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Analysis of roles of Wnt5a in alveolar bone remodeling, and their application for orthodontic tooth movement.

Research Project

Project/Area Number 21390551
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

KOBAYASHI Yasuhiro  松本歯科大学, 総合歯科医学研究所, 准教授 (20264252)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Naoyuki  松本歯科大学, 総合歯科医学研究所, 教授 (90119222)
HIRAGA Tohru  松本歯科大学, 歯学部, 准教授 (70322170)
YAMASHITA Teruhito  松本歯科大学, 総合歯科医学研究所, 講師 (90302893)
MIZOGUCHI Toshihide  松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords歯科矯正学 / 破骨細胞 / Wnt5a / 骨芽細胞特異的遺伝子欠損 / 骨吸収 / 骨形成 / 歯の移動 / 骨代謝回転 / 加齢 / Wnt / 歯槽骨 / コンディショナルノックアウト
Research Abstract

Wnt5a secreted from osteoblasts binds to Ror2 receptors in osteoclast precursors. Ror2-mediated signals promote RANK expression in osteoclast precursors, thereby enhancing RANKL-induced osteoclastogenesis. In addition, Wnt5a enhances osteoblastic differentiation and inhibits adipogenesis. Together, Wnt5a regulates osteoclastogenesis and osteogenesis in alveolar bone remodeling.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(33 results)

All 2012 2011 2010 2009

All Journal Article Presentation Book

  • [Journal Article] c-Fos plays an essential role in the up-regulation of RANK expression in osteoclast precursors within the bone microenvironment2012

    • Author(s)
      Arai A, Mizoguchi T, Harada S, Kobayashi Y, Nakamichi Y, Yasuda H, Penninger JM, Yamada K, Udagawa N, Takahashi N
    • Journal Title

      J. Cell Sci

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt による破骨細胞の分化制御機構2012

    • Author(s)
      Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
    • Journal Title

      細胞

      Volume: 24 Pages: 2176-2185

    • DOI
      10.1002/adma.201103832
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wntによる骨代謝制御機構2012

    • Author(s)
      小林泰浩
    • Journal Title

      The Bone

      Volume: 26 Pages: 151-159

    • Related Report
      2011 Final Research Report
  • [Journal Article] Nishita M, Marumo K, Martin TJ, Minami Y, Takahashi NWnt5a-Ror2 signaling betweenosteoblast-lineage cells and osteoclast precursors enhancesosteoclastgenesis.2012

    • Author(s)
      Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
    • Journal Title

      Nat Med.

      Volume: (印刷中) Pages: 405-12

    • DOI
      10.1038/nm.2653
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.2012

    • Author(s)
      Harada S et al.
    • Journal Title

      J. Bone Miner. Res.

      Volume: 27 Pages: 461-473

    • DOI
      10.1002/jbmr.555
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tetracyclines Convert the Osteoclastic-Differentiation Pathway of Progenitor Cells To Produce Dendritic Cell-like Cells2012

    • Author(s)
      Kinugawa S et al.
    • Journal Title

      J Immunology

      Volume: 188 Pages: 1772-1781

    • DOI
      10.4049/jimmunol.1101174
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone.2012

    • Author(s)
      Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
    • Journal Title

      J Bone MinerRes.Dec;

      Volume: 26 Pages: 2978-2990

    • DOI
      10.1002/jbmr.490
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming2012

    • Author(s)
      Hosoya A, Hiraga T, Ninomiya T, Yukita A, Yoshiba K, Yoshiba N, Takahashi M, Ito S, Nakamura H.
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 137(6) Pages: 733-42

    • DOI
      10.1007/s00418-012-0928-1
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices-a simple method for identifying polarized osteoclasts2011

    • Author(s)
      Nakayama T, Mizoguchi T, Uehara S, Yamashita T, Kawahara I, Kobayashi Y, Moriyama Y, Kurihara S, Sahara N, Ozawa H, Udagawa N, Takahashi N
    • Journal Title

      Bone

      Volume: 49 Pages: 1331-1339

    • URL
      http://dx.doi.org/10.1016/j.bone.2011.09.045
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E(2) receptor EP(4)-selective agonist(ONO-4819) increases bone formation by modulating mesenchymal cell differentiation2011

    • Author(s)
      Ninomiya T, Hosoya A, Hiraga T, Koide M, Yamaguchi K, Oida H, Arai Y, Sahara N, Nakamura H, Ozawa H
    • Journal Title

      Eur. J. Pharmacol

      Volume: 650 Pages: 396-402

    • URL
      http://dx.doi.org/10.1016/j.ejphar.2010.10.021
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential2011

    • Author(s)
      Hiraga T, Ito S, Nakamura H.
    • Journal Title

      Oncol. Rep

      Volume: 25(1) Pages: 289-296

    • DOI
      10.3892/or_00001073
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals2011

    • Author(s)
      Takahashi N, Maeda K, Ishihara A, Uehara S, Kobayashi Y
    • Journal Title

      Front. Biosci

      Volume: 16 Pages: 21-30

    • URL
      http://dx.doi.org/10.2741/3673
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals.2011

    • Author(s)
      Takahashi N, et.al.
    • Journal Title

      Front Biosci

      Volume: 16 Pages: 21-30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of osteoclasts in culture.2011

    • Author(s)
      Udagawa N, et.al.
    • Journal Title

      Methods Mol Biol.

