Functional analysis of sulfated glycosaminoglycans aimed at elucidating the pathology and therapy

• Project/Area Number: 21390025
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: KITAGAWA Hiroshi 神戸薬科大学, 薬学部, 教授 (40221915)
• Co-Investigator(Kenkyū-buntansha): NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578) ; MIKAMI Tadahisa 神戸薬科大学, 薬学部, 講師 (20330425)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: プロテオグリカン / グリコサミノグリカン / 糖転移酵素 / ガン抑制遺伝子 / コンドロイチン硫酸 / へパラン硫酸 / 遺伝性多発性外骨腫 / 酵素複合体 / 硫酸基転移酵素 / 軟骨形成不全 / 細胞接着分子 / 骨芽細胞分化 / 動脈硬化症 / ヘパラン硫酸 / 細胞分裂

Research Abstract

Proteoglycans carrying sulfated glycosaminoglycan chains are ubiquitously expressed at cell surfaces and in extracellular matrices, and glycosaminoglycan chains interact with numerous proteins, including growth factors, morphogens and extracellular-matrix proteins. These interactions form the basis of glycosaminoglycan-related biological phenomena. Thus, the biosynthesis of glycosaminoglycan regulates key events in embryonic development and homeostasis, and deranged glycosaminoglycan biosynthesis could cause diseases. Here, we examined glycosaminoglycan biosynthesis, the effects on cellular functions by alteration of glycosaminoglycan biosynthesis, and the possible association of the biosynthesis with several disease pathologies.

Research Products

• [Journal Article] Persistent cortical plasticity by upregulation of chondroitin 6-sulfation (2012)
  • Author(s): Miyata, S., Komatsu, Y., Yoshimura, Y., Taya, C., Kitagawa, H.
  • Journal Title: Nature Neurosci Volume: 15(3) Pages: 414-422
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11 (2012)
  • Author(s): Koike, T., Izumikawa, T., Tamura, J., Kitagawa, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 420(3) Pages: 523-529
  • Peer Reviewed
• [Journal Article] Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides (2012)
  • Author(s): Tamura, J., Tsutsumishita, N., Nakao, Y., Kawano, M., Kato, S., Takeda, N., Nadanaka, S., Kitagawa, H.
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 22(3) Pages: 1371-1374
  • Peer Reviewed
• [Journal Article] Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1 (2012)
  • Author(s): Izumikawa, T., Koike, T., Kitagawa, H.
  • Journal Title: Biochem. J. Volume: 441(2) Pages: 697-705
  • Peer Reviewed
• [Journal Article] Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1 (2012)
  • Author(s): Izumikawa, T., Koike, T., Kitagawa, H.
  • Journal Title: Biochemical journal Volume: 441 Issue: 2 Pages: 697-705
  • DOI: 10.1042/bj20111472
  • Peer Reviewed
• [Journal Article] Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides (2012)
  • Author(s): Tamura, J., et al
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 22 Issue: 3 Pages: 1371-1374
  • DOI: 10.1016/j.bmcl.2011.12.054
  • Peer Reviewed
• [Journal Article] Persistent cortical plasticity by upregulation of chondroitin 6-sulfation (2012)
  • Author(s): Miyata, S., et al
  • Journal Title: Nature Neurosci. Volume: 15 Issue: 3 Pages: 414-422
  • DOI: 10.1038/nn.3023
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to n-cadherin and cadherin-11. (2012)
  • Author(s): Koike, T., Izumikawa, T., Tamura, J., Kitagawa, H.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 420 Issue: 3 Pages: 523-529
  • DOI: 10.1016/j.bbrc.2012.03.024
  • Peer Reviewed
• [Journal Article] 6-硫酸化コンドロイチンの過剰発現にり大脳皮質の神経可塑性が維持される (2012)
  • Author(s): 宮田真路, 他
  • Journal Title: ライフサイエンス新着論文レビュー
• [Journal Article] Correlation of C4ST-1 and CnGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis (2011)
  • Author(s): Anggraeni, V. Y., Emoto, N., Yagi, K., Mayasari, D. S., Nakayama, K., Izumikawa, T., Kitagawa, H., Hirata, K.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 406(1) Pages: 36-41
  • Peer Reviewed
• [Journal Article] Chondroitin sulfate proteoglycans regulate experience-dependent neuronal plasticity (2011)
  • Author(s): Miyata, S., Kitagawa, H.
