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MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics

Research Project

Project/Area Number 21249037
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionNagoya University

Principal Investigator

TAKAHASHI Takashi  名古屋大学, 大学院・医学系研究科, 教授 (50231395)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Kiyoshi  名古屋大学, 大学院・医学系研究科, 講師 (20372112)
Co-Investigator(Renkei-kenkyūsha) ARIMA Chinatsu  名古屋大学, 大学院・医学系研究科, COE特任助教 (00534843)
GOTO Hidemi  名古屋大学, 大学院・医学系研究科, 教授 (10215501)
NAGINO Masato  名古屋大学, 大学院・医学系研究科, 教授 (20237564)
YATABE Yasushi  愛知県がんセンター, 研究所, 主任研究員 (90280809)
MATSUO Keitaro  愛知県がんセンター, 研究所, 室長 (80393122)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2010: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywords分子診断 / 網羅的発現解析 / プロテオミクス / マイクロRNA
Research Abstract

MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics
We aimed to establish novel molecular diagnostic means for "hard-to-cure "cancers such as pancreatic cancer. We successfully identified four miRNAs present at high levels only in sera of pancreatic cancer patients but not in those of healthy individuals, which allowed us to develop diagnostic classifies for pancreatic cancers based on the expression profiles. In addition, we have successfully catalogued 40, 000 proteins from normal and pancreatic cancer tissues, which should serve as valuable basis for identification of biomarkers of pancreatic cancer. Interestingly, we identified one such protein, high expression of which appeared to confer resistance to endoplasmic reticulum stress in pancreatic cancer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (84 results)

All 2012 2011 2010 2009 Other

All Journal Article (58 results) (of which Peer Reviewed: 58 results) Presentation (22 results) Remarks (4 results)

  • [Journal Article] MYBPH, atranscriptional target of TTF-1, inhibitsROCK1, and reduces cell motility andmetastasis.2012

    • Author(s)
      Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T
    • Journal Title

      EMBO J

      Volume: 31 Pages: 481-493

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A critical role for tumor cell-derived angiopoientin-like protein 2 in metastasis2012

    • Author(s)
      Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, Oike Y
    • Journal Title

      Cancer Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma2012

    • Author(s)
      Yamaguchi T, et al
    • Journal Title

      Cancer Cell

      Volume: 21 Issue: 3 Pages: 348-361

    • DOI

      10.1016/j.ccr.2012.02.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis2012

    • Author(s)
      Endo M, et al
    • Journal Title

      Cancer Research

      Volume: 72 Issue: 7 Pages: 1784

    • DOI

      10.1158/0008-5472.can-11-3878

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis2012

    • Author(s)
      Hosono Y, et al
    • Journal Title

      EMBO Journal

      Volume: 31 Issue: 2 Pages: 481-493

    • DOI

      10.1038/emboj.2011.416

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer2011

    • Author(s)
      Nishikawa E, Osada H, Okazaki Y, Arima C, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Yatabe Y, Toyokuni S, Sekido Y, and Takahashi T
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 6165-6173

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas2011

    • Author(s)
      Matsuyama, Y., Suzuki, M., Arima, C., Huang, Q. M., Tomida, S., Takeuchi, T., Sugiyama, R., Itoh, Y., Yatabe, Y., Goto, H. and Takahashi, T
    • Journal Title

      Mol. Carcinog

      Volume: 50 Pages: 301-309

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition2011

    • Author(s)
      Shimamura, T., Imoto, S., Shimada, Y., Hosono, Y., Niida, A., Nagasaki, M., Yamaguchi, R., Takahashi, T., Miyano, S
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 6 Pages: e20804-e20804

    • DOI

      10.1371/journal.pone.0020804

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Epstein-Barr virus LMP 1 and TGF-. 1 synergistically induce EMT in lung epithelial cells.2011

    • Author(s)
      Sides, M., Klingsberg, R. C., Shan, B., Gordon, K. A., Nguyen, H. T., Lin, Z., Takahashi, T., Flemington, E. K., and Lasky, J. A
    • Journal Title

