Molecular basis for the Id2-dependent growth and differentiation controls of gastrointestinal epithelial cells.

• Project/Area Number: 21390092
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: University of Fukui
• Principal Investigator: YOKOTA Yoshifumi 福井大学, 医学部, 教授 (50222386)
• Co-Investigator(Kenkyū-buntansha): KUROOKA Hisanori 福井大学, 医学部, 准教授 (00293879) ; MORI Kentaro 福井大学, 医学部, 助教 (50397296) ; BIYAJIMA Kyoko 福井大学, 医学部, 特命助教 (30552020)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 消化管 / 上皮細胞 / 運命決定 / 転写調節因子 / 転写因子 / 遺伝子ネットワーク / Id2

Research Abstract

Mice deficient for Id2, a transcription regulator, develop intestinal tumors. By utilizing genetically engineered mice, we have disclosed that Id2 is an important factor in the gene network that determines the regional specificity of the gastrointestinal tract during development.

Research Products

• [Journal Article] Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis (2012)
  • Author(s): Sakata-Goto T
  • Journal Title: Bone Volume: 50 Issue: 1 Pages: 69-78
  • DOI: 10.1016/j.bone.2011.09.049
  • Peer Reviewed
• [Journal Article] Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-fos and Id protein expression (2012)
  • Author(s): Oh, J., et al
  • Journal Title: J.Cell.Physiol. Volume: 227 Issue: 5 Pages: 1851-1860
  • DOI: 10.1002/jcp.22913
  • Peer Reviewed
• [Journal Article] BMP signaling is responsible for serum-induced Id2 expression (2012)
  • Author(s): Kurooka, H., et al
  • Journal Title: Biochem.Biophys.Res.Com. Volume: 420 Issue: 2 Pages: 281-287
  • DOI: 10.1016/j.bbrc.2012.02.150
  • Peer Reviewed
• [Journal Article] Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. (2012)
  • Author(s): Kim DY, Fukuyama S, Nagatake T, Takamura K, Kong IG, Yokota Y, Lee CH, Kiyono H.
  • Journal Title: Allergy Volume: 67 Issue: 4 Pages: 502-9
  • DOI: 10.1111/j.1398-9995.2011.02782.x
  • Peer Reviewed
• [Journal Article] The airway antigen sampling system : respiratory M cells as an alternative gateway for inhaled antigens (2011)
  • Author(s): Kim DY, et al
  • Journal Title: J Immunol Volume: 186(7) Issue: 7 Pages: 4253-4262
  • DOI: 10.4049/jimmunol.0903794
  • Peer Reviewed
• [Journal Article] The small-molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells (2011)
  • Author(s): Egusa, H., et al.
  • Journal Title: Bone Volume: 49 Issue: 2 Pages: 264-274
  • DOI: 10.1016/j.bone.2011.04.003
  • Peer Reviewed
• [Journal Article] Gittenberger-De Groot, A.C. : Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice (2011)
  • Author(s): Jongbloed, M.R.M., Vicente-Steijn, R., Douglas, Y.L., Wisse, L.J., Mori, K., Yokota, Y., Bartelings, M.M., Schalij, M.J., Mahtab, E.A., Poelmann, R.E
  • Journal Title: Dev. Dyn. Volume: 240 Issue: 11 Pages: 2561-2577
  • DOI: 10.1002/dvdy.22762
  • Peer Reviewed
• [Journal Article] heway way antigen sampling system:respiratory M cells as an ltemative ateway for inhaled antiens.cells as an (2011)
  • Author(s): Kim, D.Y., et al.
  • Journal Title: J.Immunol. Volume: 186 Pages: 4253-4262
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line (2010)
  • Author(s): Hosono, N., Kishi, S., Iho, S., Urasaki, Y., Yoshida, A., Kurooka, H., Yokota, Y. and Ueda, T
  • Journal Title: Cancer Sci. Volume: 101 Issue: 3 Pages: 767-773
  • DOI: 10.1111/j.1349-7006.2009.01432.x
  • NAID: 10026589943
  • Peer Reviewed
• [Journal Article] Identification of BMP responsive elements in the mouse Id2 gene (2010)
  • Author(s): Nakahiro, T., Kurooka, H., Mori, K., Sano, K. and Yokota, Y
  • Journal Title: Biochem. Biophys. Res. Com. Volume: 399 Issue: 3 Pages: 416-421
  • DOI: 10.1016/j.bbrc.2010.07.090
  • Peer Reviewed
• [Journal Article] Identification of BMP responsiveelements in the mouse Id2 gene (2010)
  • Author(s): Nakahiro, T., et al.
  • Journal Title: Biochem. Biophys. Res.Com. Volume: 399 Pages: 416-421
  • Peer Reviewed
• [Journal Article] Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line. (2010)
  • Author(s): Hosono, N., et al.
  • Journal Title: Cancer Sci. 101 Pages: 767-773
  • Peer Reviewed
• [Journal Article] Id2-, RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity (2009)
  • Author(s): Nagatake, T., et al.
  • Journal Title: J. Exp. Med. Volume: 206 Issue: 11 Pages: 2351-2364
  • DOI: 10.1084/jem.20091436
  • Peer Reviewed
• [Journal Article] Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis (2009)
  • Author(s): Tokuriki, A., Iyoda, T., Inaba, K., Ikuta, K., Fujimoto, S., Kumakiri, M. and Yokota, Y
  • Journal Title: Carcinogenesis Volume: 30 Issue: 9 Pages: 1645-1650
  • DOI: 10.1093/carcin/bgp172
  • Peer Reviewed
• [Journal Article] RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity. (2009)
  • Author(s): Nagatake, T., et al.
  • Journal Title: J.Exp.Med. 206 Pages: 2351-2364
  • Peer Reviewed
• [Journal Article] Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis. (2009)
  • Author(s): Tokuriki, A., et al.
  • Journal Title: Carcinogenesis 30 Pages: 1645-1650
  • Peer Reviewed
• [Journal Article] The small-molecule harmine regulates NEATc1n and Id2 expression in osteoclast proenitor cells.
  • Author(s): Egusa, H., et al.
  • Journal Title: Bone Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Lineage specification of gastrointestinal cells by helix-loop-helix transcription factor Id2 (2011)
  • Author(s): Mori, K., et al
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] 転写調節因子Id2 による消化管上皮細胞の運命決定機構 (2011)
  • Author(s): 森 健太郎、中村ハルミ、宮地 均、玉田紘太、Chi-Chung Hui、内匠 透、横田義史
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Lineage specification of gastrointestinal cells by helix-loop-helix transcription factor Id2 (2011)
  • Author(s): Mori, K., Nakamura, H., Kurooka, H., Tamada, K., Takumi, T. and Yokota, Y.
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄県宜野湾市
• [Presentation] 酸化ストレスにより形成されるHLHタンパク質の分子間ジスルフィド結合 (2010)
  • Author(s): 黒岡尚徳、横田義史
  • Organizer: 第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 酸化ストレスにより形成されるHLH タンパク質の分子間ジスルフィド結合 (2010)
  • Author(s): 黒岡尚徳、横田義史
  • Organizer: 第33回日本分子生物学会年会/第83 回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://seika1.med.lab.u-fukui.ac.jp/
• [Remarks]
  • URL: http://www1.fukui-med.ac.jp/SEIKA1/welcome.html