New insulin resistance regulatory factor "susceptibility to fat loading"

• Project/Area Number: 21300255
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Juntendo University
• Principal Investigator: KAWAMORI Ryuzo 順天堂大学, 医学研究科, 特任教授 (00116021)
• Co-Investigator(Kenkyū-buntansha): WATADA Hirotaka 順天堂大学, 医学部, 教授 (60343480) ; TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 骨格筋細胞内脂質 / インスリン抵抗性 / 糖尿病 / 身体活動 / アディポネクチン

Research Abstract

(Aim) We investigated the effect of high fat diet(HFD) on metabolism in skeletal muscle.(Method) Three days HFD were provided to healthy men after 3 days normal fat diet.(Results) We observed negative correlation between changes in intramyocellular lipid(IMCL) and changes insulin sensitivity(GIR) after HFD. Microarray analysis demonstrated that significant changes of metabolic pathway was observed in high responder group(HR ; increased IMCL and decreased GIR after HFD), but not in low responder group(LR). Gene expression level of fat uptake and oxidation were elevated in HR group.(Conclusion) Our data suggested that gene expression response after HFD in skeletal muscle is associated with IMCL and GIR changes.

Research Products

• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men (2011)
  • Author(s): Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
  • Journal Title: Diabetes Invest Volume: 2 Pages: 310-317
• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men (2011)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Journal Title: J Diabetes Invest Volume: 2 Pages: 310-317
  • Peer Reviewed
• [Journal Article] Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects (2011)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Journal Title: J Diabetes Invest Volume: 2 Issue: 5 Pages: 356-358
  • DOI: 10.1111/j.2040-1124.2011.00108.x
  • Peer Reviewed
• [Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men. (2011)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Journal Title: J Diabetes Invest Volume: (In press)
  • Peer Reviewed
• [Presentation] Changes in intramyocellular lipid accumulation and Insulin sensitivity after High-Fat Loading are associated with transcriptional response in human skeletal muscle (2011)
  • Author(s): Kakehi S, Tamura Y, Kawamori R, Watada H., et al
  • Organizer: American Diabetes Association 71st scientific sessions
• [Presentation] Changes in intramyocellular lipid accumulation and Insulin sensitivity after High-Fat Loading are associated with transcriptional response in human skeletal muscle (2011)
  • Author(s): Kakehi S, T, et al
  • Organizer: American Diabetes Association 71st scientific sessions
  • Place of Presentation: San Diego
• [Presentation] Susceptible Factors for Intramyocellular Lipid Accumulation by Dietary Fat Loading in Non-Obese Men (2010)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Organizer: American Diabetes Association 70^<th> Scientific sessions
  • Year and Date: 2010-06-26
• [Presentation] Susceptible Factors for Intramyocellular Lipid Accumulation by Dietary Fat Loading in Non-Obese Men. (2010)
  • Author(s): 櫻井裕子、田村好史、河盛隆造、綿田裕孝
  • Organizer: American Diabetes Association 70^<th> Scientific sessions
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2010-06-26
• [Presentation] Intramyocellular lipid accumulation and insulin sensitivity (2010)
  • Author(s): 田村好史、綿田裕孝、河盛隆造
  • Organizer: 日本農芸化学会
  • Year and Date: 2010-03-30
• [Presentation] Intramyocellular lipid accumulation and insulin sensitivity (2010)
  • Author(s): 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-30
• [Presentation] Diabetes and Exercise : Intramycellular Lipid Accumulation and Insulin Sensitivity (2009)
  • Author(s): 田村好史、綿田裕孝、河盛隆造
  • Organizer: The 15th Korea-Japan Symposium on Diabetes Mellitus
  • Year and Date: 2009-11-21
• [Presentation] Diabetes and Exercise : Intramycellular Lipid Accumulation and Insulin Sensitivity (2009)
  • Author(s): 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: The 15th Korea-Japan Symposium on Diabetes Mellitus
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-21
• [Presentation] Anatomic and functional imaging of the body (2009)
  • Author(s): 田村好史、綿田裕孝、河盛隆造
  • Organizer: 日米医学協力研究会合同会議
  • Year and Date: 2009-11-09
• [Presentation] Anatomic and functional imaging of the body (2009)
  • Author(s): 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: 日米医学協力研究会合同会議
  • Place of Presentation: Baton Rouge, USA
  • Year and Date: 2009-11-09
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 田村好史、綿田裕孝、河盛隆造
  • Organizer: 第64回日本体力医学会
  • Year and Date: 2009-09-18
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: 第64回日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-18
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 田村好史、綿田裕孝、河盛隆造
  • Organizer: 第59回日本体質医学会
  • Year and Date: 2009-07-26
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: 第59回日本体質医学会
  • Place of Presentation: 東京・学士会館
  • Year and Date: 2009-07-26
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 櫻井裕子、田村好史、綿田裕孝、河盛隆造
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Year and Date: 2009-05-22
• [Presentation] ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子 (2009)
  • Author(s): 櫻井裕子, 田村好史, 綿田裕孝, 河盛隆造, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Book] 異所性脂肪メタボリックシンドロームの新常識 (2010)
  • Author(s): 田村好史, 他
  • Total Pages: 136
  • Publisher: 日本医事新報社
• [Book] 異所性脂肪 メタボリックシンドロームの新常識 (2010)
  • Author(s): 田村好史, 他
  • Total Pages: 124
  • Publisher: 日本医事新報社