Nano-scale analysis and control of biomaterial-hard tissue interfaces.

• Project/Area Number: 21390514
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Okayama University
• Principal Investigator: YOSHIDA Yasuhiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90281162)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 界面 / 歯 / 骨 / 機能性モノマー / アパタイト / 再生 / 層状構造 / メカニカルストレス / インプラント / チタン / 再生医療 / 骨折 / 未分化間葉細胞

Research Abstract

Hard tissue-material interfaces were comprehensively analyzed and their interfacial structures were functionally controlled. As a result of chemical investigation for tooth bonding, nano-controlled functional monomer interaction at the biomaterial-hard tissue interface can improve bond durability. The advanced analytical techniques for hard tissue-biomaterial interaction also provide a basis to develop functional materials, such as phosphorylated polysaccharides and a photo-reactive gelatin, for bone regeneration and reconstruction.

Research Products

• [Journal Article] Effect of functional monomer and photo-initiator on the degree of conversion of a dental adhesive. (2012)
  • Author(s): Oguri, M., Yoshida, Y., Yoshihara, K., Miyauchi, T., Nakamura, Y., Shimoda, S., Hanabusa, M., Momoi, Y., Van Meerbeek, B.
  • Journal Title: Acta Biomaterialia Volume: 8 Pages: 1928-1934
  • Peer Reviewed
• [Journal Article] Real-time assessment of surface interactions with titanium passivation layer by surface plasmon resonance. (2012)
  • Author(s): Hirata, I., Yoshida, Y., Nagaoka, N., Hiasa, K., Abe, Y., Maekawa, K., Kuboki, T., Akagawa, Y., Suzuki, K., Van Meerbeek, B., Messersmith, P. B., Okazaki, M.
  • Journal Title: Acta Biomaterialia Volume: 8 Pages: 1260-1266
  • NAID: 120005308253
  • Peer Reviewed
• [Journal Article] 生体材料は高齢者の健康維持にどのように貢献できるか (2012)
  • Author(s): 吉田靖弘
  • Journal Title: 老年歯科医学 Volume: 26 Pages: 387-393
  • NAID: 10031137175
• [Journal Article] Real time assessment of surface interactions with a titanium passivation layerby surface plasmon resonance (2012)
  • Author(s): Hirata, I., Yoshida, Y., et al
  • Journal Title: Acta Biomaterialia Volume: 8 Issue: 3 Pages: 1260-1266
  • DOI: 10.1016/j.actbio.2011.11.025
  • Peer Reviewed
• [Journal Article] Nano-layering of phosphoric-acid ester monomer at enamel and dentin. (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Irie, M., Ogawa, T., Van Landuyt K. L., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B.
  • Journal Title: Acta Biomaterialia Volume: 7 Pages: 3187-3195
  • Peer Reviewed
• [Journal Article] Sox9 expression during fracture repair. (2011)
  • Author(s): Shintaku, Y., Murakami, T., Yanagita, T., Kawanabe, N., Fukunaga, T., Matsuzaki, K., Matsuoka, S., Yoshida, Y., Kamioka, H., Takano-Yamamoto, T., Takada, K., Yamashiro, T.
  • Journal Title: Cells Tissues Organs Volume: 194 Pages: 38-48
  • Peer Reviewed
• [Journal Article] Detection of synthetic RGDS(PO_3H_2) PA peptide adsorption using a titanium surface plasmon resonance(SPR) biosensor. (2011)
  • Author(s): Abe, Y., Hiasa, K., Hirata, I., Okazaki, Y., Nogami, K., Mizumachi, W., Yoshida, Y., Suzuki, K., Okazaki, M., Akagawa, Y.
  • Journal Title: Journal of Materials Science : Materials in Medicine Volume: 22 Pages: 657-661
  • Peer Reviewed
• [Journal Article] Hydrolytic stability of one-step self-etch adhesives bonded to dentin. (2011)
  • Author(s): Fukuoka, A., Koshiro, K., Inoue, S., Yoshida, Y., Tanaka, T., Ikeda, T., Suzuki, K., Sano, H., Van Meerbeek, B.
