Development of anti-HIV agents targeting dynamic supramolecular mechanism and feedback mechanism

• Project/Area Number: 21390029
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAMAMURA Hiraokazu 東京医科歯科大学, 生体材料工学研究所, 教授 (80217182)
• Co-Investigator(Kenkyū-buntansha): NOMURA Wataru 東京医科歯科大学, 生体材料工学研究所, 講師 (80463909)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: HIV / CXCR4 / CD4ミミック / アンタゴニスト / インテグラーゼ阻害剤 / マトリックス蛋白

Research Abstract

In the development of drugs for treatments of HIV infectious disease and AIDS, we have synthesized HIV entry inhibitors having dynamic supramolecular mechanism such CXCR4 antagonists and other novel agents having different action mechanism. 1. Novel CXCR4 antagonists having xylene scaffold and potent bivalent CXCR4 antagonists were developed. 2. Small CD4 mimic derivatives having significant inhibitory activity against HIV entry and causing an increase of binding affinity for neutralizing antibodies were found. 3. Integrase inhibitors were discovered from Vpr fragments. 4. Anti-HIV agents derived from matrix fragments with cell membrane penetrating signals were developed.

Research Products

• [Journal Article] Development of Anti-HIV Agents Based on Chemical Biology (2012)
  • Author(s): 玉村啓和
  • Journal Title: YAKUGAKU ZASSHI Volume: 132 Issue: 1 Pages: 69-78
  • DOI: 10.1248/yakushi.132.69
  • NAID: 130001871964
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2012-01-01
  • Peer Reviewed
• [Journal Article] Pharmacophore-based Small Molecule CXCR4 Ligands (2012)
  • Author(s): Narumi T, Nomura W, Tamamura H, 他8人、11番目
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines (2012)
  • Author(s): Hashimoto C, Nomura W, Tamamura H, 他7人、10番目
  • Journal Title: Bioorg. Med. Chem. Volume: (in press)
  • Peer Reviewed
• [Journal Article] ケミカルバイオロジーを基盤とした抗HIV剤の創製 (2012)
  • Author(s): 玉村啓和, 他0人、1番目
  • Journal Title: 薬学雑誌(日本薬学会) Volume: 131(1)巻 Pages: 69-78
  • NAID: 130001871964
• [Journal Article] Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency (2012)
  • Author(s): Nomura W, Yamamoto N, Tamamura H, 他8人、11番目
  • Journal Title: Chem Med Chem Volume: 7巻 Pages: 205-208
  • Peer Reviewed
• [Journal Article] Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins (2012)
  • Author(s): Narumi T, Nomura W, Tamamura H, 他8人、11番目
  • Journal Title: Bioorg. Med. Chem. Volume: 20巻 Pages: 1468-1474
  • Peer Reviewed
• [Journal Article] Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific ChimericRecombinases Determined by a Facile Fluorescent System (2012)
  • Author(s): Nomura W, Yamamoto N, Tamamura H, 他5人、8番目
  • Journal Title: Biochemistry Volume: 51巻 Pages: 1510-1517
  • Peer Reviewed
• [Journal Article] Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines (2012)
  • Author(s): Hashimoto C, Nomura W, Yamamoto N, Tamamura H, et al.
  • Journal Title: Bioorg.Med.Chem. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System (2012)
  • Author(s): Nomura, W., Masuda, A., Ohba, K., Urabe, A., Ito, N., Ryo, A., Yamamoto, N., Tamamura, H.
  • Journal Title: Biochemistry Volume: 51 Issue: 7 Pages: 1510-1517
  • DOI: 10.1021/bi201878x
  • Peer Reviewed
• [Journal Article] Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency (2012)
  • Author(s): W.Nomura, T.Tanaka, et.al.