      Volume: 690 Pages: 273-284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice2010

    • Author(s)
      Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT.
    • Journal Title

      Biochem. Pharmacol

      Volume: 80 Pages: 352-361

    • URL
      http://dx.doi.org/10.1016/j.bcp.2010.04.014
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade : a potential mechanism of inflammatory pain2010

    • Author(s)
      Nakanishi M, Hata K, Nagayama T, SakuraiT, Nishisho T, Wakabayashi H, Hiraga T, Ebisu S, Yoneda T.
    • Journal Title

      Mol. Biol. Cell

      Volume: 21(15) Pages: 2568-2577

    • DOI
      10.1091/mbc.e10-01-0049
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administration of the bisphosphonate zoledronic acid during tooth development inhibits tooth eruption and formation and induces dental abnormalities in rats2010

    • Author(s)
      Hiraga T, Ninomiya T, Hosoya A, Nakamura H.
    • Journal Title

      Calcif. Tissue Int

      Volume: 86(6) Pages: 502-10

    • DOI
      10.1007/s00223-010-9366-z
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.2010

    • Author(s)
      Lee JW, et.al.
    • Journal Title

      Biochem Pharmacol.

      Volume: 80 Pages: 352-361

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alisol-B, a novel phyto-steroid, suppressed the RANKL-induced osteoclast formation and prevents bone loss in mice.2010

    • Author(s)
      Lee JW, et al.
    • Journal Title

      Biochem Pharmacol. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Action of RANKL and OPG for osteoclastogenesis2009

    • Author(s)
      Kobayashi Y, Udagawa N, Takahashi N
    • Journal Title

      Crit. Rev. Eukaryot. Gene Expr

      Volume: 19 Pages: 61-72

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009

    • Author(s)
      Koide M, et al.
    • Journal Title

      J Bone Miner Res. 24

      Pages: 1469-1480

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Wnt5a-Ror2シグナルによる破骨細胞分化制御機構2012

    • Author(s)
      小林泰浩
    • Organizer
      第10回口腔医科学フロンティア学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Wntシグナルによる破骨細胞分化調節機構の解析2010

    • Author(s)
      小林泰浩、溝口利英、上原俊介、高橋直之、宇田川信之
    • Organizer
      第71回松本歯科大学学会例会
    • Place of Presentation
      塩尻
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Wnt5aはRANKの発現を亢進し、破骨細胞分化を促進する2010

    • Author(s)
      小林泰浩, 前田和洋、上原俊介、高田伊知郎、加藤茂明、丸毛啓史、宇田川信之、高橋直之
    • Organizer
      第28回日本骨代謝学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 漢方牛蒡子由来のアルクチゲニンは破骨細胞の機能と分化を抑制する2010

    • Author(s)
      山下照仁、上原俊介、小林泰浩、宇田川信之、高橋直之
    • Organizer
      第28回日本骨代謝学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions2010

    • Author(s)
      Kobayashi Y, et al
    • Organizer
      3^<rd> International conference on osteoimmun ology
    • Place of Presentation
      Santorini, Greece
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions2010

    • Author(s)
      Kobayayahi Yasuhiro
    • Organizer
      3rd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal systems
    • Place of Presentation
      Nomikos Conference Center, Santorini
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ror2-mediated noncanonical Wnt signaling enhances RANKL-induced osteoclast formation in physiological and pathological conditions2009

    • Author(s)
      小林泰浩
    • Organizer
      第26回 内藤カンファレンスOsteobiology
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ror2-mediated noncanonical Wnt signaling stimulates physiological and pathological osteoclastogenesis in a cell autonomous manner2009

    • Author(s)
      Kobayashi Y
    • Organizer
      第6回Bone Biology Forum
    • Place of Presentation
      裾野
    • Year and Date
      2009-08-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Ror2-mediated noncanonical Wnt signaling stimulates physiological and pathological osteoclastogenesis in a cell autonomous manner2009

    • Author(s)
      小林泰浩
    • Organizer
      第6回 Bone Biology Forum
    • Place of Presentation
      帝人富士教育研修所
    • Year and Date
      2009-08-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性骨疾患におけるWntの役割2009

    • Author(s)
      小林泰浩
    • Organizer
      第27回日本骨代謝学会、ミニシンポジウムOsteoimmunology 11
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症性骨疾患におけるWntシグナルの役割2009

    • Author(s)
      小林泰浩
    • Organizer
      第27回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Book] Identification of osteoclasts in culture2011

    • Author(s)
      Udagawa N, Yamashita T, Kobayashi Y, Takahashi N, Nicole I zur Nieden
    • Publisher
      Springer Science
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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