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Development of Profiling Method for the Health Effect Evaluation of Exposure against Hazardous Environmental Chemicals by analyzing Human Samples

Research Project

Project/Area Number 21310027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental impact assessment/Environmental policy
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

SHIBATA Yasuyuki  独立行政法人国立環境研究所, 環境計測研究センター, 上級主席研究員 (80154251)

Co-Investigator(Kenkyū-buntansha) NAKANO Takeshi  財団法人ひょうご環境創造協会, 兵庫県環境研究センター, 参与 (00446791)
HASHIMOTO Shunji  独立行政法人国立環境研究所, 環境計測研究センター, 主任研究員 (80321719)
NAKAYAMA Shoji  独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (00368705)
Co-Investigator(Renkei-kenkyūsha) INOUE Yoshinori  大阪市立大学, 大学院・医学研究科, 非常勤講師 (90382225)
TAKASUGA Takumi  愛媛大学, 沿岸環境科学研究センター, 客員教授 (10451379)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords網羅分析 / 抱合体捕集法 / オンライン抽出LCMSMS / GCxGC-TOF/MSMS / 化学物質曝露評価 / 尿中代謝物分析 / GCxGC/TOF / LC-Q-TOF、LC-TOF / 水酸化PCB / POPs / 尿中化学物質分析 / プロファイリング / LC-TOF / GCxGC / MSMS / 固相抽出材
Research Abstract

A series of analytical methods, including extraction/trapping/clean-up and analysis have been developed by the use of advanced analytical techniques, such as GCxGC/HRTOF and on-line SPE-LCMSMS, in order to establish sound management of chemicals by the global profiling of exposure status to the environmental chemicals and assessment of their effects as well as tracing their major sources.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (27 results)

  • [Journal Article] Distribution of polybrominated diphenyl ethers in various Japanese autopsy samples., Environmental risk assessment and concentration trend of atmospheric volatile organic compounds in Hyogo Prefecture2012

    • Author(s)
      Hirai, T., Fujimine, Y., Watanabe, S. and Nakano, T.
    • Journal Title

      Japan, Environ Sci Pollut Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of polybrominated diphenyl ethers in various Japanese autopsy samples., Environmental risk assessment and concentration trend of atmospheric volatile organic compounds in Hyogo Prefecture, Japan2012

    • Author(s)
      Hirai, T., Fujimine, Y., Watanabe, S., Nakano, T.
    • Journal Title

      Environ Sci Pollut Res

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood-sampling method for POPs and other chemicals analysis in Japanese birth cohort study Japan Environment and Children's Study2011

    • Author(s)
      Shibata Y, Yoshikane M, Takagi M, Tanabe K, Hashimoto S, Sasaki Y, Ito H, Nitta H, Satoh H
    • Journal Title

      Organohalogen Comp

      Volume: 73 Pages: 1464-67

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Hydroxylated Polychlorinated Biphenyl(OH-PCBs) Analytical Method in Human Urine With UPLC/Q-TOF MS2011

    • Author(s)
      Suzuki M, Okuno T, Matsumura C, Sato N, Yonekubo J, Ezaki T, Inoue Y, Imaishi H, Nakano T
    • Journal Title

      Organohalogen Comp

      Volume: 73 Pages: 1215-18

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Hydroxylated Polychlorinated Biphenyl (OH-PCBs) Analytical Method in Human Urine With UPLC/Q-TOF MS2011

    • Author(s)
      Suzuki M, Okuno T, Matsumura C, Sato N, Yonekubo J, Ezaki T, Inoue Y, Imaishi H, Nakano T
    • Journal Title

      Organohalogen Compounds

      Volume: 73 Pages: 1215-1218

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood-sampling method for POPs and other chemicals analysis in Japanese birth cohort study "Japan Environment and Children's Study"2011

    • Author(s)
      Shibata Y, Yoshikane M, Takagi M, Tanabe K, Hashimoto S, Sasaki Y, Ito H, Nitta H, Satoh H
    • Journal Title

      Organohalogen Comp

      Volume: 73 Pages: 1464-1407

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有機フッ素化合物の環境汚染実態とその影響2011

    • Author(s)
      柴田康行・吉兼光葉
    • Journal Title

      産業と環境

      Volume: 8 Pages: 27-30

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 多次元ガスクロマトグラフ-飛行時間型質量分析計による水酸化PCBの測定に関する検討2010