  • Journal Title: Chem Med Chem Volume: 7 Issue: 2 Pages: 205-208
  • DOI: 10.1002/cmdc.201100542
  • Peer Reviewed
• [Journal Article] Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins (2012)
  • Author(s): T.Narumi, T.Tanaka, et al
  • Journal Title: Biochemistry & Medicinal Chemistry Volume: 20 Issue: 4 Pages: 1468-1474
  • DOI: 10.1016/j.bmc.2011.12.055
  • Peer Reviewed
• [Journal Article] Small Molecular CD4 Mimics as HIV Entry Inhibitors (2011)
  • Author(s): T. Narumi, W. Nomura, H. Tamamura, 他4人、7番目
  • Journal Title: Bioorg. Med. Chem Volume: 19巻 Pages: 6735-6742
  • Peer Reviewed
• [Journal Article] The Success and Failures of HIV Drug Discovery (2011)
  • Author(s): C. Hashimoto, W. Nomura, H. Tamamura, 他2人、5番目
  • Journal Title: Expert Opin. Drug Discovery Volume: 6巻 Pages: 1067-1090
  • Peer Reviewed
• [Journal Article] Azamacrocyclic-metal Complexes as CXCR4 Antagonists (2011)
  • Author(s): T. Tanaka, W. Nomura, N. Yamamoto, H. Tamamura, 他7人、11番目
  • Journal Title: Chem Med Chem Volume: 6巻 Pages: 834-839
  • Peer Reviewed
• [Journal Article] Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore (2011)
  • Author(s): W. Nomura, H. Tamamura, 他5人、7番目
  • Journal Title: Bioconjugate Chem Volume: 22巻 Pages: 923-930
  • Peer Reviewed
• [Journal Article] Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C (2011)
  • Author(s): W. Nomura, T. H. Tamamura, 他6人、8番目
  • Journal Title: Chem Bio Chem Volume: 12巻 Pages: 535-539
  • Peer Reviewed
• [Journal Article] Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδas Reporters of Specific High Affinity Ligand Binding (2011)
  • Author(s): N. Ohashi, W. Nomura, H. Tamamura, 他4人、7番目
  • Journal Title: Bioconjugate Chem Volume: 22巻 Pages: 82-87
  • Peer Reviewed
• [Journal Article] Intense Blue Fluorescence in a Leucine Zipper Assembly (2011)
  • Author(s): H. Tsutsumi, W. Nomura, H. Tamamura, 他2人、5番目
  • Journal Title: Chem Bio Chem Volume: 12巻 Pages: 691-694
  • Peer Reviewed
• [Journal Article] Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environ mentally Sensitive Fluorophore (2011)
  • Author(s): Nomura, Wataru
  • Journal Title: Bioconjugate Chem Volume: VOL.22 Issue: 5 Pages: 923-930
  • DOI: 10.1021/bc100567k
  • Peer Reviewed
• [Journal Article] Azamacrocyclic-metal Complexes as CXCR4 Antagonists (2011)
  • Author(s): T.Tanaka, et.al.
  • Journal Title: ChemMedChem Volume: 6 Issue: 5 Pages: 834-839
  • DOI: 10.1002/cmdc.201000548
  • Peer Reviewed
• [Journal Article] Intense blue fluorescence in a leucine zipper assembly (2011)
  • Author(s): Tsutsumi H, Abe S, Mino T, Nomura W, Tamamura H
  • Journal Title: ChemBioChem Volume: 12 Issue: 5 Pages: 691-694
  • DOI: 10.1002/cbic.201000692
  • Peer Reviewed
• [Journal Article] Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C (2011)
  • Author(s): Nomura, Wataru
  • Journal Title: ChemBioChem Volume: VOL.12 Issue: 4 Pages: 535-539
  • DOI: 10.1002/cbic.201000670
  • Peer Reviewed
• [Journal Article] Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding (2011)
  • Author(s): Ohashi N, Nomura W, Tamamura H, et al.
  • Journal Title: Bioconjugate Chem Volume: 22 Issue: 1 Pages: 82-87
  • DOI: 10.1021/bc100414a
  • Peer Reviewed
• [Journal Article] Small Molecular CD4 Mimics as HIV Entry Inhibitors (2011)
  • Author(s): Narumi T, Nomura W, Matsushita S, Tamamura H, et al.
  • Journal Title: Bioorg Med Chem Volume: 19 Issue: 22 Pages: 6735-6742
  • DOI: 10.1016/j.bmc.2011.09.045
  • Peer Reviewed
• [Journal Article] The Success and Failures of HIV Drug Discovery (2011)
  • Author(s): C.Hashimoto, T.Tanaka, et.al.
  • Journal Title: Expert Opinion in Drug Discovery Volume: 6 Issue: 10 Pages: 1067-1090
  • DOI: 10.1517/17460441.2011.611129
  • Peer Reviewed
• [Journal Article] HIV-1 gp120 Enhances Outward Potassium Current via CXCR4 and cAMP-Dependent Protein Kinase a Signaling in Cultured Rat Microglia (2011)
  • Author(s): Xu C, Liu J, Chen L, Liang S, Fujii N, Tamamura H, Xiong H
  • Journal Title: Glia Volume: 59 Issue: 6 Pages: 997-1007
  • DOI: 10.1002/glia.21171
  • Peer Reviewed
• [Journal Article] The Increase in Surface CXCR4 Expression on Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury (2011)
  • Author(s): Yamada M, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M, et al.
  • Journal Title: Cell Mol Immunol Volume: 8 Issue: 4 Pages: 305-314
  • DOI: 10.1038/cmi.2011.8
  • Peer Reviewed
• [Journal Article] Azamacrocyclic-metal Complexes as CXCR4 Antagonists (2011)
  • Author(s): Tanaka T, Nomura W, Murakami T, Yamamoto N, Tamamura H, et al.
