Development of new bioactive devices for neuroendovascular therapy

• Project/Area Number: 21390410
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Mie University
• Principal Investigator: TAKI Waro 三重大学, 大学院・医学系研究科, 教授 (70144368)
• Co-Investigator(Kenkyū-buntansha): MATSUSHIMA Satoshi 三重大学, 大学院・医学系研究科, 准教授 (50252367) ; SAKAIDA Hiroshi 三重大学, 大学院・医学系研究科, 准教授 (40273362) ; ASAKURA Fumio 三重大学, 医学部附属病院, 助教 (90322362) ; TOMA Naoki 三重大学, 大学院・医学系研究科, 助教 (80362341)
• Co-Investigator(Renkei-kenkyūsha): IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 脳血管内外科学 / 医用工学 / デバイス / コイル / ステント / 脳血管内治療 / 生理活性物質

Research Abstract

We developed new bioactive devices for neuroendovascular therapy. 1) Implantation of gellan sulfate core platinum coils with tenascin-C promoted organization of cavities and reduced lumen size in a rat aneurysm model. 2) We developed a novel stent graft consists of a single stent and nanofiber with the use of electros deposition. 3) Filter type embolic protection device for carotid artery stenting immersed into urokinase solution inhibited fibrin net formation and suppressed aggregation of platelets covering the filter membrane.

