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Analysis of optimal dose of anticancer drug in superselective intra-arterial infusion using computational fluid dynamics based on biomedical engineering

Research Project

Project/Area Number 21390542
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionYokohama City University

Principal Investigator

TOHNAI Iwai  横浜市立大学, 医学研究科, 教授 (50172127)

Co-Investigator(Kenkyū-buntansha) MITSUDOU Kenji  横浜市立大学, 医学部, 准教授 (70303641)
IWAI Toshinori  横浜市立大学, 附属病院, 助教 (00468191)
Co-Investigator(Renkei-kenkyūsha) OSHIMA Marie  東京大学, 情報学環, 教授 (40242127)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2009: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords口腔癌 / 動注化学療法 / 流体解析 / 流体シミュレーション / 血流シミュレーション / 抗癌剤 / シミュレーション / 超選択的動注法 / 化学療法 / 血流 / 医工連携
Research Abstract

To clarify distribution of anticancer drug to tumor feeding artery or metastatic lymph node in intra-arterial infusion for oral cancer, we developed blood flow simulation of the external carotid artery and its branch using computational fluid dynamics. For accurate simulation, we applied 0D model with peripheral network and assessment of the simulation was performed using blood flow of the superficial temporal artery. The error of this simulation was about 5%, and the base of patient-specific blood flow simulation of the external carotid artery and its branch was established.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2011

All Presentation (2 results)

  • [Presentation] 外頸動脈における血流動態の基礎的研究-流体解析を用いた血流シミュレーション-2011

    • Author(s)
      大原良仁, 岩井俊憲, 矢島康治, 大屋貴志, 光藤健司, 藤内祝
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 外頸動脈における血流動態の基礎的研究-流体解析を用いた血流シミュレーション-2011

    • Author(s)
      大原良仁, 岩井俊憲, 矢島康治, 大屋貴志, 光藤健司, 藤内祝
    • Organizer
      第50回日本口腔外科学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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