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Bisphosphonate-induced jawbone necrosis : studies for its mechanism, prevention, and treatment

Research Project

Project/Area Number 21390529
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

ENDO Yasuo  東北大学, 大学院・歯学研究科, 大学院非常勤講師 (50005039)

Co-Investigator(Kenkyū-buntansha) 横山 政宣  東北大学, 大学院・歯学研究科, 助教 (20396500)
永井 康裕  東北大学, 大学院・歯学研究科, 助教 (90508962)
Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI Kouji  東北大学, 大学院・歯学研究科, 大学院非常勤講師 (10372319)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsビスフォスフォネート / 顎骨壊死 / 骨吸収抑制薬 / 炎症 / 壊死 / 薬物副作用
Research Abstract

Bisphosphonates(BPs)are widely used as anti-bone-resorptive drugs, and nitrogen-containing BPs(NBPs)are much more powerful than non-nitrogen-containing BPs(non-NBPs). However, NBPs have inflammatory and necrotic side effects including jawbone necrosis. We have discovered that the non-NBPs etidronate and clodronate lack such side effects. On the contrary, they can prevent or reduce the NBPs'side effects. During the period of this project, we could accumulate many findings concerning the mechanisms underlying the NBPs'side effects and non-NBPs' protective effects and the effects of their combination on bone. In addition, we noted that the non-NBPs have a potent analgesic effect(lacked in NBPs and independent of their anti-bone-resorptive effects). Based on these findings, we propose that(i)etidronate and clodronate can be used as a substitution drug to NBPs and a combination drug with an NBP, respectively, and(ii)they warrant reappraisal as safe drugs for osteoporosis.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (57 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (47 results)

  • [Journal Article] Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice2011

    • Author(s)
      Harue Takahashi, Masayuki Kinbara, Naoki Sato, Keiichi Sasaki, Shunji Sugawara, Yasuo Endo
    • Journal Title

      International Immunopharmacol

      Volume: 11 Pages: 1534-1540

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice2011

    • Author(s)
      Takahashi H, Kinbara M, Sato N, Sasaki K, Sugawara S, Endo Y
    • Journal Title

      International Immunopharmacology

      Volume: 11(10)巻 Issue: 10 Pages: 1534-1540

    • DOI

      10.1016/j.intimp.2011.05.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pro-IL-1ss accumulation in macrophages by alendronate and its prevention by clodronate2010

    • Author(s)
      Yosuke Shikama, Yasuhiro Nagai, Satoru Okada, Takefumi Oizumi, Hidetoshi Shimauchi, Shunji Sugawara, Yasuo Endo
    • Journal Title

      Toxicol Lett

      Volume: 199 Pages: 123-128

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of necrotic actions of nitrogen-containing bisphosphonates(NBPs)and their elimination from bone by etidronate(a Non-NBP): a proposal for possible utilization of etidronate as a substitution drug for NBPs2010

    • Author(s)
      Takefumi Oizumi, Hiromi Funayama, Kouji Yamaguchi, Masayoshi Yokoyama, Harue Takahashi, Miou Yamamoto, Toshinobu Kuroishi, Hiroyuki Kumamoto, Keiichi Sasaki, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
    • Journal Title

      J Oral Maxillofacial Surgery

      Volume: 68 Pages: 1043-1054

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteonecrosis of the jawbones in 2 osteoporosis patients treated with a nitrogen-containing bisphosphonate : osteonecrosis reduction replacing NBP with non-NBP(etidronate)and rationale2010

    • Author(s)
      Kouji Yamaguchi, Takefumi Oizumi, Hiromi Funayama, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 68 Pages: 889-897

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of necroticactions of nitrogen-containing bisphosphonates (NBPs) and their elimination from bone by etidronate (a Non-NBP) : a proposal for possible utilization of etidronate as a substitution drug for NBPs.2010

    • Author(s)
      Takefumi Oizumi, Hiromi Funayama, Kouji Yamaguchi, Masayoshi Yokoyama, Harue Takahashi, Miou Yamamoto, Toshinobu Kuroishi, Hiroyuki Kumamoto, Keiic hiSasaki, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo.
    • Journal Title

      J Oral Maxillofacial Surgery

      Volume: 68 Pages: 1043-1054

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate.2010

    • Author(s)
      Yosuke Shikama, Yasuhiro Nagai , Satoru Okada, Takefumi Oizum i, Hidetoshi Shimauchi, Shunji Sugawara, Yasuo Endo.
    • Journal Title

      Toxicology Letters

      Volume: 199 Pages: 123-128

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteonecrosis of jawbones in two osteoporosis patients treated with a nitrogen-containing bisphosphonate(NBP) : attempts at osteonecrosis reduction by replacing NBP with non-NBP(etidronate)and the rationale for such therapy.2010

