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Identification of endogenous SID-1 ligands

Research Project

Project/Area Number 21390063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionTokyo Women's Medical University

Principal Investigator

MITANI Shohei  東京女子医科大学, 医学部, 教授 (90192757)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords分子 / 細胞生理学 / 線虫 / RNA干渉 / SID-1 / RNAi伝播 / RNAi / リガンド
Research Abstract

RNAi(RNA interference) is now a popular method to downregulate gene functions of interest. In C. elegans, it has been known that dsRNAs transmit from cells to other cells. This phenomenon is called as systemic RNAi and SID-1 protein is the representative gene that is required for dsRNA uptake in systemic RNAi. We searched for molecules involved in the phenomenon and found that animals are resistant to gon-1 RNAi in the vps-45 mutant background. GON-1 protein is a metalloprotease and necessary for secretion of various proteins from distal tip cells and body wall muscle cells. We found that GON domain alone is important for this secretion.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (83 results)

All 2012 2011 2010 2009 Other

All Journal Article (63 results) (of which Peer Reviewed: 32 results) Presentation (13 results) Book (4 results) Remarks (3 results)

  • [Journal Article] The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs2012

    • Author(s)
      Billi AC, Alessi AF, Khivansara V, Han T, Freeberg M, Mitani S and Kim JK
    • Journal Title

      PLoS Genetics

      Volume: 8(4)

    • Related Report
      2011 Final Research Report
  • [Journal Article] GPI anchor synthesis in the distal tip cells is indispensable for development and differentiation of germline cells of the nematode Caenorhabditis elegans2012

    • Author(s)
      Murata D, Nomura KH, Dejima K, Mizuguchi S, Kawasaki N, Matsuishi-Nakajima Y, Ito S, Gengyo-Ando K, Kage-Nakadai E, Mitani S and Nomura K
    • Journal Title

      Mol. Biol. Cell

      Volume: 23(6) Pages: 982-995

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phosphorylation of α-synuclein at Ser129 reduces neuronal dysfunction by lowering its membrane-binding property in Caenorhabditis elegans2012

    • Author(s)
      Kuwahara T, Tonegawa R, Mitani S, Iwatsubo T
    • Journal Title

      J Biol Chem.

      Volume: 287(10) Pages: 7098-109

    • Related Report
      2011 Final Research Report
  • [Journal Article] LYCAT, a homologue of C. elegans acl-8, acl-9 and acl-10, determines the fatty acid composition of phosphatidylinositol in mice2012

    • Author(s)
      Imae R, Inoue T, Nakasaki Y, Uchida Y, Ohba Y, Mitani S and Arai H
    • Journal Title

      J. Lipid Res.

      Volume: 53(3) Pages: 335-47

    • Related Report
      2011 Final Research Report
  • [Journal Article] Single/Low-copy integration of transgenes in Canehorhabditis elegans by an ultraviolet and trimethylpsolaren method2012

    • Author(s)
      Kage-Nakadai E, Kobuna H, Funatsu O, Otori M, Gengyo-Ando K, Yoshina S, Hori S and Mitani S
    • Journal Title

      BMC Biotechnology

      Volume: 12(1) Pages: 1-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of ATP sensor protein in Caenorhabditis elegans2012

    • Author(s)
      Kishikawa J, Fujikawa M, Imamura H, Yasuda K, Noji H, Ishii N, Mitani S, and Yokoyama K
    • Journal Title

      Microscopy Research and Technique

      Volume: 75(1) Pages: 15-19

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of ATP sensor protein in Caenorhabditis elegans2012

    • Author(s)
      J. Kishikawa, M. Fujikawa, H. Imamura, K. Yasuda, H. Noji, N. Ishii, S. Mitani, and K. Yokoyama
    • Journal Title

      Microsc. Res. Tech

      Volume: 75(1) Issue: 1 Pages: 15-9

    • DOI

      10.1002/jemt.21103

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single/Low-copy integration of transgenes in Canehorhabditis elegans by an ultraviolet and trimethylpsolaren method2012

    • Author(s)
      Kage-Nakadai E, et al
    • Journal Title

      BMC Biotechnology

      Volume: 12(1) Pages: 40-917

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LYCAT, a homologue of C.elegans ac1-8, ac1-9 and ac1-10, determines the fatty acid composition of phosphatidylinositol in mice2012

