Analysis of roles of Wnt5a in alveolar bone remodeling, and their application for orthodontic tooth movement.
| Project/Area Number |
21390551
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Naoyuki 松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
HIRAGA Tohru 松本歯科大学, 歯学部, 准教授 (70322170)
YAMASHITA Teruhito 松本歯科大学, 総合歯科医学研究所, 講師 (90302893)
MIZOGUCHI Toshihide 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 歯科矯正学 / 破骨細胞 / Wnt5a / 骨芽細胞特異的遺伝子欠損 / 骨吸収 / 骨形成 / 歯の移動 / 骨代謝回転 / 加齢 / Wnt / 歯槽骨 / コンディショナルノックアウト |
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| Research Abstract |
Wnt5a secreted from osteoblasts binds to Ror2 receptors in osteoclast precursors. Ror2-mediated signals promote RANK expression in osteoclast precursors, thereby enhancing RANKL-induced osteoclastogenesis. In addition, Wnt5a enhances osteoblastic differentiation and inhibits adipogenesis. Together, Wnt5a regulates osteoclastogenesis and osteogenesis in alveolar bone remodeling.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Wnt による破骨細胞の分化制御機構2012
Author(s)
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
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Journal Title
細胞
Volume: 24
Pages: 2176-2185
DOI
Related Report
Peer Reviewed
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[Journal Article] Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi NWnt5a-Ror2 signaling betweenosteoblast-lineage cells and osteoclast precursors enhancesosteoclastgenesis.2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat Med.
Volume: (印刷中)
Pages: 405-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone.2012
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
J Bone MinerRes.Dec;
Volume: 26
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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[Journal Article] Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices-a simple method for identifying polarized osteoclasts2011
Author(s)
Nakayama T, Mizoguchi T, Uehara S, Yamashita T, Kawahara I, Kobayashi Y, Moriyama Y, Kurihara S, Sahara N, Ozawa H, Udagawa N, Takahashi N
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Journal Title
Bone
Volume: 49
Pages: 1331-1339
URL
Related Report
Peer Reviewed
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[Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice2010
Author(s)
Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT.
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Journal Title
Biochem. Pharmacol
Volume: 80
Pages: 352-361
URL
Related Report
Peer Reviewed
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