Comprehensive mapping of the neuropeptide-expressing cells in insect.

• Project/Area Number: 21380040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied entomology
• Research Institution: National Institute of Agrobiological Sciences
• Principal Investigator: TANAKA Yoshiaki 独立行政法人農業生物資源研究所, 昆虫成長制御研究ユニット, 上級研究員 (90355735)
• Co-Investigator(Kenkyū-buntansha): MIZOGUCHI Akira 名古屋大学, 大学院・理学系研究科, 准教授 (60183109)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 昆虫 / 脳・神経 / 応用動物 / 受容体 / ゲノム

Research Abstract

We mapped the expression of neuropeptide and their receptor genes in the nervous system of the silkworm Bombyx mori to explore the network of neuropeptides regulating insect development. We have identified several neuropeptides which are involved in the regulation of ecdysteroidogenesis or ecdysis behavior. These results suggest that complex networks of neuropeptide signaling regulate insect development.

Research Products

• [Journal Article] Recent topics on the regulatory mechanism of ecdysteroidogenesis by the prothoracic glands in insects (2011)
  • Author(s): Tanaka Y
  • Journal Title: Front. Endocrin Volume: 2 Pages: 107-107
  • DOI: 10.3389/fendo.2011.00107
  • Peer Reviewed
• [Journal Article] 比較ゲノムから見えてきた昆虫の神経ペプチド関連遺伝子群の特徴と害虫防除への利用展望 (2011)
  • Author(s): 田中良明
  • Journal Title: 植物防疫 Volume: 65 Pages: 139-143
• [Journal Article] Bombyx orcokinins are brain-gut peptides involved in the neuronal regulation of ecdysteroidogenesis (2011)
  • Author(s): Yamanaka N, Roller L,. it. an D, Satake H, Mizoguchi A, Kataoka H, Tanaka Y
  • Journal Title: J. Comp. Neurol Volume: 519 Issue: 2 Pages: 238-246
  • DOI: 10.1002/cne.22517
  • Peer Reviewed
• [Journal Article] Bombyx orcokinins are brain-gut peptides involved in the neuronal regulation of ecdysteroidogenesis. (2011)
  • Author(s): Yamanaka N., et al.
  • Journal Title: The Journal of Comparative neurology Volume: 519 Pages: 238-246
  • Peer Reviewed
• [Journal Article] 比較ゲノムから見えてきた昆虫の神経ペプチド関連遺伝子の特徴と害虫防除への利用展望 (2011)
  • Author(s): 田中良明
  • Journal Title: 植物防疫 Volume: 65 Pages: 139-143
• [Journal Article] MIPs are Ancestral Ligands for the Sex Peptide Receptor (2010)
  • Author(s): Kim Y-J, Bartalska K, Audsley N, Yamanaka N, Yapici N, Lee J-Y, Kim Y-C, Markovic M, Isaac R, Tanaka Y, Dickson B
  • Journal Title: Proc. Natl. Sci. USA Volume: 107 Issue: 14 Pages: 6520-6525
  • DOI: 10.1073/pnas.0914764107
  • Peer Reviewed
• [Journal Article] Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis (2010)
  • Author(s): Yamanaka N., Hua Y-J., Roller L., Spalovska-Valachova I., Mizoguchi A., Kataoka H., Tanaka Y
  • Journal Title: Proc. Natl. Sci. USA Volume: 107 Issue: 5 Pages: 2060-2065
  • DOI: 10.1073/pnas.0907471107
  • Peer Reviewed
• [Journal Article] MIPs are Ancestral Ligands for the Sex Peptide Receptor. (2010)
  • Author(s): Kim Y-J., et al.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 Pages: 6520-6525
  • Peer Reviewed
• [Journal Article] Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis (2010)
  • Author(s): Yamanaka N., et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 107 Pages: 2060-2065
  • Peer Reviewed
• [Journal Article] Ecdysis triggering hormone signaling in arthropods. (2010)
  • Author(s): Roller L., et al.
  • Journal Title: Peptides 31 Pages: 429-441
  • Peer Reviewed
• [Journal Article] Ecdysis triggering hormone signaling in arthropods (2009)
  • Author(s): Roller L, Zitnanova I, Dai L, Simo L, Park Y, Satake H, Tanaka Y, Adams M. E, Zitnan D
  • Journal Title: Peptides Volume: 31 Issue: 3 Pages: 429-441
  • DOI: 10.1016/j.peptides.2009.11.022
  • Peer Reviewed
• [Journal Article] Novel gene encoding precursor protein consisting of possible several neuropeptides expressed in brain and frontal ganglion of the silkworm (2009)
  • Author(s): Mitsumasu K, Tanaka Y, Niimi T, Yamashita O, Yaginuma T
  • Journal Title: Bombyx mori. Peptides Volume: 30 Issue: 7 Pages: 1233-1240
  • DOI: 10.1016/j.peptides.2009.03.023
  • Peer Reviewed
• [Journal Article] カイコのゲノムから見えてきた今後のホルモン研究 (2009)
  • Author(s): 田中良明
  • Journal Title: 蚕糸・昆虫バイオテック Volume: 78 Pages: 109-112
  • NAID: 10027209679
• [Journal Article] Novel gene encoding precursor protein consisting of possible several neuropeptides expressed in brain and frontal ganglion of the silkworm, Bombyx mori. (2009)
  • Author(s): Mitsumasu K., et al.
  • Journal Title: Peptides 30 Pages: 1233-1240
  • Peer Reviewed
• [Presentation] カイコ神経ペプチド関連遺伝子発現細胞の網羅的マッピング (2011)
  • Author(s): 田中良明,行弘文子, Roller L, Zitnan D.,溝口明
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川市神楽地区公共施設群(北海道)
  • Year and Date: 2011-09-23
• [Presentation] PTTH以外の神経ペプチドによる前胸腺活性制御機構 (2010)
  • Author(s): 田中良明
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2010-09-23
• [Presentation] 比較ゲノムから見えてきた昆虫の神経ペプチド関連遺伝子群の特徴と害虫防除への利用展望 (2010)
  • Author(s): 田中良明
  • Organizer: NIASシンポジウム「ポストゲノム時代の害虫防除研究のあり方第3回」
  • Place of Presentation: 秋葉原コンベンションホール(東京都)
  • Year and Date: 2010-09-10
• [Presentation] カイコのゲノムから見えてきた今後のホルモン研究 (2009)
  • Author(s): 田中良明
  • Organizer: 日本蚕糸学会関東支部第60回大会
  • Place of Presentation: 宇都宮大学(栃木県)
  • Year and Date: 2009-11-07
• [Book] 脱皮と変態の生物学 (2011)
  • Author(s): 田中良明
  • Total Pages: 496
  • Publisher: 東海大学出版会
• [Book] 脱皮と変態の生物学 (2011)
  • Author(s): 田中良明, 溝口明
  • Total Pages: 496
  • Publisher: 東海大学出版会
• [Remarks]
  • URL: http://www.nias.affrc.go.jp/org/DivInsect/GrowthRegulation/page01.html