Expression aging-related genes and healthy life longevity in elderly twins

• Project/Area Number: 21390205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka University
• Principal Investigator: HAYAKAWA Kazuo 大阪大学, 医学(系)研究科(研究院), 教授 (70142594)
• Co-Investigator(Kenkyū-buntansha): 西原 玲子 大阪大学, 医学系研究科, 助教 (10452434)
• Co-Investigator(Renkei-kenkyūsha): OHMURA Kayoko 大阪大学, 大学院医学系研究科, 講師 (30722839) ; KAMIDE Kei 大阪大学, 大学院医学系研究科, 教授 (80393239)
• Project Period (FY): 2009-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 老化予防 / 老年病 / 双生児研究 / 健康増進 / 健康寿命 / 双生児 / 高年齢 / 老化遺伝子 / メチル化 / エピジェネチックス / 生活環境 / ライフスタイル / 予防医学 / 高齢双子 / 老化防止 / 高齢者

Outline of Final Research Achievements

Large scale of elderly twin cohort study is a extremely importnat subjects in the field of preventive medicine including dental science. One of the research results of our study have won the First Prize in the area of Geriatric Oral Research at the International Conference of International Association for Dental Research.
This result indicated that our twin study accomplished a very importnat progress in the fied of preventive medicine nad dental science.

Research Products

• [Journal Article] Common genetic factors influence hand strength, processing speed and working memory (2014)
  • Author(s): Ogata,K, Kato K, Hayakawa K,et al.
  • Journal Title: Journal of Epidemiology Volume: ２４ Pages: 31-38
  • NAID: 130003383375
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Twin studies on the effect of genetic factors on serum agalactosyl immunoglobulin G levels (2014)
  • Author(s): Azuma K, Shinzaki S, Asazawa H,Kuroki e, Miyosi E, Hayakawa k, et al.
  • Journal Title: Biomedical Reports Volume: 2 Issue: 2 Pages: 21-26
  • DOI: 10.3892/br.2014.216
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An Overview of Multidisciplinary Research Resource at the Osaka University Center for Twin Research (2013)
  • Author(s): Kazuo Hayakawa
  • Journal Title: Twin Research and Human Genetics Volume: 16(1) Pages: 217-220
  • Peer Reviewed
• [Journal Article] Thje Conrtinueing Value of Twin Studies in the Omics Era (2012)
  • Author(s): Dongen J, Hayakawa K
  • Journal Title: Nature Review Genetics Volume: 3243 Issue: 9 Pages: 1013-1013
  • DOI: 10.1038/nrg3243
  • Peer Reviewed
• [Journal Article] 予防医学における双生児研究の重要性:エピジェネティクス時代の遺伝・環境 (2011)
  • Author(s): 早川和生
  • Journal Title: 日本衛生学雑誌 Volume: 66 Pages: 29-30
  • Peer Reviewed
• [Journal Article] Association of functional GITR gene polymorphysm related to expression of GITR molecules with prognosisof autoimmune thyroid (2011)
  • Author(s): Tomizawa R, Hayakawa K, et.al
  • Journal Title: Clinical and Experimental Immunology Volume: 169 Pages: 83-96
  • Peer Reviewed
• [Journal Article] 予防医学における双生児研究の重要性:エピジェネテックス時代の遺伝・環境因子の行楽研究 (2011)
  • Author(s): 早川和生
  • Journal Title: 日本衛生学雑誌 Volume: 66巻 Pages: 29-30
  • Peer Reviewed
• [Journal Article] 高齢一卵性双生児における生活機能のペア内差異の解明 (2010)
  • Author(s): 西原玲子、早川和生
  • Journal Title: 千代田健康開発事業団社会構成事業医学研究報告集 Volume: 第55巻 Pages: 59-67
• [Journal Article] Heritability of Serum Apolipoprotein Concentrations in Middle-Aged Japanese Twins (2009)
  • Author(s): YangPing Cai, Kazuo Hayakawa
  • Journal Title: Journal of Epidemiology 19巻 Pages: 260-265
  • NAID: 10026250823
  • Peer Reviewed
• [Journal Article] 高齢一卵性双生児1,200組の同胞間比較からみた老年期の人生満足度に関与する遺伝と環境要因の研究 (2009)
  • Author(s): 早川和生、西原玲子、蔡陽平、門田憲亮、大野智代、佐伯志穗
  • Journal Title: 大阪ガスグループ福祉財団研究報告書 22巻 Pages: 83-87
• [Presentation] Influence of genetic and environmental factors on oral diseases and function in aged twins (2014)
  • Author(s): Kurushima Y, Ikebe K, Hayakawa K, et al.
  • Organizer: The 67th Annual Scientific Meeting of Gerontological Society of America
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2014-11-05 – 2014-11-09
• [Presentation] 双子研究から明らかになったIgG糖鎖構造の遺伝性について (2011)
  • Author(s): 浅澤瞳美、早川和生、三善英知
  • Organizer: 第58回日本臨床検査医学会学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2011-11-20
• [Presentation] 高齢双生児レジストリーに基づく大規模バイオバンクの構築 (2011)
  • Author(s): 早川和生
  • Organizer: 日本双生児研究会第25回学術講演会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-01-29
• [Presentation] 血液型と性格に関する研究-MN式血液型およびルイス式血液型を用いて (2010)
  • Author(s): 桝谷理紗、早川和生、西原玲子
  • Organizer: 第69回日本公衆衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-29
• [Presentation] ABO型血液型と性格に関する研究 (2010)
  • Author(s): 濱秀聡、早川和生、西原玲子
  • Organizer: 第69回日本公衆衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-29
• [Presentation] Genetic Inheritance of Time-discounting Behabiour (2010)
  • Author(s): Kenji Hirata, Kazuo Hayagawa
  • Organizer: 日本経済学会2010年春季大会
  • Place of Presentation: 千葉市(招待講演)
  • Year and Date: 2010-06-05
• [Presentation] 高齢双生児の社会的役割・手段的日常生活動作に関連する遺伝的要因につにての研究 (2010)
  • Author(s): 西原玲子、乾富士夫、加藤憲司、富沢理惠、早川和生
  • Organizer: 日本双生児研究学会第24回学術講演会
  • Place of Presentation: 金沢市
  • Year and Date: 2010-01-23
• [Presentation] Genetic and Environmental Influence on Oral Condition Among Elder Twins
  • Author(s): Yoko Kurusima, Kazuo Hayakawa
  • Organizer: International Asspociation for Dental Research
  • Place of Presentation: シアトル市、U.S.A.
• [Book] 「エピジェネチクス」in看護学大事典 (2010)
  • Author(s): 早川和生
  • Total Pages: 365
  • Publisher: 医学書院