  • Journal Title: Trends Glycosci. Glycotechnol Volume: 23(133) Pages: 239-247
  • NAID: 10030389175
  • Peer Reviewed
• [Journal Article] Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies (2011)
  • Author(s): Saigoh, K., Izumikawa, T., Koike, T., Shimizu, J., Kitagawa, H., Kusunoki, S.
  • Journal Title: J. Hum. Genet. Volume: 56(2) Pages: 143-146
  • NAID: 10030657886
  • Peer Reviewed
• [Journal Article] Chondroitin 4-Osulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2 (2011)
  • Author(s): Izumikawa, T., Okuura, Y., Koike, T., Sakoda, N., Kitagawa, H.
  • Journal Title: Biochem. J. Volume: 434(2) Pages: 321-331
  • Peer Reviewed
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., Kitagawa, H.
  • Journal Title: J. Biol. Chem. Volume: 286(6) Pages: 4199-4208
  • Peer Reviewed
• [Journal Article] Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin (2011)
  • Author(s): Nakagawa, N., Izumikawa, T., Kitagawa, H., Oka, S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 415(1) Pages: 109-113
  • NAID: 120003610112
  • Peer Reviewed
• [Journal Article] 硫酸化糖鎖による形態形成因子Wntのシグナル伝達と拡散の調節機構 (2011)
  • Author(s): 灘中里美, 北川裕之
  • Journal Title: 生化学 Volume: 第83巻、第11号 Pages: 1027-1031
  • NAID: 10030345658
• [Journal Article] 神経系におけるコンドロイチン硫酸鎖の糖鎖暗号 (2011)
  • Author(s): 三上雅久、北川裕之
  • Journal Title: 生化学 Volume: 第83巻、第3号 Pages: 231-239
  • NAID: 10029067897
• [Journal Article] 特集糖鎖と神経疾患グリコサミノグリカン、コンドロイチン硫酸と神経可塑性 (2011)
  • Author(s): 宮田真路、北川裕之
  • Journal Title: 脳21 Volume: Vol.14 No.1 Pages: 16-21
• [Journal Article] Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain onthrombomodulin (2011)
  • Author(s): N. Nakagawa, T. Izumikawa, H. Kitagawa andS. Oka
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 415(1) Issue: 1 Pages: 109-13
  • DOI: 10.1016/j.bbrc.2011.10.023
  • Peer Reviewed
• [Journal Article] Chondroitin Sulfate Proteoglycans Regulate Experience-Dependent Neuronal Plasticity (2011)
  • Author(s): Miyata, S., et al
  • Journal Title: Trends in Glycoscience and Glycotechnology Volume: 23 Issue: 133 Pages: 239-247
  • DOI: 10.4052/tigg.23.239
  • NAID: 10030389175
  • ISSN: 0915-7352, 1883-2113
  • Peer Reviewed
• [Journal Article] 硫酸化糖鎖による形態形成因子Wntのシグナル伝達と拡散の調節機構 (2011)
  • Author(s): 灘中里美, 他
  • Journal Title: 生化学 Volume: 83 Pages: 1027-1031
  • NAID: 10030345658
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a. (2011)
  • Author(s): Nadanaka, S., et al.
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 4199-4208
  • Peer Reviewed
• [Journal Article] Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies. (2011)
  • Author(s): Saigoh, K., et al.
  • Journal Title: J.Hum.Genet. Volume: 56 Pages: 143-146
  • Peer Reviewed
• [Journal Article] Correlation of C4ST-1 and CnGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. (2011)
  • Author(s): Anggraeni, V.Y., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 406 Pages: 36-41
  • Peer Reviewed
• [Journal Article] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2. (2011)
  • Author(s): Izumikawa, T., et al.
  • Journal Title: Biochem.J. Volume: 434(2) Pages: 321-331
  • Peer Reviewed
• [Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice (2010)
  • Author(s): Izumikawa T., Kanagawa N., Watamoto Y., Okada M., Saeki M., Sakano M., Sugahara K., Sugihara K., Asano M., Kitagawa H.
