Transplantation of iPS cell derived neural stem cells for spinal cord injury

• Project/Area Number: 21390426
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: NAKAMURA Masaya 慶應義塾大学, 医学部, 講師 (30217898)
• Co-Investigator(Kenkyū-buntansha): TOYAMA Yoshiaki 慶應義塾大学, 医学部, 教授 (40129549) ; 石井 賢 慶應義塾大学, 医学部, 講師 (00276289)
• Co-Investigator(Renkei-kenkyūsha): ISHII Ken 慶應義塾大学, 医学部, 講師 (00276289)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: 脊髄損傷 / 人工多能性幹細胞 / 移植 / 再生医療 / 細胞移植 / コモンマーモセット

Research Abstract

In the present study, we demonstrated that transplantation of mouse induced pluripotent stem cells(iPSC) derived neural stem/progenitor cells(NS/PCs) promoted functional recovery after spinal cord injury(SCI) in mice. Furthermore, transplantation of human iPSC-NS/PC also promoted functional recovery after SCI in NOD/scid mice as well as common marmosets without any tumor formation as long as pre-evaluated''safe" human iPSC-NS/PCs were used as a cell source. Pre-evaluated'safe' human iPSC-NS/PCs s may be a promising cell source for transplantation therapy for patients with SCI.

Research Products

• [Journal Article] Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells (2011)
  • Author(s): Tsuji O, Miura K, Fujiyoshi K, Momoshima S, Nakamura M, Okano H.
  • Journal Title: Neurotherapeutics Volume: 8 Pages: 668-676
  • Peer Reviewed
• [Journal Article] Toward using iPS cells to treat spinal cord injury : their safety and therapeutic efficacy (2011)
  • Author(s): Miura K, Tsuji O, Nakamura M, Okano H
  • Journal Title: Inflammation and Regeneration Volume: 31 Pages: 1-9
  • NAID: 130004943768
  • Peer Reviewed
• [Journal Article] Grafted human-induced pluripotent stem cell. derived neurospheres promote motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori S, Okada Y, Yasudaa A, Tsuji O, Takahashi Y, Kobayashia Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Journal Title: Pro Nat Acad Sci USA Volume: 108 Pages: 16825-16830
  • Peer Reviewed
• [Journal Article] Significance of re-myelination by neural stem/progenitor cells transplanted into the injured spinal cord (2011)
  • Author(s): Yasuda A, Tsuji O, Shibata S, Nori S, Takano M, Kobayashi Y, Takahashi Y, Fujiyoshi K, Miyauchi Hara C, Miyawaki A, Okano JH, Toyama Y, Nakamura M, Okano H
  • Journal Title: Stem Cells Volume: 29 Pages: 1983-1994
  • Peer Reviewed
• [Journal Article] Comparative study of methods for administering neural stem/progenitor cells to treat spinal cord injury in mice (2011)
  • Author(s): TakahashiY, Tsuji O, KumagaiG, Miyauchi Hara C, Okano JH, Miyawaki A, Toyama Y, Okano H, NakamuraM
  • Journal Title: Cell Transplant Volume: 20 Pages: 727-739
  • Peer Reviewed
• [Journal Article] Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cellsg (2011)
  • Author(s): Nakamura M, Tsuji O, Bregman BS, Toyama Y, Okano H
  • Journal Title: PLos ONE Volume: e20717 Issue: 6 Pages: 6-6
  • DOI: 10.1371/journal.pone.0020717
  • Peer Reviewed
• [Journal Article] Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition (2011)
  • Author(s): Renault-Mihara F, Toyama Y, Nakamura M, Okano H
  • Journal Title: EMBO Molecular Medicine Volume: 3(11) Pages: 682-69
  • Peer Reviewed
• [Journal Article] Significance of Re-myelination by Neural Stem/Progenitor Cells Transplanted Into the Injured Spinal Cord (2011)
  • Author(s): Yasuda A, Tsuji O, Nakamura M (co-correspondence), Okano H