  • Journal Title: ChemMedChem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells (2010)
  • Author(s): T. Tanaka, W. Nomura, H. Tamamura, 他2人、5番目
  • Journal Title: J. Am. Chem. Soc.(Commun.) Volume: 132巻 Pages: 15899-15901
  • Peer Reviewed
• [Journal Article] Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins (2010)
  • Author(s): W. Nomura, H. Tamamura, 他6人、8番目
  • Journal Title: Biopolymers Volume: 94巻 Pages: 843-852
  • Peer Reviewed
• [Journal Article] Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products (2010)
  • Author(s): S. Suzuki, E. W. Nomura, H. Tamamura, 他19人、22番目
  • Journal Title: J. Med. Chem Volume: 53(14)巻 Pages: 5356-5360
  • Peer Reviewed
• [Journal Article] Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products : Structure-Activity Relationship Studies (2010)
  • Author(s): S. Suzuki, W. Nomura, N. Yamamoto, H. Tamamura, 他11人、15番目
  • Journal Title: Bioorg. Med. Chem Volume: 18巻 Pages: 6771-6775
  • Peer Reviewed
• [Journal Article] CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist (2010)
  • Author(s): T. Narumi, W. Nomura, H. Arai, T. Ozaki, N. Ohashi, S. Matsushita, H. Tamamura, 他4人、11番目
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 20巻 Pages: 5853-5858
  • Peer Reviewed
• [Journal Article] Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies (2010)
  • Author(s): T. Nakahara, W. Nomura, T. Narumi, N. Yamamoto, H. Tamamura, 他5人、10番目
  • Journal Title: Bioconjugate Chem Volume: 21(4)巻 Pages: 709-714
  • Peer Reviewed
• [Journal Article] CD4 Mimics Targeting the Mechanism of HIV (2010)
  • Author(s): Y. Yamada, W. Nomura, H. Tamamura, 他7人、10番目
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 20巻 Pages: 354-358
  • Peer Reviewed
• [Journal Article] ペプチドミメティックによる創薬研究 (2010)
  • Author(s): 鳴海哲夫、玉村啓和, 他0人、2番目
  • Journal Title: 「生化学」特集号「ペプチド科学と生化学の接点」(日本生化学会東京) Volume: 82巻6号 Pages: 515-523
  • NAID: 10026900008
• [Journal Article] エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製 (2010)
  • Author(s): 野村渉、玉村啓和, 他1人、3番目
  • Journal Title: 「生化学」ミニレビュウ(日本生化学会東京) Volume: 82巻5号 Pages: 393-397
  • NAID: 10026425888
• [Journal Article] CD4 mimics targeting the mechanism of HIV (2010)
  • Author(s): Yamada Y, Nomura W, Matsushita S, Tamamura H, et al.
  • Journal Title: Bioorg Med Chem Lett Volume: 20 Pages: 354-358
  • Peer Reviewed
• [Journal Article] Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies (2010)
  • Author(s): Nakahara T, Nomura W, Yamamoto N, Tamamura H, et al.
  • Journal Title: Bioconjugate Chem Volume: 21(4) Pages: 709-714
  • Peer Reviewed
• [Journal Article] Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors (2010)
  • Author(s): Melchionna R, Carlo AD, Fujii N, Tamamura H, Napolitano CM, Germani A, et al.
  • Journal Title: Muscle Nerve Volume: 41(6) Pages: 828-835
  • Peer Reviewed
• [Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds (2010)
  • Author(s): Yoshimura K, Tamamura H, Matsushita S, et al.
  • Journal Title: J Virol Volume: 84(15) Pages: 7558-7568
  • Peer Reviewed
• [Journal Article] Peptide HIV-1 integrase inhibitors from HIV-1 gene products (2010)
  • Author(s): Suzuki S, Yamamoto N, Tamamura H, et al.
  • Journal Title: J Med Chem Volume: 53(14) Pages: 5356-5360
  • Peer Reviewed
• [Journal Article] Peptidic HIV integrase inhibitors derived from HIV gene products : Structure-activity relationship studies (2010)
  • Author(s): Suzuki S, Yamamoto N, Pommier Y, Nomura W, Tamamura H, et al.
  • Journal Title: Bioorg Med Chem Volume: 18 Pages: 6771-6775
  • Peer Reviewed
• [Journal Article] CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist (2010)
  • Author(s): Narumi T, Nomura W, Matsushita S, Tamamura H, et al.
  • Journal Title: Bioorg Med Chem Lett Volume: 20 Pages: 5853-5858
  • Peer Reviewed
• [Journal Article] Bivalent ligands of CXCR4 with rigid linkers for elucidation of dimerization state in cells (2010)
  • Author(s): Tanaka T, Nomura W, Narumi T, Masuda A, Tamamura H
  • Journal Title: J Am Chem Soc Volume: 132(45) Pages: 15899-15901
  • Peer Reviewed
• [Journal Article] Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins (2010)
  • Author(s): Nomura W, Tsutsumi H, Tamamura H, et al.
  • Journal Title: Biopolymers : Peptide Science Volume: 94 Pages: 843-852
  • Peer Reviewed
• [Journal Article] Improvement of lentiviral vector-mediated gene transduction by genetic engineering of the structural protein Pr55Gag (2010)
  • Author(s): Aoki T, Tamamura H, Yamamoto N, Komano J, et al.
  • Journal Title: Gene Ther Volume: 17(9) Pages: 1124-1133
  • Peer Reviewed
• [Journal Article] CD4 Mimics Targeting the Mechanism of HIV (2010)
  • Author(s): Yamada Y, Nomura W, Tamamura H, et al.