    • Author(s)
      Imae R, et al
    • Journal Title

      J.Lipid Res

      Volume: 53(3) Pages: 335-347

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of α-synuclein at Ser129 reduces neuronal dysfunction by lowering its membrane-binding property in Caenorhabditis elegans2012

    • Author(s)
      Kuwahara T, et al
    • Journal Title

      J Biol Chem

      Volume: 287(10) Pages: 7098-7109

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPI anchor synthesis in the distal tip cells is indispensable for development and differentiation of germline cells of the nematode Caenorhabditis elegans2012

    • Author(s)
      Murata D, et al
    • Journal Title

      Mol.Biol.Cell

      Volume: 23(6) Pages: 982-995

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Caenorhabditis elegans HEN1 ortholog, REM-1, methylates and stabilizes select subclasses of germline small RNAs2012

    • Author(s)
      Billi AC, et al
    • Journal Title

      PLoS Genetics

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Expression of BTBD10, an Akt activator, Drives Impairment of Motor Function2012

    • Author(s)
      Nawa M, et al
    • Journal Title

      Cell Death and Differentiation

      Volume: (in press) Issue: 8 Pages: 1398-1407

    • DOI

      10.1038/cdd.2012.19

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel ADAMTS9/G0N-1 function for protein transport from the ER to the Golgi2012

    • Author(s)
      Yoshina S, et al
    • Journal Title

      Mol.Biol.Cell

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osmotic shock results in hmit induction in C. elegans glial and excretory canal cells2011

    • Author(s)
      Kage-Nakadai E, Uehara T and Mitani S
    • Journal Title

      Biochem. Biophys. Res. Comm

      Volume: 410 Pages: 471-477

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ceramide glucosyltransferease of the nematode Caenorhabditis elegans is involved in oocyte maturation and in early embryonic cell division2011

    • Author(s)
      Nomura K, Murata D, Hayashi Y, Dejima K, Mizuguchi S, Kage-Nakadai E, Gengyo-Ando K, Mitani S, Hirabayashi Y, Ito M and Nomura K
    • Journal Title

      Glycobiology

      Volume: 21 Pages: 834-848

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte maturation and in early embryonic cell division2011

    • Author(s)
      Nomura, et al
    • Journal Title

      Gycobiology

      Volume: 21 Pages: 834-848

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osmotic shock results in hmit induction in C.elegans glial and excretory canal cells2011

    • Author(s)
      Kage-Nakadai, et al
    • Journal Title

      Biochem.Biophys.Res.Comm.

      Volume: 410 Pages: 471-477

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division.2011

    • Author(s)
      Nomura, et al.
    • Journal Title

      Glycobiology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular PLA1 and acyltransferase involved in C. elegans stem cell divisions determine the sn-1 fatty acyl chain of phosphatidylinositol2010

    • Author(s)
      Imae R, Inoue T, Kimura M, Kanamori T, Hara N, Kage-Nakadai E, Mitani S, and Arai H
    • Journal Title

      Mol. Biol. Cell

      Volume: 21 Pages: 3114-3124

    • Related Report
      2011 Final Research Report
  • [Journal Article] Two Golgi-resident 3'-phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans2010

    • Author(s)
      Dejima K, Murata D, Mizuguchi S, Nomura KH, Izumikawa T, Kitagawa H, Gengyo-Ando K, Yoshina S, Ichimiya T, Nishihara S, Mitani S and Nomura K
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 24717-24728

    • Related Report
      2011 Final Research Report
  • [Journal Article] Multivesicular Body Formation Requires OSBP. Related Proteins and Cholesterol2010

    • Author(s)
      Kobuna H, Inoue T, Shibata M, Gengyo-Ando K, Yamamoto K, Mitani S, Arai H
    • Journal Title

      PLoS Genetics

      Volume: 6(8)

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans2010

    • Author(s)
      Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T
    • Journal Title

      Mol. Biol. Cell

      Volume: 21 Pages: 2434-2442

    • Related Report
      2011 Final Research Report
  • [Journal Article] EAK-7 controls development and lifespan by regulating nuclear DAF-16/FoxO activity2010

    • Author(s)
      Alam H, Williams T, Yoshina S, Mitani S, and Hu PJ
    • Journal Title

      Cell Metabolism

      Volume: 12 Pages: 30-41

    • Related Report
      2011 Final Research Report
  • [Journal Article] C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by CED-1 phagocyte receptor2010