  • Journal Title: J. Biol. Chem. Volume: 285(16) Pages: 12190-12196
  • Peer Reviewed
• [Journal Article] Biosynthesis of heparan sulfate in EXT1-deficient cells (2010)
  • Author(s): Okada M., Nadanaka S., Shoji N., Tamura J., Kitagawa H.
  • Journal Title: Biochem. J. Volume: 428(3) Pages: 463-471
  • Peer Reviewed
• [Journal Article] Two Golgiresident 3'-phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans (2010)
  • Author(s): Dejima K., Kitagawa H., et al.
  • Journal Title: J. Biol. Chem. Volume: 285(32) Pages: 24717-24728
  • Peer Reviewed
• [Journal Article] Chondoroitin sulfate Nacetylgalactosaminyltransferase-1 is required for normal cartilage development (2010)
  • Author(s): Watanabe, Y., Takeuchi, K., Higa-Onaga, S., Sato M., Tsujita, M., Abe, M., Natsume R., Li, M., Furuichi, T., Saeki, M., Izumikawa, T., Hasegawa, A., Yokoyama, M., Ikegawa, S., Sakimura, K., Amizuka, N., Kitagawa, H., Igarashi, M.
  • Journal Title: Biochem. J. Volume: 432(1) Pages: 47-55
  • Peer Reviewed
• [Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice. (2010)
  • Author(s): Izumikawa T., et al.
  • Journal Title: J.Biol.Chem. Volume: 285(16) Pages: 12190-12196
  • Peer Reviewed
• [Journal Article] Two Golgi-resident 3'-phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans. (2010)
  • Author(s): Dejima K., et al.
  • Journal Title: J.Biol.Chem. Volume: 285(32) Pages: 24717-24728
  • Peer Reviewed
• [Journal Article] Chondoroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. (2010)
  • Author(s): Watanabe, Y., et al.
  • Journal Title: Biochem.J. Volume: 432 Pages: 47-55
  • Peer Reviewed
• [Journal Article] Impairment of embryonic cell division and glycosaminoglycan biosynthesis in glucuronyltransferase-I-deficient mice (2010)
  • Author(s): Izumikawa, T., et al.
  • Journal Title: J.Biol. Chem. (in press)
  • Peer Reviewed
• [Journal Article] Chondroitin 4-0-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish (2009)
  • Author(s): Mizumoto S., Mikami T., Yasunaga D., Kobayashi N., Yamauchi H., Miyake A., Itoh N., Kitagawa H., Sugahara K.
  • Journal Title: Biochem. J. Volume: 419(2) Pages: 387-399
  • Peer Reviewed
• [Journal Article] FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region (2009)
  • Author(s): Koike T., Izumikawa T., Tamura J., Kitagawa H.
  • Journal Title: Biochem. J. Volume: 421(2) Pages: 157-162
  • Peer Reviewed
• [Journal Article] Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish (2009)
  • Author(s): Mizumoto S., et al.
  • Journal Title: Biochem. J. 419(2) Pages: 387-399
  • Peer Reviewed
• [Journal Article] FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region (2009)
  • Author(s): Koike T., et al.
  • Journal Title: Biochem. J. 421(2) Pages: 157-162
  • Peer Reviewed
• [Presentation] 脳の柔らかさのはなし (2012)
  • Author(s): 北川裕之, 他
  • Organizer: 名古屋大学オープンレクチャー2012
  • Place of Presentation: 名古屋
  • Year and Date: 2012-03-23
• [Presentation] コンドロイチン硫酸鎖による骨格筋分化と神経可塑性の制御 (2012)
  • Author(s): 北川裕之
  • Organizer: 第19回プロテオグリカンフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2012-02-11
• [Presentation] コンドロイチン硫酸鎖による骨格筋分化と神経可塑性の制御 (2012)
  • Author(s): 北川裕之
  • Organizer: 第19回プロテオグリカンフォーラム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-02-11
• [Presentation] コンドロイチン4-O-硫酸基転移酵素-2は、コンドロイチンN-アセチルガラクトサミン転移酵素-1によるコンドロイチン鎖の本数合成を制御する (2012)
  • Author(s): 泉川友美, 北川裕之, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
• [Presentation] ビオチンリンカーに結合したコンドロイチン硫酸オリゴ糖の合成と糖-Midkine間の相互作用 (2012)
  • Author(s): 武田尚子, 灘中里美, 北川裕之, 他
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都
• [Presentation] ヒアルロン酸やコンドロイチンなどの糖鎖の機能 (2011)
  • Author(s): 北川裕之
  • Organizer: 神戸薬科大学同窓会南九州支部生涯研修セミナー
  • Place of Presentation: 宮崎(招待講演)
  • Year and Date: 2011-11-13
• [Presentation] Sugar code regulates Wnt signaling and diffusion. (2011)
  • Author(s): Kitagawa, H.