    • Author(s)
      Kouji Yamaguchi, Takefumi Oizumi, Hiromi Funayama, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
    • Journal Title

      J Oral Maxillofac Surg 68

      Pages: 889-897

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necrotic actions of nitrogen-containing bisphosphonates(NBPs)and their inhibition by clodronate(a non-NBP)in mice : potential for utilization of clodronate as a combination drug with an NBP2009

    • Author(s)
      Takefumi Oizum, Kouji Yamaguchi, Hiromi Funayama, Toshinobu Kuroishi, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
    • Journal Title

      Basic Clin Pharmacol Toxicol

      Volume: 104 Pages: 384-392

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Necrotic actions of nitrogen-containing bisphosphonates(NBPs)and their inhibition by clodronate(a non-NBP)in mice : potential for utilization of clodronate as a combination drug with an NBP2009

    • Author(s)
      Takefumi Oizumi, Kouji Yamaguchi, Hiromi Funayama, Toshinobu Kuroishi, Hiroshi Kawamura, Shunji Sugawara, Yasuo Endo
    • Journal Title

      Basic Clin Pharmacol Toxicol 104

      Pages: 384-392

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 窒素含有bisphosphonates(NBPs)による顎骨壊死 : etidronate(non-NBP)への切り換えを試みた5症例2011

    • Author(s)
      山口晃史, 大泉丈史, 岡田諭, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト・マウスの種々の細胞におよぼすzoledronateとetidronateのin vitroでの効果2011

    • Author(s)
      大泉丈史, 田中志典, 大木, 亜紀子(小澤, 亜紀子), 黒石智誠, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Bisphosphonates(BPs)の細胞内取り込み:マウス耳介皮膚でのBP構造類似物質および^3H-alendronate(^3H-Ale)を用いた検討2011

    • Author(s)
      岡田諭, 田中志典, 大泉丈史, 山口晃史, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] マウスにおけるminodronateの骨吸収抑制作用と炎症・壊死作用:他のbisphosphonatesとの比較2011

    • Author(s)
      木山朋美, 坂東加南, 岡田諭, 山口晃史, 金始瑛, 長谷川正和, 佐々木啓一, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛効果2011

    • Author(s)
      清流正弘, 金始瑛, 岡田諭, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス炎症性サイトカインに対するbisphosphonatesの効果2011

    • Author(s)
      船山ひろみ, 宗正隆明, 岡田諭, 遠藤康男, 朝田芳信
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)による顎骨壊死 : etidronate(non-NBP)への切り換えを試みた5症例2011

    • Author(s)
      山口晃史, 大泉丈史, 岡田諭, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト歯周組織細胞におよぼすzoledronateおよびetidronateのin vitroでの効果:他の細胞との比較(# 優秀ポスター賞)2011

    • Author(s)
      田中志典, 大泉丈史, 木山朋美, 岡田諭, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Bisphosphonates(BPs)の細胞内取り込み:マウス耳介皮膚でのBP構造類似物質および^3H-alendronate(^3H-Ale)を用いた検討2011

    • Author(s)
      岡田諭, 田中志典, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] マウスにおけるminodronateの骨吸収抑制作用と炎症・壊死作用:他のbisphosphonatesとの比較2011

    • Author(s)
      坂東加南, 山口晃史, 金始瑛, 岡田諭, 大泉丈史, 山本照子, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛効果2011

    • Author(s)
      金始瑛, 岡田諭, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates (BPs)の鎮痛効果2011

    • Author(s)
      金始瑛, 岡田諭, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bisphosphonates (BPs)の細胞内取り込み:マウス耳介皮膚でのBP構造類似物質および^3H-alendronate (^3H-Ale)を用いた検討2011

    • Author(s)
      岡田諭, 田中志典, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト歯周組織細胞におよぼすzoledronateおよびetidronateのin vitroでの効果:他の細胞との比較2011

    • Author(s)
      田中志典, 大泉丈史, 木山朋美, 岡田諭, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪(優秀ポスター賞受賞)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates (NBPs)による顎骨壊死:etidronate (non-NBP)への切り換えを試みた5症例2011

    • Author(s)
      山口晃史, 大泉丈史, 岡田諭, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates (BPs)の鎮痛効果2011

    • Author(s)
      清流正弘, 金始瑛, 岡田諭, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bisphosphonates (BPs)の細胞内取り込み:マウス耳介皮膚でのBP構造類似物質および^3H-alendronate (^3H-Ale)を用いた検討2011

    • Author(s)
      岡田諭, 田中志典, 大泉丈史, 山口晃史, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates (NBPs)による顎骨壊死:etidronate (non-NBP)への切り換えを試みた5症例2011