Research Products

• [Journal Article] PRESAT group. Determinants of poor outcome after aneurysmal subarachnoid hemorrhage when both clipping and coiling are available : Prospective Registry of Subarachnoid Aneurysms Treatment(PRESAT) in Japan (2011)
  • Author(s): Taki W, Sakai N, Suzuki H
  • Journal Title: World Neurosurg Volume: 76 Pages: 437-445
  • Peer Reviewed
• [Journal Article] Factors predicting retreatment and residual aneurysms at 1 year after endovascular coiling for ruptured cerebral aneurysms : Prospective Registry of Subarachnoid Aneurysms Treatment(PRESAT) in Japan (2011)
  • Author(s): Taki W
  • Journal Title: Neuroradiology Volume: 23
  • Peer Reviewed
• [Journal Article] 血管内治療の技量の継承 (2011)
  • Author(s): 滝和郎
  • Journal Title: 脳神経外科ジャーナル Volume: 20 Pages: 513-516
  • Peer Reviewed
• [Journal Article] Simple immersion of filter devices into an urokinase solution prevents fibrin net formation during carotid artery stenting (2010)
  • Author(s): Hamada K, Matsushima S, Toma N, Totani T, Toda M, Ogawa S, Asakura F, Sakaida H, Iwata H, Taki W.
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: 95 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Memorial review celebrating the 50th year of publication of NMC-neuroendovascular therapy (2010)
  • Author(s): Taki W
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 50 Pages: 809-823
  • NAID: 10030693622
  • Peer Reviewed
• [Journal Article] Memorial review celebrating the 50th year of publication of NMC-neuroendovascular therapy. (2010)
  • Author(s): Taki W
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 50 Pages: 809-823
  • NAID: 10030693622
  • Peer Reviewed
• [Journal Article] Simple immersion of filter devices into an urokinase solution prevents fibrin net formation during carotid artery stenting. (2010)
  • Author(s): Hamada K, Matsushima S, Toma N, Totani T, Toda M, Ogawa S, Asakura F, Sakaida H, Iwata H. Taki W.
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: 95 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Development of nanofiber-covered stents using electrospinning : in vitro and acute phase in vivo experiments (2009)
  • Author(s): Kuraishi K, Iwata H, Nakano S, Kubota S, Tonami H, Toda M, Toma N, Matsushima S, Hamada K, Ogawa S, Taki W
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: 88 Pages: 230-239
  • Peer Reviewed
• [Journal Article] 脳血管内治療の過去・現在・未来 (2009)
  • Author(s): 滝和郎
  • Journal Title: 脳神経外科速報 Volume: 19 Pages: 364-373
• [Journal Article] 技量の継承.血管内治療の場合 (2009)
  • Author(s): 滝和郎
  • Journal Title: 脳卒中の外科 Volume: 37 Pages: 426-428
  • NAID: 10025951813
• [Journal Article] Development of nanofiber-covered stents using electrospinning : in vitro and acute phase in vivo experiments (2009)
  • Author(s): Kuraishi K, Iwata H, Nakano S, Kubota S, Tonami H, Toda M, Toma N, Matsushima S, Hamada K, Ogawa S, Taki W.
  • Journal Title: J Biomed Mater Res B Appl Biomater 88 Pages: 230-239
  • Peer Reviewed
• [Presentation] Electodeposition Polyurethane Covered Stentの開発 (2011)
  • Author(s): 濱田和秀,松島聡,外波弘之,倉石慶太,当麻直樹,小川覚,戸田満秋,岩田博夫,滝和郎
  • Organizer: 第26回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 千葉市
• [Presentation] 硫酸化ジェラン線維性素材を用いたBioactive Coilの開発研究 (2011)
  • Author(s): 松島聡、濱田和秀、種村浩、三浦洋一、当麻直樹、宮本啓一、今中-吉田恭子、吉田利通、滝和郎
  • Organizer: 第70回日本脳神経外科学会学術総会
  • Place of Presentation: 横浜市
• [Presentation] The present and future of carotid stenting (2011)
  • Author(s): Taki W
  • Organizer: 29th Annual Spring Meeting of the Korean Neurosurgical Society
  • Place of Presentation: Inchon
• [Presentation] Electodeposition Polyurethane Covered Stentの開発 (2011)
  • Author(s): 廣田和秀, 松島聡, 外波弘之, 倉石慶太, 当麻直樹, 小川覚, 戸田満秋, 岩田博夫, 滝和郎
  • Organizer: 第26回日本脳神経血管内治療学会学術総会
  • Place of Presentation: 幕張メッセ(千葉市)
• [Presentation] 硫酸化シェラン線維性素材を用いたBioactive Coilの開発研究 (2011)
  • Author(s): 松島聡、濱田和秀、種村浩、三浦洋一、当麻直樹、宮本啓一、今中-吉田恭子、吉田利通、滝和郎
  • Organizer: 第70回日本脳神経外科学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] The present and future of carotid stenting (2011)
  • Author(s): Taki W.
  • Organizer: 29th Annual Spring Meeting of the Korean Neurosurgical Society
  • Place of Presentation: Inchon, Korea(招待講演)
• [Presentation] Urokinase Coating Angioguard XP使用症例におけるslow flowの検討 (2009)
  • Author(s): 濱田和秀、当麻直樹、松島聡、朝倉文夫、阪井田博司、小川覚、戸谷貴彦、戸田満秋、岩田博夫、滝和郎
  • Organizer: 第10回近畿脳神経血管内治療学会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-09-12
• [Presentation] Gellan sulfate core platinum coils binding tenascin-Cの開発と血管内腔の器質化促進能の検討 (2009)
  • Author(s): 濱田和秀、当麻直樹、宮本啓一、今中-吉田恭子、吉田利通、松島聡、滝和郎
  • Organizer: 第25回日本脳神経血管内治療学会総会
  • Place of Presentation: 富山市
• [Presentation] 脳血管内治療用カバードステントの作製と評価 (2009)
  • Author(s): 外波弘之、濱田和秀、中野恵之、窪田真一郎、戸田満秋、当麻直樹、松島聡、滝和郎、岩田博夫
  • Organizer: 第31回日本バイオマテリアル学会大会
  • Place of Presentation: 京都市
• [Presentation] Fabrication and Evaluation of Electrospun Polyurethane-Covered Stent for Treatment of Cerebral Aneurysm (2009)
  • Author(s): Tonami H, Hamada K, Iwata H, Nakano S, Kubota S, Toda M, Toma N, Matsushima S, Ogawa S, Taki W
  • Organizer: 6th International Intracranial Stent Meeting
  • Place of Presentation: Sendai
• [Presentation] Urokinase Coating Angioguard XPの有用性についての検討 (2009)
  • Author(s): 濱田和秀、当麻直樹、松島聡、朝倉文夫、阪井田博司、畑崎聖二、佐藤裕、市川直巳、山道茜、小川覚、戸谷貴彦、戸田満秋、岩田博夫、滝和郎
  • Organizer: 第8回日本頚部脳血管治療学会
  • Place of Presentation: 北九州市
• [Presentation] Fabrication and Evaluation of Electrospun Polyurethane-Covered Stent for Treatment of Cerebral Aneurysm (2009)
  • Author(s): H.Tonami, K.Hamada, H.Iwata, S.Nakano, S.Kubota, M.Toda, N.Toma, S.Matsushima, S.Ogawa, W.Taki
  • Organizer: The 6th International Intracranial Stent Meeting
  • Place of Presentation: Sendai, Japan
• [Presentation] Gellan sulfate core platinum coils binding tenascin-Cの開発と血管内腔の器質化促進能の検討 (2009)
  • Author(s): 濱田和秀, 当麻直樹, 宮本啓一, 今中-吉田恭子, 吉田利通, 松島聡, 滝和郎
  • Organizer: 第25回日本脳神経血管内治療学会
  • Place of Presentation: 富山