Aiming at a new development of the postmortem diagnosis of the drug-related cadaver : Investigation of genetic background
Project/Area Number |
21390218
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Legal medicine
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Research Institution | Fukuoka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HARA Kenji 福岡大学, 医学部, 講師 (00090738)
KASHIWAGI Masayuki 福岡大学, 医学部, 助教 (70301687)
MATSUSUE Aya 福岡大学, 医学部, 助教 (70309920)
WATERS Brian 福岡大学, 医学部, 助教 (00609480)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | 法医学 / 覚醒剤 / 死因 / 横紋筋融解症 / 遺伝子 / 変異 / 薬毒物 / 遺伝子変異 |
Research Abstract |
There is a possibility that rhabdomyolysis related to drug can be caused by genetic background. We analyzed potential rhabdomyolysis-susceptibility genes in autopsy cases of drug poisoning such as methamphetamine. Some mutations were found, then, using algorithms analysis, several mutation were considered potentially to impact on protein function. These results reveal the possibility that the onset of rhabdomyolysis is associated with both the mutation in the rhabdomyolysis-susceptibility gene and the concentration of methamphetamine or the hyperthermia induced by methamphetamine. A lot more autopsy cases of rhabdomyolysis were required and investigation of other rhabdomyolysis-susceptibility genes helps to clear association between rhabdomyolysis and genetic background.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] An autopsy case of rhabdomyolysis related to vegetamin and genetic analysis of the rhabdomyolysis-associated genes2010
Author(s)
Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
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Journal Title
J Forensic Leg Med
Volume: 17(1)
Pages: 46-9
Related Report
Peer Reviewed
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[Journal Article] Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene : An autopsy case of neuroleptic malignant syndrome related to vegetamin2009
Author(s)
Matsusue A, Hara K, Kageura M, Kashiwagi M, Wang L, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T, Kubo S.
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Journal Title
NAID
Related Report
Peer Reviewed
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