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Analysis of the ageing mechanism induced by Apop

Research Project

Project/Area Number 21390222
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

RAKUGI Hiromi  大阪大学, 医学系研究科, 教授 (20252679)

Co-Investigator(Kenkyū-buntansha) YASUDA Osamu  熊本大学, 医学部附属病院, 准教授 (00372615)
福尾 惠介 (福尾 恵介)  武庫川女子大学, 生活環境学部, 教授 (40156758)
大石 充  鹿児島大学, 医歯(薬)学総合研究科, 教授 (50335345)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords老化 / ミトコンドリア / 代謝 / 動脈硬化 / 酸化ストレス / Apop / アポトーシス
Research Abstract

We found that the expression of Apoptogenic Protein (Apop) is implicated in oxidative stress production and senescence of cells. In addition, we found that Apop expression affected the activation of mitochondrial metabolism. Apop gene inhibition enhance fatty acid metabolism, and improved serum cholesterol level and body weight. Therefore, Apop could be to a novel therapeutic target for the treatment of dyslipidemia and obesity.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (242 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (190 results) (of which Peer Reviewed: 190 results,  Open Access: 1 results) Presentation (39 results) (of which Invited: 4 results) Book (10 results) Remarks (3 results)

  • [Journal Article] Molecular Mechanisms and Implications in Human Health2013

    • Author(s)
      Congrains A, Kamide K, Ohishi M, Rakugi H. ANRIL
    • Journal Title

      nt J Mol Sci.

      Volume: 14 Pages: 1278-1292

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin (1-7) and other AngiotensinPeptides.2013

    • Author(s)
      Ohishi M, Yamamoto K, Rakugi H.
    • Journal Title

      Curr Pharm Des

      Volume: 19 Pages: 3060-3064

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis ofhepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet2013

    • Author(s)
      Nojima K, Sugimoto K, Ueda H, Babaya N, Ikegami H, Rakugi H.
    • Journal Title

      Endocr J.

      Volume: 60 Pages: 261-274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice.2013

    • Author(s)
      Takeda M, Yamamoto K, Takemura Y, Takeshita H, Hongyo K, Kawai T,Hanasaki-Yamamoto H, Oguro R, Takami Y, Tatara Y, Takeya Y, Sugimoto K, Kamide K, Ohishi M, Rakugi H.
    • Journal Title

      Diabetes.

      Volume: 62 Pages: 223-233

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice2013

    • Author(s)
      Nakagami F
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e60493-e60493

    • DOI

      10.1371/journal.pone.0060493

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age and prediction of remission and relapse of proteinuria and corticosteroid-related adverse events in adult-onset minimal-change disease: a retrospective cohort study2013

    • Author(s)
      Shinzawa M
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in Fatty Liver Shionogi mouse2013

    • Author(s)
      Wang X
    • Journal Title

      Hepatol Res

      Volume: 印刷中 Issue: 1 Pages: 102-13

    • DOI

      10.1111/hepr.12092

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study2013

    • Author(s)
      Ohishi M
    • Journal Title

      Hypertens Res

      Volume: 印刷中 Issue: 7 Pages: 620-626

    • DOI

      10.1038/hr.2013.10

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats2013

    • Author(s)
      Matsui I
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 304 Issue: 6 Pages: 751-60

    • DOI

      10.1152/ajprenal.00329.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANRIL: Molecular Mechanisms and Implications in Human Health2013

    • Author(s)
      Congrains A
    • Journal Title

      Int J Mol Sci

      Volume: 14 Issue: 1 Pages: 1278-1292

    • DOI

      10.3390/ijms14011278

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cut-Off Value of Brachial-Ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study2013

    • Author(s)
      Kawai T
    • Journal Title

      J Atheroscler Thromb

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan modulates mitochondrial function in vascular smooth muscle cells2013

    • Author(s)
      Takeuchi K
    • Journal Title

      Hypertens Res

      Volume: 印刷中 Issue: 5 Pages: 433-439

    • DOI

      10.1038/hr.2012.199

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Impact on Uric Acid Concentration and Hyperuricemia in the Japanese Population2013

    • Author(s)
      Takeuchi F
    • Journal Title

      J Atheroscler Thromb

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin (1-7) and other angiotensin peptide2013

    • Author(s)
      Ohishi M
    • Journal Title

      Curr Pharm Des

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet2013

    • Author(s)
      Nojima K
    • Journal Title

      Endocr J

      Volume: 60 Pages: 261-274

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of left ventricular hypertrophy observed at dialysis initiation depends on the pre-dialysis use of erythropoiesis-stimulating agents2013

    • Author(s)
      Hayashi T
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single daily dose enhances the adherence to immunosuppressive treatment in kidney transplant recipients: a cross-sectional study2013

    • Author(s)
      Obi Y
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences between daytime and nighttime blood pressure variability regarding systemic atherosclerotic change and renal function2013

    • Author(s)
      Kawai T
    • Journal Title

      Hypertens Res

      Volume: 36 Issue: 3 Pages: 232-239

    • DOI

      10.1038/hr.2012.162

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] -374 T/A Polymorphism in RAGE Gene is Associated with Onset of Diabetes Mellitus, Atherosclerosis, and Renal Dysfunction in Patients with Hypertension2013

    • Author(s)
      Kawai T
    • Journal Title

      Clin Exp Hypertens

      Volume: 35 Issue: 3 Pages: 236-241

    • DOI

      10.3109/10641963.2012.721840

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity2013

    • Author(s)
      Benigni A
    • Journal Title

      Age

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of renin angiotensin system gene polymorphisms onvisit-to-visit blood pressure variability in hypertensive patients.2012

    • Author(s)
      Kawai T, Ohishi M, Onishi M, Takeya Y, Ito N, Kato N, Yamamoto K, Kamide K,Rakugi H.
    • Journal Title

      Am J Hypertens.

      Volume: 25 Pages: 1249-1255

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.2012

    • Author(s)
      Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, Kusunoki Y,Takabatake Y, Hirata M, Nishiyama A, Tsubakihara Y, Isaka Y, Rakugi H.
    • Journal Title

      Lab Invest.

