New development of bFGF/ poly-phosphate adsorbed artificial bone

• Project/Area Number: 21390517
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: AKAGAWA Yasumasa 広島大学, 大学院・医歯薬学総合研究科, 教授 (00127599)
• Co-Investigator(Kenkyū-buntansha): KUBO Takayasu 広島大学, 病院, 講師 (60240876) ; KORETAKE Katsuniri 広島大学, 大学院・医歯薬学総合研究科, 助教 (50346508) ; DOI Kazuya 広島大学, 大学院・医歯薬学総合研究科, 助教 (80444686)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 骨再生 / 連通多孔性アパタイト / ポリリン酸 / 再生医療 / bFGF / 人工骨 / 多孔性ハイドロキシアパタイト

Research Abstract

The purpose of this study was to evaluate the bone formation ability of newly developed composite of bFGF and poly(P) adsorbed artificial bone. The results of this study indicate that co-application of bFGF and poly(P) may provide enhanced cell proliferation and mineralization in vitro and bone formation in vivo. It is anticipated that combined application of bFGF and poly(P) adsorbed artificial bone can provide a novel method for guided bone regeneration in clinical use

Research Products

• [Journal Article] Comparative evaluation of bone regenerationusing spherical and irregularly shaped granules ofinterconnected porous hydroxylapatite (2011)
  • Author(s): Kubo T, Doi K, Hayashi K, Morita K, Matsuura A, Teixeira ER Akagawa Y
  • Journal Title: A beagledog study Volume: 55 Pages: 104-9
  • Peer Reviewed
• [Journal Article] Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxylapatite. A beagle dog study. (2011)
  • Author(s): T Kubo
  • Journal Title: Journal of Prosthodontic Research Volume: 55 Pages: 104-109
  • NAID: 130004546600
  • Peer Reviewed
• [Journal Article] Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite (2010)
  • Author(s): Morita K, Doi K, Kubo T, Takeshita R, Kato S, Shiba T, Akagawa Y
  • Journal Title: Acta Biomater Volume: 6 Pages: 2808-15
  • Peer Reviewed
• [Journal Article] Enhanced initial bone regeneration with inorganic polyphosphate-adsor bed hydroxapatite (2010)
  • Author(s): K Morita
  • Journal Title: Acta Biomaterialia (In press)
  • Peer Reviewed
• [Journal Article] ポリリン酸吸着型連通多孔性ハイドロキシアパタイト人工骨の新規開発 (2009)
  • Author(s): 森田晃司
  • Journal Title: 広島大学歯学雑誌 Volume: 41(1) Pages: 57-70
  • Peer Reviewed
• [Presentation] 連通多孔性ハイドロキシアパタイトによる骨再建部位におけるオッセオインテグレーションの様相The aspects of osseointegration of the implants placed in the reconstr ucted bone with using interconnected calcium hydroxyapatite (2011)
  • Author(s): 梶原志穂, 土井一矢, 久保隆靖, 森田晃司, 赤川安正
  • Organizer: 第50回広島県歯科医学会」併催「第95回広島大学歯学会」
  • Place of Presentation: 広島
  • Year and Date: 2011-11-13
• [Presentation] Development ofimplantinterconnected porous calcium hydroxyapatite complex (2011)
  • Author(s): Hiroshi Oue et al
  • Organizer: 4th Hiroshima Conference on Education and Science inDentistry
  • Place of Presentation: Hiroshima(Japan)
  • Year and Date: 2011-10-09
• [Presentation] The aspects of osseointegration of the implants placed in the reconstructed bone by using interconnected porous calcium hydroxyapatite (2011)
  • Author(s): Shiho Kajihara et al
  • Organizer: 4th Hiroshima Conference on Education and Science in Dentistry
  • Place of Presentation: Hiroshima(Japan)
  • Year and Date: 2011-10-09
• [Presentation] 連通多孔性ハイドロキシアパタイトを用いた骨再建部位におけるオッセオインテグレーションの様相 (2011)
  • Author(s): 梶原志穂他
  • Organizer: 第41回日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-09-17
• [Presentation] Development of implant/ interconnected prorous calcium hydroxyapatite complex (2011)
