Development of fluorescent imaging system for diseases and pathological conditions
| Project/Area Number |
21300151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Junko 筑波大学, 医学医療系, 助教 (30517793)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUDA Satoshi 関西医科大学, 医学部, 准教授 (00286444)
IRIE Kenji 筑波大学, 医学医療系, 教授 (90232628)
YOSHIDA Hiroshi 九州大学, 数理学研究院, 特任准教授 (60401262)
KOBAYASHI Makoto 筑波大学, 医学医療系, 講師 (50254941)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | イメージング / 近赤外 / 蛍光 / 動物実験技術 / 分子認識 / バイオテクノロジー / 遺伝子組換え / 細胞・組織 / 神経科学 |
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| Research Abstract |
The purpose of this research is development of novel fluorescent imaging system in mouse as a model animal to enhance lifescience research and animal welfare. We succeeded to develop novel fluorescent protein-based probes and small molecule chemical probes. Furthermore taking advantage of these fluorescent probes, we also succeeded to establish chemical screening systems for drug discovery and in vivo non-invasive imaging systems.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1in human prostate carcinoma PC-3 cells2009
Author(s)
Kawakami Y, Kubota N, Ekuni N, Suzuki-Yamamoto T, Kimoto M, Yamashita H, Tsuji H, Yoshimoto T, Jisaka M, Tanaka J, Fujimura HF, Miwa Y, Takahashi Y
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Journal Title
Biosci Biotechnol Biochem
Volume: 73
Pages: 1811-7
Related Report
Peer Reviewed
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