Adjuvant cellular immnunotherapy for head and neck cancer

• Project/Area Number: 21390458
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Chiba University
• Principal Investigator: OKAMOTO Yoshitaka 千葉大学, 大学院・医学研究院, 教授 (40169157)
• Co-Investigator(Kenkyū-buntansha): HORIGUCHI Shigetoshi 千葉大学, 大学院・医学研究院, 講師 (30293468)
• Co-Investigator(Renkei-kenkyūsha): YAMASAKI Kazuki 千葉大学, 医学部・附属病院, 医員 (00422238)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: 頭頸部癌 / 免疫療法 / NKT細胞 / 粘膜投与 / 抗原提示細胞

Research Abstract

In order to improve the prognosis of patients with head and neck cancer, We have conducted clinical studies with α-GalCer-pulsed antigen presenting cells (APCs) administered in the nasal submucosa of patients with advanced pharyngeal cancer after standard therapies or with malignant head and neck melanoma after heavy iron therapy as an adjuvant therapy and evaluated the safety and feasibility of such an adjuvant therapy. Although median follow-up period is only 2 years and it is difficult to say definitive conclusion, overall survival seems to be improved in immunotherapy group with α-GalCer-pulsed APCs. Further studies to certify the clinical benefits are required.

Research Products

• [Journal Article] Migration and immunological reaction after the administration of α-GalCer-pulsed- antigen-presenting cells into the submucosa of patients with head and neck cancer (2011)
  • Author(s): Kurosaki, M., Horiguchi, S., Yamasaki, K., Uchida, Y., Motohashi, S., Nakayama, T., Sugimoto, A., Okamoto, Y
  • Journal Title: Cancer Immunology and Immunotherapy Volume: 60 Pages: 207-215
  • Peer Reviewed
• [Journal Article] Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy (2011)
  • Author(s): Yamasaki, K., Horiguchi, S., Kurosaki, M., Kunii, N., Nagato, K., Hanaoka, H., Shimizu, N., Ueno, N., Yamamoto, S., Taniguchi, M., Motohashi, S., Nakayama, T., Okamoto, Y
  • Journal Title: Clinical Immunology Volume: 138 Pages: 255-265
  • Peer Reviewed
• [Journal Article] Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in cancer immunotherapy (2011)
  • Author(s): Okamoto Y, Fujikawa A, Kurosaki M, Yamasaki K, Sakurai D, Horiguchi S, Nakayama T
  • Journal Title: Advances in Oto-Rhino-Laryngology Volume: 72 Pages: 149-152
  • Peer Reviewed
• [Journal Article] Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer (2011)
  • Author(s): Motohashi S, Okamoto Y, Yoshino I, Nakayama T
  • Journal Title: Clinical Immunology Volume: 140 Pages: 167-176
  • Peer Reviewed
• [Journal Article] Migration and immunological reaction after the administration of αGalCer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer (2011)
  • Author(s): Kurosaki M
  • Journal Title: Cancer Immunology and Immunotherapy Volume: 60 Pages: 207-215
  • Peer Reviewed
• [Journal Article] Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in cancer immunotherapy (2011)
  • Author(s): Okamoto Y
  • Journal Title: Oto-Rhino-Laryngology Volume: 72 Pages: 149-152
  • Peer Reviewed
• [Journal Article] Migration and immunological reaction after the administration of αGa1Cer-pulsed antigen-presenting cells into the submucosa of patients with head and neck cancer. (2011)
  • Author(s): Kurosaki M
  • Journal Title: Cancer Immunol Immunother. Volume: 60 Pages: 207-215
  • Peer Reviewed
• [Journal Article] Induction of NKT cell-specific immane responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. (2011)
  • Author(s): Yamasaki K
  • Journal Title: Clin lmmunol. Volume: 138 Pages: 255-265
  • Peer Reviewed
• [Journal Article] The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer (2010)
  • Author(s): Kobayashi, K., Tanaka, Y., Horiguchi, S., Yamamoto, S., Nakayama, T., Sugimoto, A., Okamoto, Y
  • Journal Title: Cancer Immunology and Immunotherapy Volume: 59 Pages: 1503-1509
  • Peer Reviewed
• [Journal Article] The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer. (2010)
  • Author(s): Kobayashi K
