Effects of Exercise on Intensities of Expressions of Receptors onNK Cell Subsets

• Project/Area Number: 21300257
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Meiji University
• Principal Investigator: SUZUI Masatoshi 明治大学, 経営学部, 教授 (10187693)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: NK 細胞 / 運動 / レセプター / CD56dim / CD56bright / NK細胞 / ナチュラルキラー細胞 / CD56^<dim> / CD56^<bright> / NKG2D / DNAM-1 / NKp46 / NKG2A / 一過性運動 / NKG2DA / トレーニング

Research Abstract

In these studies，we examined the impacts of acute and chronic exercise on the functional receptors on NK cell in human. The results indicated that both induced changes in the expressions of molecules. These changes were mainly found in CD56dim NK cell. Some of changes in adhesion molecules seemed to contribute to cell mobilization. However, changes in activating/inhibitory receptors did not directly relate to the cell cytotoxicity. We also indicated the possibility that acute exercise stimulated cell turnover in the liver in mice.

Research Products

• [Journal Article] トレーニングがNK 細胞の活性化レセプターにおよぼす影響 (2013)
  • Author(s): 鈴井正敏
  • Journal Title: 明治大学人文科学研究所紀要 Volume: 74 Pages: 39-64
  • NAID: 120005386981
  • Peer Reviewed
• [Journal Article] 運動と免疫-NK 細胞の動態を中心に- (2012)
  • Author(s): 鈴井正敏
  • Journal Title: 登山医学,招待論文 Volume: 32(1) Pages: 10-14
• [Journal Article] 運動と免疫 － NK細胞の動態を中心として － (2012)
  • Author(s): 鈴井正敏
  • Journal Title: 登山医学 Volume: 32(1) Pages: 10-14
• [Journal Article] 運動すればかぜをひかなくなりますか? (2011)
  • Author(s): 鈴井正敏
  • Journal Title: 明治大学経営学部人文科学論集 Volume: 57 Pages: 37-48
  • NAID: 10013003742
• [Journal Article] 強いトレーニングにおける自律神経の変動と NK 細胞機能の関係について (2011)
  • Author(s): 鈴井正敏
  • Journal Title: 明治大学人文科学研究所紀要 Volume: 68 Pages: 139-166
  • NAID: 120005258592
  • Peer Reviewed
• [Journal Article] 強いトレーニングにおける自律神経の変動とNK細胞機能の関係について (2011)
  • Author(s): 鈴井正敏
  • Journal Title: 明治大学人文科学研究所紀要 Volume: 68(印刷中)
  • NAID: 120005258592
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 鈴井正敏(黒澤尚編)
  • Journal Title: 運動器慢性疾患に対する運動療法,第I章 基礎編「6.運動と免疫」(金原書店)
• [Presentation] 運動と免疫 -NK 細胞の動態を 中心に- (2012)
  • Author(s): 鈴井正敏
  • Organizer: 第32回日本登山医学 会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-06-16
• [Presentation] Shephard, Effects of Acute Exercise on Expressions of Natural Killer Cell Receptors (2012)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J
  • Organizer: American College of Sports Medicine 59th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-06-01
• [Presentation] Effects of Acute Exercise on Expressions of Natural Killer Cell Receptors (2012)
  • Author(s): Masatoshi Suzui
  • Organizer: American College of Sports Medicine 59th Annual Meeting
  • Place of Presentation: San Francisco, California, U.S.A.
• [Presentation] 運動と免疫 － NK細胞の動態を中心として － (2012)
  • Author(s): 鈴井正敏
  • Organizer: 第32回日本登山医学会学術集会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Effect of OLL 1073R-1 Yogurt Intake on NK cell Cytolytic Activities during Intense Training, International Society of Exercise Immunology (2011)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Shuji Ikegami, Hiroyuki Ito, Hideo Yagita, Pang N. Shek, Roy J. Shephard, Ko Okumura
  • Organizer: The 10th Symposium
  • Place of Presentation: Oxford, UK
  • Year and Date: 2011-07-21
• [Presentation] Effect of OLL1073R-1 Yogurt Intake on NK cell Cytolytic Activities during Intense Training (2011)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Shuji Ikegami, Hiroyuki Ito, Hideo Yagita, Pang N.Shek, Roy J.Shephard, Ko Okumura
  • Organizer: International Society of Exercise Immunology, The 10th Symposium
  • Place of Presentation: Oxford, UK