      Am. J. Resp. Cell Mol. Biol

      Volume: 44 Pages: 852-862

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells2011

    • Author(s)
      Attoub S, Hassan AH, Vanhoecke B, Iratni R, Takahashi T, Gaben AM, Bracke M, Awad S, Kamalboor JA, Al Sultan MAH, Arafat K, Gespach C and Petroianu G
    • Journal Title

      Eur. J. Pharmacol

      Volume: 651 Pages: 18-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of amiodarone and desethylamiodarone cytotoxicity in non-transformed human peripheral lung epithelial cells2011

    • Author(s)
      Mulder, J. E., Brien, J. F., Racz, W. J., Takahashi, T. and Massey, T
    • Journal Title

      Exp. Ther

      Volume: 336 Pages: 551-559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] International Association for the Study of Lung Cancer/Amerian Thoracic Society/European Respiratory Society International Multidisciplinary Classification of lung adenocarcinoma2011

    • Author(s)
      Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Eiely GJ, Van Schil PE, Garg, K, Austin JHM, Asamura H, Rusch, VW, Hirsch FR, Scagliotti G, MisudomiT, Huber RM, Ishikawa Y, Jett, J, Sanchez-Cespedes, M, Sculier, JP, Takahashi T, Tsuboi, M, Vansteenkiste J, Wistuba I, Yang, P-C, Aberle D, Brambilla C, Flieder D, Franklin W, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, pertersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
    • Journal Title

      J Thorac. Oncol

      Volume: 6 Pages: 244-285

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dqjendent manner in lung cancer2011

    • Author(s)
      Nishikawa E, et al
    • Journal Title

      Cancer Research

      Volume: 71 Issue: 19 Pages: 6165-6173

    • DOI

      10.1158/0008-5472.can-11-1020

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas2011

    • Author(s)
      Matsuyama Y, et al
    • Journal Title

      Molecular Carcinogenesis

      Volume: 50 Issue: 4 Pages: 301-309

    • DOI

      10.1002/mc.20632

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Epstein-Barr virus LMP 1 and TGF-β1 synergistically induce EMT in lung epithelial cells2011

    • Author(s)
      Sides M, et al
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 44 Issue: 6 Pages: 852-862

    • DOI

      10.1165/rcmb.2009-0232oc

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International Association for the Study of Lung Cancer/Amerian Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma2011

    • Author(s)
      Travis WD, et al
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 6 Issue: 2 Pages: 244-285

    • DOI

      10.1097/jto.0b013e318206a221

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of amiodarone and desethylamiodarone cytotoxicity in non-transformed human peripheral lung epithelial cells2011

    • Author(s)
      Mulder JE, et al
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 336 Issue: 2 Pages: 551-559

    • DOI

      10.1124/jpet.110.173120

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells2011

    • Author(s)
      Attoub S, et al
    • Journal Title

      European Journal of Pharmacology

      Volume: 651 Issue: 1-3 Pages: 18-25

    • DOI

      10.1016/j.ejphar.2010.10.063

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] let-7 and miR-17-92 : Small-sized major players in lung cancer development2011

    • Author(s)
      Osada H, Takahashi T
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 1 Pages: 9-17

    • DOI

      10.1111/j.1349-7006.2010.01707.x

    • NAID

      10029287990

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.2011

    • Author(s)
      Attoub S, et al.
    • Journal Title

      Eur.J.Pharmacol.

      Volume: 651 Pages: 18-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Epstein-Barr virus LMP 1 and TGF-□1 synergistically induce EMT in lung epithelial cells.2011

    • Author(s)
      Sides M, et al.
    • Journal Title

      Am.J.Resp.Cell Mol.Biol.

      Volume: (in press,未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of amiodarone and desethylamiodarone cytotoxicity in non-transformed human peripheral lung epithelial cells.2011

    • Author(s)
      Mulder JE, et al.
    • Journal Title

      J.Pharmacol.Exp.Ther.