  • Organizer: The 7^<th> International Conference on Proteoglycams
  • Place of Presentation: Sydney
  • Year and Date: 2011-10-18
• [Presentation] "Sugar code" regulates Wnt signaling and diffusion (2011)
  • Author(s): Kitagawa, H.
  • Organizer: The 7^<th> International Conference on Proteoglycams
  • Place of Presentation: Sydney(招待講演)
  • Year and Date: 2011-10-18
• [Presentation] A Sugar code controls Wnt signaling and diffusion. (2011)
  • Author(s): Kitagawa, H.
  • Organizer: Glycobiology Japan-Netherland Joint Seminar 2011
  • Place of Presentation: Nagoya
  • Year and Date: 2011-10-09
• [Presentation] A Sugar code controls Wnt signaling and diffusion (2011)
  • Author(s): Kitagawa, H.
  • Organizer: Glycobiology Japan-Netherland Joint Seminar 2011
  • Place of Presentation: Nagoya(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] コンドロイチン硫酸による骨格筋分化の制御 (2011)
  • Author(s): 北川裕之
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] Sulfation patterns of chondroitin sulfate proteoglycans regulate critical period plasticity in the visual cortex (2011)
  • Author(s): Miyata, S., et al
  • Organizer: 第31回内藤記念コンファレンス
  • Place of Presentation: 札幌
  • Year and Date: 2011-09-13
• [Presentation] Biosynthetic mechanism of chondroitin sulfate chain elongation. (2011)
  • Author(s): Kitagawa, H.
  • Organizer: Second Joint Austria/Japan Seminar on Comparative and Developmental Glycobiology
  • Place of Presentation: Vienna
  • Year and Date: 2011-08-20
• [Presentation] Biosynthetic mechanism of chondroitin sulfate chain elongation (2011)
  • Author(s): Kitagawa, H.
  • Organizer: Second Joint Austria/Japan Seminar on Comparative and Developmental Glycobiology
  • Place of Presentation: Vienna(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] マウス初期胚および胚性幹細胞におけるグリコサミノグリカンの機能解析 (2011)
  • Author(s): 泉川友美, 北川裕之
  • Organizer: 第58回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2011-05-21
• [Presentation] コンドロイチン硫酸鎖の硫酸化コードによる神経機能の制御 (2011)
  • Author(s): 北川裕之
  • Organizer: 第2回新潟プロテオグリカン研究会
  • Place of Presentation: 新潟
  • Year and Date: 2011-02-04
• [Presentation] 骨芽細胞分化におけるコンドロイチン硫酸鎖の機能 (2011)
  • Author(s): 小池敏靖, 北川裕之, 他
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Downregulation of Chondroitin 4-O-sulfotransferase-1 by Wnt Signaling Triggers Diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kitagawa, H., et al.
  • Organizer: The 7^<th> International Conference on Proteoglycans
  • Place of Presentation: Sydney
• [Presentation] コンドロイチンN-アセチルガラクトサミン転移酵素-1によるコンドロイチン硫酸鎖の本数の制御機構 (2011)
  • Author(s): 泉川友美, 北川裕之, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin Nacetylgalactosaminyltransferase-2. (2011)
  • Author(s): Izumikawa, T., Kitagawa, H., et al.
