Article] Differential prefrontal white matter development in chimpanzees and humans. (2011)
  • Author(s): Sakai T, Mikami A, Tomonaga M, Matsui M,Suzuki J, Hamada Y, Tanaka M, Miyabe-Nishiwaki T,Makishita H, Nakatsukasa M, Matsuzawa T
  • Journal Title: Current Biol. Volume: 21 Pages: 1397-1402
  • Peer Reviewed
• [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia (2011)
  • Author(s): Nakayama, K., et al
  • Journal Title: Journal of Human Genetics Volume: 56 Pages: 828-833
  • Peer Reviewed
• [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates (2011)
  • Author(s): Ohtani, H., et al
  • Journal Title: Immunogenetics Volume: 63 Pages: 435-444
  • Peer Reviewed
• [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand (2011)
  • Author(s): Settheetham-Ishida, W., et al
  • Journal Title: Asian Pacific J.Cancer Prev. Volume: 12 Pages: 963-966
  • Peer Reviewed
• [Journal Article] Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques. (2010)
  • Author(s): Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T.
  • Journal Title: Journal of Mammalian Evolution Volume: 17 Pages: 211-214
  • Peer Reviewed
• [Journal Article] Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand Int. (2010)
  • Author(s): Kietthubthew, S., Wickliffe, J., Sriplung, H.,Ishida, T., Chonmaitree, T. and Au, W.
  • Journal Title: J. Hyg. Environ. Health Volume: 213 Pages: 146-152
  • Peer Reviewed
• [Journal Article] The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders. (2010)
  • Author(s): Furusawa, T., Naka, I., Yamauchi, T.,Natsuhara, K., Kimura, R., Nakazawa, M., Ishida,T., Inaoka, T., Matsumura, Y., Ataka, Y., Nishida,N.,Tsuchiya, N., Ohtsuka, R. and Ohashi, J.
  • Journal Title: Human Genetics Volume: 127 Pages: 287-294
  • Peer Reviewed
• [Journal Article] Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand. (2010)
  • Author(s): Kietthubthew, S., et al.
  • Journal Title: Int.J.Hyg.Environ.Health Volume: 213 Pages: 146-152
  • Peer Reviewed
• [Journal Article] FGFR2,but not EDA, is associated with hair thickness in Asian populations. (2009)
  • Author(s): Fujimoto, A., Nishida, N., Kimura, R., Miyagawa, T., Yuliwulandari, R., Batubara, L., Mustofa, M.S., Samakkarn, U.,Settheetham-Ishida, W., Ishida, T., Morishita, Y.,Tsunoda, T.,Tokunaga, K. and Ohashi, J.
  • Journal Title: Journal of Human Genetics Volume: 54 Pages: 461-465
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase (GSTM1 and GSTT1) Polymorphisms in Cervical Cancer in Northeastern Thailand. (2009)
  • Author(s): Settheetham-Ishida, W., Yuenyao, P., Kularbkaew, C., Settheetham, D. and Ishida, T.
  • Journal Title: Asian Pacific J Cancer Prev Volume: 10 Pages: 365-368
  • Peer Reviewed
• [Journal Article] Risk factors for cervical cancer in northeastern Thailand: detailed analyses for the sexual and smoking behaviors.
  • Author(s): Natphopsuk, S., Settheetham-Ishida, W., Sinawat, S., Pientong, C., Yuenyao, P. and Ishida,T.
  • Journal Title: Asian Pacific J. Cancer Prev. Volume: (in press)
  • Peer Reviewed
• [Presentation] Thrombocytopenia caused by SRV-4 in Japanese macaques (Macaca fuscata). (2012)
  • Author(s): Suzuki, J., Akari, H., Okamoto, M., Yoshida,T., Okabayashi, S.
  • Organizer: Satellite Symposium of the 5th Annual Meeting of the ASZWM
  • Place of Presentation: Chiang Mai, Thailand
• [Presentation] Stress and immunity (2011)
  • Author(s): Ishida, T
  • Organizer: The 40th Annual Meeting of the Physiological Society of Thailand, International Conference
  • Place of Presentation: Khon Kaen, Thailand(招待講演)
  • Year and Date: 2011-05-03
• [Presentation] "Stress and Immunity"The 40th Annual Meeting of the Physiological Society of Thailand (2011)
  • Author(s): Ishida, T.
  • Organizer: International Conference
  • Place of Presentation: Khon Kaen, Thailand
• [Presentation] Primate cell repository now: 20-year interval since IPS-1990 and its contribution to the primate molecular studies. (2010)
  • Author(s): Ishida, T.
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] Health management of macaque outdoor colonies with focus on hepatitis E infection. (2010)
  • Author(s): Suzuki, J., Yamamoto, H., Ishida, T., Li, T-C,Takeda, N.
  • Organizer: International Primatological Society 13th Congress Kyoto 2010
  • Place of Presentation: Kyoto, Japan
• [Presentation] Establishment of a wild/zoo mammalian DNA/cell repository (2009)
  • Author(s): Ishida, T.
  • Organizer: The 3rd int. Workshop Asian Soc. Zoo and Wildlife Med.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-08-19