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HOMINIZATION IN LIFESPAN AND ADAPTATION

Research Project

Project/Area Number 21247039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical anthropology
Research InstitutionThe University of Tokyo

Principal Investigator

ISHIDA Takafumi  東京大学, 大学院・理学系研究科, 准教授 (20184533)

Co-Investigator(Kenkyū-buntansha) SUZUKI Juri  京都大学, 霊長類研究所, 准教授 (10175408)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2011: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2010: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2009: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywordsゲノム / バイオリソース / 適応 / ヒト化 / ゲノム維持 / 老化 / 細胞 / p53 / GST
Research Abstract

Mammalian cell and DNA repository was established for more than 100 species. Primate p53 genes were highly conserved in the coding regions; however,cellular constraints on the p53 modification during cell senescence were strengthened along hominization. In humans, p53 codon 72 polymorphism is ubiquitously observed with a variety of frequencies; a meta-analysis for this polymorphism suggested an association between its prevalence and UV.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (6 results)

  • [Journal Article] Molecular requirements for T cell recognition of N-myristoylated peptides derived from the simian immunodeficiency virus Nef protein2013

    • Author(s)
      Morita D, Yamamoto Y, Suzuki J, Mori N, Igarashi T, Sugita M
    • Journal Title

      Journal of Virology

      Volume: 87(1) Pages: 482-488

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous T/NK-cell lymphoma associated with simian lymphocryptovirus in a Japanese macaque (Macaca fuscata)2013

    • Author(s)
      Hirata A, Tachikawa Y, Hashimoto K, Sakai H, Kaneko A, Suzuki J, Eguchi K, Shigematsu K,Nikami H, Yanai T
    • Journal Title

      Journal of Comparative Pathology

      Volume: 148 Pages: 43-46

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia2013

    • Author(s)
      Furusawa T
    • Journal Title

      Journal of Human Genetics

      Volume: (in press) Issue: 3 Pages: 142-149

    • DOI

      10.1038/jhg.2012.147

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A "functional SNP upstream of the beta-2 adrenergic receptor gene (ADRE2)is associated with obesity in Oceanic populations2013

    • Author(s)
      Naka l
    • Journal Title

      International Journal of Obesity

      Volume: (in press) Issue: 9 Pages: 1204-1210

    • DOI

      10.1038/ijo.2012.206

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertension Susceptibility Gene Prevalence in the Pacific Islands and Associations with Hypertension in Melanesia.2012

    • Author(s)
      Furusawa, T., Naka, I., Yamauchi, T.,Natsuhara, K., Eddie, R., Kimura, R., Nakazawa, M., Ishida, T., Inaoka, T., Matsumura, Y., Ataka,Y., Ohtsuka, R. and Ohashi, J.
    • Journal Title

      Journal of Human Genetics

      Pages: 147-147

    • NAID

      10031164071

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional promoter polymorphism of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations.2012

    • Author(s)
      Naka, I., Hikami, K., Nakayama, K., Koga, M., NIshida, N., Kimura, R., Furusawa, T., Natsuhara,K., Yamauchi, T., Nakazawa, M., Ataka, Y.,Ishida, T., Inaoka, T., Munkhtulga, L., Iwamoto,S., Matsumura, Y., Ohtsuka, R. Tsuchiya, N. and Ohashi, J.
    • Journal Title

      International Journal of Obesity

      Pages: 206-206

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.2012

    • Author(s)
      Ohtani, H., Naruse, T.K., Iwasaki, Y., Akari, H., Ishida, T., Matano, T. and Kimura, A.
    • Journal Title

      Immunogenetics

      Volume: 64 Pages: 669-678

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DRD4 VNTR polymorphism in Oceanic populations.2012

    • Author(s)
      Naka, I., Ohashi, J., Kimura, R., Furusawa, T.,Yamauchi, T., Nakazawa, M., Natsuhara, K., Ataka, Y., Nishida, N., Ishida, T., Inaoka, T.,Matsumura, Y. and Ohtsuka, R.
    • Journal Title

      Anthropological Science

      Volume: 120 Pages: 151-155

    • NAID

      10031057349

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome.2012

    • Author(s)
      Kurosaki, T., Ueda, S., Ishida, T., Abe, K.,Ohno, K. and Matsuura, T.
    • Journal Title

      PLos One

      Volume: 7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan.2012

    • Author(s)
      Sakae, C. and Ishida, T.
    • Journal Title

      J. Parasitology

      Volume: 98 Pages: 224-225

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis E virus outbreak in monkey facility, Japan.2012

    • Author(s)
      Yamamoto H, Suzuki J, Matsuda A, Ishida T,Ami Y, Suzaki Y, Adachi I, Wakita T, Takeda N,Li T-C
    • Journal Title

      Emerging Infectious Diseases

      Volume: 18 (12) Pages: 2032-2034

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] <i>DRD4</i> VNTR polymorphism in Oceanic populations2012

    • Author(s)
      Naka, I. et al.
    • Journal Title

      Anthropological Science

      Volume: 120 Issue: 2 Pages: 151-155

    • DOI

      10.1537/ase.110901

    • NAID

      10031057349

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of an anti-ypertriglyceridemic variant of the MLXIPL gene in Central Asia.2011

    • Author(s)
      Nakayama, K., Yanagisawa, Y., Ogawa, A.,Ishizuka, Y., Munkhtulga, L., Charupoonphol, P.,Supannnatas, S., Kuartei, S., Chimedregzen, U.,Koda, Y., Ishida, T., Kagawa, Y. and Iwamoto, S.
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 828-833

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand.2011

    • Author(s)
      Settheetham-Ishida, W., Yuenyao, P., Natphopsuk, S., Settheetham, D. and Ishida, T.
    • Journal Title

      Asian Pacific J.Cancer Prev.