  • Journal Title: Bioorg.Med.Chem.Lett. 20 Pages: 354-358
  • Peer Reviewed
• [Journal Article] Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells (2009)
  • Author(s): H. Tsutsumi, W. Nomura, H. Tamamura, 他8人、11番目
  • Journal Title: Angew. Chem., Int. Ed. Volume: 48巻 Pages: 9164-9166
  • Peer Reviewed
• [Journal Article] Structure-Activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold : the Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids (2009)
  • Author(s): T. Tanaka, W. Nomura, H. Tamamura, 他9人、12番目
  • Journal Title: Org. Biomol. Chem Volume: 7巻 Pages: 3805-3809
  • Peer Reviewed
• [Journal Article] Synthesis of Protein Kinase CδC1b Domain by Native Chemical Ligation Methodology and Characterization of its Folding and Ligand Binding (2009)
  • Author(s): N. Ohashi, W. Nomura, H. Tamamura, 他4人、7番目
  • Journal Title: J. Pept. Sci Volume: 15(10)巻 Pages: 642-646
  • Peer Reviewed
• [Journal Article] 種々の作用点をターゲットとした抗HIV剤の創製 (2009)
  • Author(s): 玉村啓和, 他0人、1番目
  • Journal Title: 日本エイズ学会誌 Volume: 11巻2号 Pages: 100-101
• [Journal Article] Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold : the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids (2009)
  • Author(s): Tanaka T, Nomura W, Tamamura H, et al.
  • Journal Title: Org.Biomol.Chem. 7 Pages: 3805-3809
  • Peer Reviewed
• [Journal Article] Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus (2009)
  • Author(s): Mizukoshi F, Tamamura H, Fujii N, Tsujimoto H, et al.
  • Journal Title: J.Vet.Med.Sci. 71(1) Pages: 121-124
  • NAID: 110007055389
  • Peer Reviewed
• [Journal Article] Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding (2009)
  • Author(s): Ohashi N, Nomura W, Tamamura H, et al.
  • Journal Title: J.Pept.Sci. 15(10) Pages: 642-646
  • Peer Reviewed
• [Journal Article] Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells (2009)
  • Author(s): Tsutsumi H, Nomura W, Tamamura H, et al.
  • Journal Title: Angew.Chem., Int.Ed. 48 Pages: 9164-9166
  • Peer Reviewed
• [Journal Article] A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor (2009)
  • Author(s): Inaba Y, Tamamura H, Yamamoto K, et al.
  • Journal Title: J.Med.Chem. 52(5) Pages: 1438-1449
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 玉村啓和
  • Journal Title: 日本エイズ学会誌11巻、2号(日本エイズ学会) Pages: 100-101
• [Presentation] ペプチド化学を基盤としたケミカルバイオロジー (2011)
  • Author(s): 玉村啓和
  • Organizer: 第14回ペプチドフォーラム
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-12-16
• [Presentation] HIVタンパク質Vprを基にしたインテグラーゼ阻害剤の構造活性相関研究 (2011)
  • Author(s): 尾崎太郎,野村渉,玉村啓和など
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] HIV外被タンパク質gp120の構造変化を誘起する低分子CD4ミミックの構造活性相関研究 (2011)
  • Author(s): 新井啓之, 鳴海哲夫, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] CXCR4二量化状態解析のための2価結合型リガンドの合成 (2011)
  • Author(s): 相馬晃, 玉村啓和, など
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-08
• [Presentation] HIV-1エンベロープ蛋白質を標的とした治療を評価するためのサル/ヒト免疫不全ウイルスの作製とin vitroにおける中和感受性の評価 (2011)
  • Author(s): 大附寛幸, 三浦智行, 玉村啓和, 松下修三, 五十嵐樹彦, など
  • Organizer: 第25回近畿エイズ研究会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-06-18
• [Presentation] Study of Small Molecular CD4 Mimics Targeting the Dynamic Supramolecular Mechanism of HIV Entry and Their Hybrid Molecules with a CXCR4 Antagonist (2011)
  • Author(s): Narumi T, Nomura W, Tamamura H, et. al.
  • Organizer: The 12th Kumamoto AIDS Seminar・GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Several HIV Inhibitors Targeting Entry, Fusion, Integrase and Matrix (2011)
  • Author(s): Narumi T, Nomura W, Tamamura H, et. al
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] ケミカルバイオロジーを基盤とした抗HIV剤の創製.シンポジウム「新しい抗感染症剤研究の最前線-発見、ケミカルバイオロジーそして創薬へ-.」 (2011)
  • Author(s): 玉村啓和
  • Organizer: 日本薬学会第131年会(中止)
  • Place of Presentation: 静岡
• [Presentation] HIV外被タンパク質gp 120の構造変化を誘起する低分子CD4ミミックの構造活性相関研究 (2011)
  • Author(s): 鳴海哲夫,野村渉,玉村啓和など
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] 低分子型CD4ミミック: HIV外被タンパク質の構造変化を促すHIV侵入阻害剤 (2011)
  • Author(s): 鳴海哲夫,野村渉,松下修三,玉村啓和など
  • Organizer: 第25回日本エイズ学会学術集会・総会日本エイズ学会
  • Place of Presentation: 東京
• [Presentation] Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins (2011)
  • Author(s): Nomura W, Nakahara T, Narumi T, Yamamoto N, Tamamura T, et al.
  • Organizer: 22nd American Peptide Symposium
  • Place of Presentation: Southern California, USA
• [Presentation] Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells (2011)
  • Author(s): Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H
  • Organizer: 22nd American Peptide Symposium
  • Place of Presentation: Southern California, USA
• [Presentation] Identification of Anti-HIV Peptides Derived from Matrix Proteins (2011)
  • Author(s): Narumi T, Murakami T, Tamamura H, et al.
