The construction and maintenance of titanium-tissue interface by the enhancement of both t issue response and titanium functionalization

• Project/Area Number: 21390520
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University
• Principal Investigator: KIYOSHI Koyano 九州大学, 大学院・歯学研究院, 教授 (50195872)
• Co-Investigator(Kenkyū-buntansha): AYUKAWA Yasunori 九州大学, 大学病院, 講師 (50304697) ; OGINO Yoichiro 九州大学, 大学病院, 助教 (50380431) ; ATSUTA Ikiru 九州大学, 大学院・歯学研究院, 助教 (30423487)
• Co-Investigator(Renkei-kenkyūsha): ISHIKAWA Kunio 九州大学, 大学院・歯学研究院, 教授 (90202952)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: インターフェース / インプラント / 骨 / 上皮

Research Abstract

The purpose of this study was to achieve strong and sustainable interface between dental implant and oral tissue such as bone and gingival soft tissue.
The interface between soft tissue and titanium was supposed to be weaker than tooth. The hydrothermal treatment of titanium under the presence of divalent cation enhanced adhesion of both epithelial and fibroblastic cells.
In regard to the bone-titanium interface, statins with PLGA microsphere as a carrier enhanced osteogenesis around the implant. Divalent cation treatment of titanium also enhanced bone-titanium contact.

Research Products

• [Journal Article] インプラントアバットメント材料としてのジルコニアに対する上皮性付着および生物学的幅径の形成 (2012)
  • Author(s): 古橋明大、鮎川保則、熱田生、坂口真実、山根晃一、ラフマティアYD、大川内秀幸、古谷野潔
  • Journal Title: 別冊Quintessence Year Book 2012 Pages: 184-90
• [Journal Article] Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts (2012)
  • Author(s): H. Okawachi, Y. Ayukawa, I. Atsuta, A. Furuhashi, M. Sakaguchi, K. Yamane, K. Koyano
  • Journal Title: Biointerphases, in press Volume: 7:27 Issue: 1 Pages: 1-8
  • DOI: 10.1007/s13758-012-0027-9
  • NAID: 120006024220
  • Peer Reviewed
• [Journal Article] インプラントアバットメント材料としてのジルコニアに対する上皮性付着および生物学的幅径の形成 (2012)
  • Author(s): 古橋明大、鮎川保則、熱田、坂口真実、山根晃一、ラフマティアYD,大川内秀幸、古谷野潔
  • Journal Title: 別冊Quintessence Year Book 2012 Pages: 184-190
• [Journal Article] The difference of fibroblast behavior on titanium substrata with different surface characteristics (2011)
  • Author(s): A. Furuhashi, Y. Ayukawa, I. Atsuta, H. Okawachi and K. Koyano
  • Journal Title: Odontology, in press Volume: 100 Issue: 2 Pages: 199-205
  • DOI: 10.1007/s10266-011-0029-y
  • NAID: 10030958595
  • Year and Date: 2011-06-21
• [Journal Article] Tissue-response to calcium-bonded titanium surface (2010)
  • Author(s): L. Zhang, Y. Ayukawa, R. Z. LeGeros, S. Matsuya, K. Koyano and K. Ishikawa
  • Journal Title: J Biomed Mater Res A Volume: Vol.95, No.1 Pages: 33-9
• [Journal Article] The effect of a single remote injection of statin-impregnated poly(lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia (2010)
  • Author(s): T. Masuzaki, Y. Ayukawa, Y. Moriyama, Y. Jinno, I. Atsuta, Y. Ogino and K. Koyano
  • Journal Title: Biomaterials Volume: Vol.31, No.12 Pages: 3327-34
• [Journal Article] Tissue-response to calcium-bonded titanium surface. (2010)
  • Author(s): Zhang L, Ayukawa Y, Koyano K, 他3名
  • Journal Title: Journal of Biomedical Materials Research Volume: 95A Pages: 33-39
  • Peer Reviewed
• [Journal Article] The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia (2010)
  • Author(s): Masuzaki T, Ayukawa Y, Koyano K, 他4名
  • Journal Title: Biomaterials Volume: 31 Pages: 3327-3334
  • Peer Reviewed
• [Journal Article] The effect of a single remote injection of statin-impregnated poly(lactic-co-glycolic acid)microspheres on osteogenesis around titanium implants in rat tibia (2010)
  • Author(s): Masuzaki, Ayukawa, Koyano, ら
  • Journal Title: Biomaterials 31(12) Pages: 3327-3334
  • Peer Reviewed
• [Journal Article] The difference of fibroblast behavior on titanium substrata with different surface characteristics
  • Author(s): Furuhashi A, Ayukawa Y, Atsuta I, Okawachi H, Koyano K.
  • Journal Title: Odontology Volume: (印刷中)
  • NAID: 10030958595
  • Peer Reviewed
• [Presentation] 歯科領域におけるInterface制御-歯科インプラントにおけるインターフェース形成と制御- (2011)
  • Author(s): 鮎川保則
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2011-11-22
• [Presentation] 歯科領域におけるInterface制御-歯科インプラントにおけるインターフェース形成と制御- (2011)
  • Author(s): 鮎川保則
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2011-11-22
• [Presentation] バイオエンジニアリングが拓く補綴歯科イノベーション-臨床ニーズに即した骨再生のストラテジー- (2011)
  • Author(s): 鮎川保則
  • Organizer: 日本補綴歯科学会第120回記念学術大会
  • Place of Presentation: 広島市
  • Year and Date: 2011-05-21
• [Presentation] バイオエンジニアリングが拓く補綴歯科イノベーション-臨床ニーズに即した骨再生のストラテジー- (2011)
  • Author(s): 鮎川保則
  • Organizer: 日本補綴歯科学会第120回記念学術大会
  • Place of Presentation: 広島市(招待講演)
  • Year and Date: 2011-05-21
• [Presentation] Injectable PLGA-fluvastatin Microspheres Improve Bone Quality around Titanium Implants. (2010)
  • Author(s): Masuzaki T, Ayukawa Y, Koyano K, 他二名
  • Organizer: 88th General Session of the IADR
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] Injectable PLGA-fluvastatin Microspheres Improve Bone Quality around Titanium Implants (2010)
  • Author(s): T. Masuzaki, Y. Ayukawa, Y. Mor iyama, Y. Jinno, K. Koyano
  • Organizer: 88th General Session of the IADR
  • Place of Presentation: Barcelona
• [Remarks]
  • URL: http://www.implantgishi.dent.kyushu-u.ac.jp/index.html
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/koza/koku_kinou_shufuku/soshaku_kinou_saiken/webpages/research.html