  • Journal Title: Journal of Adhesive Dentistry Volume: 13 Pages: 243-248
  • Peer Reviewed
• [Journal Article] Self-etch monomer-calcium salt deposition on dentin. (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Torii, Y., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B., Van Landuyt K. L.
  • Journal Title: Journal of Dental Research Volume: 90 Pages: 602-606
  • Peer Reviewed
• [Journal Article] Effect of functional monomers in all-in-one adhesive systems on formation of enamel/dentin acid-base resistant zone. (2011)
  • Author(s): Nikaido, T., Ichikawa, C., Li, N., Takagaki, T., Sadr, A., Yoshida, Y., Suzuki, K., Tagami. J.
  • Journal Title: Dental Materials Journal Volume: 30 Pages: 576-582
  • NAID: 10029480351
  • Peer Reviewed
• [Journal Article] 誌上フォーラム:接着試験法.従来法-引っ張り接着強さと剪断接着強さの測定-. (2011)
  • Author(s): 吉田靖弘, 沖原巧, 長岡紀幸, 井上哲, 鳥井康弘
  • Journal Title: 接着歯学 Volume: 29 Pages: 90-94
• [Journal Article] State of the art of self-etch adhesives. (2011)
  • Author(s): Van Meerbeek, B., Yoshihara, K., Yoshida, Y., Mine, A., De Munck, J., Van Landuyt, K. L.
  • Journal Title: Dental Materials Volume: 27 Pages: 17-28
• [Journal Article] Nano-layering of phosphoric-acid ester monomer at enamel and dentin (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., et al
  • Journal Title: Acta Biomaterialia Volume: 7 Issue: 8 Pages: 3187-3195
  • DOI: 10.1016/j.actbio.2011.04.026
  • Peer Reviewed
• [Journal Article] Nano-layering of phosphoric-acid ester monomer at enamel and dentin (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., et al
  • Journal Title: Journal of Dental Research Volume: 90 Issue: 5 Pages: 602-606
  • DOI: 10.1177/0022034510397197
  • Peer Reviewed
• [Journal Article] Enamel-smear compromises bonding by mild self-etch adhesives (2010)
  • Author(s): Mine, A., De Munck, J., Vivan Cardoso, M., Van Landuyt, K. L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B.
  • Journal Title: Journal of Dental Research Volume: 89 Pages: 1505-1509
  • Peer Reviewed
• [Journal Article] Degree of immobilization of synthetic RGDS(PO_3H_2) PA peptides on titanium surfaces. (2010)
  • Author(s): Abe, Y., Okazaki, Y., Hiasa, K., Hirata, I., Yoshida, Y., Taji, T., Suzuki, K., Okazaki, M., Akagawa, Y.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 668-672
  • NAID: 10026962580
  • Peer Reviewed
• [Journal Article] The quasi-3D marginal leakage of full-coverage crowns : resin coating method versus sodium hypochlorite treatment. (2010)
  • Author(s): Kawahara, D., Mine, A., De Munck, J., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B., Yatani, H.
  • Journal Title: The International Journal of Prosthodontics Volume: 23 Pages: 406-409
  • Peer Reviewed
• [Journal Article] Visible light-induced cross-linkable gelatin. (2010)
  • Author(s): Son, T. I., Sakuragi, M., Takahashi, S., Obuse, S., Kang, J. H., Fujishiro, M., Matsushita, H., Gong, J., Shimizu, S., Tajima, Y., Yoshida, Y., Suzuki, K., Yamamoto, T., Nakamura, M., Ito, Y.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 4005-4010
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction. (2010)
  • Author(s): Yoshihara, K., Yoshida, Y., Nagaoka, N., Fukegawa, D., Hayakawa, S., Mine, A., Nakamura, M., Minagi, S., Osaka, A., Suzuki, K., Van Meerbeek, B.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] TEM characterization of a silorane composite bonded to enamel/dentin. (2010)
  • Author(s): Mine, A., De Munck, J., Van Ende, A., Cardoso, M. V., Kuboki, T., Yoshida, Y., Van Meerbeek, B.