      Volume: 12 Pages: 963-966

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates.2011

    • Author(s)
      Ohtani, H., Nakajima, T., Akari, H., Ishida, T.and Kimura, A.
    • Journal Title

      Immunogenetics

      Volume: 63 Pages: 417-428

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization.2011

    • Author(s)
      Furusawa, T., Naka, I., Yamauchi, T., Kimura, R., Nakazawa, M., Ishida, T., Nishida, N., Eddie, R., Ohtsuka, R. and Ohashi, J.
    • Journal Title

      American Journal of Human Biology

      Volume: 23 Pages: 435-444

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential prefrontal white matter development in chimpanzees and humans.2011

    • Author(s)
      Sakai T, Mikami A, Tomonaga M, Matsui M,Suzuki J, Hamada Y, Tanaka M, Miyabe-Nishiwaki T,Makishita H, Nakatsukasa M, Matsuzawa T
    • Journal Title

      Current Biol.

      Volume: 21 Pages: 1397-1402

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia2011

    • Author(s)
      Nakayama, K., et al
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Pages: 828-833

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates2011

    • Author(s)
      Ohtani, H., et al
    • Journal Title

      Immunogenetics

      Volume: 63 Pages: 435-444

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Risk of DNA Repair Gene Polymorphisms (XRCC1 and XRCC3) for High Risk Human Papillomavirus Negative Cervical Cancer in Northeast Thailand2011

    • Author(s)
      Settheetham-Ishida, W., et al
    • Journal Title

      Asian Pacific J.Cancer Prev.

      Volume: 12 Pages: 963-966

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations in the coding region of the agouti signaling protein gene do not explain agouti/non-agouti phenotypes in macaques.2010

    • Author(s)
      Nakayama, K., Shotake, T., Takenaka, O. and Ishida, T.
    • Journal Title

      Journal of Mammalian Evolution

      Volume: 17 Pages: 211-214

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand Int.2010

    • Author(s)
      Kietthubthew, S., Wickliffe, J., Sriplung, H.,Ishida, T., Chonmaitree, T. and Au, W.
    • Journal Title

      J. Hyg. Environ. Health

      Volume: 213 Pages: 146-152

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders.2010

    • Author(s)
      Furusawa, T., Naka, I., Yamauchi, T.,Natsuhara, K., Kimura, R., Nakazawa, M., Ishida,T., Inaoka, T., Matsumura, Y., Ataka, Y., Nishida,N.,Tsuchiya, N., Ohtsuka, R. and Ohashi, J.
    • Journal Title

      Human Genetics

      Volume: 127 Pages: 287-294

    • Related Report
      2011 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of polymorphisms in proinflammatory cytokine genes with the development of oral cancer in Southern Thailand.2010

    • Author(s)
      Kietthubthew, S., et al.
    • Journal Title

      Int.J.Hyg.Environ.Health

      Volume: 213 Pages: 146-152

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGFR2,but not EDA, is associated with hair thickness in Asian populations.2009

    • Author(s)
      Fujimoto, A., Nishida, N., Kimura, R., Miyagawa, T., Yuliwulandari, R., Batubara, L., Mustofa, M.S., Samakkarn, U.,Settheetham-Ishida, W., Ishida, T., Morishita, Y.,Tsunoda, T.,Tokunaga, K. and Ohashi, J.
    • Journal Title

      Journal of Human Genetics

      Volume: 54 Pages: 461-465

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione S-transferase (GSTM1 and GSTT1) Polymorphisms in Cervical Cancer in Northeastern Thailand.2009

    • Author(s)
      Settheetham-Ishida, W., Yuenyao, P., Kularbkaew, C., Settheetham, D. and Ishida, T.
    • Journal Title

      Asian Pacific J Cancer Prev

      Volume: 10 Pages: 365-368

    • Related Report
      2011 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for cervical cancer in northeastern Thailand: detailed analyses for the sexual and smoking behaviors.

    • Author(s)
      Natphopsuk, S., Settheetham-Ishida, W., Sinawat, S., Pientong, C., Yuenyao, P. and Ishida,T.
    • Journal Title

      Asian Pacific J. Cancer Prev.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Thrombocytopenia caused by SRV-4 in Japanese macaques (Macaca fuscata).2012

    • Author(s)
      Suzuki, J., Akari, H., Okamoto, M., Yoshida,T., Okabayashi, S.
    • Organizer
      Satellite Symposium of the 5th Annual Meeting of the ASZWM
    • Place of Presentation
      Chiang Mai, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Stress and immunity2011

    • Author(s)
      Ishida, T
    • Organizer
      The 40th Annual Meeting of the Physiological Society of Thailand, International Conference
    • Place of Presentation
      Khon Kaen, Thailand(招待講演)
    • Year and Date
      2011-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] "Stress and Immunity"The 40th Annual Meeting of the Physiological Society of Thailand2011

    • Author(s)
      Ishida, T.
    • Organizer
      International Conference
    • Place of Presentation
      Khon Kaen, Thailand
    • Related Report
      2011 Final Research Report
  • [Presentation] Primate cell repository now: 20-year interval since IPS-1990 and its contribution to the primate molecular studies.2010

    • Author(s)
      Ishida, T.
    • Organizer
      International Primatological Society XXIII Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Health management of macaque outdoor colonies with focus on hepatitis E infection.2010

    • Author(s)
      Suzuki, J., Yamamoto, H., Ishida, T., Li, T-C,Takeda, N.
    • Organizer
      International Primatological Society 13th Congress Kyoto 2010
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Establishment of a wild/zoo mammalian DNA/cell repository2009

    • Author(s)
      Ishida, T.
    • Organizer
      The 3rd int. Workshop Asian Soc. Zoo and Wildlife Med.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-08-19
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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