Developmental research on novel brain tumor therapy using recombinant oncolytic herpes viruses
| Project/Area Number |
21390404
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TODO Tomoki 東京大学, 医学部附属病院, 教授 (80272566)
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| Co-Investigator(Renkei-kenkyūsha) |
INO Yasushi 東京大学, 医科学研究所, 准教授 (50372371)
FUKUHARA Hiroshi 東京大学, 医学部附属病院, 講師 (20292948)
TANAKA Minoru 東京大学, 医科学研究所, 特任講師 (50332581)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 脳腫瘍 / ウイルス療法 / 単純ヘルペスウイルスI型 / ウイルスベクター / 腫瘍免疫 |
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| Research Abstract |
We performed a developmental research on recombinant oncolytic viruses that possess certain antitumor functions and are useful for brain tumor therapy. A third-generation oncolytic herpes simplex virus type 1(G47.) was used as the backbone to insert foreign sequences. Oncolytic viruses that express immune-stimulatory factors or luciferase, or that use tumor-specific promoters, were constructed and evaluated, and proved to be highly useful. G47. is expected as a new drug for brain tumors in the near future, and a progress has been made in the basic development of next generation onoclytic virus therapy.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] NKX2. 2 suppresses self-renewal of glioma-initiating cells2011
Author(s)
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii H, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J
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Journal Title
Cancer Res
Volume: 71
Issue: 3
Pages: 1135-45
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009
Author(s)
Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T
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Journal Title
Neuro-Oncolog
Volume: Vol.11、No.2
Issue: 4
Pages: 446-451
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplast ic features by means of stereotactic irradiation.2009
Author(s)
Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R., Saito N, Todo T
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Journal Title
Neuro-Oncology 11(4)
Pages: 446-451
Related Report
Peer Reviewed
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