|Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
We found that the expression of Apoptogenic Protein (Apop) is implicated in oxidative stress production and senescence of cells. In addition, we found that Apop expression affected the activation of mitochondrial metabolism. Apop gene inhibition enhance fatty acid metabolism, and improved serum cholesterol level and body weight. Therefore, Apop could be to a novel therapeutic target for the treatment of dyslipidemia and obesity.