  • Organizer: 21st International Symposium on Glycoconjugates
  • Place of Presentation: Vienna
• [Presentation] 硫酸化糖鎖による形態形成因子Wntのシグンル伝達と拡散の調節機構 (2011)
  • Author(s): 灘中里美, 北川裕之, 他
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
• [Presentation] グリコサミノグリカンのマウス初期胚および胚性幹細胞における機能解析 (2011)
  • Author(s): 泉川友美, 北川裕之, 他
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
• [Presentation] コンドロイチン硫酸によるDickkopf-1高発現乳がん細胞の浸潤能の制御 (2011)
  • Author(s): 北川裕之
  • Organizer: 第3回次世代シグナル伝達医学グローバルCOE研究討論会
  • Place of Presentation: 淡路
• [Presentation] コンドロイチン硫酸基合成酵素KOマウスにおける機能解析 (2011)
  • Author(s): 武内恒成, 他
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
• [Presentation] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2 (2011)
  • Author(s): Izumikawa, T., et al
  • Organizer: 21st International Symposium on Glycoconjugates
  • Place of Presentation: Vienna
• [Presentation] コンドロイチン硫酸合成に関する遺伝子改変マウスの神経系発生再生解析 (2011)
  • Author(s): 武内恒成, 他
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] Down-regulation of Chondroitin 4-O-sulfotransferase-1 by Wnt Signaling Triggers Diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., et al
  • Organizer: The 7^<th> International Conference on Proteoglycans
  • Place of Presentation: Sydney
• [Presentation] コンドロイチン硫酸鎖の硫酸化パターンによる視覚野「臨界期」の制御 (2010)
  • Author(s): 北川裕之
  • Organizer: BMB2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] グルクロン酸転移酵素-Iノックアウトマウスを用いたグリコサミノグリカンのマウス初期胚および胚性幹細胞における機能解析 (2010)
  • Author(s): 泉川友美, 北川裕之
  • Organizer: BMB2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] ヒアルロン酸やコンドロイチンなどの糖鎖の機能-若さと健康と保つには必須だけど…- (2010)
  • Author(s): 北川裕之
  • Organizer: 第1回神戸薬科大学健康食品講座
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-22
• [Presentation] コンドロイチン硫酸の生合成と機能-医療への応用を目指してー (2010)
  • Author(s): 北川裕之
  • Organizer: 九州大学理学部研究セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2010-02-04
• [Presentation] コンドロイチン硫酸の生合成と機能-医療への応用を目指して- (2010)
  • Author(s): 北川裕之
  • Organizer: 九州大学理学部研究セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2010-02-04
• [Presentation] コンドロイチン-4-O-硫酸基転移酵素-1によるWnt-3aシグナリングの微細調節 (2010)
  • Author(s): 灘中里美, 他
  • Organizer: CRESTシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-01-20
• [Presentation] コンドロイチン硫酸の生合成と機能-病態の解明を目指して- (2010)
  • Author(s): 北川裕之
  • Organizer: 第6回グルコミサン研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-08
• [Presentation] 高硫酸化コンドロイチン硫酸による神経突起伸長制御とそのメカニズムの解析 (2010)
  • Author(s): 金澤弘訓, 三上雅久, 北川裕之, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] 経験依存的な神経可塑性におけるコンドロイチン硫酸の機能 (2010)
  • Author(s): 宮田真路, 北川裕之, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] 筋分化過程におけるコンドロイチン硫酸の機能解析 (2010)
  • Author(s): 小山慎司, 三上雅久, 北川裕之, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] コンドロイチン4-O-硫酸基転移酵素-1によるWnt-3aの拡散制御 (2010)
  • Author(s): 木内啓貴, 灘中里美, 北川裕之, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] コンドロイチン硫酸合成酵素欠損マウスにおける脳発達障害 (2010)
  • Author(s): Susumu Higa Onaga, 北川裕之, 他
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
• [Presentation] コンドロイチン4-O-硫酸基転移酵素によるWnt-3aシグナリングの微細調節 (2010)
  • Author(s): 灘中里美, 北川裕之, 他
  • Organizer: 第42回日本結合組織学会・第57回マトリックス研究会合同学術研究会
  • Place of Presentation: 秋田
• [Presentation] Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E : Implication of a potential role for chondroitin sulfate sugar chains as extracellular signaling molecules. (2010)
  • Author(s): Mikami T., Kitagawa H., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium(ICS2010)
  • Place of Presentation: Chiba
• [Presentation] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2. (2010)
  • Author(s): Koike T., Kitagawa H., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium(ICS2010)
  • Place of Presentation: Chiba
• [Presentation] Impairment of Embryonic Cell Division and Glycosaminoglycan Biosynthesis in Glucuronyltransferase-I-Deficient Mice. (2010)
  • Author(s): Izumikawa T., Kitagawa H., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium(ICS2010)
  • Place of Presentation: Chiba
• [Presentation] Importance of chondroitin sulfate chains during development. (2010)
  • Author(s): Kitagawa H.