  • Journal Title: Dental Materials Volume: 26 Pages: 524-532
  • Peer Reviewed
• [Journal Article] 歯質接着における化学分析の応用 (2010)
  • Author(s): 吉田靖弘, 中山陽一, 吉原久美子, 英將生, 峯篤史, 井上哲, 鈴木一臣, Van Meerbeek, B.
  • Journal Title: 接着歯学 Volume: 28 Pages: 1-13
  • NAID: 10026425396
• [Journal Article] Visible light-induced crass-linkable gelatin (2010)
  • Author(s): Son, T.I.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 4005-4010
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction (2010)
  • Author(s): Yoshihara, K.
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] Bonding effectiveness of two contemporary self-etch adhesives to enamel and dentin. (2009)
  • Author(s): Mine, A., De Munck, J., Cardoso, M. V., Van Landuyt, K. L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Lambrechts, P., Van Meerbeek, B.
  • Journal Title: Journal of Dentistry Volume: 37 Pages: 872-883
  • Peer Reviewed
• [Journal Article] Antibacterial effect of bactericide immobilized in resin matrix. (2009)
  • Author(s): Namba, N., Yoshida, Y., Nagaoka, N., Takashima, S., Matsuura-Yoshimoto, K., Maeda, H., Van Meerbeek, B., Suzuki, K., Takashiba, S.
  • Journal Title: Dental Materials Volume: 25 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Polyphosphoric acid treatment promotes bone regeneration around titanium implants. (2009)
  • Author(s): Maekawa, K., Shimono, K., Oshima, M., Yoshida, Y., Van Meerbeek, B., Suzuki, K., Kuboki, T.
  • Journal Title: Journal of Oral Rehabilitation Volume: 36 Pages: 362-367
  • Peer Reviewed
• [Journal Article] スミヤー層が1ステップ接着システムの短長期的象牙質接着性能に及ぼす影響. (2009)
  • Author(s): 福岡杏理, 小城賢一, 井上哲, 吉田靖弘, 田中享, 池田考績, 鈴木一臣, 小松久憲, 佐野英彦.
  • Journal Title: 日本歯科保存学会誌 Volume: 52 Pages: 27-38
  • NAID: 110007228047
  • Peer Reviewed
• [Journal Article] 表面・界面研究が明日の歯科医療を創る (2009)
  • Author(s): 吉田靖弘, 鈴木一臣
  • Journal Title: 今月の表紙.日本歯科評論 Volume: 69 Pages: 39-40
• [Journal Article] 最新の接着技術を駆使した「G-ボンドプラス」の接着メカニズムと性能 (2009)
  • Author(s): 鈴木一臣, 吉田靖弘, 吉原久美子, 皆木省吾
  • Journal Title: GC CIRCLE Volume: No.130 Pages: 26-29
• [Journal Article] う蝕・歯周病予防のための抗菌性コーティング材の開発. (2009)
  • Author(s): 吉田靖弘
  • Journal Title: 日本歯科医学会誌 Volume: 28 Pages: 39-43
  • NAID: 10025692880
• [Journal Article] 疑問に答えて:著者から読者へ(DE No.165, 166):歯質接着界面のナノスケールにおける解析 (2009)
  • Author(s): 吉田靖弘
  • Journal Title: The Journal of Dental Engineering Volume: 169 Pages: 38-39
• [Presentation] 接着技術を活かした生体硬組織の再生・再建 (2012)
  • Author(s): 吉田靖弘
  • Organizer: 第50回臨床応用を目指した三次元臓器造形研究会
  • Place of Presentation: 東京大学医学部附属病院.東京
  • Year and Date: 2012-01-28
• [Presentation] 接着技術を活かした生体硬組織の再生・再建 (2012)
  • Author(s): 吉田靖弘
  • Organizer: 第50回臨床応用を目指した三次元臓器造形研究会
  • Place of Presentation: 東京大学医学部附属病院
  • Year and Date: 2012-01-28
• [Presentation] リン酸化プルランを用いた高機能医用材料の開発 (2011)
  • Author(s): 吉田靖弘
  • Organizer: 第90回岡山県医用工学研究会・メディカルテクノおかやま平成23年度第2回セミナー
  • Place of Presentation: 岡山
  • Year and Date: 2011-10-12
• [Presentation] リン酸化プルランを用いた高機能医用材料の開発 (2011)
  • Author(s): 吉田靖弘
  • Organizer: 第90回岡山県医用工学研究会・メディカルテクノおかやま平成23年度第2回セミナー
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-10-12
• [Presentation] Phosphopullulan bioadhesive for hard-tissue reconstruction (2011)
  • Author(s): Yoshida, Y.