      Volume: 92 Pages: 1686-1697

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacogenomic approaches to study the effects of antihypertensive drugs.2012

    • Author(s)
      Kamide K, Kawano Y, Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 35 Pages: 796-799

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography.2012

    • Author(s)
      Kawai T, Kamide K, Onishi M, Hongyo K, Yamamoto-Hanasaki H, Oguro R, Maekawa Y, Yamamoto K, Takeya Y, Sugimoto K, Ohishi M, Rakugi H.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 16 Pages: 786-791

    • NAID

      10031122268

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CVD-associated non-coding RNA, ANRIL, modulates expression ofatherogenic pathways in VSMC.2012

    • Author(s)
      Congrains A, Kamide K, Katsuya T, Yasuda O, Oguro R, Yamamoto K, Ohishi M, Rakugi H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 419 Pages: 612-616

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined use of vitamin D status andFGF23 for risk stratification of renal outcome.2012

    • Author(s)
      Nakano C, Hamano T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y,Okada N, Tsubakihara Y, Isaka Y, Rakugi H.
    • Journal Title

      Clin J Am Soc Nephrol.

      Volume: 7 Pages: 810-819

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy.2012

    • Author(s)
      Omori H, Kawada N, Inoue K, Ueda Y, Yamamoto R, Matsui I, Kaimori J,Takabatake Y, Moriyama T, Isaka Y, Rakugi H.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 16 Pages: 549-556

    • NAID

      10031058092

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy guards against cisplatin-induced acutekidney injury.2012

    • Author(s)
      Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H.
    • Journal Title

      Am J Pathol.

      Volume: 180 Pages: 517-525

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene isassociated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration.2012

    • Author(s)
      Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Miura T, Rakugi H.
    • Journal Title

      Exp Gerontol.

      Volume: 47 Pages: 183-187

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.2012

    • Author(s)
      Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T,Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H.
    • Journal Title

      Atherosclerosis

      Volume: 220 Pages: 449-455

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene polymorphisms contributing to hypertension in immunoglobulin Anephropathy.2012

    • Author(s)
      Shinzawa M, Y amamoto R, Nagasawa Y, Shoji T, Obi Y, Namba T, Kitamura H,Kaneko T, Okada N, Iwatani H, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 16 Pages: 250-258

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Ab40/42 production detected using fusion constructs2012

    • Author(s)
      Sato N
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e48551-e48551

    • DOI

      10.1371/journal.pone.0048551

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma B-type natriuretic peptide level predicts kidney prognosis in patients with predialysis chronic kidney disease2012

    • Author(s)
      Yasuda K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27 Issue: 10 Pages: 3885-3891

    • DOI

      10.1093/ndt/gfs365

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy2012

    • Author(s)
      Iwatani H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 428 Issue: 3 Pages: 339-342

    • DOI

      10.1016/j.bbrc.2012.10.049

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic option of plasmid-DNA based gene transfer2012

    • Author(s)
      Taniyama Y
    • Journal Title

      Curr Top Med Chem

      Volume: 12 Pages: 1630-1637

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease2012

    • Author(s)
      Ozaki K
    • Journal Title

      Curr Gene Ther

      Volume: 12 Pages: 484-492

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals2012

    • Author(s)
      Takeuchi F
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e46385-e46385

    • DOI

      10.1371/journal.pone.0046385

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress2012

    • Author(s)
      Tsuda H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 427 Issue: 2 Pages: 266-272

    • DOI

      10.1016/j.bbrc.2012.09.032

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation2012

    • Author(s)
      Shimizu K
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 11 Pages: 2687-2693

    • DOI

      10.1161/atvbaha.112.300041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of renin angiotensin system gene polymorphisms on visit-to-visit blood pressure variability in hypertensive patients2012

    • Author(s)
      Kawai T
    • Journal Title

      Am J Hypertens

      Volume: 25 Pages: 1249-55

    • DOI

      10.1038/ajh.2012.118

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad32012

    • Author(s)
      Inoue K
    • Journal Title

      Lab Invest

      Volume: 92 Issue: 12 Pages: 1686-1697

    • DOI

      10.1038/labinvest.2012.107

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orally active vitamin d for potential chemoprevention of posttransplant malignancy2012

    • Author(s)
      Obi Y
    • Journal Title

      Cancer Prev Res

      Volume: 5 Issue: 10 Pages: 1229-1235

    • DOI

      10.1158/1940-6207.capr-12-0218

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral Glucose Loading Modulates Plasma β-Amyloid Level in Alzheimer's Disease Patients : Potential Diagnostic Method for Alzheimer's Disease.2012

    • Author(s)
      Shuko Takeda, et al.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 9;34(1) Issue: 1 Pages: 25-30

    • DOI

      10.1159/000338704

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease2012

    • Author(s)
      Niihata K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27 Issue: 12 Pages: 4378-4385

    • DOI

      10.1093/ndt/gfs322

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dialysis vintage and parathyroid hormone level, not fibroblast growth factor-23, determines chronic-phase phosphate wasting after renal transplantation2012

    • Author(s)
      Tomida K
    • Journal Title

      Bone

      Volume: 51 Issue: 4 Pages: 729-736

    • DOI

      10.1016/j.bone.2012.06.027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacogenomic approaches to study the effects of antihypertensive drugs2012

    • Author(s)
      Kamide K
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 8 Pages: 796

    • DOI

      10.1038/hr.2012.82

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney2012

    • Author(s)
      Imamura R
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 6 Pages: 852-862

    • DOI

      10.1007/s10157-012-0647-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease2012

    • Author(s)
      Sakaguchi Y
    • Journal Title

      Diabetes Care

      Volume: 35 Issue: 7 Pages: 1591-1577

    • DOI

      10.2337/dc12-0226

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography2012

    • Author(s)
      Kawai T
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 5 Pages: 786-791

    • DOI

      10.1007/s10157-012-0627-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of nephrocalcinosis associated with primary aldosteronism2012

    • Author(s)
      Yasuda K
    • Journal Title

      Intern Med

      Volume: 51 Pages: 625-627

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the efficacy and tolerability of combination therapy with candesartan cilexetil and amlodipine besilate compared with candesartan cilexetil monotherapy and amlodipine besilate monotherapy in Japanese patients with mild-to-moderate essential hypertension: a multicenter, 12-week, randomized, double-blind, placebo-controlled, parallel-group study2012