    • Author(s)
      Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, and Xue D
    • Journal Title

      Nature Cell Biol

      Volume: 12 Pages: 655-664

    • Related Report
      2011 Final Research Report
  • [Journal Article] An Arf-like small G protein, ARL-8, Promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation2010

    • Author(s)
      Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T and Shen K
    • Journal Title

      Neuron

      Volume: 66 Pages: 710-723

    • Related Report
      2011 Final Research Report
  • [Journal Article] Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans2010

    • Author(s)
      Ogura K, Mitani S, Gengyo-Ando K, Baillie DL, Kohara Y and Goshima Y
    • Journal Title

      Development

      Volume: 137 Pages: 1657-1667

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease2010

    • Author(s)
      Nakagawa A, Shi Y, Kage-Nakadai, Mitani S and Xue D
    • Journal Title

      Science

      Volume: 328 Pages: 327-334

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Combinatorial regulation of three TRPM channels governs magnesium homeostasis2010

    • Author(s)
      Teramoto T, Sternick LA, Kage-Nakadai E, Sajjadi S, Siembida J, Mitani S, Iwasaki K and Lambie EJ
    • Journal Title

      PLoS One

      Volume: 5(3)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Two Very Long Chain Fatty Acid Acyl-CoA Synthetase Genes, acs-20 and acs-22, Have Roles in the Cuticle Surface Barrier in Caenorhabditis elegans2010

    • Author(s)
      Kage-Nakadai E, Kobuna H, Kimura M, Gengyo-Ando K, Inoue T, Arai H, Mitani S
    • Journal Title

      PLoS One

      Volume: 5(1)

    • Related Report
      2011 Final Research Report
  • [Journal Article] NBRP databases : Databases of biological resources in Japan2010

    • Author(s)
      Yamazaki Y, Akashi R, Banno Y, Endo T, Ezura H, Fukami-Kobayashi K, Inaba K, Isa T, Kamei K, Kasai F, Kobayashi M, Kurata N, Kusaba M, Matuzawa T, Mitani S, Nakamura T, Nakamura Y, Nakatsuji N, Naruse K, Niki H, Nitasaka E, Obata Y, Okamoto H, Okuma M, Sato K, Serikawa T, Shiroishi T, Sugawara H, Urushibara H, Yamamoto M, Yaoita Y, Yoshiki A, and Kohara Y
    • Journal Title

      Nucl. Acid Res

      Volume: 38

    • Related Report
      2011 Final Research Report
  • [Journal Article] The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans2010

    • Author(s)
      Nakae, et al.
    • Journal Title

      Mol.Biol.Cell

      Volume: 21 Pages: 2434-2442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor2010

    • Author(s)
      Wang, et al.
    • Journal Title

      Nat.Cell Biol.

      Volume: 12 Pages: 655-664

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans2010

    • Author(s)
      Dejima, et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 24717-24728

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation2010

    • Author(s)
      Klassen, et al.
    • Journal Title

      Neuron

      Volume: 66 Pages: 710-723

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity2010

    • Author(s)
      Alam, et al.
    • Journal Title

      Cell Metab.

      Volume: 12 Pages: 30-41

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol2010

    • Author(s)
      Imae, et al.
    • Journal Title

      Mol.Biol.Cell

      Volume: 21 Pages: 3114-3124

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multivesicular body formation requires OSBP-related proteins and cholesterol2010

    • Author(s)
      Kobuna, et al.
    • Journal Title

      PLoS Genetics

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NBRP databases : Databases of biological resources in Japan.2010

    • Author(s)
      Yamazaki Y., et al.
    • Journal Title

      Nucl.Acid Res 38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Very Long Chain Fatty Acid Acyl-CoA Synthetase Genes, acs-20 and acs-22, Have Roles in the Cuticle Surface Barrier in Caenorhabditis elegans.2010

    • Author(s)
      Kage-Nakadai E., et al.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combinatorial regulation of three TRPM channels governs magnesium homeostasis.2010

    • Author(s)
      Teramoto T., et al.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.2010

    • Author(s)
      Nakagawa A., et al.
    • Journal Title

      Science (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.2010

    • Author(s)
      Ogura K., et al.
    • Journal Title

      Development (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline2009

    • Author(s)
      Gu W, Shirayama M, Conte D Jr, Vasale JJ, Batista PJ, Claycomb JM, Keys J, Chen CG, Chaves DA, Duan SE, Kasschau KD, Falgren N, Mitani S, Carrington JC, Mello CC
    • Journal Title

