Development of Profiling Method for the Health Effect Evaluation of Exposure against Hazardous Environmental Chemicals by analyzing Human Samples
| Project/Area Number |
21310027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
SHIBATA Yasuyuki 独立行政法人国立環境研究所, 環境計測研究センター, 上級主席研究員 (80154251)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Takeshi 財団法人ひょうご環境創造協会, 兵庫県環境研究センター, 参与 (00446791)
HASHIMOTO Shunji 独立行政法人国立環境研究所, 環境計測研究センター, 主任研究員 (80321719)
NAKAYAMA Shoji 独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (00368705)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Yoshinori 大阪市立大学, 大学院・医学研究科, 非常勤講師 (90382225)
TAKASUGA Takumi 愛媛大学, 沿岸環境科学研究センター, 客員教授 (10451379)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 網羅分析 / 抱合体捕集法 / オンライン抽出LCMSMS / GCxGC-TOF/MSMS / 化学物質曝露評価 / 尿中代謝物分析 / GCxGC/TOF / LC-Q-TOF、LC-TOF / 水酸化PCB / POPs / 尿中化学物質分析 / プロファイリング / LC-TOF / GCxGC / MSMS / 固相抽出材 |
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| Research Abstract |
A series of analytical methods, including extraction/trapping/clean-up and analysis have been developed by the use of advanced analytical techniques, such as GCxGC/HRTOF and on-line SPE-LCMSMS, in order to establish sound management of chemicals by the global profiling of exposure status to the environmental chemicals and assessment of their effects as well as tracing their major sources.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3, 3, 4, 4, 5-pentachlorobiphenyl2010
Author(s)
Yamazaki, K., Suzuki, M., Itoh, T., Yamamoto, K., Kanemitsu, M., Matsumura, C., Nakano, T., Sakaki, T., Fukami, Y., Imaishi, H., Inui, H
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Journal Title
Journal of Biochemistry
Volume: 149
Pages: 487-494
NAID
Related Report
Peer Reviewed
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