    • Author(s)
      Rakugi H
    • Journal Title

      Clin Ther

      Volume: 34 Issue: 4 Pages: 838-848

    • DOI

      10.1016/j.clinthera.2012.02.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis2012

    • Author(s)
      Nakano C
    • Journal Title

      Bone

      Volume: 50 Issue: 6 Pages: 1266-1274

    • DOI

      10.1016/j.bone.2012.02.634

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy2012

    • Author(s)
      Omori H
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 4 Pages: 549-556

    • DOI

      10.1007/s10157-012-0609-3

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual effects of statins on Aβ metabolism: upregulation of the degradation of APP-CTF and Aβ clearance2012

    • Author(s)
      Sato N
    • Journal Title

      Neurodegener Dis

      Volume: 10 Issue: 1-4 Pages: 305-308

    • DOI

      10.1159/000334534

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the efficacy and safety of azilsartan with that of candesartan cilexetil in Japanese patients with gradeI-II essential hypertension2012

    • Author(s)
      Rakugi H
    • Journal Title

      Hypertens Res

      Volume: (印刷中) Issue: 5 Pages: 552-528

    • DOI

      10.1038/hr.2012.8

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination therapy for hypertension in the elderly : a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial2012

    • Author(s)
      Ogihara T
    • Journal Title

      Hypertens Res

      Volume: (印刷中) Issue: 4 Pages: 441-448

    • DOI

      10.1038/hr.2011.216

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy2012

    • Author(s)
      Shinzawa M
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Issue: 2 Pages: 250-258

    • DOI

      10.1007/s10157-011-0553-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of coronary artery disease in the Japanese2012

    • Author(s)
      Fumihiko Takeuchi, Mitsuhiro Yokota, et al.(他23名、3番目)
    • Journal Title

      Eur J Hum Genet

      Volume: 20 Issue: 3 Pages: 333

    • DOI

      10.1038/ejhg.2011.184

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC2012

    • Author(s)
      Congrains A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome2012

    • Author(s)
      Nakano C
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-γ/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade2012

    • Author(s)
      Kusunoki H
    • Journal Title

      Hypertension

      Volume: 59(2) Pages: 308-316

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual Effects of Statins on AβMetabolism : Upregulation of the Degradation of APP-CTF and Aβ Clearance2012

    • Author(s)
      Sato N
    • Journal Title

      Neurodegener Dis

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy guards against cisplatin-induced acute kidney injury2012

    • Author(s)
      Takahashi A
    • Journal Title

      Am J Pathol

      Volume: 180(2) Pages: 517-525

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration2012

    • Author(s)
      Oguro R
    • Journal Title

      Exp Gerontol

      Volume: 47(2) Pages: 183-187

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case report of a long-surviving Werner syndrome patient with severe aortic valve stenosis2012

    • Author(s)
      Kawai T, Yasuda O, et al.(他12名12番目)
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12 Issue: 1 Pages: 174-175

    • DOI

      10.1111/j.1447-0594.2011.00748.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.Atherosclerosis2012

    • Author(s)
      Congrains A
    • Journal Title

      Atherosclerosis

      Volume: 220(2) Pages: 449-455

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of serotonin in angiogenesis : induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice2012

    • Author(s)
      Iwabayashi M
    • Journal Title

      Atherosclerosis

      Volume: 220(2) Pages: 337-342

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking and chronic kidney diseases2012

    • Author(s)
      Nagasawa Y
    • Journal Title

      Hypertens Res

      Volume: 35(3) Issue: 3 Pages: 261-265

    • DOI

      10.1038/hr.2011.205

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice2012

    • Author(s)
      Hayashi D
    • Journal Title

      Gastroenterology

      Volume: 142(2) Pages: 292-304

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported Sleep Duration and Prediction of Proteinuria : A Retrospective Cohort Study2012

    • Author(s)
      Yamamoto R
    • Journal Title

      Am J Kidney Dis

      Volume: 59(3) Pages: 343-355

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of visit-to-visit variability in blood pressure on renal function2012

    • Author(s)
      Kawai T
    • Journal Title

      Hypertens Res

      Volume: 35(2) Issue: 2 Pages: 239-43

    • DOI

      10.1038/hr.2011.170

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel2012

    • Author(s)
      Shimizu H
    • Journal Title

      Hypertens Res

      Volume: 35(1) Issue: 1 Pages: 77-81

    • DOI

      10.1038/hr.2011.143

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients2012

    • Author(s)
      Okumi M
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Pages: 907-915

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise2012

    • Author(s)
      Masuo K
    • Journal Title

      Hypertens Res

      Volume: 35(1) Issue: 1 Pages: 41-47

    • DOI

      10.1038/hr.2011.134

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease patients : a cross-sectional study. Nephrol Dial Transplant2012

    • Author(s)
      Uehata T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(3) Pages: 1076-1083

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A candidate gene approach to genetic contributors to the development of IgA nephropathy2012

    • Author(s)
      Yamamoto R
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(3) Pages: 1020-1030

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme single nucleotide polymorphism is a genetic riskfactor for cardiovascular disease: a cohort study of hypertensive patients.2011

    • Author(s)
      Kato N, Tatara Y, Ohishi M, Takeya Y, Onishi M, Maekawa Y, Rakugi H.
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 728-734

    • NAID

      10031163244

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of the resistive index in renal Doppler ultrasonography as an indicator of vascular damage in patients with risks of atherosclerosis.2011

    • Author(s)
      Kawai T, Kamide K, Onishi M, Yamamoto-Hanasaki H, Baba Y, Hongyo K, Shimaoka I, Tatara Y, Takeya Y, Ohishi M, Rakugi H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 26 Pages: 3256-3262

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of concomitant diabetes and chronic kidney disease on preload-induced changes in left ventricular diastolic filling in hypertensive patients.2011

    • Author(s)
      Iwashima Y, Horio T, Suzuki Y, Takagi T, Kamide K, Ohishi M, Ogihara T, Yoshikawa J, Kawano Y, Rakugi H.
    • Journal Title

      J Hypertens

      Volume: 29 Pages: 144-153

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary type IV collagen in nondiabetic kidney disease.2011

    • Author(s)
      Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Nephron Clin Pract.