      Volume: (in press,未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas.2011

    • Author(s)
      Matsuyama Y, et al.
    • Journal Title

      Mol.Carcinogenesis

      Volume: (in press,未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress response pathways2010

    • Author(s)
      Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H, and Takahashi T
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 9949-58

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions of base selection step in human DNA polymerase alpha2010

    • Author(s)
      Tanaka, S., Cao, K., Niimi, A., Limsirichaikul, S., Huang, Q., Nakamura, N., Murate, T., Hasegawa, Y., Takahashi, T. and Suzuki M.
    • Journal Title

      DNA Repair

      Volume: 9 Pages: 534-541

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer2010

    • Author(s)
      Huang, Q. A., Tomida, S., Masuda, Y., Arima, C., Cao, K, Kisahara, T., Osada, H., Yatabe, Y., Kamiya, K., Takahashi, T., and Suzuki, M
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 8407-8416

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of POLD4, smallest subunit of DNA polymeraseδin nuclear structures and genomic stability of human cells2010

    • Author(s)
      Huang, Q. A., Akashi, T., Matsuda, Y., Kamiya, K., Takahashi, T. and Suzuki, M
    • Journal Title

      Biophys. Res. Comm

      Volume: 391 Pages: 542-546

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma2010

    • Author(s)
      Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, and Toyokuni S
    • Journal Title

      Lab. Invest

      Volume: 90 Pages: 360-373

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous angiogenesis inhibitor vasohibin1 exhibits a broad-spectrum anti-lymphangiogenic activity and suppresses lymph node metastasis2010

    • Author(s)
      Heishi, T., Hosaka, T., Suzuki, H., Suzuki, Y., Miyashita, H., Oike, Y., Takahashi, T., Nakamura, T., Arioka, S., Mitsuda, Y., Takakura, T., Hojo, K., Matsumoto, M., Yamauchi, C., Ohta, H., Sonoda, H., and Sato, Y
    • Journal Title

      Am. J. Pathol

      Volume: 176 Pages: 1950-1958

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tetraspanin CD151 regulates TGF-βsignalling : implication in tumour metastasis2010

    • Author(s)
      Sadej R, Romanska H, Kavanagh D, Baldwin G, Takahashi T, Kalia N, Berditchevski F
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 6059-6070

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotensin receptor 1 determines the outcome of non-small cell lung cancer2010

    • Author(s)
      Alifano, M., Souaze, F., Dupouy, S., Camilleri-Broet, S., Takahashi, T., Ahmed-Zaid, S., Cancellieri, A., Damiani, S., Boaron, M., Broet, P., Miller, L. D., Gespach, G., Regnard, J. F., and Forgez, P
    • Journal Title

      Clin. Cancer Res

      Volume: 16 Pages: 4401-4410

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways2010

    • Author(s)
      Bryant, C. M., Albertus, D. L., Kim, S., Guedj, M., Travis, W. D., Yatabe, Y., Takahashi, T., Brambilla, E, and Beer, D. G
    • Journal Title

      PLoS One

      Volume: 5 Issue: 7 Pages: e11712-e11712

    • DOI

      10.1371/journal.pone.0011712

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations2010

    • Author(s)
      Miki, D., Kubo, M., Takahashi, A., Yoon, K.-A., Kim, J., Lee, G. K., Zo, J. I., Lee, J. S., Hosono, N., Morizono, T., Tsunoda, T., Kamatani, N., Chayama, K., Takahashi, T., Inazawa, J., Nakamura, Y., and Daigo, Y
    • Journal Title

      Nature Genet

      Volume: 42 Pages: 893-896

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress response pathways.2010

    • Author(s)
      Yanagisawa K, et al.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 9949-9958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.2010

    • Author(s)
      Huang QA, et al.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 8407-8416

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous angiogenesis inhibitor vasohibinl exhibits a broad-spectrumanti-lymphangiogenic activity and suppresses lymph node metastasis.2010

    • Author(s)
      Heishi T, et al.
    • Journal Title

      Am.J.Pathol.

      Volume: 176 Pages: 1950-1958

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation in TP63 is associated with lung adenocarcinom a susceptibility in Japanese and Korean populations.2010

    • Author(s)
      Miki D, et al.
    • Journal Title

      Nature Genet.

      Volume: 42 Pages: 893-896

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotensin receptor 1 determines the outcome of non-small cell lung cancer.2010

    • Author(s)
      Alifano M, et al.
    • Journal Title

      Clin.Cancer Res.

      Volume: 16 Pages: 4401-4410

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD151 regulates TGF-β signalling : implication in tumour metastasis.2010

    • Author(s)
      Sadej R, et al.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 6059-6070

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways.2010

    • Author(s)
      Bryant CM, et al.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 6059-6070

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells.2010

    • Author(s)
      Huang QA, et al.
    • Journal Title

      Biochem.Biophys.Res.Comm.