  • Organizer: ACS Meeting Fall2011
  • Place of Presentation: Denver, Colorado, USA
• [Presentation] HIV-1 Co-Receptor CXCR4-Derived Peptides Targeting AIDS Vaccines (2011)
  • Author(s): Hashimoto C, Narumi T, Nomura W, Yamamoto N, Tamamura H
  • Organizer: The 9th Australian Peptide Conference
  • Place of Presentation: Hamilton Island, Queensland, Australia
• [Presentation] SAR Study of Small Molecular CD4 Mimics Targeting the Dynamic Supramolecular Mechanism of HIV Entry and Their Hybrid Molecules with a CXCR4 Antagonist (2011)
  • Author(s): Narumi T, Arai H, Nomura W, Matsushita S, Tamamura H, et al.
  • Organizer: The 12th Kumamoto AIDS Seminar・GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Design, Synthesis and Biological Evaluation of CD4 Mimics Targeting the Interaction with Asp368 and Val430 in Gp120 (2011)
  • Author(s): Arai H, Nomura W, Matsushita S, Tamamura H, et al.
  • Organizer: The 12th Kumamoto AIDS Seminar・GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] SAR Studies of Small Molecular CD4 Mimics Targeting the HIV Entry Mechanism (2011)
  • Author(s): Narumi T, Arai H, Nomura W, Matsushita S, Tamamura H, et al.
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] Synthetic Antigens for Induction of Structure-Specific Antibodies against Trimer-Form of gp41 (2011)
  • Author(s): Nomura W, Yamamoto N, Tamamura H, et al.
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] CXCR4-Derived Peptides Targeting AIDS Vaccines (2011)
  • Author(s): Hashimoto C, Yamamoto N, Tamamura H, et al.
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] 新規HIV侵入阻害剤の創製研究:低分子型CD4ミミック-CXCR4アンタゴニストのハイブリッド分子の設計と合成 (2011)
  • Author(s): 鳴海哲夫, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp120の構造変化を誘起する低分子CD4ミミックの構造活性相関研究 (2011)
  • Author(s): 鳴海哲夫, 新井啓之, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp41-C34 3量体の合成とその抗HIV作用 (2011)
  • Author(s): 橋本知恵, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] 二核亜鉛錯体型CXCR4アンタゴニストの構造活性相関研究 (2011)
  • Author(s): 尾崎太郎, 野村渉, 村上努, 山本直樹, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] 細胞表面におけるCXCR4二量体構造解析のための堅固なリンカーを有する二価型リガンドの開発 (2011)
  • Author(s): 野村渉, 田中智博, 相馬晃, 鳴海哲夫, 増田朱美, 玉村啓和
  • Organizer: 日本ケミカルバイオロジー学会第6回年会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp120の構造変化を誘起する低分子CD4ミミックの構造活性相関研究 (2011)
  • Author(s): 鳴海哲夫, 野村渉, 玉村啓和, 吉村和久, 松下修三, など
  • Organizer: 創薬懇話会
  • Place of Presentation: 岡山
• [Presentation] HIV-1遺伝子産物由来のインテグラーゼ阻害剤 (2011)
  • Author(s): 玉村啓和
  • Organizer: 第16回日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 2価結合型リガンドの新規デザインによるCXCR4の細胞表面における機能解析 (2011)
  • Author(s): 野村渉, 田中智博, 増田朱美, 鳴海哲夫, 玉村啓和
  • Organizer: 第5回バイオ関連化学シンポジウム
  • Place of Presentation: 筑波
• [Presentation] 2価型CXCR4リガンドの開発と受容体結合機能の解析 (2011)
  • Author(s): 野村渉, 玉村啓和, など
  • Organizer: 第48回ペプチド討論会
  • Place of Presentation: 札幌
• [Presentation] HIVワクチンを指向したgp41の動的構造変化を模倣した抗原ペプチドの開発研究 (2011)
  • Author(s): 野村渉, 駒野淳, 山本直樹, 玉村啓和, など
  • Organizer: 第48回ペプチド討論会
  • Place of Presentation: 札幌
• [Presentation] 蛍光ラベル化した二価結合型CXCR4リガンドの創製と応用 (2011)
  • Author(s): 相川春夫, 玉村啓和, など
  • Organizer: 第37回反応と合成の進歩シンポジウム
  • Place of Presentation: 徳島
• [Presentation] 低分子型CD4ミミック:HIV外被タンパク質の構造変化を促すHIV侵入阻害剤 (2011)
  • Author(s): 鳴海哲夫, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 第25回日本エイズ学会学術集会・総会日本エイズ学会
  • Place of Presentation: 東京
• [Presentation] HIV-1第二受容体CXCR4の細胞外ドメインを基にしたエイズワクチンの開発研究 (2011)
  • Author(s): 橋本知恵, 鳴海哲夫, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第25回日本エイズ学会学術集会・総会日本エイズ学会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp120の構造変化誘起を指向した低分子CD4ミミックの構造活性相関研究 (2011)
  • Author(s): 鳴海哲夫, 吉村和久, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 第25回日本エイズ学会学術集会・総会日本エイズ学会
  • Place of Presentation: 東京
• [Presentation] Vpr由来インテグラーゼ阻害剤の構造活性相関 (2011)
  • Author(s): 尾崎太郎, 野村渉, 山本直樹, 駒野淳, など
  • Organizer: 第25回日本エイズ学会学術集会・総会日本エイズ学会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp120の構造変化誘起を指向した低分子CD4ミミックの創製 (2010)