      Volume: 117

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Salt-inducible kinase 1 influences' Na(+), K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure2011

    • Author(s)
      Popov S
    • Journal Title

      Hypertens

      Volume: 29(12) Pages: 2395-2403

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasmid DNA-based gene transfer with ultrasound and microbubbles2011

    • Author(s)
      Taniyama Y
    • Journal Title

      Curr Gene Ther

      Volume: 11(6) Pages: 485-490

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of tonsils of IgA nephropathy patients2011

    • Author(s)
      Iwatani H
    • Journal Title

      Adv Otorhinolaryngol

      Volume: 72 Pages: 75-78

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease2011

    • Author(s)
      Kimura T
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Pages: 854-860

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: The Ohasama study2011

    • Author(s)
      Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi Shin-Ichi, Rakugi H, Takahashi K and Imai Y.
    • Journal Title

      Hypertens Res

      Volume: 34 Issue: 12 Pages: 1327

    • DOI

      10.1038/hr.2011.131

    • NAID

      10030278155

    • URL

      https://pure.teikyo.jp/en/publications/c51f3549-e97e-4798-9b77-6dc626a1f435

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient2011

    • Author(s)
      Yasuda K
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(6) Pages: 927-932

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of chronic kidney disease and increased arterial stiffness is a predictor for stroke and cardiovascular disease in hypertensive patients2011

    • Author(s)
      Ohishi M
    • Journal Title

      Hypertens Res

      Volume: 34(11) Issue: 11 Pages: 1209-1215

    • DOI

      10.1038/hr.2011.117

    • NAID

      10030277442

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population2011

    • Author(s)
      Nakayama H
    • Journal Title

      Hypertens Res

      Volume: 34(10) Issue: 10 Pages: 1141-1146

    • DOI

      10.1038/hr.2011.102

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway2011

    • Author(s)
      Iekushi K
    • Journal Title

      Hypertension

      Volume: 58(2) Pages: 190-196

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guideline-practice gap in the management of predialysis chronic kidney disease mineral bone disorder in Japan2011

    • Author(s)
      Hamano T
    • Journal Title

      Ther Apher Dial

      Volume: 15 Suppl 1 Issue: s1 Pages: 2-8

    • DOI

      10.1111/j.1744-9987.2011.00918.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of weight loss on renal function in overweight Japanese men2011

    • Author(s)
      Masuo K
    • Journal Title

      Hypertens Res

      Volume: 34(8) Issue: 8 Pages: 915-921

    • DOI

      10.1038/hr.2011.47

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse2011

    • Author(s)
      Takeda S
    • Journal Title

      Neuroscience

      Volume: 186 Pages: 110-119

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klotho protein diminislies endothehal apoptosis and senescence via a mitogen-activated kinase pathway2011

    • Author(s)
      Maekawa Y
    • Journal Title

      Geriatr Gerontol Int

      Volume: 11(4) Issue: 4 Pages: 510-516

    • DOI

      10.1111/j.1447-0594.2011.00699.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy protects the proximal tubule from degeneration and acute is chemic injury2011

    • Author(s)
      Kimura T
    • Journal Title

      J Am Soc Nephrol

      Volume: 22(5) Pages: 902-913

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats2011

    • Author(s)
      Takabatake Y
    • Journal Title

      Mol Med

      Volume: 17(7-8) Issue: 7-8 Pages: 686-696

    • DOI

      10.2119/molmed.2010.00229

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population2011

    • Author(s)
      Kamide K
    • Journal Title

      Hypertens Res

      Volume: 34(6) Pages: 740-746

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms linking diabetes mellitus and Alzheimer disease : beta-amyloid peptide, insulin signaling, and neuronal function2011

    • Author(s)
      Takeda S
    • Journal Title

      Mol Biosyst

      Volume: 7(6) Pages: 1822-1827

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan2011

    • Author(s)
      Sakaguchi Y
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 6(5) Pages: 995-1000

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease2011

    • Author(s)
      Kato N
    • Journal Title

      Hypertens Res

      Volume: 34(6) Pages: 728-734

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practitioner's trial on the efficacy of antihypertensive treatment in elderly patients with hypertension II (PATE-hypertension II study) in Japan2011

    • Author(s)
      Ogihara T
    • Journal Title

      Geriatr Gerontol Int

      Volume: 11(4) Issue: 4 Pages: 414-421

    • DOI

      10.1111/j.1447-0594.2011.00690.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of the resistive index in renal Doppler ultrasonography as an indicator of vascular damage in patients with risks of atherosclerosis2011

    • Author(s)
      Kawai T
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(10) Pages: 3256-3262

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease : a cohort study with hypertensive patients2011

    • Author(s)
      Iwamoto Y
    • Journal Title

      Hypertens Kes

      Volume: 34(5) Pages: 573-537

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus : a missing link to therapeutic potential2011

    • Author(s)
      Sato N
    • Journal Title

      Curr Aging Sci

      Volume: 4(2) Pages: 118-127

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study2011

    • Author(s)
      Hirose T
    • Journal Title

      Hypertens Res

      Volume: 34(4) Pages: 530-535

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease : a cohort study with hypertensive patients2011

    • Author(s)
      Iwamoto Y
    • Journal Title

      Hypertens Res

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Insulin Signaling in the Interaction Between Alzheimer Disease and Diabetes Mellitus : A Missing Link to Therapeutic Potential2011

    • Author(s)
      Sato N
    • Journal Title

      Curr Aging Sci

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women2011

    • Author(s)
      Hirose T
    • Journal Title

      Hypertens Res

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats2011

    • Author(s)
      Miyasato K
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Pages: 50-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chronic kidney disease and post-angiographic acute kidney injury on long-term prognosis after coronary artery angiography2011

    • Author(s)
      Kimura T
    • Journal Title

      Nephrol Dial Transplant

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of concomitant diabetes and chronic kidney disease on preload-induced changes in left ventricular diastolic filling in hypertensive patients2011

