Biomarker using 3TMRI for application of rtPA therapy in patients with brain infarction
| Project/Area Number |
21390346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HARADA Masahumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20228654)
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| Co-Investigator(Kenkyū-buntansha) |
KAJI Ryuji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00214304)
NAGAHIRO Shinji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60145315)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Hitoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00325292)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 脳卒中 / バイオマーカー / 血栓溶解療法 / 脳梗塞 / 脳灌流 / 拡散強調像 / ASL法 / 一過性脳虚血発作 / 危険因子 / MRI / バイオマーカ / stroke / T2*-WI / infarction / 3 Tesla / hemorrahge |
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| Research Abstract |
To compare the cerebral blood flow(CBF) obtained by pulsed-continuous arterial spin labeling(ASL) technique and Iodine-123-N-isopropyl-p-iodoamphetamin(IMP) single-photon-emission CT using 3DSRT that is operator' s bias free automatically ROI setting software on the anatomical regions of brain. Fifteen patients with cerebrovascular occlusive disease underwent ASL and IMP imaging. We compare rCBF values of each anatomically regions and calculated the correlation coefficients between ASL and IMP. Moreover, the Asymmetry Index(AI) was calculated using ROIs of ambilateral regions of hemispheres as follows : 100×{(left-right)/(left+ right)}. The rCBF in most of segments indicated comparable values both ASL and IMP. However, rCBF in thalamus and hippocampus obtained by ASL were significantly higher than that of IMP(P<0. 0001 and P=0. 0009). Furthermore, rCBF in white matter obtained by ASL were significantly lower than that of IMP(P=0. 0074). The calculated AI had significant relationships between both methods(r=0. 80, p<0. 0001). However, AI of ASL were tended to higher than IMP. The rCBF obtained by ASL had positively relationships with IMP. However, it should be considered that ASL has tendency of low relationships with IMP in some normal regions and affected regions with cerebrovascular occlusive disease.
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Report
(4 results)
Research Products
(14 results)
