| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Research Abstract |
There is a possibility that rhabdomyolysis related to drug can be caused by genetic background. We analyzed potential rhabdomyolysis-susceptibility genes in autopsy cases of drug poisoning such as methamphetamine. Some mutations were found, then, using algorithms analysis, several mutation were considered potentially to impact on protein function. These results reveal the possibility that the onset of rhabdomyolysis is associated with both the mutation in the rhabdomyolysis-susceptibility gene and the concentration of methamphetamine or the hyperthermia induced by methamphetamine. A lot more autopsy cases of rhabdomyolysis were required and investigation of other rhabdomyolysis-susceptibility genes helps to clear association between rhabdomyolysis and genetic background.
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