  • Author(s): 鳴海哲夫, 新井啓之, 落合千裕, 松下修三, 玉村啓和, など
  • Organizer: 第54回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] HIV-1マトリックスタンパク質を基にした新規抗HIVペプチドの創出 (2010)
  • Author(s): 小森谷真央, 村上努, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第54回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] 二核亜鉛錯体型CXCR4アンタゴニストの構造活性相関研究 (2010)
  • Author(s): 尾崎太郎, 田中智博, 野村渉, 村上努, 玉村啓和, など
  • Organizer: 第54回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] GPCR 2 量体構造解析を指向したツールの開発 (2010)
  • Author(s): 田中智博
  • Organizer: 第9回バイオテクノロジー国際会議
  • Place of Presentation: 東京
  • Year and Date: 2010-06-30
• [Presentation] Elucidation of a Dimerization State of a Chemokine Receptor CXCR4 via Chemical Biology Approach Utilizing Novel Bivalent Ligands with Rigid Polyproline Linkers (2010)
  • Author(s): Tanaka T, Nomura W, Tamamura H, et. al
  • Organizer: The 13th Akabori Conference Leipzig 2010 : Japanese-German Symposium on Peptide Science
  • Place of Presentation: Leipzig, Germany
• [Presentation] Anti-HIV Inhibitors and AIDS Vaccines (2010)
  • Author(s): Tamamura H
  • Organizer: International Summer Program 2010
  • Place of Presentation: Tokyo, Japan
• [Presentation] Elucidation of a Dimerization State of a Chemokine Receptor CXCR4 via Chemical Biology Approach Utilizing Novel Bivalent Lig ands with Rigid Polyproline Linkers (2010)
  • Author(s): Tanaka T, Nomura W, Narumi T, Tamamura H
  • Organizer: The 13th Akabori Conference Leipzig 2010 Japanese-German Symposium on Peptide Science
  • Place of Presentation: Leipzig, Germany
• [Presentation] Peptidic HIV Integrase Inhibitors Derived from HIV Gene Produ Cts (2010)
  • Author(s): Tamamura H
  • Organizer: 11th KUMAMOTO AIDS Seminer GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Structure-Activity Relationships of CXCR4 Antagonists Having the Dipicolylamine/Azamacro-Cyclic-Metal Complex Structures (2010)
  • Author(s): Ozaki T, Yamamoto N, Tamamura H, et al.
  • Organizer: 11th KUMAMOTO AIDS Seminer GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Development of Small CD4 Mimic Molecules that Induce Confor mational Changes in gp120 (2010)
  • Author(s): Arai H, Matsushita S, Tamamura H, et al.
  • Organizer: 11th KUMAMOTO AIDS Seminer GCOE Joint International Symposium
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker (2010)
  • Author(s): Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H
  • Organizer: 5th International Peptide Symposium
  • Place of Presentation: Kyoto, Japan
• [Presentation] ケミカルバイオロジーを基盤とした抗HIV剤の創製 (2010)
  • Author(s): 玉村啓和
  • Organizer: 創薬懇話会2010 in 蔵王、次世代を担う若手のためのメディシナルケミストリーフォーラム
  • Place of Presentation: 宮城
• [Presentation] リバースからフォワードヘケミカルゲノミクスを活用した抗HIV剤の創製 (2010)
  • Author(s): 田中智博, 山本直樹, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第5回年会
  • Place of Presentation: 横浜
• [Presentation] 堅固なリンカーを有する二価結合型CXCR4リガンドの開発と応用 (2010)
  • Author(s): 田中智博, 野村渉, 鳴海哲夫, 増田朱美, 玉村啓和
  • Organizer: 日本ケミカルバイオロジー学会 第5回年会
  • Place of Presentation: 横浜
• [Presentation] HIV-1マトリックスタンパク質を基にした新規抗HIVペプチドの創出 (2010)
  • Author(s): 小森谷真央, 山本直樹, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会 第5回年会
  • Place of Presentation: 横浜
• [Presentation] 2価結合型リガンドの新規デザインによるCXCR4の細胞表面における機能解析 (2010)
  • Author(s): 野村渉, 田中智博, 増田朱美, 鳴海哲夫, 玉村啓和
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪
• [Presentation] マトリックスタンパク質を基にした新規抗HIVペプチド (2010)
  • Author(s): 小森谷真央, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
• [Presentation] HIV-1外被タンパク質gp120の構造変化誘起を指向した低分子CD4ミミックの構造活性相関研究 (2010)
  • Author(s): 鳴海哲夫, 新井啓之, 落合千裕, 吉村和久, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
• [Presentation] 細胞膜透過性MA部分ペプチドライブラリーを用いた新規抗HIV-1ペプチドの探索と創出 (2010)
  • Author(s): 村上努, 小森谷真央, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] HIV-1遺伝子産物由来のインテグラーゼ阻害剤の創出 (2010)
  • Author(s): 橋本知恵, 野村渉, Maddali K, Pommier Y,山本直樹, 駒野淳, 玉村啓和, など
