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Analysis of usefulness of the susceptible mouse strain in higher functional toxicity evaluation of environmental chemicals

Research Project

Project/Area Number 21390198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

FUJIMAKI Hidekazu  独立行政法人国立環境研究所, 環境リスク研究センター, 主席研究員 (00124355)

Co-Investigator(Kenkyū-buntansha) TIN-TIN Win-shwe  独立行政法人国立環境研究所, 環境健康研究センター, 研究員 (00391128)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords産業衛生 / 環境化学物質 / 脳・神経 / 免疫 / 乳仔期 / 感受性 / 炎症反応
Research Abstract

Using the animal model developed by exposure research of volatile organic compounds, the effects of different chemical on inflammatory response in higher functions were investigated and compared to toluene for verification the usefulness of elucidation of hypersensitivity and searching new biomarkers. It was the same as that of the result of toluene exposure, diazinon exposure during neonatal period affects the nervous and immune functions in later life. Furthermore, the present study showed a new finding indicating that a different pattern of higher functions was found in neonatal diazinon exposure.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (17 results)

  • [Journal Article] Involvement of TLR4 in diazinon-induced neurotoxicity in mice2012

    • Author(s)
      Win-Shwe TT, Nakajima D, Fujimaki H
    • Journal Title

      J UOEH

      Volume: Vol.34, No.1 Pages: 1-13

    • NAID

      110009418871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure2012

    • Author(s)
      Win-Shwe TT, Kunugita N, Nakajima D, Yoshida Y, Fujimaki H
    • Journal Title

      Toxicology Letters

      Volume: Vol.208, No.2 Pages: 133-141

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of TLR4 in diazinon-induced neurotoxicity in mice2012

    • Author(s)
      Win-Shwe, et al
    • Journal Title

      J UOEH

      Volume: 34(1) Pages: 1-13

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental stage-specific changes in immunological biomarkers in male C3H/HeN mice after early life toluene exposure2012

    • Author(s)
      Win-Shwe, et al
    • Journal Title

      Toxicology Letters

      Volume: 208(2) Pages: 133-141

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of immune responses in an allergic mouse model following low-level toluene exposure2011

    • Author(s)
      Fujimaki H, Win-Shwe TT, Yoshida Y, Kunugita N, Arashidani K
    • Journal Title

      Toxicology

      Volume: Vol.286, No.1-3 Pages: 28-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of immune responses in an allergic mouse model following low-level toluene exposure2011

    • Author(s)
      Fujimaki, et al
    • Journal Title

      Toxicology

      Volume: 286(1-3) Pages: 28-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain differences influence N-methyl-D-aspartate receptor subunit gene expression in the olfactory bulb of an allergic mouse model following toluene exposure2010

    • Author(s)
      Win-Shwe TT, Kunugita N, Yamamoto S, Arashidani K, Fujimaki H
    • Journal Title

      Neuroimmunomodulation

      Volume: Vol.17, No.5 Pages: 340-347

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotoxicity of toluene2010

    • Author(s)
      Win-Shwe TT, Fujimaki H
    • Journal Title

      Toxicology Letters

      Volume: Vol.198, No.2 Pages: 93-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does early life toluene exposure alter the expression of NMDA receptor subunits and signal transduction pathway in infant mouse hippocampus2010

    • Author(s)
      Win-Shwe TT, Yoshida Y, Kunugita N, Tsukahara S, Fujimaki H
    • Journal Title

      Neurotoxicology

      Volume: Vol.31, No.6 Pages: 647-653

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different sensitivity in expression of transcription factor mRNAs in congenic mice following exposure to low-level toluene2010

    • Author(s)
      Fujimaki H, Win-Shwe TT, Yamamoto S, Kunugita N, Yoshida Y, Arashidani K
    • Journal Title

      Inhalation Toxicology

      Volume: Vol.22, No.11 Pages: 903-909

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurotoxicity of toluene2010

    • Author(s)
      Win-Shwe, Fujimaki
    • Journal Title

      Toxicology Letters

      Volume: 198 Pages: 93-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does early life toluene exposure alter the expression of NMDA receptor subunits and signal transduction pathway in infant mouse hippocampus?2010

    • Author(s)
      Win-Shwe, et al.
    • Journal Title

      Neurotoxicology

      Volume: 31 Pages: 647-653

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different sensitivity in expression of transcription factor mRNAs in congenic mice following exposure to low-level toluene2010

    • Author(s)
      Fujimaki, et al.
    • Journal Title

      Inhalation Toxicology

      Volume: 22 Pages: 903-909

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain differences influence N-methyl-D-aspartate receptor subunit gene expression in the olgactory bulb of an allergic mouse model following toluene exposure2010

