| Project/Area Number |
21249074
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
TAKIGAWA Toshikazu 京都大学, 工学(系)研究科(研究院), 教授 (50201603)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2011: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2010: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2009: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | ips / 複合材料 / 胸部外科 / 人工気管 / コラーゲン / 再生医学 / ビーグル犬 / 代用気管 / iPS / 組織工学 / 気道 / 気管 / 胸部外科学 / 気管狭窄 / 臨床応用 |
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| Research Abstract |
In this project, we challenged the improvement of biocompartibility of the artificial trachea using a new collagen matrix. Enhancement of epithelisation was also tried with somatic stem cells in an attempt to future clinical application. Establishment of canine iPS cells, that was the first report of the world, was achieved. MSC or autologous bone? marrow aspirate promotes the epithelisation of lumina' surface, and that the air? way of smaller diameter, such as the left main bronchus can be safely reconstructed. As a prominent spin? off of this project, the fastest method of were established making human iPS cells using a combination of 4 factors(Oct 3/4, Sox 2, Klf 4, n? Myc) and several chemical substances.
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