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A safety evaluation study on dietary fat in the miniature pig. Focusing on the endocrine disrupting effect.

Research Project

Project/Area Number 21300283
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKinjo Gakuin University

Principal Investigator

OHARA Naoki  金城学院大学, 薬学部, 教授 (20426422)

Co-Investigator(Kenkyū-buntansha) OKUYAMA Harumi  金城学院大学, 薬学部, 特任教授 (90080176)
YAMADA Kazuyo  金城学院大学, 薬学部, 准教授 (90080217)
NAGATA Tomoko  財団法人食品薬品安全センター, 秦野研究所, 副所長 (50426425)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords脂質 / ミニブタ / 病理学 / 内分泌撹乱 / カノーラ油 / 内分泌
Research Abstract

Canola oil ingestion shortens the life-span of stroke-prone spontaneously hypertensive rats(SHRSP). In this study we examined the effects of canola oil ingestion in miniature pigs. Miniature pigs were given canola oil or soybean oil(as the control) at 10w/w% in diet for 18 months from weaning. The animals were then autopsied. Decreased number of germ cells in the seminiferous tubule was found. Gene expression in the testis and the adrenal gland examined by means of DNA microarray technique revealed a possible influence on the metabolism of steroid hormones.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (9 results)

  • [Journal Article] Biochemical responses to dietary alpha-linolenic acid restriction proceed differently among brain regions in mice2011

    • Author(s)
      Daisuke Miyazawa, Yuko Yasui, Kazuyo Yamada, Naoki Ohara, Harumi Okuyama
    • Journal Title

      Biochemical Research

      Volume: Vol.32 Pages: 237-245

    • NAID

      130004903821

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ラットに対するカノーラ油および水素添加大豆油の有害作用と油中の微量因子ジヒドロビタミンK1様物質の関与の可能性2011

    • Author(s)
      大原直樹、内藤由紀子、奥山治美
    • Journal Title

      J Lipid Nutr

      Volume: Vol.20 Pages: 9-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] Biochemical responses to dietary alpha-linolenic acid restriction proceed differently among brain regions in mice2011

    • Author(s)
      Miyazawa D, Yasui Y, Yamada K, Ohara N, Okuyama H
    • Journal Title

      Biomedical Research

      Volume: 32 Pages: 237-245

    • NAID

      130004903821

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Testosterone-lowering activity of canola oil and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat2011

    • Author(s)
      Okuyama, Naoki Ohara, Kenjiro Tatematsu, Shinya Fuma, Tomoyuki Nonogaki, Kazuyo Yamada, Yuko Ichikawa, Daisuke Miyazawa, Yuko Yasui, Seijiro Honma
    • Journal Title

      Journal of Toxicological Sciences

      Volume: 35 Pages: 743-747

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラットに対するカノーラ油および水素添加大豆油の有害作用と油中の微量因子-ジヒドロビタミンK1様物質の関与の可能性-2011

    • Author(s)
      大原直樹、内藤由紀子、奥山治美
    • Journal Title

      脂質栄養

      Volume: 20 Pages: 9-22

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat2010

    • Author(s)
      Harumi Okuyama, Naoki Ohara, Kenjiro Tatematsu, Shinya Fuma, Tomoyuki Nonogaki, Kazuyo Yamada, Yuko Ichikawa, Daisuke Miyazawa, Yuko Yasui and Seijiro Honma
    • Journal Title

      Journal of Toxicological Sciences

      Volume: Vol.35 Pages: 743-747

    • NAID

      10026669321

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet2010

    • Author(s)
      Daisuke Miyazawa, Yuko Yasui, Kazuyo Yamada, Naoki Ohara, Harumi Okuyama
    • Journal Title

      Neurotrophin content and protein kinase activity Life Sciences

      Volume: Vol.87 Pages: 490-494

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet : Neurotrophin content and protein kinase activity2010

    • Author(s)
      Daisuke Miyazawa, Yuko Yasui, Kazuyo Yamada, Naoki Ohara, Harumi Okuyama
    • Journal Title

      Life Sciences

      Volume: 87 Pages: 490-494

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミニブタ組織のステロイドホルモンに対する植物油脂長期投与の影響2011

    • Author(s)
      宮澤大介, 大原直樹, 桜井杏, 安井裕子, 北森一哉, 斉藤義明, 臼見憲司, 山田和代, 今井唯, 山田英里, 大橋彩乃, 水谷友香, 野々垣常正, 小林身哉, 奥山治美
    • Organizer
      日本脂質栄養学会第20回大会
    • Place of Presentation
      埼玉
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高脂肪高コレステロール食が脳の生化学パラメータに及ぼす影響-脳由来神経栄養因子産生とプロテインキナーゼ活性-2011

    • Author(s)
      今井唯, 宮澤大介, 北森一哉, 安井裕子, 大原直樹, 奥山治美、家森幸男、山田和代
    • Organizer
      第57回日本薬学会東海支部大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミニブタ組織のステロイドホルモンに対する植物油脂長期投与の影響2011

    • Author(s)
      宮澤大介、大原直樹、桜井杏、安井裕子、北森一哉、斉藤義明、臼見憲司、山田和代、今井唯、山田英里、大橋彩乃、水谷友香、野々垣常正、小林身哉、奥山治美
    • Organizer
      日本脂質栄養学会第20回大会
    • Place of Presentation
      坂戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 食用油投与によるミニブタの病理組織学的変化2011

    • Author(s)
      斉藤義明、臼見憲司、古谷真美、立花滋博、内藤由紀子、永田伴子、宮澤大介、安井裕子、山田和代、大原直樹、奥山治美
    • Organizer
      第27回日本毒性病理学会学術年会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] ミニブタにおけるカノーラ油長期摂取の影響2010

    • Author(s)
      立花滋博、内藤由紀子、永田伴子、斉藤義明、臼見憲司、古谷真美、宮澤大介、安井裕子、北森一哉、山田和代、大原直樹、奥山治美
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高リノール酸食、高αリノレン酸食を給餌したマウスの脳の神経栄養因子産生とプロテインキナーゼ活性2010

    • Author(s)
      宮澤大介、安井裕子、山田和代、大原直樹、奥山治美
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高リノール酸食、高α-リノレン酸食を給餌したマウス脳の神経栄養因子産生とプロテインキナーゼ活性2010

    • Author(s)
      宮澤大介、安井裕子、山田和代、大原直樹、奥山治美
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山
    • Related Report
      2011 Final Research Report
  • [Presentation] ミニブタにおけるカノーラ油の長期摂取の影響2010

    • Author(s)
      立花滋博、内藤由紀子、永田伴子、斉藤義明、臼見憲司、古谷真美、宮澤大介、安井裕子、北森一哉、山田和代、大原直樹、奥山治美
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山
    • Related Report
      2011 Final Research Report
  • [Presentation] 植物油摂取によってラットで認められる有害効果2010

    • Author(s)
      大原直樹、内藤由紀子、奥山治美
    • Organizer
      日本脂質栄養学会第19回大会
    • Place of Presentation
      犬山
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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