display of synthetic antigens on intestinal bacteria based on chemicalbiology and their applications for mucosal vaccines
| Project/Area Number |
21350090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Ochanomizu University |
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Principal Investigator |
SADAMOTO Reiko お茶の水女子大学, お茶大アカデミック・プロダクション, 特任助教 (50372264)
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| Co-Investigator(Kenkyū-buntansha) |
KODA Toshiaki 北海道大学, 先端生命科学研究院, 教授 (20170186)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 乳酸菌 / 大腸菌 / バクテリア細胞壁 / 糖ペプチド / バクテリア / 細胞壁 / リポ多糖 / 0抗原糖鎖 / グラム陰性細菌 / O抗原 / 生体機能利用 / 生体分子 / 感染症 / 癌 / 細菌 |
|---|
| Research Abstract |
The bacterial cell-wall precursor GlcLev-1-P was not displayed on the mammalian cell surface. To confirm the orthogonal properties, bacteria-specific surface display in a co-culture system of intestinal epithelial cells(Caco-2, HT29, LS180) and bacteria is currently underway.
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Report
(4 results)
Research Products
(16 results)
