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Study of the correlation between disseminated cancer cells and host factors in establishment of recurrence and metastasis of hepatocellular carcinoma

Research Project

Project/Area Number 21390369
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHokkaido University

Principal Investigator

KAMIYAMA Toshiya  北海道大学, 大学院・医学研究科, 准教授 (80322816)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Kazuaki  北海道大学, 大学院・医学研究科, 特任助教 (80374338)
YOKOO Hideki  北海道大学, 北海道大学病院, 医員 (70399947)
TAHARA Munenori  北海道大学, 北海道大学病院, 医員 (30306576)
TODO Satoru  北海道大学, 大学院・医学研究科, 特任教授 (60136463)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywords遊離癌細胞 / 癌幹細胞 / CD133 / 肝細胞癌 / 大腸癌 / AFPmRNA / VEGFR1mRNA
Research Abstract

Cytoplasmic expression of CD133 in HCC is associated with elevated serum AFP level, histologically high-grade tumor, and tumor invasion to the major branch of the portal vein. Positive cytoplasmic expression of CD133 represented the risk of poor prognosis. CD133 overexpression was an independent prognostic factor for PS of colorectal cancer (CRC) patients. Evaluation of the frequency and pattern of CD133 expression is useful for predicting prognosis, recurrence, and chemosensitivity in CRC patients. We found a significant tendency for patients who were positive for BM-AFP mRNA to experience recurrence within 1 year after surgery compared to those negative for BM-AFP mRNA. The BM-VEGFR-1 mRNA level of all HCC patients was higher than that of normal controls and the PH-VEGFR-1 mRNA level of almost all patients was higher that of normal controls. The classification by BM-VEGFR-1 mRNA/BM-AFP mRNA was a significant risk factor for recurrence within 1 year after surgery. The importance of the coexistence of disseminated cancer cells and VEGFR-1-positive hematopoietic bone marrow progenitor cells was also proved because the DFS curve of patients negative for BM-AFP mRNA and BM-VEGFR-1 mRNA ; low was better in the other 3 groups. The evaluation of BM-AFP and BM-VEGFR-1 mRNA in patients with HCC may be a valuable predictor of disease recurrence following curative resection.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (13 results)

  • [Journal Article] alpha-Fetoprotein, vascular endothelial growth factor receptor-1 and early recurrence of hepatoma2012

    • Author(s)
      Toshiya Kamiyama, Masato Takahashi, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Nozomi Kobayashi, Michitaka Ozaki, Satoru Todo
    • Journal Title

      World Journal of Gastrenterology

      Volume: 18(4) Issue: 4 Pages: 340-348

    • DOI

      10.3748/wjg.v18.i4.340

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of Using Ultrasonically Activated Scalpel in Combination with Radiofrequency Dissecting Sealer or Irrigation Bipolar for Hepatic Resection2012

    • Author(s)
      Hideki Yokoo, Toshiya Kamiyama, Kazuaki Nakanishi, Munenori Tahara : Daisuke Fukumori, Hirofumi Kamachi, Michiaki Matsushita, Satoru Todo
    • Journal Title

      Hepatogastroenterology

      Volume: 59(115) Pages: 831-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between Diffusion-Weighted Magnetic Resonance Imaging and Histological Tumor Grading of Hepatocellular Carcinoma2012

    • Author(s)
      Nakanishi M, Chuma M, Hige S, Omatsu T, Yokoo H, Nakanishi K, Kamiyama T, Kubota K, Haga H, Matsuno Y, Onodera Y, Kato M, Asaka M.
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Issue: 4 Pages: 1302-1309

    • DOI

      10.1245/s10434-011-2066-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] rm outcome of laparoscopic hepatectomy in patients with hepatocellular ca2012

    • Author(s)
      Kamiyama T
    • Journal Title

      Hepato-Gastroenterology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the risk factors for hyperbilirubinemia after hepatectomy2011

    • Author(s)
      Daisuke Fukumori, Toshiya Kamiyama, Kazuaki Nakanishi, Hideki okoo, Munenori Tahara, Hirofumi Kamachi, Michiaki Matsushita, Satoru Todo
    • Journal Title

      Hepatobiliary Pancreat Sci

      Volume: 18(5) Issue: 5 Pages: 724-30

    • DOI

      10.1007/s00534-011-0394-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-expression of Mesothelin and CA125 Correlates with Unfavorable Patient Outcome in Pancreatic Ductal Adenocarcinoma2011