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 1503-1509
  • Peer Reviewed
• [Journal Article] Combination Therapy of In vitro Expanded Natural Killer T Cells and α-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma (2009)
  • Author(s): Kumii, N., Horiguchi, S., Motohashi, S., Yamamoto, H., Ueno, N., Yamamoto, S., Sakurai, D., Taniguchi, M., Nakayama, T., Okamoto, Y
  • Journal Title: Cancer Science Volume: 100 Pages: 1092-1098
  • NAID: 10025146740
  • Peer Reviewed
• [Journal Article] Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy (2009)
  • Author(s): Yanagi T, Mizoe JE, Hasegawa A, Takagi R, Bessho H, Onda T, Kamada T, Okamoto Y, Tsujii H
  • Journal Title: International Journal of Radiation Oncology Volume: 74 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Combination Therapy of In vitro Expanded Natural Killer T Cells and α-Galactosylceramide-pulsed Antigen Presenting Cells in Patients with Recurrent Head and Neck Carcinoma (2009)
  • Author(s): Kumii N
  • Journal Title: Cancer Science 100 Pages: 1092-1098
  • Peer Reviewed
• [Journal Article] 上気道の粘膜:基礎から臨床へ-鼻アレルギー・頭頸部癌の免疫治療への展開 (2009)
  • Author(s): 岡本美孝
  • Journal Title: 耳鼻咽喉科・頭頸部外科 81 Pages: 887-896
• [Presentation] 新しい頭頸部癌治療の展望:自然免疫系(NKT細胞)を利用した細胞免疫療法 (2011)
  • Author(s): 山崎一樹, 茶薗英明, 堀口茂俊, 花澤豊行, 岡本美孝
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-06-09
• [Presentation] 新しい頭頸部癌治療の展望3.自然免疫系(NKT細胞)を利用した細胞免疫治療 (2011)
  • Author(s): 山崎一樹
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-06-09
• [Presentation] Phase II study of Activated NKT Cells and α-GalCer-pulsed DCs in Patients with recurrent and operable Head and Neck Carcinoma (2010)
  • Author(s): Yamasaki K, Katada K, Kikkawa N, Yonekura S, Okamoto Y
  • Organizer: 13th KJ Joint Meeting of Otorhinolaryngology Head & Neck Surgery
  • Place of Presentation: Seoul/ Kore
  • Year and Date: 2010-09-10
• [Presentation] Phase II study of Activated NKT Cells and α-GalCer-pulsed DCsin Patients with recurrent and operable Head and Neck Carcinoma. (2010)
  • Author(s): Yamasaki K
  • Organizer: 13th KJ Joint Meeting of Otorhinolaryngology Head & Neck Surge
  • Place of Presentation: Seoul/Korea
  • Year and Date: 2010-09-10
• [Presentation] NKT cell-based immunotherapy for cancer:Nasal sumucosal administration of antigen-presenting cells may induce effective anti-tumor immune responses (2010)
  • Author(s): 岡本美孝
  • Organizer: 第4回千葉大学Global COEシンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 2010-08-20
• [Presentation] 頭頸部扁平上皮癌に対する活性化NKT細胞とα-GalCerパルス抗原提示細胞投与による第二相臨床試験 (2010)
  • Author(s): 山崎一樹, 堀口茂俊, 藤川陽, 佐々原剛, 米倉修二, 花澤豊行, 岡本美孝
  • Organizer: 第111回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-21
• [Presentation] Nasal submucosal administration of antigen-presenting cells induces effective immunological responses in immunotherapy. (2010)
  • Author(s): Fujikawa A
  • Organizer: 39th Korean rhinologic Society Meeting
  • Place of Presentation: Daejeon(Korea)
  • Year and Date: 2010-03-14
• [Presentation] Nasal submucosal administration of antigen-presenting cells indued effective immunological response in cancer immunotherap (2010)
  • Author(s): 岡本美孝, 藤川陽, 稲嶺絢子
  • Organizer: 第7回国際上気道粘膜・扁桃学会
  • Place of Presentation: 旭川
• [Presentation] Nasal submucosal administration of antigen-presenting cells indued effective immunological response in cancer immunotherapy (2010)
  • Author(s): 岡本美孝
  • Organizer: 第7回国際上気道粘膜・扁桃学会
  • Place of Presentation: 旭川
• [Presentation] 頭頸部癌再発、salvage手術適応症例を対象にした活性化NKT細胞動注及びα-GalactosylCeramideパルス抗原提示細胞の鼻粘膜下投与 (2009)
  • Author(s): Yamasaki K
  • Organizer: 第39回日本免疫学会総会・学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Phase II study of Acticated NKT Cells and GalCer-pulsed APCs in Patients with recurrent and operable Head and Neck Carcinoma (2009)
  • Author(s): Yamasaki K
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
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