    • Author(s)
      Iwashima Y
    • Journal Title

      J Hypertens

      Volume: 29 Pages: 144-153

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor attenuates renal fibrosis through TGF-β1 suppression by apoptosis of myofibroblasts2011

    • Author(s)
      Iekushi K
    • Journal Title

      J Hypertens

      Volume: 28 Pages: 2454-2461

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary type IV collagen in nondiabetic kidney disease2011

    • Author(s)
      Furumatsu Y
    • Journal Title

      Nephron Clin Pract

      Volume: 117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.2010

    • Author(s)
      Sugimoto K, Katsuya T, Kamide K, Fujisawa T, Shimaoka I, Ohishi M, Morishita R, Ogihara T, Rakugi H.
    • Journal Title

      Int J Hypertens

      Volume: 2010 Pages: 196307-196307

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strong suppression of the renin-angiotensin system has arenal-protective effect in hypertensive patients: high-dose ARB with ACEinhibitor (Hawaii) study.2010

    • Author(s)
      Ohishi M, Takeya Y, Tatara Y, Yamamoto K, Onishi M, Maekawa Y, Kamide K,Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 33 Pages: 1150-1154

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The counterregulating role of ACE2 andACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation invascular cells.2010

    • Author(s)
      Hayashi N, Yamamoto K, Ohishi M, Tatara Y, Takeya Y, Shiota A, Oguro R,Iwamoto Y, Takeda M, Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 33 Pages: 1182-1185

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of strictand mild-blood pressure control in elderly hypertensive patients: a per-protocol analysis of JATOS.2010

    • Author(s)
      Rakugi H, Ogihara T, Goto Y, Ishii M; JATOS Study Group.
    • Journal Title

      Hypertens Res.

      Volume: 33 Pages: 1124-1128

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nifedipine inhibits vascular smooth muscle cell dedifferentiation via downregulation of Akt signaling.2010

    • Author(s)
      Kaimoto T, Yasuda O, Ohishi M, Mogi M, Takemura Y, Suhara T, Ogihara T, FukuoK, Rakugi H.
    • Journal Title

      Hypertension.

      Volume: 56 Pages: 247-252

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.2010

    • Author(s)
      Shindo N, Fujisawa T, Sugimoto K, Nojima K, Oze-Fukai A, Yoshikawa Y, Wang X, Yasuda O, Ikegami H, Rakugi H.
    • Journal Title

      J Hepatol.

      Volume: 52 Pages: 903-912

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Campylobacter fetus peritonitis in a patient with an unused embedded subcutaneous peritoneal catheter.2010

    • Author(s)
      Inoue K, Kitamura H, Nagasawa Y, Kawada N, Isaka Y, Rakugi H.
    • Journal Title

      Perit Dial Int.

      Volume: 30 Pages: 253-254

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.2010

    • Author(s)
      Shiota A, Yamamoto K, Ohishi M, Tatara Y, Ohnishi M, Maekawa Y, Iwamoto Y, Takeda M, Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 33 Pages: 298-307

    • NAID

      10026127523

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of tonsils in immunoglobulin A nephropathy patients.2010

    • Author(s)
      Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Horii A, Okuzaki D, Furumatsu Y, Inohara H, Nojima H, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393 Pages: 565-570

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] E-cadherin andclaudin-4 expression has circadian rhythm in adult rat kidney.2010

    • Author(s)
      Yamato M, Ito T, Iwatani H, Yamato M, Imai E, Rakugi H.
    • Journal Title

      J Nephrol

      Volume: 23 Pages: 102-110

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specialist care and improvedlong-term survival of dialysis patients.2010

    • Author(s)
      Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 25 Pages: 1930-1935

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment2010

    • Author(s)
      Sugimoto K
    • Journal Title

      Int J Hypertens

      Volume: 2010 Pages: 196307-196313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fetuin-mineral complex reflects extraosseous calcification stress in CKD2010

    • Author(s)
      Hamano T
    • Journal Title

      J Am Soc Nephrol

      Volume: 21 Pages: 1998-2007

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells2010

    • Author(s)
      Hayashi N
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 1182-1185

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of strict- and mild-blood pressure control in elderly hypertensive patients : a per-protocol analysis of JATOS2010

    • Author(s)
      Rakugi H
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 1124-1128

    • NAID

      10027475856

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population2010

    • Author(s)
      Koriyama H
    • Journal Title

      J Atheroscler Thromb

      Volume: 17 Pages: 1054-1062

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANG II inhibits insulin-mediated production of PI 3,4,5-trisphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes2010

    • Author(s)
      Ikushima M
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen inhibits vascular calcification via vascular RANKL system : common mechanism of osteoporosis and vascular calcification2010

    • Author(s)
      Osako MK
    • Journal Title

      Circ Res

      Volume: 107 Pages: 466-475

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort2010

    • Author(s)
      Obi Y
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 5 Pages: 1558-1565

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan in Elderly Isolated Systolic Hypertension Study Group. Target blood pressure for treatment of isolated systolic hypertension in the elderly : valsartan in elderly isolated systolic hypertension study2010

    • Author(s)
      Ogihara T
    • Journal Title

      Hypertension

      Volume: 56 Pages: 196-202

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nifedipine inhibits vascular smooth muscle cell dedifferentiation via downregulation of Akt signaling2010

    • Author(s)
      Kaimoto T
    • Journal Title

      Hypertension

      Volume: 56 Pages: 247-252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance2010

    • Author(s)
      Shinohara M
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 22091-22102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoking and progression of IgA nephropathy2010

    • Author(s)
      Yamamoto R
    • Journal Title

      Am J Kidney Dis

      Volume: 56 Pages: 313-324

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model2010

    • Author(s)
      Shindo N
    • Journal Title

      J Hepatol

      Volume: 52 Pages: 903-912

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension2010

    • Author(s)
      Oguro R
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Pages: 311-318

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of sympathetic nervous activity in renal injury and end-stage renal disease2010

    • Author(s)
      Masuo K
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 521-528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes2010

    • Author(s)
      Takeda S
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 7036-7041

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation in OSBPL10 is associated with dyslipidemia2010

    • Author(s)
      Koriyama H
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 511-514

