| Project/Area Number |
21390547
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMASHIRO Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70294428)
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| Co-Investigator(Kenkyū-buntansha) |
YABUUCHI Toshinori 岡山大学, 岡山大学病院, 医員 (00452582)
KAWABE Noriaki (KUROSAKA Hiroshi) 岡山大学, 岡山大学病院, 講師 (00397879)
NAKAGAWA Ichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (70294113)
黒坂 寛 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20509369)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUSHIMA Noboru 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10353434)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | オートファジー / 口蓋の形成 / 口蓋突起 / 骨組織 / ERストレス / ATG5 / LC3 / 小胞体ストレス / 口唇口蓋裂 / 骨形成 / 口蓋 / 顎顔面 / 骨格 / 骨芽細胞 |
|---|
| Research Abstract |
Autophagy is a bulk protein degradation system and important for various physiological processes such as cell survival under starvation, development, immune responses, tumor suppression, and antiaging. The present study demonstrated that autophagy is involved in the palatal fusion in palatogenesis. Our study also indicated autophagy is also involved in osteogeneis and suggested that autopahgy might regulate the ER stress responses presumably to maintain cellular homeostasis.
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