Development of new bioactive devices for neuroendovascular therapy
| Project/Area Number |
21390410
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Mie University |
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Principal Investigator |
TAKI Waro 三重大学, 大学院・医学系研究科, 教授 (70144368)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Satoshi 三重大学, 大学院・医学系研究科, 准教授 (50252367)
SAKAIDA Hiroshi 三重大学, 大学院・医学系研究科, 准教授 (40273362)
ASAKURA Fumio 三重大学, 医学部附属病院, 助教 (90322362)
TOMA Naoki 三重大学, 大学院・医学系研究科, 助教 (80362341)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 脳血管内外科学 / 医用工学 / デバイス / コイル / ステント / 脳血管内治療 / 生理活性物質 |
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| Research Abstract |
We developed new bioactive devices for neuroendovascular therapy. 1) Implantation of gellan sulfate core platinum coils with tenascin-C promoted organization of cavities and reduced lumen size in a rat aneurysm model. 2) We developed a novel stent graft consists of a single stent and nanofiber with the use of electros deposition. 3) Filter type embolic protection device for carotid artery stenting immersed into urokinase solution inhibited fibrin net formation and suppressed aggregation of platelets covering the filter membrane.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Development of nanofiber-covered stents using electrospinning : in vitro and acute phase in vivo experiments2009
Author(s)
Kuraishi K, Iwata H, Nakano S, Kubota S, Tonami H, Toda M, Toma N, Matsushima S, Hamada K, Ogawa S, Taki W
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: 88
Pages: 230-239
Related Report
Peer Reviewed
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[Journal Article] Development of nanofiber-covered stents using electrospinning : in vitro and acute phase in vivo experiments2009
Author(s)
Kuraishi K, Iwata H, Nakano S, Kubota S, Tonami H, Toda M, Toma N, Matsushima S, Hamada K, Ogawa S, Taki W.
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Journal Title
J Biomed Mater Res B Appl Biomater 88
Pages: 230-239
Related Report
Peer Reviewed
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[Presentation] Fabrication and Evaluation of Electrospun Polyurethane-Covered Stent for Treatment of Cerebral Aneurysm2009
Author(s)
H.Tonami, K.Hamada, H.Iwata, S.Nakano, S.Kubota, M.Toda, N.Toma, S.Matsushima, S.Ogawa, W.Taki
Organizer
The 6th International Intracranial Stent Meeting
Place of Presentation
Sendai, Japan
Related Report
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