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Campylobacter fetus Peritonitis in a Patient with an Unused Embedded Subcutaneous Peritoneal Catheter2010

    • Author(s)
      Inoue K
    • Journal Title

      Perit Dial Int

      Volume: 30 Pages: 253-254

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice2010

    • Author(s)
      Shiota A
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 298-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen attenuates vascular remodeling in Lp(a) transgenic mice2010

    • Author(s)
      Nakagami F
    • Journal Title

      Atherosclerosis

      Volume: 211 Pages: 41-47

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specialist care and improved long-term survival of dialysis patients2010

    • Author(s)
      Furumatsu Y
    • Journal Title

      Nephrol Dial Transplant

      Volume: 25 Pages: 1930-1935

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.2010

    • Author(s)
      Shiota A, Yamamoto K, Ohishi M, Tatara Y, Rakugi H, et al
    • Journal Title

      Hypertens Res 印刷中

    • NAID

      10026127523

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microarray analysis of tonsils in immunoglobulin A nephropathy patients.2010

    • Author(s)
      Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Rakugi H, et al
    • Journal Title

      Biochem Biophys Res Commun 印刷中

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen attenuates vascular remodeling in Lp (a) transgenic mice2010

    • Author(s)
      Nakagami F, Nakagami H, Rakugi H, Morishita R, et al
    • Journal Title

      Atherosclerosis 印刷中

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E-cadherin and claudin-4 expression has circadian rhythm in adult ratkidney2010

    • Author(s)
      Yamato M, Ito T, Iwatani H, Yalnato M, Imai E, Rakugi H, et al
    • Journal Title

      J Nephrol 23

      Pages: 102-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese2010

    • Author(s)
      Shimaoka I, Kamide K, Ohishi M, Katsuya T, Rakugi H, et al
    • Journal Title

      Hypertens Res 印刷中

    • NAID

      10026126909

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specialist care and improved long-term survival of dialysis patients2010

    • Author(s)
      Furumatsu Y, Nagasawa Y, Yamamoto R, Rakugi H, et al
    • Journal Title

      Nephrol Dial Transplant 印刷中

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additive interaction of metabolic syndrome and chronic kidney disease on cardiac hypertrophy, and risk of cardiovascular disease in hypertension.2010

    • Author(s)
      Iwashima Y, Horio T, Kamide K, RakugiH, Kawano Y, et al
    • Journal Title

      Am J Hypertens 23

      Pages: 290-298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiovascular and Renal Complications of Type 2 Diabetes in Obesity : Role of Sympathetic Nerve Activity and Insulin Resistance2010

    • Author(s)
      Masuo K, Rakugi H, Ogihara T, Esler MD, Lambert GW, et al
    • Journal Title

      Curr Diabetes Rev 印刷中

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-upfrom the Ohasama study2010

    • Author(s)
      Watanabe Y, Metoki H, Rakugi H, Miki T, Imai Y, et al
    • Journal Title

      Hypertens Res 33

      Pages: 129-134

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T elmisartan-induced inhibition of vascular cell proliferation beyond angiotensin receptor blockade and peroxisome proliferator-activated receptor-gamma activation.2009

    • Author(s)
      Yamamoto K, Ohishi M, Ho C, Kurtz TW, Rakugi H.
    • Journal Title

      Hypertension.

      Volume: 54 Pages: 1353-1359

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Timp-3 deficiency impairs cognitive function in mice.2009

    • Author(s)
      Baba Y, Yasuda O, Takemura Y, Ishikawa Y, Ohishi M, Iwanami J, Mogi M, Doe N, Horiuchi M, Maeda N, Fukuo K, Rakugi H.
    • Journal Title

      Lab Invest

      Volume: 89 Pages: 1340-1347

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The impact of diabetes mellituson vitamin D metabolism in predialysis patients.2009

    • Author(s)
      Tanaka H, Hamano T, Fujii N, Tomida K, Matsui I, Mikami S, Nagasawa Y, Ito T,Moriyama T, Horio M, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Bone.

      Volume: 45 Pages: 949-955

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT -IgAN).2009

    • Author(s)
      Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 24 Pages: 3686-3694

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation.2009

    • Author(s)
      Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, Takemura Y,Ohishi M, Katsuya T, Rakugi H.
    • Journal Title

      Endocrine.

      Volume: 35 Pages: 341-346

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan-induced inhibition of vascular cell proliferation beyond angiotensin receptor blockade and peroxisome proliferator-activated receptor-gamma activation2009

    • Author(s)
      Yamamoto K, Ohishi M, Ho C, Kurtz TW, Rakugi H, et al
    • Journal Title

      Hypertension 54

      Pages: 1353-1359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome2009

    • Author(s)
      Kimura T, Iio KI, Imai E, Rakugi H, Isaka Y, HayashiT, et al
    • Journal Title

      Clin Exp Nephrol 印刷中

    • NAID

      10027228620

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Timp-3 deficiency impairs cognitive function in mice.2009

    • Author(s)
      Baba Y, Yasuda O, Rakugi H, et al
    • Journal Title

      Lab Invest 89

      Pages: 1340-1347

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling2009

    • Author(s)
      Takeda S, Sato N, Takeuchi D, Rakugi H, Morishita R, et al
    • Journal Title

      Hypertension 54(6) :

      Pages: 1345-1352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure2009

    • Author(s)
      Ochiai R, Chikama A, Kataoka K, Rakugi H, Mikami H, et al
    • Journal Title

      Hypertens Res 32

      Pages: 969-974

    • NAID

      10026124231

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C allele of angiotensin II type 1 receptor gene A1166C polymorphism affbcts plasma adiponectin concentrations in healthy young Japanese women2009

    • Author(s)
      Miyanaga K, Fukuo K, AkasakaRakugi H, Kazumi T, et al
    • Journal Title

      Hypertens Res 32

      Pages: 901-905

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A promoter polymorphism of laminA/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study).2009

    • Author(s)
      Akasaka H, Katsuya T, Rakugi H, Ogihara T, Shimamoto K, et al
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 404-409

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of diabetes mellitus on vitamin D metabolism in predialysis patients2009

    • Author(s)
      Tanaka H, Hamano T, Fujii N, Tomida K, Rakugi H, et al
    • Journal Title

