New insulin resistance regulatory factor "susceptibility to fat loading"
Project/Area Number |
21300255
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
|
Research Institution | Juntendo University |
Principal Investigator |
KAWAMORI Ryuzo 順天堂大学, 医学研究科, 特任教授 (00116021)
|
Co-Investigator(Kenkyū-buntansha) |
WATADA Hirotaka 順天堂大学, 医学部, 教授 (60343480)
TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
Keywords | 骨格筋細胞内脂質 / インスリン抵抗性 / 糖尿病 / 身体活動 / アディポネクチン |
Research Abstract |
(Aim) We investigated the effect of high fat diet(HFD) on metabolism in skeletal muscle.(Method) Three days HFD were provided to healthy men after 3 days normal fat diet.(Results) We observed negative correlation between changes in intramyocellular lipid(IMCL) and changes insulin sensitivity(GIR) after HFD. Microarray analysis demonstrated that significant changes of metabolic pathway was observed in high responder group(HR ; increased IMCL and decreased GIR after HFD), but not in low responder group(LR). Gene expression level of fat uptake and oxidation were elevated in HR group.(Conclusion) Our data suggested that gene expression response after HFD in skeletal muscle is associated with IMCL and GIR changes.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men2011
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
Diabetes Invest
Volume: 2
Pages: 310-317
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