Study of Bisphenol A effect on neonatal mouse using genetically modified mouse
Project/Area Number |
21310047
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
井口 泰泉 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90128588)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
Keywords | マウス / エピジェネティクス / ビスフェノール / ビスフェノールA / エストロゲン / 新生児影響 / 化学物質影響 |
Research Abstract |
It has been known that neonatal exposure of Bisphenol A cause adverse effects on mice. Especially effect on nervous stem is one of the great concerns. In this study, I made transgenic mice expressing a marker gene under the control of regulatory region of estrogen receptor alpha and examined the effect of Bisphenol A. In addition, I also examined the effect of Bisphenol A from epigenetic point of view by immunoprecipitation of methylated genome DNA.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Development of an RNA interference method in the cladoceran crustacean Daphnia magna2012
Author(s)
Kato, Y., Shiga, Y., Kobayashi, K., Tokishita, SI., Yamagata, H., Iguchi, T. & Watanabe, H.
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Journal Title
Dev Genes Evol
Volume: 20
Pages: 337-345
Related Report
Peer Reviewed
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[Journal Article] Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice2012
Author(s)
Kakuta, H., Tanaka, M., Chambon, P., Watanabe, H., Iguchi, T., & Sato, T
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Journal Title
Reproductive Toxicology
Volume: 33
Pages: 35-44
Related Report
Peer Reviewed
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[Journal Article] Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice2012
Author(s)
Nakamura, T., Miyagawa, S., Katsu, Y., Watanabe, H., Mizutani, T., Sato, T., Morohashi, KI., Takeuchi, T., Iguchi, T., & Ohta, Y
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Journal Title
Toxycology
Volume: 296
Pages: 13-19
Related Report
Peer Reviewed
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[Journal Article] Sequence divergence and expression of a transformer gene in the branchiopod crustacean, Daphnia magna2010
Author(s)
Kato, Y., Kobayashi, K., Oda, S., Tatarazako, N., Watanabe, H. & Iguchi, T.
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Journal Title
Genomics
Volume: 95
Pages: 160-165
Related Report
Peer Reviewed
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[Journal Article] Differential involvement of insulin-like growth factor-I and estrogen on prolactin cells in the mouse anterior pituitary2010
Author(s)
Hikake, T., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T. & Sato, T.
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Journal Title
Exp Biol Med(Maywood)
Volume: 235
Pages: 974-980
Related Report
Peer Reviewed
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[Journal Article] Involvement of Estrogen Receptor beta in the Induction of Polyovular Follicles in Mouse Ovaries Exposed Neonatally to Diethylstilbestrol2009
Author(s)
Kirigaya, A., Kim, H., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T. & Sato, T.
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Journal Title
Zoological Science
Volume: 26
Pages: 704-712
Related Report
Peer Reviewed
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[Journal Article] Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries2009
Author(s)
Kim, H., Nakajima, T., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T. & Sato, T.
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Journal Title
Biol Reprod
Volume: 81
Pages: 1002-1009
Related Report
Peer Reviewed
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[Journal Article] Effects of diethylstilbestrol on ovarian follicle development in neonatal mice2009
Author(s)
Kim, H., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T. & Sato, T.
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Journal Title
Reproductive Toxicology
Volume: 27
Pages: 55-62
Related Report
Peer Reviewed
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[Journal Article] Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis2009
Author(s)
C.Kuramori, Y.Hase, K.Hoshikawa, K.Watanabe, T.Nishi, T.Hishiki, T.Soga, A.Nashimoto, Y.Kabe, Y.Yamaguchi, H.Watanabe, K.Kataoka, M.Suematsu, H.Handa
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Journal Title
Toxicol. Sci. 109
Pages: 143-51
Related Report
Peer Reviewed
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[Journal Article] Pax6-5a promotes neuronal differentiation of murine embryonic stem cells2009
Author(s)
N.Shimizu, H.Watanabe, J.Kubota, J.Wua, R.Saitoa, T.Yokoia, T.Erad, T.Iwatsubo, T.Watanabe, S.Nishina, N.Azumag, T.Katada, H.Nishina
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Journal Title
Biol. Pharm. Bull. 32
Pages: 999-1003
NAID
Related Report
Peer Reviewed
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[Presentation] Development of an RNA interference method in the cladoceran crustaceans, Daphnia magna2011
Author(s)
Kato, Y., Shiga, Y., Tokishita, S., Kobayashi, K., Yamagata, H., Iguchi, T., & Watanabe, H.
Organizer
第34回日本分子生物学会年会
Place of Presentation
横浜
Related Report
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[Presentation] Effects of Juvenile Hormone Agonists for Embryonic Development of Daphnia magna2010
Author(s)
Toyota, K., Kato, Y., Miyagawa, S., Ogino, Y., Kobayashi, K., Oda, S., Watanabe, H. Tatarazako, S., & Iguchi, T.
Organizer
環境ホルモン学会第13回研究発表会
Place of Presentation
東京
Related Report
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[Presentation] Sequence divergence and expression of a transformer gene in the branchiopod crustaceans, Daphnia magna2010
Author(s)
Kato, Y., Kobayashi, K., Oda, S., Tatarazako, N., Watanabe, H. & Iguchi, T.
Organizer
Daphnia Genomics Consortium 2010
Place of Presentation
Leuven University,(Belgium)
Related Report
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[Presentation] Molecular impact of juvenile hormone agonists on neonatal Daphnia magna2010
Author(s)
Iguchi, T., Kato, Y., Miyagawa, S., Kobayashi, K., Oda, S., Tatarazako, N., & Watanabe, H.
Organizer
Daphnia Genomics Consortium 2010
Place of Presentation
Leuven University,(Belgium)
Related Report
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[Presentation] Modulation of sex determination by juvenile hormones and their analogs in Daphnia magna2009
Author(s)
Iguchi, T., Kato, Y., Watanabe, H., Oda, S., Tatarazako, N.
Organizer
International Conference on Comparative Endocrinology, Symposium Environmental Toxicology and Endocrine Disruption
Place of Presentation
Hong Kong, China
Related Report
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