    • Author(s)
      橋本俊次,本田守,高菅卓三,生方正章,田中一夫,田邊潔,柴田康行
    • Journal Title

      環境化学

      Volume: 20 Pages: 161-172

    • NAID

      10026389513

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of low level hydroxylated polychlorinated biphenyl (OH-PCBs) analytical method in human blood with UPLC/Q-Tof MS2010

    • Author(s)
      Ezaki, T., Yonekubo, J., Suzuki, M., Matsumura, C., Nakano, T.
    • Journal Title

      Organohalogen Compounds

      Volume: 72 Pages: 1617-1620

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3, 3, 4, 4, 5-pentachlorobiphenyl2010

    • Author(s)
      Yamazaki, K., Suzuki, M., Itoh, T., Yamamoto, K., Kanemitsu, M., Matsumura, C., Nakano, T., Sakaki, T., Fukami, Y., Imaishi, H., Inui, H
    • Journal Title

      Journal of Biochemistry

      Volume: 149 Pages: 487-494

    • NAID

      10030584940

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 環境微量分析技術の開発・改良と課題2009

    • Author(s)
      柴田康行
    • Journal Title

      化学物質と環境 No.98

      Pages: 1-3

    • Related Report
      2009 Annual Research Report
  • [Journal Article] GMP and the Effectiveness Evaluation of the Stockholm Convention2009

    • Author(s)
      柴田康行
    • Journal Title

      Organohalogen Compounds 71

      Pages: 3172-3177

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 誘導体化GC/MS法を用いた生体試料中のOH-PCBs分析2011

    • Author(s)
      羽賀雄紀, 鈴木元治, 奥野俊博, 矢本善也, 鶴川正寛, 松村千里, 英保次郎, 井上嘉則, 中野武
    • Organizer
      日本水環境学会シンポジウム
    • Place of Presentation
      東北工業大学(宮城県)
    • Year and Date
      2011-09-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MS/MSを用いた生体試料中のOH-PCBs分析2011

    • Author(s)
      平井哲也, 鈴木元治, 奥野俊博, 松村千里, 井上嘉則, 中野武
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学(熊本県)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 誘導体化GC/MS法による尿中のOH-PCBs分析2011

    • Author(s)
      羽賀雄紀, 鈴木元治, 奥野俊博, 鶴川正寛, 松村千里, 英保次郎, 井上嘉則, 中野武
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学(熊本県)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高分解能LC/MSによる水酸化PCBsスクリーニング分析法の開発(II)2011

    • Author(s)
      米久保淳, 佐藤信武, 江崎達哉, 鈴木元治, 奥野俊博, 松村千里, 今石浩正, 中野武
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学(熊本県)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] オンライン固相抽出による生体試料中フタル酸モノエステル類分析の高感度・高精度化の検討2011

    • Author(s)
      高木麻衣、吉兼光葉、小林美哉子、小森住美子、矢内美幸、柴田康行
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学(熊本県)
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] LC/MSによる前躯体および中間代謝体を含む有機フッ素化合物の一斉分析法の検討2011

    • Author(s)
      矢本善也, 竹峰秀祐, 松村千里, 鈴木元治, 川崎英也, 中野武, 荒川隆一
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学(熊本県)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Environmental Analysis-Comprehensive vs Tracers-2011

    • Author(s)
      柴田康行
    • Organizer
      日中分析測定技術シンポジウム
    • Place of Presentation
      Jinhan Exhibition Centre(広州)(招待講演)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Congener-specific and enantioselective analysis of POPs2011

    • Author(s)
      Nakano, T.
    • Organizer
      UNU International Symposium on Existing and Emerging Chemicals in the Environment(招待講演)
    • Place of Presentation
      Shanghai
    • Year and Date
      2011-03-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 誘導体化GC/MS法を用いた生体試料中のOH-PCBs分析2011

    • Author(s)
      羽賀雄紀,鈴木元治,奥野俊博,矢本善也,鶴川正寛,松村千里,英保次郎,井上嘉則,中野武
    • Organizer
      日本水環境学会シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report
  • [Presentation] 誘導体化GC/MS法による尿中のOH-PCBs分析2011

    • Author(s)
      羽賀雄紀,鈴木元治,奥野俊博,鶴川正寛,松村千里,英保次郎,井上嘉則,中野武
    • Organizer
      環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] 高分解能LC/MSによる水酸化PCBsスクリーニング分析法の開発(II)2011

    • Author(s)
      米久保淳,佐藤信武,江崎達哉,鈴木元治,奥野俊博,松村千里,今石浩正,中野武
    • Organizer
      環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] LC/MS/MSを用いた生体試料中のOH-PCBs分析2011

