microRNA reguIating human drug metaboIism : innovative study for the interindividual variability
| Project/Area Number |
21390043
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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|---|
| Keywords | マイクロRNA / 転写後調節 / 核内レセプター / シトクロムP450 / 個人差 / microRNA / CYP / HNF4α |
|---|
| Research Abstract |
We found that the expression of HNF4α, PPARα, and ARNT in human liver is regulated by miRNAs. The miRNA? dependent regulation of these transcription factors affects the expression of their downstream genes, being a crucial factor of interindividual variability of drug metabolism, bile acid synthesis, lipid metabolism, detoxification of xenobiotics, and response to stimuli.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] miRNAの基礎と毒性研究2010
Author(s)
中島美紀
Organizer
第41回応用トキシコロジーリカレント講座
Place of Presentation
金沢大学サテライト・プラザ(石川県) 招待講演
Year and Date
2010-09-30
Related Report
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[Presentation] Human PPARa is regulated by miR-212010
Author(s)
Kida K, Nakajima M, Mohri T, Oda Y, Takagi S, Fukami T, Yokoi T
Organizer
9th International Society for Study of Xenobiotics Meeting
Place of Presentation
Istanbul Lutfi Kirdar Convention and Exhibition Center(Turkey)
Year and Date
2010-09-07
Related Report
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[Presentation] Human PPARU is regulated by miR-212010
Author(s)
Kida K, Nakajima M, Mohri T, Oda Y, Takagi S, Fukami T, Yokoi T
Organizer
9th International ISSX Meeting
Place of Presentation
Istanbul Lutfi Kirdar convention and Exhibition Center (Tukey)
Year and Date
2010-09-05
Related Report
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