  • Organizer: Start-up Symposium for Innovative Materials Research "A Roadmap for the Future of Oral Biomaterials"
  • Place of Presentation: Osaka, Japan
• [Presentation] 生体材料は高齢者の健康維持にどのように貢献できるか (2011)
  • Author(s): 吉田靖弘
  • Organizer: 日本老年歯科医学会第22回学術大会
  • Place of Presentation: 東京
• [Presentation] Phosphopullulan bioadhesive for hard-tissue reconstruction (2011)
  • Author(s): Yasuhiro Yoshida
  • Organizer: Start-up Symposium for Innovative Materials Research "A Roadmap for the Future of Oral Biomaterials"
  • Place of Presentation: Osaka University
• [Presentation] リン酸化プルランによる多目的医用材料の開発と製品化への検討 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 両備椰園記念財団平成22年度第32回研究助成金贈呈式記念講演
  • Place of Presentation: 岡山
  • Year and Date: 2010-10-01
• [Presentation] 接着技術の応用による医用材料の高機能化 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 日本歯科保存学2010年度会秋季学術大会(第133回)・第12回日韓歯科保存学会学術大会.シンポジウムII「機能性修復材料開発戦略のベクトルを探る」
  • Place of Presentation: 岐阜
• [Presentation] Phosphorylated Pullulan Bioadhesive for Hard-Tissue Reconstruction (2010)
  • Author(s): Yoshida, Y., Takahata, T., Nakamura, M., Irie, M., Tanaka, M., Ozaki, T., Suzuki, K., Van Meerbeek, B.
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain.
• [Presentation] 接着技術の応用による医用材料の高機能化 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 日本歯科保存学2010年度会秋季学術大会(第133回)・第12回日韓歯科保存学会学術大会
  • Place of Presentation: 岐阜
• [Presentation] 生体硬組織/材料ナノ界面制御による医用材料の高機能化 (2009)
  • Author(s): 吉田靖弘
  • Organizer: ニューセラミックス懇話会第189回研究会・バイオ関連セラミックス分科会第27回研究会「ハイドロキシアパタイトを制御した新しい医療用材料」
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-23
• [Book] Basics in adhesion technology : In Caries management-Science and Clinical Practice. Chapter 14 (2011)
  • Author(s): Van Meerbeek, B., Yoshida, Y.
• [Book] Adhesion to tooth enamel and dentin ? A view on the latest technology and future perspectives : In Statements : Diagnostics and therapy in dental medicine today and in the future (2009)
  • Author(s): Cardoso, M. V., Yoshida, Y., Van Meerbeek, B.