  • Organizer: The 28^<th> Naito Conference
  • Place of Presentation: Kanagawa
• [Presentation] グルクロン酸転移酵素-Iノックアウトマウスを用いたマウス初期胚におけるグリコサミノグリカンの機能解析 (2010)
  • Author(s): 泉川友美, 北川裕之, 他
  • Organizer: 糖鎖機能研究会
  • Place of Presentation: 岡崎
• [Presentation] Role of chondroitin sulfate in development. (2010)
  • Author(s): Kitagawa H.
  • Organizer: IASCBC
  • Place of Presentation: Singapore
• [Presentation] 高硫酸化コンドロイチン硫酸による神経突起伸長制御メカニズムの解析 (2010)
  • Author(s): 玉置祐樹, 三上雅久, 北川裕之, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] コンドロイチンN-アセチルガラクトサミン転移酵素-Iによるコンドロイチン硫酸鎖生合成機構の解析 (2010)
  • Author(s): 佐伯美香, 北川裕之, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] Wnt-3a-mediated down-regulation of chondroitin 4-O-sulfotransferase-1 gene modulates diffusion of Wnt-3a (2010)
  • Author(s): 木内啓貴, 灘中里美, 北川裕之, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] Role of chondroitin sulfate in development (2010)
  • Author(s): Kitagawa H.
  • Organizer: International Anatomical Sciences and Cell Biology Conference
  • Place of Presentation: Singapore
• [Presentation] がん抑制遺伝子EXTファミリーに属するEXTL3による基底細胞型乳がんに関連するヘパラン硫酸鎖に存在する遊離グルコサミン構造の生合成機構 (2010)
  • Author(s): 北川裕之
  • Organizer: 第2回次世代シグナル伝達医学グローバルCOE研究討論会
  • Place of Presentation: 淡路
• [Presentation] Importance of chondroitin sulfate chains during development (2010)
  • Author(s): Kitagawa H.
  • Organizer: The 28^<th> Naito Conference
  • Place of Presentation: Kanagawa
• [Presentation] Impairment of Embryonic Cell Division and Glycosaminoglycan Biosynthesis in Glucuronyltransferase-I-Deficient Mice (2010)
  • Author(s): Izumikawa T., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium
  • Place of Presentation: Chiba
• [Presentation] Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in cooperation with chondroitin N-acetylgalactosaminyltransferase-2 (2010)
  • Author(s): Koike T., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium
  • Place of Presentation: Chiba
• [Presentation] Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E : Implication of a potential roie for chondroitin sulfate sugar chains as extracellular signaling molecules (2010)
  • Author(s): Mikami T., et al.
