| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Research Abstract |
Circulating lymphocytes migrate into the parenchyma of lymph nodes through specialized blood vessels called high endothelial venules(HEVs). In this process, chemokines are important for the activation of lymphocyte integrins and the subsequent firm attachment of lymphocytes to HEVs. By generating novel HEV-specific conditional knockout mice, we demonstrate in this study that heparan sulfate sequesters chemokines on the surface of HEVs and presents them to lymphocytes to facilitate this migratory process.
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