  • Journal Title: Stem Cells Volume: 29(12) Pages: 1983-1994
  • Peer Reviewed
• [Journal Article] The dual origin of the peripheral olfactory system : placode and neural crest (2011)
  • Author(s): Katoh H, Toyama Y, Nakamura M, Okano H
  • Journal Title: Molecular Brain Volume: 23 Pages: 34-34
  • Peer Reviewed
• [Journal Article] Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori S, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Journal Title: PNAS Volume: 108 Pages: 16825-16830
  • Peer Reviewed
• [Journal Article] Transplantation of human neural stem/progenitor cells overexpressing Galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil (2011)
  • Author(s): Yamane J, Kanemura Y, Nakamura M, Toyama Y, Mizusawa H, Okano H
  • Journal Title: Molecular Brain Volume: 27 Pages: 35-35
  • Peer Reviewed
• [Journal Article] Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury (2011)
  • Author(s): Kitamura K, Aoki M, Toyama Y, Okano H, Nakamura M
  • Journal Title: PLos One Volume: 6(11)
  • Peer Reviewed
• [Journal Article] Toward using iPS cells to treat spinal cord injury : their safety and ther apeutic efficacy (2011)
  • Author(s): Miura K, Tsuji O, Nakamura M, Okano H
  • Journal Title: Inflammation and Regeneration Volume: 31 Pages: 1-9
  • NAID: 130004943768
  • Peer Reviewed
• [Journal Article] Ce ll therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells (2011)
  • Author(s): Tsuji O, Miura K, Fujiyoshi K, Nakamura M, Okano H
  • Journal Title: Neurotherapeutics Volume: 8(4) Pages: 668-676
  • Peer Reviewed
• [Journal Article] Transplantation of Galectin-1-Expressing Human Neural Stem Cells into the Injured Spinal Cord of Adult Common Marmosets (2010)
  • Author(s): Yamane J, Nakamura M, Iwanami A, Sakaguchi M, Katoh H, Yamada M, Momoshima S, Miyao S, Ishii K, Tamaoki N, Nomura T, Okano HJ, Kanemura Y, Toyama Y, Okano H
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1394-1405
  • Peer Reviewed
• [Journal Article] Therapeutic potential of appropriately evaluated 'safe' induced pluripotent stem cells for spinal cord injury (2010)
  • Author(s): Tsuji O, Miura K, Okada Y, Fujiyoshi K, Mukaino M, Nagoshi N, Kitamura K, KumagaiG, NishinoM, Tomisato S, Higashi H, NagaiT, Katoh H, Kohda K, MatsuzakiY, YuzakiM, IkedaE, ToyamaY, NakamuraM, Yamanaka S, Okano H.
  • Journal Title: Pro Nat Acad Sci USA Volume: 107 Pages: 12704-12709
  • Peer Reviewed
• [Journal Article] Transplantation of Galectin-1-Expressing Human Neural Stem Cells into the Injured Spinal Cord of Adult Common Marmosets. (2010)
  • Author(s): Yamane J, Nakamura M, Toyama Y, Okano H, et al.
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1394-1405
  • Peer Reviewed
• [Journal Article] Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. (2010)
  • Author(s): Mukaino M, Nakamura M, Liu M, Okano H, et al.
  • Journal Title: Exp Neurol Volume: 224(2) Pages: 403-414
  • Peer Reviewed
• [Journal Article] Therapeutic potential of appropriately evaluated 'safe' induced pluripotent stem cells for spinal cord injury. (2010)
  • Author(s): Tsuji O, Nakamura M, Yamanaka S, Okano H, et al.
  • Journal Title: Pro Nat Acad Sci USA Volume: 13;107(28) Pages: 12704-12709
  • Peer Reviewed
• [Journal Article] Sox10-Venus mice : a new tool for real-time labeling of neural crest line age cells and oligodendrocytes. (2010)
  • Author(s): Shibata S, Yasuda A, Nakamura M, Akazawa C, Okano H, et al.