  • Year and Date: 2011-07-12
• [Presentation] Shephard, Impact of Acute Exercise on Natural Killer Cell Subset Distributions in SelectedMouse Tissues (2011)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Yoshihiro Hayakawa, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J.
  • Organizer: American College of SportsMedicine 58th Annual Meeting
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2011-06-03
• [Presentation] Impact of Acute Exercise on Natural Killer Cell Subset Distributions in Selected Mouse Tissues (2011)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Yoshihiro Hayakawa, Hideo Yagita, Ko Okumura, Pang N.Shek, Roy J.Shephard
  • Organizer: American College of Sports Medicine 58th Annual Meeting
  • Place of Presentation: Denver, Colorado, U.S.A.
  • Year and Date: 2011-06-03
• [Presentation] 運動するとかぜをひきやすくなるのか?-オープンウィンドウ仮説への挑戦- (2010)
  • Author(s): 鈴井正敏
  • Organizer: 日本体力医学会
  • Place of Presentation: 千葉商科大学,千葉県
  • Year and Date: 2010-09-17
• [Presentation] NK細胞の運動時の変化(招待講演) (2010)
  • Author(s): 鈴井正敏
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉県
  • Year and Date: 2010-09-07
• [Presentation] Shephard, Effect of NKG2D and DNAM-1 Expression on CD56dim NK Cell and Cytotoxic Activity During Training (2010)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J
  • Organizer: American College of Sports Medicine 57th Annual Meeting
  • Place of Presentation: Baltimore, Maryland,USA
  • Year and Date: 2010-06-02
• [Presentation] Effect of NKG2D and DNAM-1 Expression on CD56^<dim> NK Cell and Cytotoxic Activity During Training (2010)
  • Author(s): Suzui, M., K Takeda, H Yagita, K Okumura, PN Shek, RJ Shephard
  • Organizer: American College of Sports Medicine
  • Place of Presentation: Baltimore, Maryland, U.S.A.
  • Year and Date: 2010-06-02
• [Presentation] Shephard, Relationship Between Autonomic Nerve Activity and Distribution of Neutrophil and Lymphocyte Subsets during Intensive Training (2009)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J
  • Organizer: The 9th Symposium of the International Society of Exercise and Immunology
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 2009-09-22
• [Presentation] Relationship Between Autonomic Nerve Activity and Distribution of Neutrophil and Lymphocyte Subsets during Intensive Training (2009)
  • Author(s): Suzui, M., K Takeda, H Yagita, K Okumura, PN Shek, RJ Shephard
  • Organizer: International Society of Exercise Immunology
  • Place of Presentation: Tubingen, Germany
  • Year and Date: 2009-09-22
• [Presentation] Shephard, Relationship Between Autonomic Nerve Activity and Distribution of Leukocyte Subsets During Intensive Training (2009)
  • Author(s): Masatoshi Suzui, Kazuyoshi Takeda, Hideo Yagita, Ko Okumura, Pang N. Shek, Roy J
  • Organizer: American College of SportsMedicine 56th Annual Meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2009-05-27
• [Presentation] Relationship Between Autonomic Nerve Activity And Distribution Of Leukocyte Subsets During Intensive Training (2009)
  • Author(s): Suzui, M., K Takeda, H Yagita, K Okumura, PN Shek, RJ Shephard
  • Organizer: American college of Sports Medicine
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2009-05-27
• [Remarks]
  • URL: http://www.isc.meiji.ac.jp/~suzui/
• [Remarks] 教員プロフィール
  • URL: http://rwdb2.mind.meiji.ac.jp/Profiles/6/0000589/profile.html
• [Remarks] 健康科学研究室
  • URL: http://www.isc.meiji.ac.jp/~suzui/
• [Remarks]
  • URL: http://www.isc.meiji.ac.jp/~suzui/
• [Remarks]
  • URL: http://www.isc.meiji.ac.jp/~suzui/
• [Remarks]
  • URL: http://www.isc.meiji.ac.jp/~suzui/