      Volume: 391 Pages: 542-546

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of base selection step in human DNA polymerase alpha DNA Repair.2010

    • Author(s)
      Tanaka S, et al.
    • Journal Title

      DNA Repair

      Volume: 9 Pages: 534-541

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.2010

    • Author(s)
      Hu Q, et al.
    • Journal Title

      Lab.Invest.

      Volume: 90 Pages: 360-373

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis2009

    • Author(s)
      Tomida, S., Takeuchi, T., Shimada, Y., Arima, C., Matsuo, K., Mitsudomi, T., Yatabe, Y., and Takahashi, T
    • Journal Title

      Clin. Oncol

      Volume: 27 Pages: 2793-2799

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi, H., Tomida, S., Takeuchi, T., Arima, C., Sato, T., Mitsudomi, T., Yatabe, Y., Osada, H., and Takahashi, T
    • Journal Title

      Cancer Res

      Volume: 69 Pages: 4027-2035

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers2009

    • Author(s)
      Ebi, H., Sato, T., Sugito, N., Hosono, Y., Suzuki, M., Yamaguchi, T., Yatabe, Y., Osada, H., and Takahashi, T
    • Journal Title

      Oncogene

      Volume: 28 Pages: 3371-3379

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PCNA Mono-ubiquitination and activation of translesion DNA polymerases by DNA polymeraseα2009

    • Author(s)
      Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Huang QM, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T, and Takahashi T
    • Journal Title

      J. Biochem

      Volume: 146 Pages: 13-21

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer2009

    • Author(s)
      Yazawa, T., Sato, H., Shimoyamada, H., Okudela, K., Woo, H., Tajiri, M., Ogura, T., Ogawa, N., Suzuki, T., Mitsui, H., Ishii, J., Miyata, C., Sakaeda, M., Goto, K., Kashiwagi, K., Masuda, M., Takahashi, T., and Kitamura, H
    • Journal Title

      Am. J. Pathol

      Volume: 175 Pages: 976-987

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of DUSP6 expression in lung cancers : its mechanism and potential role in carcinogenesis2009

    • Author(s)
      Okudera, K., Yazawa, T., Woo, T., Sakaeda, M., Ishii, J., Mitsui, H., Tajiri, M., Ogawa, N., Masuda, M., Takahashi, T., Sugimura H., and Kitamura, H
    • Journal Title

      Am. J. Pathol

      Volume: 175 Pages: 867-881

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone 2 in natural killer cell-depleted severe combined immunodeficient mice2009

    • Author(s)
      Otsuka, S., Hanibuchi, M., Ikuta, K., Yano, S., Goto, H., Ogino, H., Yamada, T., Kakiuchi, S., Nishioka, Y., Takahashi, T., and Sone, S
    • Journal Title

      Oncol. Res

      Volume: 17 Pages: 581-591

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis.2009

    • Author(s)
      Tomida S, et al.
    • Journal Title

      J.Clin.Oncol.

      Volume: 27 Pages: 2793-2799

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses.2009

    • Author(s)
      Ebi H, et al.
    • Journal Title

      Cancer Res.

      Volume: 69 Pages: 4027-2035

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers.2009

    • Author(s)
      Ebi H, et al.
    • Journal Title

      Oncogene

      Volume: 28 Pages: 3371-3379

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase α2009

    • Author(s)
      Suzuki M, et al.
    • Journal Title

      J.Biochem.

      Volume: 146 Pages: 13-21

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer.2009

    • Author(s)
      Yazawa T, et al.
    • Journal Title

      Am.J.Pathol.

      Volume: 175 Pages: 976-987

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of DUSP6 expression in lung cancers : its mechanism and potential role in carcinogenesis.2009

    • Author(s)
      Okudera K, et al.
    • Journal Title

      Am.J.Pathol.

      Volume: 175 Pages: 867-881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone 2 in natural killer cell-depleted severe combined immunodeficient mice.2009

    • Author(s)
      Otsuka S, et al.
    • Journal Title

      Oncol.Res.