    • Author(s)
      Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Takahashi K, Sasaki A, Tahara M, Okada K, Muraoka S, Kamiyama T, matsuno Y, Ozaki M, Todo S
    • Journal Title

      Pancreas

      Volume: 40(8) Issue: 8 Pages: 1276-82

    • DOI

      10.1097/mpa.0b013e318221bed8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological significance of nuclear factor -□B activation in hepatocellular carcinoma. Constitutive activation of NF-□B in advanced HCC2011

    • Author(s)
      Hideki Yokoo, Jun Yasuda, Kazuaki Nakanishi1, Makoto Chuma, Toshiya Kamiyama, Satoru Todo, Setsuo Hirohashi, and Michiie Sakamoto
    • Journal Title

      HepatologyResearch

      Volume: 41(3) Issue: 3 Pages: 240-249

    • DOI

      10.1111/j.1872-034x.2010.00758.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver transplantation for hepatocellular carcinoma : the Japanese experience.2010

    • Author(s)
      Furukawa H, Shimamura T, Suzuki T, Taniguchi M, Nakanishi K, Yamashita K, Kamiyama T, Matsushita M, Todo S
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17(5) Issue: 5 Pages: 533-8

    • DOI

      10.1007/s00534-009-0168-5

    • NAID

      10027662898

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The impact of anatomical resection for hepatocellular carcinoma that meets the milan criteria2010

    • Author(s)
      Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Matsushita M, Todo S
    • Journal Title

      J Surg Oncol

      Volume: 101(1) Issue: 1 Pages: 54-60

    • DOI

      10.1002/jso.21414

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma2010

    • Author(s)
      Sasaki A, Kamiyama T, Yokoo H, Nakanishi K, Kubota K, Haga H, Matsushita M, Ozaki M, Matsuno Y, Todo S.
    • Journal Title

      Oncol Rep

      Volume: 24(2) Issue: 2 Pages: 537-46

    • DOI

      10.3892/or_00000890

    • NAID

      120003207584

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity : Analysis of 793 Consecutive Cases in a Single Institution.2010

    • Author(s)
      Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Yamashita K, Taniguchi M, Shimamura T, Matsushita M, Todo S
    • Journal Title

      J Am Coll Surg

      Volume: 211(4) Issue: 4 Pages: 443-9

    • DOI

      10.1016/j.jamcollsurg.2010.06.005

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients2010

    • Author(s)
      Takahashi S, Kamiyama T, Tomaru U, Ishizu A, Shida T, Osaka M, Sato Y, Saji Y, Ozaki M, Todo S
    • Journal Title

      Oncol Rep

      Volume: 24(5) Issue: 5 Pages: 1201-12

    • DOI

      10.3892/or_00000973

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma2010

    • Author(s)
      Sasaki A, Kamiyama T, et al
    • Journal Title

      Oncol Rep.

      Volume: 24 Pages: 537-546

    • NAID

      120003207584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer2010

    • Author(s)
      Takahashi S, Kamiyama T, et al
    • Journal Title

      Oncol Rep.

      Volume: 24 Pages: 1201-12

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of anatomical resection for hepatocellular carcinoma that meets the milan criteria.2010

    • Author(s)
      T.Kamiyama
    • Journal Title

      J Surg Oncol. 101

      Pages: 54-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence patterns after hepatectomy of hepatocellular carcinoma : implication of milan criteria utilization.2009

    • Author(s)
      Kamiyam T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Suzuki T, Shimamura T, Furukawa H, Matsushita M, Todo S
    • Journal Title

      Ann Surg Oncol

      Volume: 16(6) Issue: 6 Pages: 1560-71

    • DOI

      10.1245/s10434-009-0407-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma2009

    • Author(s)
      Chuma M, Hige S, Kamiyama T, Meguro T, Nagasaka A, Nakanishi K, Yamamoto Y, Nakanishi M, Kohara T, Sho T, Yamamoto K, Horimoto H, Kobayashi T, Yokoo H, Matsushita M, Todo S, Asaka M
    • Journal Title

      J Gastroenterol

      Volume: 44(9) Issue: 9 Pages: 991-9

    • DOI

      10.1007/s00535-009-0093-z

    • NAID

      10025581551

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence patterns after hepatectomy of hepatocellular carcinoma : implication of milan criteria utilization.2009

    • Author(s)
      T.Kamiyama
    • Journal Title

      Ann Surg Oncol. 16

      Pages: 1560-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of laparoscopic hepatectomy in patients with hepatocellular carcinoma