      Bone 45

      Pages: 949-955

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive r2009

    • Author(s)
      Shimizu H, Nakagami H, Rakugi H, Ogihara T, Morishita R, et al
    • Journal Title

      Hypertens Res 32

      Pages: 786-790

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of interleukin-6 receptor blockage on renal in jury in apolipoprotein E-deficient mice2009

    • Author(s)
      Tomiyama-Hanayama M, Rakugi H, Kohara M, Nishimoto N, et al
    • Journal Title

      Am J Physiol Renal Physiol 279

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic basis of hypertension for the development of tailored medicine.2009

    • Author(s)
      Katsuya T, Morishita R, Rakugi H, Ogihrara T, et al
    • Journal Title

      Hypertens Res 32

      Pages: 643-648

    • NAID

      10025164481

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney.2009

    • Author(s)
      Yamato M, Ishida N, Iwatani H, Yamato M, Rakugi H, Ito T
    • Journal Title

      J Recept Signal Transduct Res 29

      Pages: 94-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of Abeta1-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease.2009

    • Author(s)
      Takeda S, Sato N, Rakugi H, Kano M, Morishita R, et al
    • Journal Title

      Brain Res 1280

      Pages: 137-147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quiz page June 2009 : worsening kidney function with a history of urolithiasis.2009

    • Author(s)
      Kimura T, Yasuda K, Obi Y, Rakugi H, Hayashi T, et al
    • Journal Title

      Am J Kidney Dis 53

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models.2009

    • Author(s)
      Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R, et al
    • Journal Title

      Biochem Biophys Res Commun 385

      Pages: 193-197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The CXCL12(SDF-1)/CXCR4 axis is essential for the development of renal vasculature.2009

    • Author(s)
      Takabatake Y, Sugiyama T, Kohara H, Rakugi H, Isaka Y, et al
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 1714-1723

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to Dlstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).2009

    • Author(s)
      Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Rakugi H, et al
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 3686-3694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuatesNF-kappaB activation2009

    • Author(s)
      Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Rakugi H, et al
    • Journal Title

      Endocrine 35

      Pages: 341-346

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluvastatin improves osteoporosis in fructose-fed insulin resistant modelrats through blockade of the classical mevalonate pathway and antioxidant action.2009

    • Author(s)
      Hanayama R, Shimizu H, Nakagami H, Rakugi H, Morishita R, et al
    • Journal Title

      Int J Mol Med 23

      Pages: 581-588

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative effects of anemia on qualit y of life and its improvement by complete correction of anemia by administration of recombinant human erythropoietin in posttransplant patients.2009

    • Author(s)
      Kawada N, Moriyama T, Rakugi H, Imai E, Takahara S, et al
    • Journal Title

      Clin Exp Nephrol 13

      Pages: 355-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications : a sub-analysis of the CASE-J trial.2009

    • Author(s)
      Ogihara T, Saruta T, Rakugi H, Higaki J, Nakao K, et al
    • Journal Title

      Hypertens Res 32

      Pages: 248-254

    • NAID

      10024830399

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of bone resorption markers in hemodialysis patients2009

    • Author(s)
      Hamano T, Tomida K, Mikami S, Rakugi H, Isaka Y, et al
    • Journal Title

      Bone 45 Suppl 1

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species2009

    • Author(s)
      Tatara Y, Ohishi M, Yamamoto K, Shiota A, Rakugi H, et al
    • Journal Title

      J Mol Cell Cardiol 47

      Pages: 104-111

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009).2009

    • Author(s)
      Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Rakugi H, et al
    • Journal Title

      Hypertens Res 32

      Pages: 3-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.2009

    • Author(s)
      Matsui I, Hamano T, Rakugi H, Imai E, Isaka Y, et al
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 2354-2361

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fas promoter region gene polymorphism is associated with an increased risk for myocardial in farction2009

    • Author(s)
      Hanasaki H, Takemura Y, Fukuo K, Ohishi M, Rakugi H, et al
    • Journal Title

      Hypertens Res 32

      Pages: 261-264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rationale, study design and implementation of the COLM study : the combination of OLMesartan and calcium channel blocker or diuretic in highrisk elderly hypertensive patients.2009

    • Author(s)
      Ogihara T, Saruta T, Rakugi H, Shimamoto K, Shimada K, et al
    • Journal Title

      Hypertens Res 32

      Pages: 163-167

    • NAID

      10024829854

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bc1-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms.2009

    • Author(s)
      Isaka Y, Suzuki C, Rakugi H, Shimizu S, Takahara S, et al
    • Journal Title

      Transplant Proc 41

      Pages: 52-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fully phosphorylated fetuin-Aforms a mineral complex in the serum of rats with adenineinduced renal failure.2009

    • Author(s)
      Matsui I, Hamano T, Rakugi H, Imai E, Isaka Y, et al
    • Journal Title

      Kidney Int 75

      Pages: 915-928

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of (pro) renin receptor gene polymorphism with blood pressure in Japanese men : the Ohasama study2009

    • Author(s)
      Hirose T, Hashimoto M, Rakugi H, Takahashi K, Imai Y, et al
    • Journal Title

      Am J Hypertens 22

      Pages: 294-299

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in nondiabetic predialysis CKD patients2009

    • Author(s)
      Tomida K, Hamano T, Mikami S, Fujii N, Rakugi H, et al
    • Journal Title

      Bone 44

      Pages: 678-683

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease : spontaneous amelioration of diabetes by augmented beta cell mass.2009

    • Author(s)
      Oze-Fukai A, Fujisawa T, Sugimoto K, Rakugi H, et al
    • Journal Title

      Endocr J 56

      Pages: 227-234

    • NAID

      10026913000

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 降圧以上にぷらあすアルファの効果は本当にあるのか?2012

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本臨床薬理学会学術総会
    • Place of Presentation
      沖縄
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 健康長寿診療ハンドブックと高齢期の疾病・介護の予防2012

    • Author(s)
      樂木宏実
    • Organizer
      第19回日本未病システム学会
    • Place of Presentation
      金沢
    • Year and Date
      2012-10-28
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Effect of azilsartan on the circadian rhythm of blood pressure in Japanese essential hypertension2012