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] HIV外被タンパク質gp120の構造変化誘起を指向した低分子CD4ミミックの創製 (2010)
  • Author(s): 鳴海哲夫, 新井啓之, 野村渉, 松下修三, 玉村啓和, など
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] HIV-1マトリックスタンパク質を基にした新規抗HIVペプチドの創出 (2010)
  • Author(s): 小森谷真央, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] gp120のCD4結合サイトを模倣した新規抗原分子の創製 (2010)
  • Author(s): 尾崎太郎, 田中智博, 宮内浩典, 野村渉, 山本直樹, 駒野淳, 玉村啓和, など
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] 合成抗原ペプチドによるHIV-1 gp41の三量体構造を認識する抗体の誘導 (2010)
  • Author(s): 野村渉, 中原徹, 大矢亜紀, 山本直樹, 玉村啓和, など
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] HIV-1外被タンパク質gp120の構造変化誘起を指向した低分子CD4ミミックの構造活性相関研究 (2010)
  • Author(s): 鳴海哲夫, 落合千裕, 山田裕子, 吉村和久, 玉村啓和, など
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] エイズワクチンを指向した宿主受容体CXCR4由来抗原分子の創製 (2010)
  • Author(s): 橋本知恵, 野村渉, 田中智博, 鳴海哲夫, 山本直樹, 玉村啓和, など
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] ペプチドミメティクを基盤とした阻害剤と新規概念によるワクチン (2009)
  • Author(s): 玉村啓和, 野村渉, 山本直樹, など
  • Organizer: 第82回日本生化学会大会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] Development of an artificial antigen inducing neutralizing antibodies specific to gp41 trimer (2009)
  • Author(s): 玉村啓和
  • Organizer: Satellite Symposium at Mt.Aso
  • Place of Presentation: 熊本
  • Year and Date: 2009-09-30
• [Presentation] Chemical biology approach utilizing novel bivalent ligands for GPCR CXCR4 leads to the elucidation of a dimeric structure (2009)
  • Author(s): Tanaka T, Nomura W, Narumi T, Tamamura H.
  • Organizer: The 3rd Asia-Pacific International Peptide Symposium
  • Place of Presentation: Jeju Island, Korea
• [Presentation] ペプチドを基盤としたケミカルバイオロジーと抗HIV剤の創製 (2009)
  • Author(s): 玉村啓和
  • Organizer: 九州ペプチドフォーラム
  • Place of Presentation: 北九州
• [Presentation] フォワードケミカルジェネティクスを応用したHIVインテグラーゼ阻害剤 (2009)
  • Author(s): 中西勇太, 玉村啓和, など
  • Organizer: 日本ケミカルバイオロジー学会第4回年会
  • Place of Presentation: 神戸
• [Presentation] Development of CD4 mimic small molecules targeted for dynamic supramolecular mechanism of HIV entry (2009)
  • Author(s): Ochiai C, Yoshimura K, Nomura W, Tamamura H, et al.
  • Organizer: 第10回熊本エイズセミナー
  • Place of Presentation: 熊本
• [Presentation] リバースからフォワードヘケミカルゲノミクスを基盤とした抗HIV剤の創製 (2009)
  • Author(s): 田中智博, 野村渉, 玉村啓和, など
  • Organizer: 第46回ペプチド討論会
  • Place of Presentation: 北九州
• [Presentation] ペプチドライブラリーを基にしたHIV-1インテグラーゼに対する阻害剤の創製 (2009)
  • Author(s): 中西勇太, 野村渉, 山本直樹, 玉村啓和, など
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
• [Book] Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells Proceedings of the Twenty-Second American Peptide Symposium (2011)
  • Author(s): Nomura W, Tamamura H, et. al
  • Publisher: American Peptide Society, San Diego
• [Book] Studies for Optimum Design of Artificial Zinc Finger Recombinases by Evaluation of Effects of DNA Binding Affinity and Linker Components on Recombination Efficiency. Proceedings of the Twenty-Second American Peptide Symposium (2011)
  • Author(s): Masuda A, Nomura, W, Ohba K, Yamamoto N, Tamamura H
  • Total Pages: 2
  • Publisher: Michal Lebl (Eds.), American Peptide Society, San Diego
• [Book] Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins. Proceedings of the Twenty-Second American Peptide Symposium (2011)
  • Author(s): Nomura W, Yamamoto N, Tamamura T, et al.
  • Total Pages: 2
  • Publisher: Michal Lebl (Eds.), American Peptide Society, San Diego
• [Book] Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells. Proceedings of the Twenty-Second American Peptide Symposium (2011)
  • Author(s): Nomura W, Tanaka T, Tamamura H, et al.
  • Total Pages: 2
  • Publisher: Michal Lebl (Eds.), American Peptide Society, San Diego
• [Book] Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells. Proceedings of the 5th International Peptide Symposium in conjunction with the 47th Japanese Peptide Symposium (2011)
  • Author(s): Nomura W, Ohashi N, Tamamura H, et al.
