Effects of Exercise on Intensities of Expressions of Receptors onNK Cell Subsets
| Project/Area Number |
21300257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | NK 細胞 / 運動 / レセプター / CD56dim / CD56bright / NK細胞 / ナチュラルキラー細胞 / CD56^<dim> / CD56^<bright> / NKG2D / DNAM-1 / NKp46 / NKG2A / 一過性運動 / NKG2DA / トレーニング |
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| Research Abstract |
In these studies，we examined the impacts of acute and chronic exercise on the functional receptors on NK cell in human. The results indicated that both induced changes in the expressions of molecules. These changes were mainly found in CD56dim NK cell. Some of changes in adhesion molecules seemed to contribute to cell mobilization. However, changes in activating/inhibitory receptors did not directly relate to the cell cytotoxicity. We also indicated the possibility that acute exercise stimulated cell turnover in the liver in mice.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article]2009
Author(s)
鈴井正敏(黒澤尚編)
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Journal Title
運動器慢性疾患に対する運動療法,第I章 基礎編「6.運動と免疫」(金原書店)
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