  • Journal Title: Mol Brain Volume: 31 Pages: 3-31
  • Peer Reviewed
• [Journal Article] Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice. (2010)
  • Author(s): Shinozaki M, Nakamura M, et al
  • Journal Title: J Biomed Bitech Volume: Article ID157458 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Regenerative medicine for spinal cord injury : Current status and open issues (2009)
  • Author(s): Nakamura M, Nagoshi N, Fujiyoshi K, Kaneko S, Toyama Y, Okano H.
  • Journal Title: Inflammation and Regeneration Volume: 29 Pages: 198-203
  • NAID: 10025625261
  • Peer Reviewed
• [Journal Article] Visualizing for Peripheral Nerve Degeneration and Regeneration : Monitoring with Diffusion Tensor Tractography (2009)
  • Author(s): Takagi T, Nakamura M, Yamada M, et al.
  • Journal Title: Neuroimage 44 Pages: 884-892
  • Peer Reviewed
• [Journal Article] Evaluation of human fetal neural stem/progenitor cells as cell sources for cell replacement therapy for neurological disorders : their property change after long in vitro maintenance and long-term tumorigenicity in vivo (2009)
  • Author(s): Ogawa D, Okada Y, Nakamura M, Shimazaki T, et al.
  • Journal Title: J Neurosci Res 87 Pages: 855-864
  • Peer Reviewed
• [Journal Article] Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset (2009)
  • Author(s): Yaguchi M, Tabuse M, Nakamura M, et al.
  • Journal Title: Neurosci Res 65 Pages: 384-392
  • Peer Reviewed
• [Journal Article] Okano H.Roles of ES Cell-Derived Gliogenic Neural Stem/Progenitor Cells in Functional Recovery after Spinal CordInjury (2009)
  • Author(s): KumagaiG, Okada Y.Yamane J, Nakamura M, et al.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Physiological signinficance of astrogliosis after CNS injury (2009)
  • Author(s): Okada S, Nakamra M, Saiwai H, et al.
  • Journal Title: Inflammationand Regeneration. 29 Pages: 35-39
  • Peer Reviewed
• [Journal Article] Neural crest-derived stem cells display a wide variety ofcharacteristics (2009)
  • Author(s): Nagoshi N, Shibata S, Nakamura M, Matsuzaki Y, et al.
  • Journal Title: Journal of Cellular Biochemistry 107 Pages: 1046-1052
  • Peer Reviewed
• [Presentation] Therapeutic potential of appropriately evaluated 'safe' induced pluripotent stem cells for spinal cord injury (2011)
  • Author(s): Tsuji O, Fujiyoshi K, Miura K, Matsumoto M, Chiba K, Toyama Y, Yamanaka S, Okano H, Nakamura M
  • Organizer: Cervical Spine Research Society 38^<th> Annual Meeting
  • Place of Presentation: Arizona, USA
• [Presentation] Transplantation of human iPSC-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: Cervical Spine Research Society 38^<th> Annual Meeting
  • Place of Presentation: Arizona, USA
• [Presentation] Pre-evaluated safe human iPS clone derived neural stem cells promoted functional recovery after spinal cord injury without tumorigenicity in adult common marmosets (2011)
  • Author(s): Kobayashi Y, Okada Y, Iwai H, Nishimura S, Nori S, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Yamanaka S, Okano H, Nakamura M
  • Organizer: Cervical Spine Research Society 38^<th> Annual Meeting, oral presentation
  • Place of Presentation: Arizona, USA
• [Presentation] Pre-evaluated safe human iPSC-derived neurospheres promote functional recovery after spinal cord injury without tumorigenecity in adult common marmosets (2011)
  • Author(s): Kobayashi Y, Okada Y, Iwai H, Nishimura S, Nori S, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Yamanaka S, Nakamura M, Okano H.
