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The development of a mini-array specific to gastric cancers to estimate biological characteristics

Research Project

Project/Area Number 21390106
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionYamaguchi University

Principal Investigator

SASAKI Kohsuke  山口大学, 大学院・医学系研究科, 教授 (80116722)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywordsがん / ゲノム / DNAコピー数 / アレイCGH / CGH / WGAS / ミニアレイ / 胃癌 / 大腸癌 / 癌病態 / 悪性度
Research Abstract

We developed the" mini-array" for gastric cancer to evaluate biological characteristics including lymph node metastasis and so on. In order to select BAC clones linked with biological characteristics, we applied a technology of array-based CGH to gastric cancers. To evaluate the" mini-array" for gastric cancer, we applied" mini-array" for another case of gastric cancers and we succeeded in predicting correctly about 70% of cases with no lymph node metastasis. This result suggests the" mini-array" a useful device for personalized treatment for cancers.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (6 results)

  • [Journal Article] Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma2011

    • Author(s)
      Oga A, Uchida K, Nakao M, Kawauchi S, Furuya T, Chochi Y, Ikemoto K, Okada T, Ueyama Y, Sasaki K, Yousefpour F
    • Journal Title

      Oncol Rep

      Volume: 26(6) Pages: 1393-1398

    • DOI

      10.3892/or.2011.1446

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centrosome amplification as a putative prognostic biomarker for the classification of urothelial carcinomas2011

    • Author(s)
      Yamamoto Y, Misumi T, Eguchi S, Nakao M, Hara T, Sakano S, Furuya T, Oga A, Kawauchi S, Sasaki K, Matsuyama H
    • Journal Title

      Hum Pathol

      Volume: 42(12) Pages: 1923-1930

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of 3p26. 3 is an independent prognostic factor in patients with oral squamous cell carcinoma2011

    • Author(s)
      Uchida K, Oga A, Nakao M, Mano T, Mihara M, Kawauchi S, Furuya T, Ueyama Y, Sasaki K
    • Journal Title

      Oncol Rep

      Volume: 26(2) Pages: 463-469

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations associated with the clinicopathological features of colorectal cancers : Identification of genomic biomarkers by array-based comparative genomic hybridization2011

    • Author(s)
      Nakao M, Kawauchi S, Uchiyama T, Adachi J, Ito H, Chochi Y, Furuya T, Oga A, Sasaki K
    • Journal Title

      Oncol Rep

      Volume: 25(6) Pages: 1603-1611

    • DOI

      10.3892/or.2011.1246

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A simple method for enhancing hybridization efficiency in chromosome and array comparative genomic hybridization2011

    • Author(s)
      Kawauchi S, Furuya T, Nakao M, Ikemoto K, Oga A, Sasaki K
    • Journal Title

      Biotech Histochem

      Volume: 86(3) Pages: 192-198

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of 3p26.3 is an independent prognostic factor in patients with oral squamous cell carcinoma2011

    • Author(s)
      Uchida K.
    • Journal Title

      Oncology Report

      Volume: 26 Pages: 463-469

    • DOI

      10.3892/or.2011.1327

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Centrosome ampliication as a putative prognostic biomarker for the classification of urothelial carcinomas2011

    • Author(s)
      Yamamoto Y
    • Journal Title

      human pathology

      Volume: 12 Pages: 1923-1930

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations associated with the clinicopathological features of colorectal cancers : Identification of genomic biomarkers by array-based comparative genomic hybridization.2011

    • Author(s)
      Nakao M
    • Journal Title

      Oncology Report

      Volume: 25 Pages: 1603-1611

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland : two case reports2010

    • Author(s)
      Uchida K, Oga A, Nagatsuka H, Ueyama Y, Sasaki K
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 203(2) Pages: 324-327

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations associated with aneuploidy and chromosomal instability in breast cancers2010

    • Author(s)
      Kawauchi S, Furuya T, Ikemoto K, Yamamoto S, Oka M, Sasaki K
    • Journal Title

      Oncol Rep

      Volume: 24(4) Pages: 875-883

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic instability and DNA ploidy are linked to DNA copy number aberrations of 8p23 and 22q11. 23 in gastric cancers2010

    • Author(s)
      Kawauchi S, Furuya T, Uchiyama T, Adachi A, Okada T, Nakao M, Oga A, Uchida K, Sasaki K
    • Journal Title