      Volume: 17 Pages: 581-591

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma

    • Author(s)
      Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, ShimadaY, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T
    • Journal Title

      Cancer Cell

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Metastasis-suppressing MYBPH as a novel transcriptional target of TTF-1 lineage-survival oncogene in lung adenocarcinoma2011

    • Author(s)
      Takahashi T
    • Organizer
      US-Japan Cancer Genomics Workshop
    • Place of Presentation
      Kyoto, Japan(招待講演)
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] miRNA alterations in the pathogenesis of human lung cancer2011

    • Author(s)
      Takahashi, T
    • Organizer
      The 8th Nikko International Symposium
    • Place of Presentation
      Shimotsuke, Japan
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] miRNA alterations in the pathogenesis of human lung cancer2011

    • Author(s)
      Takahashi T
    • Organizer
      The 8^<th> Nikko International Symposium
    • Place of Presentation
      Shimotsuke, Japan(招待講演)
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of ASH1-regulated miRNAs and lincRNAs in lung cancer development2011

    • Author(s)
      Osada H, Takahashi T
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(シンポジウム)(招待講演)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] TTF-1 lineage-survival oncogene in the pathogenesis of lung adenocarcinoma2011

    • Author(s)
      Takahashi T
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(シンポジウム)(招待講演)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metastasis-suppressing MYBPH as a novel transcriptional target of TTF-1 lineage-survival oncogene in lung adenocarcinoma2011

    • Author(s)
      Takahashi T
    • Organizer
      Japan-US workshop for Cancer Genomics and Epigenomics(発表確定)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metastasis-suppressing MYBPH as a novel transcriptional target of TTF-1 lineage-survival oncogene in lung adenocarcinoma2011

    • Author(s)
      Takahashi, T
    • Organizer
      US-Japan Cancer Genomics Workshop
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Multidirectional dissection of lung cancer pathogenesis2010

    • Author(s)
      Takahashi T
    • Organizer
      19^<th> Hiroshima Cancer Seminar
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2010-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトがんにおけるマイクロRNAの異常2010

    • Author(s)
      高橋隆
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic analyses for biomarker discovery in human intractable diseases.2010

    • Author(s)
      Yanagisawa K
    • Organizer
      25^<th> Nagoya International Cancer Treatment Symposium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers.2010

    • Author(s)
      Takahashi T
    • Organizer
      8^<th> AACR-JCA Joint Conference.
    • Place of Presentation
      Waikoloa, USA
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌の増悪・転移に関わる分子病態の網羅的発現解析を用いた探求2010

    • Author(s)
      柳澤聖
    • Organizer
      文部科学省特定領域研究合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-01-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers.2010

    • Author(s)
      Takahashi T
    • Organizer
      1^<st> AACR-IASLC Joint Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers2010

    • Author(s)
      Takahashi, T
    • Organizer
      8th AACR-JCA Joint Conference
    • Place of Presentation
      Waikoloa, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers2010

    • Author(s)
      Takahashi, T
    • Organizer
      1st AACR-IASLC Joint Conference : Molecular Origins of Lung Cancer : Prospects for Personalized Prevention and Therapy
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Multi-facetted approach for the molecular dissection of lung cancer pathogenesis2009

    • Author(s)
      Takahashi, T
    • Organizer
      Hiroshima Cancer Seminar
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2009-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト肺癌の分子病態研究への網羅的発現解析の応用2009

    • Author(s)
      高橋隆
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト肺癌の分子病態の発現プロファイルに基づく理解と応用2009

    • Author(s)
      高橋隆
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology.2009

    • Author(s)
      Takahashi T
    • Organizer
      13^<th> World Conference on Lung Cancer, IASLC.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロテオミクス技術を応用した難治性疾患バイオマーカーの探索2009

    • Author(s)
      柳澤聖
    • Organizer
      第57回日本質量分析学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers2009

    • Author(s)
      Takahashi, T
    • Organizer
      Japanese-German Cancer Workshop
    • Place of Presentation
      Hamburg, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology2009

    • Author(s)
      Takahashi, T
    • Organizer
      13th World Conference on Lung Cancer, IASLC
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/molcar/jp/research.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/molcar/jp/research.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/molcar/jp/research.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/molcar/jp/research.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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