| Project/Area Number |
21300121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松尾 直毅 藤田保健衛生大学, 総合医科学研究所, 講師 (10508956)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Naoki 京都大学, 白眉センター, 特定准教授 (10508956)
TAKAO Keizo 自然科学研究機構, 生理学研究所・行動学・心理学的解析, 特任准教授 (80420397)
TOYAMA Keiko 藤田保健衛生大学, 総合医科学研究所, 助教 (20378722)
OHIRA Koji 藤田保健衛生大学, 総合医科学研究所, 講師 (80402832)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 網羅的行動テストバッテリー / 未成熟歯状回 / 精神疾患 / コンディショナルノックアウト / 行動異常 / α CaMKII / 綱羅的行動テストバッテリー / αCaMKII |
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| Research Abstract |
Heterozygous calcium/calmodulin-dependent protein kinase II alpha subunit knockout mice(CaMKIIαHKO mice) have profoundly dysregulated behaviors and impaired neuronal development in the dentate gyrus(DG), which might serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders. In the present research project, we established conditional knockout strains of mice, in which CaMKIIα is deleted in specific brain regions, such as dentate gyrus and CA3 in hippocampus. We will subject the conditional KO mice to our comprehensive behavioral test battery to clarify which brain area is responsible for which behavioral abnormalities seen in the CaMKIIαHKO mice.
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