      Mol. Cell

      Volume: 36 Pages: 231-244

    • Related Report
      2011 Final Research Report
  • [Journal Article] The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation2009

    • Author(s)
      Claycomb JM, Batista PJ, Pang KM, Gu W, 1 Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D, Jr., and Mello CC
    • Journal Title

      Cell

      Volume: 139 Pages: 123-134

    • Related Report
      2011 Final Research Report
  • [Journal Article] Differential roles of Caenorhabditis elegans DNase II genes in apoptotic DNA degradation and development2009

    • Author(s)
      Lai H-J, Lo SJ, Kage-Nakadai E, Mitani S, Xue D
    • Journal Title

      PLoS One

      Volume: 4 Pages: 1-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] Biological function of the C. elegans glycosphingolipid-binding galectin LEC-82009

    • Author(s)
      Ideo H, Fukushima K, Gengyo-Ando K, Mitani S, Dejima K, Nomura K & Yamashita K
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 26493-501

    • Related Report
      2011 Final Research Report
  • [Journal Article] FLR-2, the glycoprotein hormone alpha 2 subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans2009

    • Author(s)
      Oishi A, Gengyo-Ando K, Mitani S, Mohri-Shiomi A, Kimura KD, Ishihara T and Katsura I
    • Journal Title

      Genes to Cells

      Volume: 14 Pages: 1141-54

    • Related Report
      2011 Final Research Report
  • [Journal Article] C. elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells2009

    • Author(s)
      Geng X, Zhou Q, Kage-Nakadai E, Shi, Yan N, Mitani S and Xue D
    • Journal Title

      Cell Death and Differentiation

      Volume: 16 Pages: 1385-94

    • Related Report
      2011 Final Research Report
  • [Journal Article] Functional analysis of GS28, an intra-Golgi v-SNARE2009

    • Author(s)
      Maekawa M, Inoue T, Kobuna H, Nishimura T, Gengyo-Ando K, Mitani S and Arai H
    • Journal Title

      C. elegans Genes to Cells

      Volume: 14 Pages: 1003-13

    • Related Report
      2011 Final Research Report
  • [Journal Article] The functional homolog of the human nucleotide-sugar transporter like protein(hUGTrel1) is involved in maintenance of ER homeostasis and essential for larval development in the nematode Caenorhabditis elegans2009

    • Author(s)
      Dejima K, Murata D, Mizuguchi S, Nomura KH, Gengyo-Ando K, Mitani S, Kamiyama S, Nishihara S, and Nomura K
    • Journal Title

      FASEB J

      Volume: 23 Pages: 2215-2225

    • Related Report
      2011 Final Research Report
  • [Journal Article] Normal formation of Caenorhabditis elegans intestinal granules requires ABC transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAPL(TAP-like)2009

    • Author(s)
      Kawai H, Tanji T, Shiraishi H, Yamada M, Iijima R, Inoue T, Kezuka Y, Ohashi K, Yoshida Y, Tohyama K, Gengyo-Ando K, Mitani S, Arai H, Ohashi-Kobayashi A, and Maeda M
    • Journal Title

      Mol. Biol. Cell

      Volume: 20 Pages: 2797-2990

    • Related Report
      2011 Final Research Report
  • [Journal Article] Normal formation of Caenorhabditis elegans intestinal granules requires ABC transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAPL (TAP-like).2009

    • Author(s)
      Kawai H., et al.
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 2797-2990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans.2009

    • Author(s)
      Maekawa M., et al.
    • Journal Title

      Genes to Cells 14

      Pages: 1003-1013

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C.elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.2009

    • Author(s)
      Gen X., et al.
    • Journal Title

      Cell Death and Differentiation 16

      Pages: 1385-1394

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FLR-2, the glycoprotein hormone alpha 2 subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans.2009

    • Author(s)
      Oishi A., et al.
    • Journal Title

      Genes to Cells 14

      Pages: 1141-1154

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological function of the C.elegans glycosphingolipid-binding galectin LEC-8.2009

    • Author(s)
      Ideo H., et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 26493-26501

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of Caenorhabditis elegans DNase II genes in apoptotic DNA degradation and development.2009

