| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
|---|
| Research Abstract |
CYP3A is the most important subfamily of cytochrome P450s in humans, which metabolizes around 50% of therapeutic agents. We have created humanized mouse (CYP3A-HAC mouse) which carries human CYP3A instead of mouse Cyp3a, using human artificial chromosome system, This mouse shows similar characteristics as human for the tissue- and stage-specific expression of CYP3A genes and metabolism of various therapeutic agents. Thus, this mouse is considered to be valuable for the prediction of human drug metabolism. As for P-glycoprotein- and pregnane X receptor-humanized mice, they have also been developed and their function and valuableness for the prediction of human drug metabolism are undertaken.
|