    • Author(s)
      Toshiya Kamiyama , Munenori Tahara, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Tatsuhiko Kakisaka, Yosuke Tsuruga, Michiaki Matsushita, Satoru Todo
    • Journal Title

      Hepato-Gastroenterology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] ION WITHIN 1 YEAR AFTER HEPATECTOMY FOR THE PATIENTS WITH HEPATOCELLULAR2012

    • Author(s)
      Kmiyama T
    • Organizer
      American Hepato-Pancreato-Biliary Association Annual Meeting
    • Place of Presentation
      Eden Roc Renaissance Resort (USA)
    • Year and Date
      2012-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再発肝細胞癌への治療戦略Salvage肝移植を考慮して2011

    • Author(s)
      神山俊哉、中西一彰、横尾英樹、蒲池浩文、田原宗徳、柿坂達彦、小丹枝裕二、山下健一郎、谷口雅彦、鈴木知己、嶋村剛、古川博之、松下通明、藤堂省
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Final Research Report
  • [Presentation] ANALYZE OF THE RISK FACTORS OF DEATH FROM CANCER PROGRESSION WITHIN 1 YEAR AFTER HEPATECTOMY FOR THE PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC)2011

    • Author(s)
      T. Kamiyama
    • Organizer
      Annual meeting American Hepato-Pancreato-Biliary Association Miami Beach
    • Place of Presentation
      Eden Roc
    • Related Report
      2011 Final Research Report
  • [Presentation] AFPmRNA and VEGFR1mRNA detacted in bone marrow by real time PCR relate early recurrence after curative hepatectomy for hapetocellular carcinoma2011

    • Author(s)
      Kamiyama T
    • Organizer
      The International Liver Cancer Association Fourth Annual Conference
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] 発現頻度・発現パターンから見た大腸癌における癌幹細胞マーカーCD133の臨床的意義についての検討2010

    • Author(s)
      高橋周作,神山俊哉,島田信吾,工藤岳秋,廣瀬邦弘,佐治裕,崎浜秀康,尾崎倫孝,外丸詩野,石津明洋,藤堂省
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌におけるCD133発現の臨床病理学的意義2010

    • Author(s)
      佐々木彩実,神山俊哉,横尾英樹,中西一彰,久保田佳奈子,羽賀博典,松下通明,尾崎倫孝,松野吉宏,藤堂省
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma.2010

    • Author(s)
      Sasaki A, Kamiyama T
    • Organizer
      The International Liver Cancer Association Fourth Annual Conference
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝細胞癌切除後再発への治療戦略-salvage肝移植を考慮して-2010

    • Author(s)
      神山俊哉、中西一彰、横尾英樹、蒲池浩文、田原宗徳、福森大介、山下健一郎、谷口雅彦、鈴木知己、嶋村剛、古川博之、松下通明、藤堂省
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      海峡メッセ下関
    • Related Report
      2011 Final Research Report
  • [Presentation] 1年以内に癌死する肝細胞癌症例の検討2010

    • Author(s)
      神山俊哉、中西一彰、横尾英樹、蒲池浩文、谷口雅彦、田原宗徳、柿坂達彦、松下通明、藤堂省
    • Organizer
      第72回日本臨床外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] AFPMRNA AND VEGFR-1IMRNA DETECTED IN BONE MARROW BY REAL-TIME QUANTITATIVE RT-PCR RELATE EARLY RECURRENCE AFTER CURATIVE HEPATECTOMY2010

    • Author(s)
      Kamiyama T
    • Organizer
      International Liver Cancer Association Fourth Annual Conference
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] The efficacy of anatomical resection forhepatocellular carcinoma within the Milan criteria2009

    • Author(s)
      Toshiya Kamiyama
    • Organizer
      2009 Annual meeting American Hepato-Pancreato-Biliary Association Miami Beach
    • Place of Presentation
      Eden Roc
    • Related Report
      2011 Final Research Report
  • [Presentation] 大腸癌症例におけるCD133の発現と臨床的意義2009

    • Author(s)
      高橋周作,神山俊哉,外丸詩野,工藤岳明,旭火華,広瀬邦弘,佐治裕,崎浜秀康,片岡昭彦,藤堂省
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 大腸癌切除症例におけるCD133陽性細胞の臨床病理学的意義2009

    • Author(s)
      高橋周作
    • Organizer
      第64回日本消化器外科学会定期学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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