    • Author(s)
      Lai H-J., et al.
    • Journal Title

      PLoS One 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation.2009

    • Author(s)
      Claycomb J.M., et al.
    • Journal Title

      Cell 139

      Pages: 123-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Argonaute-mediated 22G-RNA pathways direct genome surveillance in the C.elegans germline.2009

    • Author(s)
      Gu W., et al.
    • Journal Title

      Mol.Cell 36

      Pages: 231-244

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nematode, an Experimental Animal in the National BioResource Project.2009

    • Author(s)
      Mitani S.
    • Journal Title

      Exp.Animals 58

      Pages: 351-356

    • NAID

      130000122241

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi

    • Author(s)
      Yoshina S, Sakaki K, Yonezumi-Hayashi A, Gengyo-Ando K, Inoue H, Iino Y & Mitani S
    • Journal Title

      Mol. Biol. Cell

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reduced Expression of BTBD10, an Akt activator, Drives Impairment of Motor Function

    • Author(s)
      Nawa M, Kage-Nakadai E, Aiso S, Okamoto K, Mitani S, and Matsuoka M
    • Journal Title

      Cell Death and Differentiation

      Volume: (in press)

    • Related Report
      2011 Final Research Report
  • [Presentation] C.elegans as a living test tube2011

    • Author(s)
      Mitani S
    • Organizer
      2nd Chinese C.elegans meeting
    • Place of Presentation
      北京(招待講演)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] National BioResource Project for the Nematode2010

    • Author(s)
      S.Mitani
    • Organizer
      Asian Network of Research Resource Centers
    • Place of Presentation
      筑波理化学研究所
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] メンブレントラフィックに関与する線虫Sec1/Munc18ファミリーのゲノム機能解析2009

    • Author(s)
      安藤恵子, 他
    • Organizer
      日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] A protein-protein interaction in C.elegans ; amino acid transporter-6 requires the interaction with glycoprotein for functional expression.2009

    • Author(s)
      Kanokporn Phetdee, et al.
    • Organizer
      Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線虫におけるセラミドグルコシル転移酵素の機能解明2009

    • Author(s)
      野村和子, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] GPIアンカー整合性遺伝子機能阻害による線虫C.elegans生殖系列の表現型解析2009

    • Author(s)
      村田大輔, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線虫Caenorhabditis elegansの加齢に伴う細胞内ATP濃度の変化2009

    • Author(s)
      岸川淳一, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of acyltransferases responsible for PUFA incorporation into membrane phospholipids.2009

    • Author(s)
      Hyeon-Cheoi Lee, et al.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] アンタゴニストとして機能する線虫のインスリン様分子の生理機能比較2009

    • Author(s)
      松永洋平, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Arf-like GTPase ARL-8 is required for lysosome biogenesis in C.elegans.2009

    • Author(s)
      中江郁青, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional profile of a lysosomal ABC transporter HAF-2 in Caenorh abditis elegans.2009

    • Author(s)
      白石博久, 他
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] SLT-1の受容体、SAX-3/RoboとEVA-1の構造解析2009

    • Author(s)
      藤澤和子、三谷昌平
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Systematic isolation of mutants defective in transcription factors in C.elegans.2009

    • Author(s)
      Mitani S., et al.
    • Organizer
      Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Book] 病態生理学を学ぶための基礎「超ビジュアル病態生理学」(分担和訳)2012

    • Author(s)
      三谷昌平
    • Total Pages
      9
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 生物機能モデルと新しいリソース・リサーチツール(分担執筆)2011

    • Author(s)
      中台枝里子、三谷昌平
    • Total Pages
      6
    • Publisher
      エル・アイ・シー出版
    • Related Report
      2011 Annual Research Report
  • [Book] WormBase線虫のゲノム統合データベース、細胞工学別冊「バイオリソース&データベース活用術」2009

    • Author(s)
      三谷昌平
    • Total Pages
      5
    • Publisher
      秀潤社
    • Related Report
      2009 Annual Research Report
  • [Book] 線虫 機能ゲノミクスのためのモデル生物、細胞工学別冊「バイオリソース&データベース活用術」2009

    • Author(s)
      三谷昌平
    • Total Pages
      3
    • Publisher
      秀潤社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/Basic/physiol2/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/Basic/physiol2/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/Basic/physiol2/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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