| Project/Area Number |
21390523
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKADA Yukyo 東北大学, 大学院・歯学研究科, 准教授 (10206766)
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| Co-Investigator(Kenkyū-buntansha) |
KANETAKA Hiroyasu 東北大学, 大学院・歯学研究科, 准教授 (50292222)
SHIMIZU Yoshinaka 東北大学, 大学院・歯学研究科, 助教 (30302152)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUCHI Masafumi 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50250791)
TAKAHASHI Masatoshi 東北大学, 大学院・歯学研究科, 助教 (50400255)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | チタン合金 / Mg 合金 / 骨誘導 / Mg イオン / 細胞培養 / ALP / Ti-Mg 合金 / 骨形成 / マグネシウム合金 / Mgイオン / 血管内費細胞 / チタン / マグネシウム / インプラント / 生体材料 |
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| Research Abstract |
In this research program, we tried to develop the titanium alloy equipped with an osteoinductive property derived from sustained delivery of Mg ions. Although the Ti-Mg solid solution with the sustained delivery of Mg ions could not be obtained, under the conditions of Mg ions, the amount of DNAs and cell growth were as same as those of controls, and the ALP activity values significantly increased. Since the vascular proliferation was observed in the vascular endothelial cells and the lumen formation, we concluded that it is preferable to develop the Ti-Mg solid solution as anew functional material.
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