  • Total Pages: 1
  • Publisher: Nobutaka Fujii and Yoshiaki Kiso (Eds.), The Japanese Peptide Society, Kyoto, Japan
• [Book] Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker. Proceedings of the 5th International Peptide Symposium in conjunction with the 47th Japanese Peptide Symposium (2011)
  • Author(s): Nomura W, Tanaka T, Tamamura H, et al.
  • Total Pages: 1
  • Publisher: Nobutaka Fujii and Yoshiaki Kiso (Eds.), The Japanese Peptide Society, Kyoto, Japan
• [Book] Synthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines. Proceedings of the 5th International Peptide Symposium in conjunction with the 47th Japanese Peptide Symposium (2011)
  • Author(s): Hashimoto C, Narumi T, Nomura W, Yamamoto N, Tamamura H
  • Total Pages: 1
  • Publisher: Nobutaka Fujii and Yoshiaki Kiso (Eds.), The Japanese Peptide Society, Kyoto, Japan
• [Book] ペプチドミメティックによる創薬研究 (2010)
  • Author(s): 鳴海哲夫,玉村啓和
  • Publisher: 日本生化学会東京
• [Book] From Reverse to Forward Chemical Genomics Development of Anti-HIV Agent. Peptide Science 2009 (2010)
  • Author(s): Tanaka T, Nomura W, Yamamoto N, Tamamura H, et. al
  • Publisher: The Japanese peptide Society, Osaka
• [Book] 「ペプチド科学と生 化学の接点」(ペプチドミメティックによる創薬研究, 生化学特集号)82巻6号 (2010)
  • Author(s): 鳴海哲夫, 玉村啓和
  • Total Pages: 9
  • Publisher: 日本生化学会 東京
• [Book] エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製, 生化学ミニレビュウ 82巻-85巻 (2010)
  • Author(s): 野村渉, 増田朱美, 玉村啓和
  • Total Pages: 5
  • Publisher: 日本生化学会 東京
• [Book] From Reverse to Forward Chemical Genomics : Development of Anti-HIV Agent Peptide Science 2009 (2010)
  • Author(s): Tanaka T, Nomura W, Yamamoto N, Tamamura H, et al.
  • Total Pages: 2
  • Publisher: Kouji Okamoto (Eds.), The Japanese peptide Society, Osaka
• [Book] Synthesis and Evaluation of Artificial Antigen Peptide Based on the Trimeric Form of HIV Fusion Protein Peptide Science 2009 (2010)
  • Author(s): Ohya A, Nakahara T, Nomura W, Yamamoto N, Tamamura H, et al.
  • Total Pages: 3
  • Publisher: Kouji Okamoto (Eds.), The Japanese peptide Society, Osaka
• [Book] Caged DAG-Lactones for Study of Cellular Signaling in a Spatial-and Temporal Specific Manner Peptide Science 2009 (2010)
  • Author(s): Nomura W, Furuta T, Tamamura H, et al.
  • Total Pages: 2
  • Publisher: Kouji Okamoto (Eds.), The Japanese peptide Society, Osaka
• [Book] Fluorescnt-Based Orthogonal Sensing Methods for Double Ealuation in PKC Ligands Screening Peptide Science 2009 (2010)
  • Author(s): Ohashi N, Nomura W, Lewin NE, Blumberg PM, Tamamura H, et al.
  • Total Pages: 2
  • Publisher: Kouji Okamoto (Eds.), The Japanese peptide Society, Osaka
• [Book] 種々の作用点をターゲットとした抗HIV剤の創製 (2009)
  • Author(s): 玉村啓和
  • Publisher: 日本エイズ学会誌(日本エイズ学会)
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 東京医科歯科大学
  • Filing Date: 2011-11-11
  • Overseas
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2011-11-10
  • Overseas
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2011-11-04
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド (2011)
  • Inventor(s): 玉村啓和、鳴海哲夫、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2011-04-04
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド (2011)
  • Inventor(s): 玉村啓和、鳴海哲夫、野村渉、橋本知恵、駒野淳、宮内浩典
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Industrial Property Number: 2011-082813
  • Filing Date: 2011-04-04
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Industrial Property Number: 2011-514322
  • Filing Date: 2011-11-04
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2011-11-10
  • Overseas
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2011)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2011-11-11
  • Overseas
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2010)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2010-11-25
  • Overseas
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2010)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2010-05-14
  • Overseas
• [Patent(Industrial Property Rights)] HIV 立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2010)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2010-05-14
  • Acquisition Date: 2010-03-28
• [Patent(Industrial Property Rights)] CXCR4多量体を認識する多価型CXCR4リガンド、及びその合成方法 (2009)
  • Inventor(s): 玉村啓和、野村渉、鳴海哲夫
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2009-07-06
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法:番号: (2009)
  • Inventor(s): 玉村啓和、中原徹、野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Filing Date: 2009-05-18
• [Patent(Industrial Property Rights)] HIV立体構造認識抗体誘導ペプチド抗原、及びその合成方法 (2009)
  • Inventor(s): 玉村啓和, 中原徹, 野村渉
  • Industrial Property Rights Holder: 国立大学法人東京医科歯科大学
  • Industrial Property Number: 2009-120352
  • Filing Date: 2009-05-18