    • Author(s)
      Rakugi H
    • Organizer
      Abstracts of the 24th Meeting of the Internal Society of Hypertension
    • Place of Presentation
      Sydney
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Combination therapy in hypertension with CKD2012

    • Author(s)
      Rakugi H
    • Organizer
      Abstracts of the 24th Meeting of the Internal Society of Hypertension
    • Place of Presentation
      Sydney
    • Year and Date
      2012-10-02
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 日本 JSH20092012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] VALISH: The valsartan in elderly isolated systolic hypertension study2012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 高血圧制圧の戦略:新規降圧療法の開発2012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者高血圧の血圧正常化の有用性と安全性:VALISH 研究サブ解析2012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 実地医家の教育2012

    • Author(s)
      樂木宏実
    • Organizer
      第54回日本老年医学会学術集会・総会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-30
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 高齢者と高血圧治療2012

    • Author(s)
      樂木宏実
    • Organizer
      第54回日本老年医学会学術集会・総会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ハンドブックが目指すもの:編集者の立場から2012

    • Author(s)
      樂木宏実
    • Organizer
      第54回日本老年医学会学術集会・総会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規降圧薬の開発2012

    • Author(s)
      樂木宏実
    • Organizer
      第一回臨床高血圧フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ハンドブックが目指すもの:編集者の立場から2012

    • Author(s)
      樂木宏実
    • Organizer
      第54回日本老年医学会学術集会・総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高血圧制圧の戦略:新規降圧療法の開発2012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 日本JSH20092012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 降圧以上にぷらあすアルファの効果は本当にあるのか?2012

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本臨床薬理学会学術総会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高齢者高血圧の血圧正常化の有用性と安全性:VALISH研究サブ解析2012

    • Author(s)
      樂木宏実
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高血圧と血管老化2010

    • Author(s)
      樂木宏実
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 高血圧と血管老化2010

    • Author(s)
      樂木宏実
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 老年医学の新しい展望2010

    • Author(s)
      樂木宏実
    • Organizer
      第21回老年医学会北陸地方会
    • Place of Presentation
      福井
    • Year and Date
      2010-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 老年医学の新しい展望2010

    • Author(s)
      樂木宏実
    • Organizer
      第21回老年医学会北陸地方会
    • Place of Presentation
      福井(招待講演)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] VALISH study から2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] VALISH からのレッスン2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ガイドライン改訂の課題2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] VALISH studyから2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] VALISHからのレッスン2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] ガイドライン改訂の課題2010

    • Author(s)
      樂木宏実
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 本態性高血圧-成因・診断・治療-2010

    • Author(s)
      樂木宏実
    • Organizer
      老年医学会 北陸地方会
    • Place of Presentation
      福井
    • Year and Date
      2010-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 本態性高血圧-成因・診断・治療-2010

    • Author(s)
      樂木宏実
    • Organizer
      老年医学会 北陸地方会
    • Place of Presentation
      福井(招待講演)
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optimal Target Blood Pressure for Elderly Hypertensive Patients2010

    • Author(s)
      Rakugi H
    • Organizer
      The 23rd scientific meeting of the International Society of Hypertension
    • Place of Presentation
      Vancouver
    • Year and Date
      2010-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Optimal Target Blood Pressure for Elderly Hypertensive Patients2010

    • Author(s)
      樂木宏実
    • Organizer
      The 23^<rd> scientific meeting of the International Society of Hypertension (ISH2010)
    • Place of Presentation
      バンクーバー(カナダ)(招待講演)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高齢者高血圧の治療指針2010

    • Author(s)
      樂木宏実
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者高血圧の治療指針2010

    • Author(s)
      樂木宏実
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病患者の高血圧治療と糖尿病発症予防の高血圧治療2010

    • Author(s)
      樂木宏実
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病患者の高血圧治療と糖尿病発症予防の高血圧治療2010

    • Author(s)
      樂木宏実
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山(招待講演)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cardiovascular continuumにおけるβ遮断薬の役割 : 高血圧の立場から2009

    • Author(s)
      樂木宏実
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] ガイドラインが目指す厳格な降圧とその対策2009

    • Author(s)
      樂木宏実
    • Organizer
      第94回日本循環器学会九州・四国合同地方会ランチョンセミナー
    • Place of Presentation
      高知
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Japanese evidence of hypertension : -lessons from CASE-J & HIJ-CREATE-2009

    • Author(s)
      樂木宏実
    • Organizer
      17th A sian Pacific Congress of Cardiolog
    • Place of Presentation
      京都
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Treatment of very elderly patients with arrhythmia : from the point of geriatric medicine2009

    • Author(s)
      樂木宏実
    • Organizer
      The 73rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2009 Annual Research Report
  • [Book] 高齢者の降圧目標と薬剤選択2012

    • Author(s)
      樂木宏実
    • Publisher
      日本医事神新報社
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Book] 高血圧2012

    • Author(s)
      樂木宏実
    • Publisher
      西村書店
    • Related Report
      2012 Final Research Report
  • [Book] 西村書店2012

    • Author(s)
      樂木宏実
    • Publisher
      高血圧
    • Related Report
      2012 Annual Research Report
  • [Book] アンジオテンシン変換酵素(ACE)、内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Related Report
      2012 Final Research Report
  • [Book] 高血圧治療ガイドラインと内分泌性高血圧、内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Related Report
      2012 Final Research Report
  • [Book] 低カリウムを伴う高血圧の鑑別診断、内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Related Report
      2012 Final Research Report
  • [Book] 内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Publisher
      アンジオテンシン変換酵素(ACE)
    • Related Report
      2010 Annual Research Report
  • [Book] 内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Publisher
      高血圧治療ガイドラインと内分泌性高血圧
    • Related Report
      2010 Annual Research Report
  • [Book] 内分泌性高血圧診療マニュアル2010

    • Author(s)
      樂木宏実
    • Publisher
      低カリウムを伴う高血圧の鑑別診断
    • Related Report
      2010 Annual Research Report
  • [Book] 本態性高血圧、「2009今日の治療指針」2010

    • Author(s)
      樂木宏実
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/geriat/www/index_g.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/geriat/www/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/geriat/www/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

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