  • Author(s): Hiroshi Oue et al
  • Organizer: 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii(USA)
  • Year and Date: 2011-09-11
• [Presentation] The aspects of osseointegration of the implants placed in the reconstructed bone by using interconnected porous calcium hydroxyapatite (2011)
  • Author(s): Shiho Kajihara et al
  • Organizer: 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii(USA)
  • Year and Date: 2011-09-11
• [Presentation] Development of implant/interconnected porous calcium hydroxyapatite complex (2011)
  • Author(s): H.Oue, K.Doi, T.Kubo, K.Koretake, K.Hayashi, S.Kajihara, K.Imura, Y.Akagawa
  • Organizer: 4th Hiroshima Conference on Education and Science in Dentistry
  • Place of Presentation: Hiroshima
• [Presentation] Development of Implant/Interconnected Prorous Calcium Hydroxyapatite Complex (2011)
  • Author(s): Oue, H., Doi, K., Kubo, T, Koretake, K., Hayashi, K., Kajihara, S., Imura, K., Akagawa, Y.
  • Organizer: 14th Meeting of the International College of Prosthodontists
  • Place of Presentation: Hawaii, USA
• [Presentation] The Aspects of Osseointegration of The Implants Placed in The Reconstructed Bone by Using Interconnected Porous Calcium Hydroxyapatite (2011)
  • Author(s): KAJIHARA S, DOI K, OUE H, MATSUURA A, MORITA K, TAKESHITA R, ASAMORI C, AKAGAWA Y
  • Organizer: International College of Prosthodontists
  • Place of Presentation: Hawaii, USA
• [Presentation] 連通多孔性ハイドロキシアパタイトを用いた骨再建部位におけるオッセオインテグレーションの様相The aspects of osseointegration of the implants placed in the reconstructed bone with using interconnected calcium hydroxyapatite (2011)
  • Author(s): 梶原志穗, 土井一矢, 久保隆靖, 森田晃司, 赤川安正
  • Organizer: 日本口腔インプラント学会
  • Place of Presentation: 名古屋
• [Presentation] The Aspects of Osseointegration of The Implants Placed in The Reconstructed Bone by Using Interconnected Porous Calcium Hydroxyapatite (2011)
  • Author(s): KAJIHARA S, DOI K, KUBO T, OUE H, MATSUURA A, MORITA K, TAKESHITA R, ASAMORI C, AKAGAWA Y
  • Organizer: 4th Hiroshima Conference on Education and Science in Dentistry
  • Place of Presentation: Hiroshima
• [Presentation] 実験的に露出させたインプラント周囲のGBRに対するポリリン酸吸着人工骨の効果 (2010)
  • Author(s): 竹下亮他
  • Organizer: 第40回日本口腔インプラント学会学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-09-18
• [Presentation] 実験的に露出させたインプラント周囲のGBRに対するポリリン酸吸着人工骨の効果 (2010)
  • Author(s): 竹下亮
  • Organizer: 第40回日本航空インプラント学会学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-09-18
• [Presentation] Development of inorganic polyphosphate-adsorbed interconnected porous calcium hydroxyapatite as a new bone regeneration material (2009)
  • Author(s): Kazuya Doi et al
  • Organizer: 13th Meeting of the International College of Prosthodontists
  • Place of Presentation: Capetown(South Africa)
  • Year and Date: 2009-09-10
• [Presentation] Development of inorganic polyphosphate-adsorbed interconnected porous calcium hydroxyapatite as a new bone regeneration material (2009)
  • Author(s): Kazuya Doi
  • Organizer: The 13th Meeting of the International College of Prosthodontists
  • Place of Presentation: ケープタウン(南アフリカ)
  • Year and Date: 2009-09-10
• [Presentation] 骨再生能を有するポリリン酸吸着型人工骨の創製 (2009)
  • Author(s): 森田晃司他
  • Organizer: 第118回日本補綴歯科学会・学術総会
  • Place of Presentation: 京都市
  • Year and Date: 2009-06-09
• [Presentation] 日本補綴歯科学会第118回学術大会 (2009)
  • Author(s): 森田晃司
  • Organizer: 日本補綴歯科学会・学術総会
  • Place of Presentation: 京都市
  • Year and Date: 2009-06-06