Analysis of optimal dose of anticancer drug in superselective intra-arterial infusion using computational fluid dynamics based on biomedical engineering
| Project/Area Number |
21390542
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUDOU Kenji 横浜市立大学, 医学部, 准教授 (70303641)
IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191)
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| Co-Investigator(Renkei-kenkyūsha) |
OSHIMA Marie 東京大学, 情報学環, 教授 (40242127)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 口腔癌 / 動注化学療法 / 流体解析 / 流体シミュレーション / 血流シミュレーション / 抗癌剤 / シミュレーション / 超選択的動注法 / 化学療法 / 血流 / 医工連携 |
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| Research Abstract |
To clarify distribution of anticancer drug to tumor feeding artery or metastatic lymph node in intra-arterial infusion for oral cancer, we developed blood flow simulation of the external carotid artery and its branch using computational fluid dynamics. For accurate simulation, we applied 0D model with peripheral network and assessment of the simulation was performed using blood flow of the superficial temporal artery. The error of this simulation was about 5%, and the base of patient-specific blood flow simulation of the external carotid artery and its branch was established.
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Report
(4 results)
Research Products
(2 results)