      Int J Mol Med

      Volume: 26(3) Pages: 333-339

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The loss of 8p23. 3 is a novel marker for predicting progression and recurrence of bladder tumors without muscle invasion2010

    • Author(s)
      Eguch S, Yamamoto Y, Sakano S, Chochi Y, Nakao M, Kawauchi S, Furuya T, Oga A, Matsuyama H, Sasaki K
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 200(1) Pages: 16-22

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic alterations at 13q14 may correlate with differences in the biological behavior of prostate cancer between Japanese and Caucasian men2010

    • Author(s)
      Misumi T, Yamamoto Y, Murakami T, Ito H, Eguchi S, Yano S, Nagao K, Sakano S, Naito K, Sasaki K, Fichtner J, Matsuyama H
    • Journal Title

      Urol Int

      Volume: 84(4) Pages: 461-466

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues : comparison of the CGH profiles between cancer cell lines and primary cancer tissues2010

    • Author(s)
      Tsuji K, Kawauchi S, Saito S, Furuya T, Ikemoto K, Nakao M, Yamamoto S, Oka M, Hirano T, Sasaki K
    • Journal Title

      BMC cancer

      Volume: 14 Pages: 10-15

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic instability and DNA ploidy are linked to DNA copy number aberrations of 8p23 and 22q11.23 in gastric cancers.2010

    • Author(s)
      Kawauchi S
    • Journal Title

      Int J Mol Med

      Volume: 26 Pages: 333-339

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas.2010

    • Author(s)
      Liu XL
    • Journal Title

      Int J Mol Med

      Volume: 25 Pages: 709-716

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 9p21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology2009

    • Author(s)
      Kawauchi S, Sakai H, Ikemoto K, Nakao M, Takihara H, Shimabukuro T, Furuya T, Oga A, Matsuyama H, Sasaki K
    • Journal Title

      Hum Pathol

      Volume: 40(12) Pages: 1783-1789

    • NAID

      120001613389

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intercellular centrosome number is correlated with the copy number of chromosomes in bladder cancer2009

    • Author(s)
      Yamamoto Y, Eguchi S, Nagao K, Furuya T, Oga A, Kawauchi S, Sasaki K, Matsuyama H
    • Journal Title

      Cancer Genet Cytogenet

      Volume: 191(1) Pages: 38-42

    • NAID

      120002647753

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A copy number gain of the 6p arm is linked with advanced hepatocellular carcinoma an array-based comparative genomic hybridization study2009

    • Author(s)
      Chochi Y, Kawauchi S, Furuya T, Hasimoto K, Oga A, Sasaki K
    • Journal Title

      J Pathol

      Volume: 217(5) Pages: 677-684

    • NAID

      120002619695

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 9p21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology.2009

    • Author(s)
      Kawauchi S
    • Journal Title

      Hum Pathol. 40

      Pages: 1783-1789

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A copy number gain of the 6p arm is linked with advanced hepatocellular carcinoma : an array-based comparative genomic hybridization study.2009

    • Author(s)
      Chochi Y
    • Journal Title

      J Pathol 217

      Pages: 677-684

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intercellular centrosome number is correlated with the copy number of chromosomes in bladder cancer.2009

    • Author(s)
      Yamamoto Y
    • Journal Title

      Cancer Genet Cytogenet 191

      Pages: 38-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] がん細胞とゲノム発現2011

    • Author(s)
      佐々木功典
    • Organizer
      第52回日本臨床細胞学会総会
    • Place of Presentation
      福岡福岡国際会議場
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲノム解析のがん診療への応用2010

    • Author(s)
      佐々木功典
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      下関海峡メッセ下関
    • Year and Date
      2010-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲノム解析のがん診療への応用2010

    • Author(s)
      佐々木功典
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌とゲノム2010

    • Author(s)
      佐々木功典
    • Organizer
      第20回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京東京慈恵会医科大学
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 癌とゲノム2010

    • Author(s)
      佐々木功典
    • Organizer
      第20回日本サイトメトリー学会学術集会
    • Place of Presentation
      東京慈恵医科大学
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸癌74例のアレイCGH解析およびMDR(multifactor dimensionality reduction)法解析2009

    • Author(s)
      中尾素直
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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