    • Author(s)
      Win-Shwe, et al.
    • Journal Title

      Neuroimmunomodulation 17

      Pages: 340-347

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of CD4(+) T cells in the modulation of neurotrophin production in mice exposed to low-level toluene2009

    • Author(s)
      Fujimaki H, Win-Shwe TT, Yamamoto S, Nakajima D, Goto S
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: Vol.31, No.1 Pages: 146-149

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of nerve growth factor in mice lung following low-level toluene exposure2009

    • Author(s)
      Fujimaki H, Win-Shwe TT, Yamamoto S, Nakajima D, Goto S
    • Journal Title

      Toxicology Letters

      Volume: Vol.191, No.1-3 Pages: 240-245

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of CD4+ T cells in the modulation of neurotrophin production in mice exposed to low-level toluene2009

    • Author(s)
      Fujimaki, et al.
    • Journal Title

      Immunopharmacology and Immunotoxicology 31

      Pages: 146-149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression of nerve growth factor in mice lung following low-level toluene exposure2009

    • Author(s)
      Fujimaki, et al.
    • Journal Title

      Toxicology Letters 191

      Pages: 240-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Impact of toll-like receptor(TLR) 4 on hippocampus-dependent object recognition in early life diazinon exposure2011

    • Author(s)
      Win-Shwe TT & Fujimaki H
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of toll-like receptor (TLR) 4 on hippocampus-dependent object recognition in early life diazinon exposure2011

    • Author(s)
      Win-Shwe TT, Fujimaki H
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of diazinon injection during developmental stage on immune response in mice2011

    • Author(s)
      Fujimaki H & Win-Shwe TT
    • Organizer
      52^<nd> Annual Meeting of Japanese Society for Atmospheric Environment
    • Place of Presentation
      Nagasaki
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of diazinon injection during developmental stage on immune response in mice2011

    • Author(s)
      Fujimaki H, Win-Shwe TT
    • Organizer
      52^<nd> Annual Meeting of Japanese Society for Atmospheric Environment
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Developmental diazinon exposure induces immune dysfunction in adult mice2011

    • Author(s)
      Fujimaki H & Win-Shwe TT
    • Organizer
      47^<th> Congress of the European Society of Toxicology
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Developmental exposure to diazinon impairs novel object recognition in later life in a mouse model2011

    • Author(s)
      Win-Shwe TT, Fujimaki H
    • Organizer
      8^<th> International Brain Research Organization (IBRO) World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Developmental exposure to diazinon impairs novel object recognition in later life in a mouse model2011

    • Author(s)
      Win-Shwe TT & Fujimaki H
    • Organizer
      8^<th> International Brain Research Organization World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Modulation of the expression of transcription factors mRNAs in spleen from the mice following organophosphate pesticide exposure2010

    • Author(s)
      Fujimaki, et al
    • Organizer
      8^<th> Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Toll-like receptor 4 mediated neurotrophins, their receptor and signaling pathways in the neuroinflammation of organophosphate pesticide2010

    • Author(s)
      Win-Shwe TT, et al.
    • Organizer
      8^<th> Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Modulation of the expression of transcription factors mRNAs in spleen from the mice following organophosphate pesticide exposure2010

    • Author(s)
      Fujimaki, et al.
    • Organizer
      8^<th> Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Toll-like receptor 4 mediated neurotrophins, their receptors and signaling pathways in the neuroinflammation of organophosphate pesticides.2010

    • Author(s)
      Win-Shwe, et al.
    • Organizer
      8^<th> Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Developmental toluene exposure alters neuroimmune markers in the hippocampus of infant mice2010

    • Author(s)
      Win-Shwe TT, et al.
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Developmental toluene exposure alters neuroimmune markers in the hippocampus of infant mice2010

    • Author(s)
      Win-Shwe, et al.
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Palau de Congressos de Barcelona
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 健康影響と感受性2009

    • Author(s)
      藤巻秀和
    • Organizer
      第50回大気環境学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス系統差で探るトルエン曝露にたいする免疫系感受性要因2009

    • Author(s)
      欅田尚樹ら
    • Organizer
      第50回大気環境学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 健康影響と感受性2009

    • Author(s)
      藤巻秀和
    • Organizer
      第50回大気環境学会年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス協生館
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス系統差で探るトルエン曝露に対する免疫系感受性要因2009

    • Author(s)
      欅田尚樹, ら
    • Organizer
      第50回大気環境学会年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス協生館
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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