| Project/Area Number |
21390452
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
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| Co-Investigator(Kenkyū-buntansha) |
MANDAI Masaki 京都大学, 医学研究科, 講師 (80283597)
MATSUMURA Noriomi 京都大学, 医学研究科, 助教 (20452336)
SUZUKI Ayako 京都大学, 医学研究科, 助教 (90378696)
BABA Tsukasa 京都大学, 医学研究科, 助教 (60508240)
八木 治彦 京都大学, 医学研究科, 助教 (70402857)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / 播種性転移 / 腫瘍免疫 / TGF-beta経路 / エピジェネティクス / TGFβ / マイクロアレイ / メチル化 / 低分子化合物 |
|---|
| Research Abstract |
1) Treatment of 39 ovarian cancer cell lines and 17 primary culture samples with the inhibitor of DNA methylation, followed by expression microarray, identified genes targeted by DNA methylation in ovarian cancer. This analysis revealed TGF-beta signaling pathway is regulated by genome-wide DNA methylation. 2) We found TGF-beta pathway activity is upregulated in the omental metastases of ovarian cancer. Then we demonstrated the inhibitor of TGF-beta signaling pathway is effective against disseminated metastasis of ovarian cancer using a mouse model. 3) We found expression of PDL-1 in ovarian cancer cells suppresses activity of CD8 positive T lymphocytes, causes immune escape, and facilitates peritoneal dissemination of ovarian cancer.
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