  • Organizer: 41^<st> Annual meeting Neuroscience 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Transplantation of human iPSC-derived neurospheres promote motor functional recovery after spinal cord injury (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: NOD-scid mice41^<st> Annual meeting Neuroscience 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Pre-evaluated safe human iPS clone derived neural stem cells promoted functional recovery after spinal cord injury without tumorigenecity in adult common marmosets (2011)
  • Author(s): Kobayashi Y, Okada Y, Iwai H, Nishimura S, Nori S, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: ISSCR 2011
  • Place of Presentation: Toronto, Canada
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in nod-scid mice (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: ISSCR 2011
  • Place of Presentation: Toronto, Canada
• [Presentation] Transplantation of human iPSC-derived neurospheres promote motor functional recovery after spinal cord injury in NOD-scid mice (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: 41^<st> Annual meeting Neuroscience 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Efficient derivation of neural stem cells from common marmoset ES cells and iPS cells (2011)
  • Author(s): Shimada H, Okada Y, Tomioka I, Sasaki E, Nakamura M, Okano H
  • Organizer: 41^<st> Annual meeting Neuroscience 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] Therapeutic potential of appropriately evaluated 'safe' induced pluripotent stem cells for spinal cord injury (2011)
  • Author(s): Tsuji O, Fujiyoshi K, Miura K, Matsumoto M, Chiba K, Toyama Y, Yamanaka S, Okano H, Nakamura M
  • Organizer: CSRS 39^<th> Annual meeting
  • Place of Presentation: Arizona, USA
• [Presentation] Transplantation of human iPSC-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: CSRS 39^<th> Annual meeting
  • Place of Presentation: Arizona, USA
• [Presentation] Pre-evaluated safe human iPS clone derived neural stem cells promoted functional recovery after spinal cord injury without tumorigenicity in adult common marmosets (2011)
  • Author(s): Kobayashi Y, Okada Y, Iwai H, Nishimura S, Nori S, Konomi T, Fujiyoshi K, Tsuji O, Toyama Y, Yamanaka S, Okano H, Nakamura M
  • Organizer: CSRS 39^<th> Annual meeting
  • Place of Presentation: Arizona, USA
• [Presentation] 免疫不全マウス脊髄損傷に対するヒトips細胞由来神経幹細胞移植の検討 (2010)
  • Author(s): 海苔聡, 岡田洋平, 辻収彦, 中村雅也, 他
  • Organizer: 第6回慶應義塾先端科学技術シンポジウム 第4回 人間知性研究センターシンポジウム こころを生み出す神経基盤の解明
  • Place of Presentation: 東京
  • Year and Date: 2010-01-26
• [Presentation] 脊髄損傷において再髄鞘化が及ぼす影響の検討―脊髄損傷に対して神経幹細胞移植療法で得られる行動機能回復メカニズムの解析―.GCOE共催シンポジウム「こころを生み出す神経基盤の解明」 (2010)
  • Author(s): 安田明正, 辻収彦, 中村雅也, 他
  • Organizer: 第6回慶應義塾先端科学技術シンポジウム 第4回人間知性研究センターシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2010-01-26
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2010)
  • Author(s): Nori S, Okada Y, Tsuji O, Takahashi Y, Fujiyoshi K, Yasuda A, Kobayashi Y, Toyama Y, Yamanaka S, Nakamura M, Okano H.
  • Organizer: 40^<th> Annual meeting Neuroscience 2010
  • Place of Presentation: San Diego
• [Presentation] Therapeutic potential of appropriately evaluated 'safe' induced pluripotent stem cells for spinal cord injury (2010)
  • Author(s): Tsuji O, Miura K, Okada Y, Fujiyoshi K, Matsumoto M, Chiba K, Yamanaka S, Toyama Y, Nakamura M, Okano H
  • Organizer: 40^<th> Annual meeting Neuroscience
  • Place of Presentation: San Diego
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2010)
  • Author(s): Nori S, Okada Y, Tsuji O, Takahashi Y, Fujiyoshi K, Yasuda A, Kobayashi Y, Toyama Y, Yamanaka S, Nakamura M, Okano H.
  • Organizer: Neuro2010
  • Place of Presentation: Kobe
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice. GCOE幹細胞医学のための教育拠点成果報告シンポジウム (2010)
  • Author(s): Nori S, Okada Y, Tsuji O, Takahashi Y, Fujiyoshi K, Yasuda A, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: Global COE Program Symposium 2010 Education and Research Center for Stem Cell Medicine
  • Place of Presentation: 日慶應義塾大学信濃町キャンパス
• [Presentation] Myelin map after graded spinal cord injury in adult common marmosets. (2010)
  • Author(s): Konomi T, Nakamura M, Okano H, et al.