  • Organizer: The 25^<th> International Carbohydrate Symposium
  • Place of Presentation: Chiba
• [Presentation] キシロースリン酸化酵素によるグリコサミノグリカン生合成の制御 (2010)
  • Author(s): 小池敏靖, 他
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都
• [Presentation] キシロースリン酸化酵素であるFAM20Bによるグリコサミノグリカン生合成の制御 (2010)
  • Author(s): 小池敏靖, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] 糖ヌクレオチド輸送体SLC35D1およびSLC35D2を媒介したグリコサミノグリカン合成は初期胚の正常な分化に必要である (2010)
  • Author(s): 平岡秀一, 他
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] ビオチンリンカーに結合したコンドロイチン硫酸オリゴ糖の合成と特異タンパク質との相互作用 (2010)
  • Author(s): 田村純一, 他
  • Organizer: 2010年度日本農芸化学会大会
  • Place of Presentation: 東京
• [Presentation] コンドロイチン4-O-硫酸基転移酵素-1によるWnt-3aの核酸制御 (2010)
  • Author(s): 木内啓貴, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] コンドロイチン硫酸プロテオグリカンの糖鎖生合成酵素変異マウスにおける脳形成の解析 (2009)
  • Author(s): 武内恒成, 北川裕之, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] Roles of glycosaminoglycans during development (2009)
  • Author(s): 北川裕之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] グリコサミノグリカン鎖の生合成と機能-Sugar codeの解読を目指して (2009)
  • Author(s): 北川裕之
  • Organizer: 京都産業大学バイオフォーラム2009
  • Place of Presentation: 京都
  • Year and Date: 2009-11-05
• [Presentation] コンドロイチン-4-O-硫酸基転移酵素-1によるWnt-3aシグナリングの微細調節 (2009)
  • Author(s): 灘中里美, 北川裕之, 他
  • Organizer: 第59回薬学会近畿支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-31
• [Presentation] コンドロイチン硫酸鎖の生合成機構と病態の解明を目指した機能の解析 (2009)
  • Author(s): 北川裕之
  • Organizer: 第2回Kobe Circulation Conference
  • Place of Presentation: 神戸
  • Year and Date: 2009-07-14
• [Presentation] Role of the Sulfation Pattern of Chondroitin Sulfate in its Neuritogenic Activities (2009)
  • Author(s): Kitagawa H.
  • Organizer: 8^<th> Pan-Pacific Connective Tissue Societies Symposium
  • Place of Presentation: Yokosuka
  • Year and Date: 2009-06-05
• [Presentation] コンドロイチン-4-O-硫酸基転移酵素-1によるWnt-3aシグナリングの微細調節 (2009)
  • Author(s): 灘中里美, 北川裕之, 他
  • Organizer: 第56回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] キシロースリン酸化酵素であるFAM20Bによるグリコサミノグリカン生合成の制御 (2009)
  • Author(s): 小池敏靖, 北川裕之, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 大脳皮質の発生に伴う細胞外マトリックス形成におけるコンドロイチン硫酸の機能解析 (2009)
  • Author(s): 宮田真路, 北川裕之, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] Functional regulation of chondroitin sulfate by specific sulfation. (2009)
  • Author(s): Kitagawa H.
  • Organizer: Austria/Japan Seminar on Comparative and Developmental Glycobiology
  • Place of Presentation: Hayama
• [Presentation] Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase-1(ChGn-1) missense mutations are associated with neuropathies (2009)
  • Author(s): Saigoh K., Kitagawa H., et al.
  • Organizer: 134^<th> Annual Meeting Baltimore, American Neurological Association
  • Place of Presentation: Maryland
• [Presentation] FAM20B is a Kinase that phosphorylates Xylose in the Glycosaminoglycan-Protein Linkage Region (2009)
  • Author(s): 小池敏靖, 北川裕之, 他
  • Organizer: 比較発生糖鎖生物学とその医工学への応用に関する日本・オーストリア二国間セミナー
  • Place of Presentation: 葉山
• [Presentation] Fine-tuning of the Cellular Response to Wnt-3a by Chondroitin 4-O-sulfotransferase-1 (2009)
  • Author(s): 灘中里美, 北川裕之, 他
  • Organizer: 比較発生糖鎖生物学とその医工学への応用に関する日本・オーストリア二国間セミナー
  • Place of Presentation: 葉山
• [Presentation] Role of The Sulfation Pattern of Chondroitin Sulfate in Its Neuritogenic Activities (2009)
  • Author(s): Kitagawa H.