  • Publisher: Quintessence Publishing
• [Book] スタンダード歯科理工学-生体材料と歯科材料-第4版 (2009)
  • Author(s): 鈴木一臣, 楳本貢三, 岡崎正之, 中嶌裕, 西山典宏, 編集(幹事)・執筆:荒木吉馬, 石川邦夫, 伊藤充雄, 川島功, 荘村泰治, 高橋英和, 土井豊, 久恒邦博, 平野進, 松家茂樹, 宮崎隆, 米山隆之編集・執筆:足立正徳, 新井浩一, 石田喜紀, 亀水秀男, 菊地久二, 白石孝信, 平雅之, 谷本安浩, 寺岡文雄, 長沢悠子, 納村泰弘, 早川徹, 日比野靖, 廣瀬英晴, 福島忠男, 藤島昭宏, 吉田靖弘執筆
  • Publisher: 株式会社学建書院
• [Remarks] 受賞(計4件)(1)吉田靖弘.(財)医科学応用研究財団平成23年調査研究助成金(2011年)
• [Remarks] (2)吉田靖弘.第54回日本歯科理工学会学術講演会発表優秀賞(2010年)
• [Remarks] (3)吉田靖弘.(財)ホクト生物科学振興財団平成22年度研究奨励金(2010年)
• [Remarks] (4)吉田靖弘.(財)両備.園記念財団平成22年度研究助成金(2010年)
• [Patent(Industrial Property Rights)] リン酸化多糖の製造方法 (2012)
  • Inventor(s): 沖原巧,亀ノ上翔吾,吉田靖弘,松川昭博,難波尚子,高柴正悟
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2012-073934
  • Filing Date: 2012-03-28
• [Patent(Industrial Property Rights)] リン酸化多糖の固相合成方法 (2012)
  • Inventor(s): 沖原巧,吉田靖弘,亀ノ上翔吾,井口勉,木島菜摘,難波尚子,長岡紀幸
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2012-073933
  • Filing Date: 2012-03-28
• [Patent(Industrial Property Rights)] 生体硬組織接着用キット (2011)
  • Inventor(s): 吉田靖弘,田中雅人,鈴木一臣,尾崎敏文,高畑智宏,入江正郎,中村真理子,河島光伸,野尻大和,岡田浩一,長尾昌浩
  • Industrial Property Rights Holder: 岡山大学,順正学園
  • Filing Date: 2011-02-22
  • Overseas
• [Patent(Industrial Property Rights)] 虫歯予防剤 (2010)
  • Inventor(s): 吉田靖弘,高柴正悟,伊東孝,今村幸治,竹内英明,岡本英治
  • Industrial Property Rights Holder: 株式会社グライエンス,岡山大学
  • Industrial Property Number: 2010-105130
  • Filing Date: 2010-04-30
• [Patent(Industrial Property Rights)] 生体硬組織接着用キット (2010)
  • Inventor(s): 吉田靖弘,田中雅人,鈴木一臣,尾崎敏文,高畑智宏,入江正郎,中村真理子,河島光伸,野尻大和,岡田浩一,長尾昌浩
  • Industrial Property Rights Holder: 岡山大学,順正学園
  • Filing Date: 2010-02-22
• [Patent(Industrial Property Rights)] チタン製インプラント及びチタン製インプラントの表面処理方法 (2010)
  • Inventor(s): 阿部泰彦,赤川安正,竹内真帆,岡崎正之,吉田靖弘,渡辺清
  • Industrial Property Rights Holder: 株式会社ジーシー
  • Acquisition Date: 2010-03-22
  • Overseas
• [Patent(Industrial Property Rights)] 口腔チタンインプラント材とその製造方法 (2010)
  • Inventor(s): 吉田靖弘,内田幸夫
  • Industrial Property Rights Holder: 株式会社林原
  • Acquisition Date: 2010-03-12
• [Patent(Industrial Property Rights)] 虫歯予防剤 (2009)
  • Inventor(s): 虫歯予防剤
  • Industrial Property Rights Holder: 株式会社グライエンス,岡山大学
  • Filing Date: 2009-10-16
  • Overseas