  • Organizer: 40th Annual meeting Neuroscience 2010
  • Place of Presentation: San Diego, California, USA
• [Presentation] Myelin MR map depict demyelination and remyelination after chemical spinal cord injury in common marmosets (2010)
  • Author(s): Kanehiro Fujiyoshi, Masaya Nakamura, et al.
  • Organizer: 40th Annual meeting Neuroscience 2010
  • Place of Presentation: San Diego, California, USA
• [Presentation] 損傷脊髄における自己修復機構-内在性シュワン細胞の寄与- (2010)
  • Author(s): 名越慈人, 芝田晋介, 中村雅也, 他
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2010)
  • Author(s): 海苔聡, 岡田洋平, 中村雅也, et al
  • Organizer: GCOE幹細胞医学のための教育拠点 成果報告シンポジウム Global COE Program Symposium 2010 Education and Research Center for Stem Cell Medicine
  • Place of Presentation: 東京
• [Presentation] Transplantation of human iPS cell-derived neurospheres into injured spinal cord of NOD-scid mice (2009)
  • Author(s): 海苔聡, 岡田洋平, 中村雅也
  • Organizer: Neuroscience meeting
  • Place of Presentation: Lake Shore Drive Chicago, IL
  • Year and Date: 2009-10-20
• [Presentation] Therapeutic effect of pre-evaluated 'safe' iPS derived neurospheres for spinal cord injury (2009)
  • Author(s): Tsuji O, Miura K, Fujiyoshi K, Chiba K, Yamanaka S, Okano H, MD, Toyama Y, Nakamura M
  • Organizer: Cervical Spine Research Society 37^<th> Annual Meeting, oral presentation
  • Place of Presentation: East Lancaster, USA
• [Presentation] Transplantation of human iPS cell-derived neurospheres into injured spinal cord of NOD-scid mice (2009)
  • Author(s): Nori S, Okada Y, Tsuji O, Takahashi Y, Fujiyoshi K, Yasuda A, Shimada H, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Transplantation of human iPS cell-derived neurospheres for the treatment of spinal cord injury in NOD-scid mice (2009)
  • Author(s): 海苔聡, 岡田洋平, 中村雅也, et al
  • Organizer: 第7回幹細胞シンポジウム
  • Place of Presentation: 東京
• [Presentation] マウス脊髄損傷における Glycogen synthase kinase-3β の抑制は軸索再生と運動機能の改善を促進する (2009)
  • Author(s): 池上健, 岩波明生, 加藤裕幸, 中村雅也, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 神奈川
• [Presentation] 免疫不全マウス脊髄損傷に対するヒトiPS細胞由来神経幹細胞移植の検討 (2009)
  • Author(s): 海苔聡, 辻収彦, 岡田洋平, 中村雅也, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 神奈川
• [Presentation] Elucidation of mechanism of functional recovery after transplantation of NSPCs to SCI. (2009)
  • Author(s): 安田明正, 辻収彦, 中村雅也, 他
  • Organizer: 第7回幹細胞シンポジウム
  • Place of Presentation: 東京
• [Presentation] 損傷脊髄に対する神経堤由来細胞の寄与 (2009)
  • Author(s): 名越慈人, 芝田晋介, 中村雅也, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 神奈川
• [Presentation] Schwann cell plasticity after spinal cord injury shown by neural crestlineage tracing (2009)
  • Author(s): Nagoshi N, Nakamura M, Shibato S, et al
  • Organizer: Cervical Spine Research Society 37th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
• [Presentation] Elucidation of mechanism of functional recovery after transplantation of NSPCs to SCI. (2009)
  • Author(s): Yasuda A, Tsuji O, Nori S, Nakamura M, et al
  • Organizer: Neuroscience meeting 2009
  • Place of Presentation: Chicago, IL, USA