  • Organizer: The 6^<th> International Proteoglycan Meeting
  • Place of Presentation: France
• [Presentation] 線虫における硫酸化関連遺伝子の遺伝子ノックアウト (2009)
  • Author(s): 野村一也, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] 神経可塑性を制御する細胞外マトリックス形成におけるコンドロイチン硫酸の機能解析 (2009)
  • Author(s): 宮田真路, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] Involvement of EXT gene family members in the biosynthesis of heparan sulfate (2009)
  • Author(s): 久世彩加, 灘中里美, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] Wnt-3a-mediated down-regulation of chondroitin 4-O-sulfotransferase-1 gene modulates diffusion of Wnt-3a (2009)
  • Author(s): 木内啓貴, 灘中里美, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] FAM20B is a Kinase that Phosphorylates Xylose in the Glycosaminoglycan-Protein Linkage Region (2009)
  • Author(s): 小池敏靖, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] A mechanism controlling the chain length of chondroitin sulfate by chondroitin 4-O-sulfotransferase-1 (2009)
  • Author(s): 泉川友美, 北川裕之, 他
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山
• [Presentation] 神経可塑性におけるコンドロイチン硫酸の機能解析 (2009)
  • Author(s): 宮田真路, 他
  • Organizer: 第1回シグナル伝達医学GCOE研究討論会
  • Place of Presentation: 淡路
• [Presentation] Functional regulation of chondroitin sulfate by specific sulfation (2009)
  • Author(s): 北川裕之
  • Organizer: Austria/Japan Seminar on Comparative and Developmental Glycobiology
  • Place of Presentation: Hayama
• [Presentation] Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase-1(ChGn-1)missense mutations are associated with neuropathies (2009)
  • Author(s): Kazumasa Saigoh, et al.
  • Organizer: 134^<th> Annual Meeting Baltimore, American Neurological Association
  • Place of Presentation: Maryland
• [Book] グリコサミノグリカングルクロン酸転移酵素-I, Glucuronyltransferase-I : GlcAT-I<seriesモデル動物利用マニュアル>生物機能モデルと新しいリソース・リサーチツール (2011)
  • Author(s): 泉川友美、北川裕之
• [Book] グリコサミノグリカングルクロン酸転移酵素-I (2011)
  • Author(s): 泉川友美, 他
  • Publisher: エル・アイ・シー
• [Book] 1H-NMR{(2)オリゴ糖} (2011)
  • Author(s): 北川裕之
  • Publisher: 廣川書店
• [Book] Enzyme assay of GAG glycosyltransferases for chondroitin sulfate (2011)
  • Author(s): Nadanaka,, et al
  • Publisher: GlycoPOD : GlycoScience Protocol Online http://jcggdb.jp/GlycoPOD/
• [Book] Enzyme assay of GAG glycosyltransferases for heparan sulfate (2011)
  • Author(s): Nadanaka, S., et al
  • Publisher: GlycoPOD : GlycoScience Protocol Online http://jcggdb.jp/GlycoPOD/
• [Book] Enzyme assay of xylosyltransferase (2011)
  • Author(s): Koike, T., et al
  • Publisher: GlycoPOD : GlycoScience Protocol Online http://jcggdb.jp/GlycoPOD/
• [Book] Mice deficient in glucuronyltransferase-I (2010)
  • Author(s): Izumikawa T., Kitagawa H.
• [Book] Mice deficient in glucuronyltransferase-I. (2010)
  • Author(s): Izumikawa T., et al.
  • Publisher: in Prog.Mol.Biol.Transl.Sci.(Lijuan Zhang, ed.)
• [Remarks]
• [Remarks]
  • URL: http://www.kobepharma-u.ac.jp/~biochem/
• [Remarks]
  • URL: http://www.kobepharma-u.ac.jp/~biochem/
• [Remarks]
  • URL: http://www.kobepharma-u.ac.jp/~biochem/
• [Patent(Industrial Property Rights)] 骨格筋再生促進剤 (2011)
  • Inventor(s): 北川裕之,三上雅久
  • Industrial Property Rights Holder: 北川裕之,三上雅久
  • Industrial Property Number: 2011-202470
  • Filing Date: 2011-09-16
• [Patent(Industrial Property Rights)] 骨格筋再生促進剤 (2011)
  • Inventor(s): 北川裕之, 三上雅久
  • Industrial Property Rights Holder: 北川裕之, 三上雅久
  • Industrial Property Number: 2011-202470
  • Filing Date: 2011-09-16
• [Patent(Industrial Property Rights)] コンドロイチン重合化因子の同定と、その利用 (2010)
  • Inventor(s): 北川裕之,菅原一幸
  • Industrial Property Rights Holder: 北川裕之,菅原一幸
  • Acquisition Date: 2010-05-21
• [Patent(Industrial Property Rights)] コンドロイチン重合化因子の同定と、その利用 (2010)
  • Inventor(s): 北川裕之, 菅原一幸
  • Industrial Property Rights Holder: 北川裕之, 菅原一幸
  • Acquisition Date: 2010-05-21