    • Author(s)
      平井哲也,鈴木元治,奥野俊博,松村千里,井上嘉則,中野武
    • Organizer
      環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] LC/MSによる前躯体および中間代謝体を含む有機フッ素化合物の一斉分析法の検討2011

    • Author(s)
      矢本善也,竹峰秀祐,松村千里,鈴木元治,川崎英也,中野武,荒川隆一
    • Organizer
      環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] オンライン固相抽出による生体試料中フタル酸モノエステル類分析の高感度・高精度化の検討2011

    • Author(s)
      高木麻衣、吉兼光葉、小林美哉子、小森住美子、矢内美幸、柴田康行
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本
    • Related Report
      2011 Final Research Report
  • [Presentation] GCxGC-MS/MSによる環境および生体試料中の有機ハロゲン系化合物の網羅分析の検討2010

    • Author(s)
      橋本俊次,伏見暁洋,高澤嘉一,田邊潔,柴田康行
    • Organizer
      2nd Korea-Jpn. Symp. Environ. Chem./韓国環境分析学会秋季学術大会
    • Place of Presentation
      ソウル
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] A Preliminary study on the analysis of chemicals in blood/urine samples by LC-TOF2010

    • Author(s)
      M Yoshikane, Y Takazawa, K Tanabe, Y Shibata
    • Organizer
      2nd Korea-Jpn. Symp. Environ. Chem./韓国環境分析学会秋季学術大会
    • Place of Presentation
      ソウル
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] GCxGC-MS/MSによる環境および生体試料中の有機ハロゲン系化合物の網羅分析の検討2010

    • Author(s)
      橋本俊次, 伏見暁洋, 高澤嘉一, 田邊潔, 柴田康行
    • Organizer
      2nd Korea-Jpn.Symp.Environ.Chem./韓国環境分析学会秋季学術大会
    • Place of Presentation
      淑明女子大学(ソウル)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Preliminary study on the analysis of chemicals in blood/urine samples by LC-TOF2010

    • Author(s)
      M Yoshikane, Y Takazawa.K Tanabe, Y Shibata
    • Organizer
      2nd Korea-Jpn.Symp.Environ.Chem./韓国環境分析学会秋季学術大会
    • Place of Presentation
      淑明女子大学(ソウル)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環境計測の現在と将来-Next 50 Years-2010

    • Author(s)
      柴田康行
    • Organizer
      2nd Korea-Jpn. Symp. Environ. Chem./韓国環境分析学会秋季学術大会(基調講演)
    • Place of Presentation
      ソウル
    • Year and Date
      2010-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 環境計測の現在と将来-Next 50 Years-2010

    • Author(s)
      柴田康行
    • Organizer
      2nd Korea-Jpn.Symp.Environ.Chem./韓国環境分析学会秋季学術大会
    • Place of Presentation
      淑明女子大学(ソウル)(基調講演)
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト生体試料中の有機フッ素化合物の組成2010

    • Author(s)
      鈴木元治、竹峰秀祐、鶴川正寛、松村千里、中野武、奧野俊博、今石浩正
    • Organizer
      第13回水環境学会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト生体試料中の有機フッ素化合物の組成2010

    • Author(s)
      鈴木元治、竹峰秀祐、鶴川正寛、松村千里、中野武、奥野俊博、今石浩正
    • Organizer
      第13回水環境学会シンポジウム
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] LC-TOFによる尿中化学物質のプロファイリング-1.分析条件の検討2010

    • Author(s)
      柴田康行, 高澤嘉一, 吉兼光葉, 田邊潔
    • Organizer
      第19回環境化学討論会
    • Place of Presentation
      中部大学(春日井)
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Branched isomer profiles of perfluoroalkyl carboxylates in Japanese environment2010

    • Author(s)
      M Yoshikane, Y Shibata, N Shimizu
    • Organizer
      PFAA Days III
    • Place of Presentation
      EPA-Research Triangle Park, USA
    • Year and Date
      2010-06-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] GMP and the Effectiveness Evaluation of the Stockholm Convention2010

    • Author(s)
      柴田康行
    • Organizer
      Capacity Building of POPs Analysis in Core Media
    • Place of Presentation
      バンコク
    • Year and Date
      2010-01-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Environmental Time Capsule Program Today and Tomorrow2009

    • Author(s)
      柴田康行
    • Organizer
      International Symposium on Environmental Specimen Bank
    • Place of Presentation
      愛媛大学(愛媛県)
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生物モニタリングと試料長期保存2009

    • Author(s)
      柴田康行、吉兼光葉
    • Organizer
      有機フッ素化合物問題に関するワークショップ
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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