    • Author(s)
      山口晃史, 大泉丈史, 岡田諭, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 窒素含有bisphosphonatesのマウスでの炎症・壊死作用へのIL-18の関与2010

    • Author(s)
      船山ひろみ, 田島格, 遠藤康男, 朝田芳信
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] マクロファージにおけるAlendronateによるpro-IL-1b産生誘導とそのclodronateによる抑制2010

    • Author(s)
      四釜洋介, 永井康裕, 岡田諭, 大泉丈史, 島内英俊, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討2010

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 永井康裕, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛作用2010

    • Author(s)
      金始瑛, 永井康裕, 山本照子, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Alendronateによるマクロファージにおけるpro-IL-1ss産生誘導とclodronateによる抑制2010

    • Author(s)
      遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討2010

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス耳介でのzoledronateの炎症・壊死作用:炎症性サイトカインの関与2010

    • Author(s)
      船山ひろみ, 田島格, 遠藤康男, 朝田芳信
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討.2010

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男.
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alendronateによるマクロファージにおけるpro-IL-1β産生誘導とclodronate による抑制.2010

    • Author(s)
      遠藤康男.
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス耳介でのzonledronate の炎症・壊死作用:炎症性サイトカインの関与.2010

    • Author(s)
      船山ひろみ, 田島格, 遠藤康男, 朝田芳信.
    • Organizer
      骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛作用.2010

    • Author(s)
      金始瑛, 永井康裕, 山本照子, 菅原俊二, 遠藤康男.
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bisphosphonates(BPs)の炎症・壊死作用:マウス耳介皮膚での検討.2010

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 永井康裕, 菅原俊二, 遠藤康男.
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] マクロファーシにおけるAlendronateによるpro-IL-1β産生誘導とそのclodronateによる抑制.2010

    • Author(s)
      四釜洋介, 永井康裕, 岡田諭, 大泉丈史, 島内英俊, 菅原俊二, 遠藤康男.
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の壊死作用に対する組織サイトカインの関与:LPSによる増強とclodronate(non-NBP)による抑制2009

    • Author(s)
      船山ひろみ, 田島格, 遠藤康男, 朝田芳信
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 骨粗鬆症患者における窒素含有ビスホスホネート(NBPs)による顎骨壊死:Etidronate(non-NBP)への切り換えの試み2009

    • Author(s)
      山口晃史, 大泉丈史, 岡田諭, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Bisphosphonates (BPs)の高齢マウス脛骨での効果2009

    • Author(s)
      大泉丈史, 岡田諭, 山口晃史, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の壊死作用:NBPsの細胞内取り込みに関する検討2009

    • Author(s)
      木山朋美, 大泉丈史, 山口晃史, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Bisphosphonates(BPs)の高齢マウス脛骨での効果2009

    • Author(s)
      大泉丈史, 岡田諭, 山口晃史, 菅原俊二, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 窒素含有bisphosphonateの骨との結合におよぼすetidronateの効果に関する分子イメージング的検討2009

    • Author(s)
      山本未央, 横山政宣, 高橋春江, 遠藤康男, 佐々木啓一
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の骨への結合: non-NBPsの効果2009

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の骨への結合:non-NBPsの効果2009

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の骨への結合: non-NBPsの効果2009

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の骨への結合:non-NBPsの効果2009

    • Author(s)
      岡田諭, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の壊死作用: NBPsの細胞内取り込みに関する検討2009

    • Author(s)
      木山朋美, 大泉丈史, 山口晃史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨粗鬆症患者における窒素含有bisphosphonates(NBPs)による顎骨壊死: Etidronate(non-NBP)への切り換えを試みた3症例2009

    • Author(s)
      山口晃史, 大泉丈史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有bisphosphonateの骨との結合におよぼすetidronateの効果(BP-Update)2009

    • Author(s)
      岡田諭, 大泉丈史, 横山政宣, 高橋春江, 山本未央, 山口晃史, 佐々木啓一, 川村仁, 菅原俊二, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有 bisphosphonateの骨との結合におよぼすetidronateの効果(招待講演)2009

    • Author(s)
      岡田諭, 大泉丈史, 横山政宣, 高橋春江, 山本未央, 山口晃史, 佐々木啓一, 川村仁, 菅原俊二, 遠藤康男
    • Organizer
      骨代謝学会:BP-Update
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨粗鬆症患者における窒素含有bisphosphonates(NBPs)による顎骨壊死:Etidronate(non-NBP)への切り換えを試みた3症例2009

    • Author(s)
      山口晃史, 大泉丈史, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 窒素含有bisphosphonates(NBPs)の壊死作用:NBPsの細胞内取り込みに関する検討2009

    • Author(s)
      木山朋美, 大泉丈史, 山口晃, 遠藤康男
    • Organizer
      骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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